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公开(公告)号:US20110237529A1
公开(公告)日:2011-09-29
申请号:US12515033
申请日:2007-11-16
申请人: Efrat Ben-Zeev , Vincent Jacques , Yael Marantz , A. Sekar Reddy , Zhaoda Zhang , Oren Becker , Dilara Mccauley , Pini Orbach , Sharon Shacham , Ashis K. Saha , Michael Xie
发明人: Efrat Ben-Zeev , Vincent Jacques , Yael Marantz , A. Sekar Reddy , Zhaoda Zhang , Oren Becker , Dilara Mccauley , Pini Orbach , Sharon Shacham , Ashis K. Saha , Michael Xie
IPC分类号: A61K31/7076 , C07H15/203 , C07H7/04 , C07H7/06 , C07H17/02 , C07H19/20 , A61K31/7064 , A61P11/00 , A61P1/04 , A61P1/02 , A61P1/00 , A61P1/10 , C12N5/071
CPC分类号: A61K31/7076 , A61K31/7034 , A61K31/7072 , C07H15/203 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00
摘要: The invention provides adenosine analog compounds that act at P2Y receptors, e.g., the P2Y2 receptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer.
摘要翻译: 本发明提供了在P2Y受体(例如P2Y2受体)上起作用的腺苷类似物化合物,包括药物组合物; (COPD),哮喘,便秘,慢性特发性便秘,口干(口腔干燥症),牙龈疾病 ,以及由辐射和化学治疗癌症引起的胃肠道问题。
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公开(公告)号:US08569259B2
公开(公告)日:2013-10-29
申请号:US12515033
申请日:2007-11-16
申请人: Efrat Ben-Zeev , Vincent Jacques , Yael Marantz , A. Sekar Reddy , Zhaoda Zhang , Oren Becker , Dilara McCauley , Pini Orbach , Sharon Shacham , Ashis K. Saha , Michael Xie
发明人: Efrat Ben-Zeev , Vincent Jacques , Yael Marantz , A. Sekar Reddy , Zhaoda Zhang , Oren Becker , Dilara McCauley , Pini Orbach , Sharon Shacham , Ashis K. Saha , Michael Xie
CPC分类号: A61K31/7076 , A61K31/7034 , A61K31/7072 , C07H15/203 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00
摘要: Provided are adenosine analog compounds of the general formula that act as P2Y receptors, e.g., the P2Y2 receptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer.
摘要翻译: 提供了作为P2Y受体的通式的腺苷类似物化合物,例如P2Y2受体,包括药物组合物; (COPD),哮喘,便秘,慢性特发性便秘,口干(口腔干燥症),牙龈疾病 ,以及由辐射和化学治疗癌症引起的胃肠道问题。
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公开(公告)号:US08937065B2
公开(公告)日:2015-01-20
申请号:US13491069
申请日:2012-06-07
申请人: Oren M. Becker , Itai Bloch , Efrat Ben-Zeev , Alina Shitrit , Avihai Yacovan , Sharon Gazal , Vered Behar , Alexander Konson , Nili Schutz , Sima Mirilashvili , Gali Golan
发明人: Oren M. Becker , Itai Bloch , Efrat Ben-Zeev , Alina Shitrit , Avihai Yacovan , Sharon Gazal , Vered Behar , Alexander Konson , Nili Schutz , Sima Mirilashvili , Gali Golan
IPC分类号: A61K31/5377 , A61K31/427 , C07D413/14 , C07D417/14 , C07D417/12 , C07D417/04 , C07D471/04 , C07D487/04 , C07D491/113 , C07D491/147 , C07D495/04 , C07D495/22 , C07D513/04
CPC分类号: C07D417/04 , A61K31/427 , A61K31/5377 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/113 , C07D491/147 , C07D495/04 , C07D495/22 , C07D513/04
摘要: The invention relates to compounds and methods for modulating one or more components of a kinase signaling cascade.
摘要翻译: 本发明涉及用于调节激酶信号级联的一种或多种成分的化合物和方法。
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公开(公告)号:US08692001B2
公开(公告)日:2014-04-08
申请号:US13281929
申请日:2011-10-26
申请人: Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Tzofit Kehat , Sima Mirilashvili , Alex Aizikovich , Daniel Sherman , Vered Behar , Osnat Kashtan
发明人: Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Tzofit Kehat , Sima Mirilashvili , Alex Aizikovich , Daniel Sherman , Vered Behar , Osnat Kashtan
IPC分类号: C07D405/02 , A61K31/405
CPC分类号: C07D209/08 , C07D319/18 , C07D403/12 , C07D413/12 , C07D413/14
摘要: The invention relates to sulfonamide compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.
摘要翻译: 本发明涉及磺酰胺化合物和激活PKM2的方法。 所述化合物和方法可用于治疗或预防选自癌症,细胞增殖性疾病,炎症性疾病,代谢紊乱和免疫系统疾病的疾病或病症。
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公开(公告)号:US20120316148A1
公开(公告)日:2012-12-13
申请号:US13491069
申请日:2012-06-07
申请人: Oren M. Becker , Itai Bloch , Efrat Ben-Zeev , Alina Shitrit , Avihai Yacovan , Sharon Gazal , Vered Behar , Alexander Konson , Nili Schutz , Sima Mirilashvili , Gali Golan
发明人: Oren M. Becker , Itai Bloch , Efrat Ben-Zeev , Alina Shitrit , Avihai Yacovan , Sharon Gazal , Vered Behar , Alexander Konson , Nili Schutz , Sima Mirilashvili , Gali Golan
IPC分类号: A61K31/427 , A61K31/496 , A61K31/5377 , A61K31/454 , A61K31/4439 , A61K31/497 , C07D417/04 , C07D491/113 , A61K31/438 , A61K31/55 , C07D495/04 , A61K31/4365 , C07D471/04 , C07D487/04 , A61P35/00 , A61P37/00 , A61P37/06 , A61P29/00 , A61P27/02 , A61P17/06 , A61P19/02 , A61P25/00 , C07D417/14
CPC分类号: C07D417/04 , A61K31/427 , A61K31/5377 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/113 , C07D491/147 , C07D495/04 , C07D495/22 , C07D513/04
摘要: The invention relates to compounds and methods for modulating one or more components of a kinase signaling cascade.
