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公开(公告)号：US20140371209A1
公开(公告)日：2014-12-18
申请号：US13983489
申请日：2012-02-03
Applicant: Jermaine Thomas , Sha Mi , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Kevin Guckian , Gnanasambandam Kumaravel
Inventor： Jermaine Thomas , Sha Mi , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin Guckian , Gnanasambandam Kumaravel
IPC: C07D401/06 , C07D211/62 , C07D215/20
CPC classification number: A61K31/445 , A61K31/225 , A61K31/4545 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/55 , A61K31/695 , A61K38/21 , A61K39/3955 , C07D211/34 , C07D211/60 , C07D211/62 , C07D215/20 , C07D401/06 , C07D405/12 , C07K16/2842
Abstract: Compounds of formula (I) or (II) can modulate the activity of SIP receptors.
Abstract translation: 式（I）或（II）的化合物可以调节SIP受体的活性。
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公开(公告)号：US08269043B2
公开(公告)日：2012-09-18
申请号：US12588883
申请日：2009-10-30
Applicant: Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
Inventor： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC: C07C211/00 , C09B11/02 , A61K31/66
CPC classification number: A61K31/135 , A61K31/27 , C07C205/26 , C07C205/50 , C07C217/52 , C07C217/60 , C07C229/32 , C07C271/16 , C07D263/38 , C07F9/091 , C07F9/093 , C07F9/653 , C07F9/65744
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
Abstract translation: 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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3.发明申请Arylphenylamino-,Arylphenylamide-, and Arylphenylether-Sulfide Derivatives 审中-公开芳基苯基氨基 - ，芳基苯基酰胺 - 和芳基苯基醚 - 硫化物衍生物
公开(公告)号：US20070259863A1
公开(公告)日：2007-11-08
申请号：US11587732
申请日：2005-04-28
Applicant: Donovan Chin , Thomas Durand-Reville , Francine Farouz , Kerry Fowler , Kevin Guckian , Irina Jaconbson , Ramesh Kasar , Russell Petter , Daniel Scott , C. Gregory Sowell , Eugene Thorsett , Edward Yin-Shiang Lin
Inventor： Donovan Chin , Thomas Durand-Reville , Francine Farouz , Kerry Fowler , Kevin Guckian , Irina Jaconbson , Ramesh Kasar , Russell Petter , Daniel Scott , C. Gregory Sowell , Eugene Thorsett , Edward Yin-Shiang Lin
IPC: C07D307/54
CPC classification number: C07D233/64 , C07C323/62 , C07C2601/14 , C07C2602/44 , C07D207/14 , C07D207/26 , C07D211/56 , C07D211/58 , C07D213/34 , C07D213/56 , C07D231/40 , C07D257/04 , C07D261/08 , C07D261/10 , C07D295/185 , C07D307/54 , C07D309/14 , C07D333/34 , C07D335/02 , C07D401/12 , C07D405/12 , C07D409/12 , C07D451/02 , C07D451/04
Abstract: The present invention relates in part to compounds of formulas I and III: and pharmaceutically-acceptable salts and prodrugs thereof. These compounds can be useful for treating diseases such as inflammatory and immune diseases. The present invention also relates to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a subject.
Abstract translation: 本发明部分地涉及式I和III的化合物及其药学上可接受的盐和前药。 这些化合物可用于治疗疾病如炎症和免疫疾病。 本发明还涉及包含这些化合物的药物组合物，以及抑制受试者的炎症或抑制免疫应答的方法。
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公开(公告)号：US20140309190A1
公开(公告)日：2014-10-16
申请号：US14306231
申请日：2014-06-17
Applicant: Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Ma Bin , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
Inventor： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Ma Bin , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: A61K31/695 , A61K31/11 , A61K31/18 , A61K31/216 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/683 , A61K31/662 , A61K31/47 , A61K31/277 , A61K31/41 , A61K31/4709 , A61K31/472 , A61K31/337 , A61K31/517 , A61K31/428 , A61K31/404 , A61K45/06 , C07C43/247 , C07C47/575 , C07C311/51 , C07C229/14 , C07D205/04 , C07D207/16 , C07D211/62 , C07F9/40 , C07D215/227 , C07C255/54 , C07D257/04 , C07F7/08 , C07D401/06 , C07D217/04 , C07D305/08 , C07D239/74 , C07D277/64 , C07D209/08 , C07F9/38 , A61K31/085
CPC classification number: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
Abstract translation: 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是肌氨酸 - 甙类似物，磷酸化后，可以作为S1P受体的激动剂。
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公开(公告)号：US08802659B2
公开(公告)日：2014-08-12
申请号：US13389054
申请日：2010-08-05
Applicant: Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
Inventor： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: C07C43/00 , C07C47/575 , C07C229/36 , C07C311/51 , C07D205/04 , C07D207/16 , C07D211/62 , C07D215/227 , C07D239/74 , C07D403/06
CPC classification number: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
Abstract translation: 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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公开(公告)号：US08546359B2
公开(公告)日：2013-10-01
申请号：US13608227
申请日：2012-09-10
Applicant: Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
Inventor： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC: A01N57/00 , C07C211/00
CPC classification number: A61K31/135 , A61K31/27 , C07C205/26 , C07C205/50 , C07C217/52 , C07C217/60 , C07C229/32 , C07C271/16 , C07D263/38 , C07F9/091 , C07F9/093 , C07F9/653 , C07F9/65744
Abstract: Compounds that have agonist activity at one or more of the SIP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SIP receptors.