摘要翻译: 本发明涉及用于调节激酶信号级联的一种或多种成分的化合物和方法。
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公开(公告)号:US20120302609A1
公开(公告)日:2012-11-29
申请号:US13479131
申请日:2012-05-23
申请人: Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Daniel Sherman , Vered Behar , Osnat Kashtan , Alexander Konson
发明人: Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Daniel Sherman , Vered Behar , Osnat Kashtan , Alexander Konson
IPC分类号: A61K31/4155 , A61K31/415 , C07D405/10 , C07D405/14 , C07D401/06 , A61P35/00 , C07D409/04 , A61P37/00 , A61P37/06 , A61P29/00 , A61P3/00 , C07D231/06 , A61K31/4439
CPC分类号: C07D231/06 , C07D401/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04
摘要: The invention relates to pyrazoline substituted compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.
摘要翻译: 本发明涉及吡唑啉取代的化合物和激活PKM2的方法。 所述化合物和方法可用于治疗或预防选自癌症,细胞增殖性疾病,炎症性疾病,代谢紊乱和免疫系统疾病的疾病或病症。
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公开(公告)号:US20120108631A1
公开(公告)日:2012-05-03
申请号:US13281929
申请日:2011-10-26
申请人: Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Tzofit Kehat , Sima Mirilashvili , Alex Aizikovich , Daniel Sherman , Vered Behar , Osnat Kashtan
发明人: Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Tzofit Kehat , Sima Mirilashvili , Alex Aizikovich , Daniel Sherman , Vered Behar , Osnat Kashtan
IPC分类号: A61K31/404 , C07D319/18 , C07D403/12 , C07D209/08 , A61P37/00 , A61K31/4709 , A61K31/357 , A61P35/00 , A61P29/00 , A61P3/00 , C07D405/12 , C07D405/14
CPC分类号: C07D209/08 , C07D319/18 , C07D403/12 , C07D413/12 , C07D413/14
摘要: The invention relates to sulfonamide compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.
摘要翻译: 本发明涉及磺酰胺化合物和激活PKM2的方法。 所述化合物和方法可用于治疗或预防选自癌症,细胞增殖性疾病,炎性疾病,代谢紊乱和免疫系统疾病的疾病或病症。
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公开(公告)号:US08569282B2
公开(公告)日:2013-10-29
申请号:US12747109
申请日:2008-12-11
申请人: Efrat Ben-Zeev , Dongli Chen , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumna Mohanty , Sharon Shacham , Zhaoda Zhang
发明人: Efrat Ben-Zeev , Dongli Chen , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumna Mohanty , Sharon Shacham , Zhaoda Zhang
IPC分类号: C07D471/04 , A61K31/4375
CPC分类号: C07D471/04
摘要: Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.
摘要翻译: 本文描述了趋化因子受体拮抗剂,特别是作为趋化因子CCR2受体的拮抗剂的式(I-A)化合物,包括药物组合物及其用于治疗或预防与单核细胞积聚,淋巴细胞积聚或白细胞积聚相关的疾病的用途。
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公开(公告)号:US20100331298A1
公开(公告)日:2010-12-30
申请号:US12747106
申请日:2008-12-10
申请人: Efrat Ben-Zeev , Dongli Chen , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumna Mohanty , Sharon Shacham , Zhaoda Zhang
发明人: Efrat Ben-Zeev , Dongli Chen , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumna Mohanty , Sharon Shacham , Zhaoda Zhang
IPC分类号: A61K31/538 , C07D401/06 , C07D405/06 , C07D413/06 , C07D403/06 , C07D417/06 , C07D413/14 , A61K31/4709 , A61K31/453 , A61K31/454 , A61K31/4725 , A61K31/416 , A61K31/423 , A61K31/496 , A61P19/02 , A61P29/00 , A61P17/06 , A61P9/10 , A61P37/06 , A61P3/10 , A61P3/00 , A61P3/04
CPC分类号: C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D413/14 , C07D417/06
摘要: Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.
摘要翻译: 本文描述了趋化因子受体拮抗剂,特别是作为趋化因子CCR2受体的拮抗剂的式(I)化合物,包括药物组合物及其用于治疗或预防与单核细胞积聚,淋巴细胞积聚或白细胞积聚相关的疾病的用途。
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公开(公告)号:US20100324035A1
公开(公告)日:2010-12-23
申请号:US12747109
申请日:2008-12-11
申请人: Efrat Ben-Zeev , Dongli Chenl , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumma Mohanty , Sharon Shacham , Zhaoda Zhang
发明人: Efrat Ben-Zeev , Dongli Chenl , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumma Mohanty , Sharon Shacham , Zhaoda Zhang
IPC分类号: A61K31/538 , A61K31/501 , A61K31/4375 , C07D471/02
CPC分类号: C07D471/04
摘要: Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.
摘要翻译: 本文描述了趋化因子受体拮抗剂,特别是作为趋化因子CCR2受体的拮抗剂的式(I-A)化合物,包括药物组合物及其用于治疗或预防与单核细胞积聚,淋巴细胞积聚或白细胞积聚相关的疾病的用途。
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