Abstract translation: 提供了在一种或多种SIP受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为SIP受体的激动剂。
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公开(公告)号：US20130059821A1
公开(公告)日：2013-03-07
申请号：US13608227
申请日：2012-09-10
Applicant: Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
Inventor： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC: A61K31/137 , A61K31/421 , A61K31/337 , A61K31/505 , A61K31/56 , A61P25/00 , A61P37/00 , A61P3/10 , A61P19/02 , A61P1/00 , A61P17/06 , A61K31/661 , A61P29/00
CPC classification number: A61K31/135 , A61K31/27 , C07C205/26 , C07C205/50 , C07C217/52 , C07C217/60 , C07C229/32 , C07C271/16 , C07D263/38 , C07F9/091 , C07F9/093 , C07F9/653 , C07F9/65744
Abstract: Compounds that have agonist activity at one or more of the SIP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SIP receptors.
Abstract translation: 提供了在一种或多种SIP受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为SIP受体的激动剂。
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公开(公告)号：US08349849B2
公开(公告)日：2013-01-08
申请号：US12588882
申请日：2009-10-30
Applicant: Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
Inventor： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC: A61K31/517
CPC classification number: A61K31/135 , A61K31/22 , C07C217/52 , C07C217/74 , C07C2602/10 , C07D215/20 , C07D239/74
Abstract: Compounds of formula (I): that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
Abstract translation: 提供式（I）化合物：在一种或多种S1P受体上具有激动剂活性。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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9.发明申请Indazole derivatives as modulators of interleukin-1 receptor-associated kinase 有权吲唑衍生物作为白细胞介素-1受体相关激酶的调节剂
公开(公告)号：US20110152260A1
公开(公告)日：2011-06-23
申请号：US12440163
申请日：2007-09-07
Applicant: Kevin Guckian , Charles Jewell , Patrick Conlon , Edward Yin Shiang Lin , Timothy Chan
Inventor： Kevin Guckian , Charles Jewell , Patrick Conlon , Edward Yin Shiang Lin , Timothy Chan
IPC: A61K31/5377 , C07D403/02 , A61K31/4184 , C07D401/14 , A61K31/4439 , C07D413/14 , A61K31/4545 , A61K31/496 , A61P19/02 , A61P1/00 , A61P25/28 , A61P17/06 , A61P35/00 , A61P37/08 , A61P3/00 , A61P37/06
CPC classification number: C07D403/12 , C07D401/14 , C07D403/14
Abstract: The present invention relates to modulators of IRAK kinases of formula (I) and provides compositions comprising such modulators, as well as methods therewith for treating IRAK-mediated or IRAK-associated conditions or diseases.
Abstract translation: 本发明涉及式（I）的IRAK激酶的调节剂，并提供包含这种调节剂的组合物，以及其用于治疗IRAK介导的或与IRAK相关的病症或疾病的方法。
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公开(公告)号：US20100160357A1
公开(公告)日：2010-06-24
申请号：US12588882
申请日：2009-10-30
Applicant: Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
Inventor： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC: A61K31/517 , G01N33/53 , A61K31/47 , A61K31/421 , C07D239/74 , C07D215/14 , C07D215/20 , C07D263/24 , A61P25/00 , A61P37/00 , A61P1/00 , A61P11/06
CPC classification number: A61K31/135 , A61K31/22 , C07C217/52 , C07C217/74 , C07C2602/10 , C07D215/20 , C07D239/74
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
Abstract translation: 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
