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    Dibenzocycloheptene compound
    5.
    发明授权
    Dibenzocycloheptene compound 失效
    二苯并环庚烯化合物

    公开(公告)号：US07309718B2

    公开(公告)日：2007-12-18

    申请号：US10481752

    申请日：2002-06-27

    申请人： Yoshiaki Kuroki ,  Hitoshi Ueno ,  Tetsushi Katsube ,  Tetsuo Kawaguchi ,  Eiji Okanari ,  Ichiro Tanaka ,  Masayuki Tanaka ,  Masahiko Hagihara

    发明人： Yoshiaki Kuroki ,  Hitoshi Ueno ,  Tetsushi Katsube ,  Tetsuo Kawaguchi ,  Eiji Okanari ,  Ichiro Tanaka ,  Masayuki Tanaka ,  Masahiko Hagihara

    IPC分类号： A61K31/19 ,  C07C61/00 ,  C07C63/00

    CPC分类号： C07D215/18 ,  C07D215/12

    摘要： The present invention discloses a dibenzocycloheptene compound represented by the formula (I): wherein R1: hydrogen atom, halogen atom, etc., R2: hydrogen atom, halogen atom, etc., A: 5-membered or 6-membered heteroaromatic ring group containing 1 to 3 hetero atom(s) selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom, and the heteroaromatic ring group, etc. may have halogen atom, nitrogen atom, etc. as substituent(s), B: formula; —CH═CH—, formula; —CH2O—, etc., Y: C1-C10 alkylene group which may have halogen atom, etc. as substituent(s), etc., Z: carboxyl group which may be protected, etc., m: an integer of 1 to 4, n: an integer of 1 to 3, represents a single bond or a double bond, or a pharmaceutically acceptable salt thereof and a medical composition containing the same as an effective ingredient which has leukotriene C4 antagonistic action and leukotriene E4 antagonistic action in addition to potent leukotriene D4 antagonistic action, and useful as antiasthmatic agent, antiallergic agent and anti-inflammatory agent.

    摘要翻译： 本发明公开了式（I）表示的二苯并环庚烯化合物：其中R 1：氢原子，卤素原子等，R 2：氢原子，卤素原子 等，含有1〜3个选自氮原子，氧原子和硫原子的杂原子的5元或6元杂芳族环基和杂芳环基等可以具有 卤素原子，氮原子等作为取代基，B：式; -CH-CH-，式 -CH 2 O - 等，Y：C 1 -C 10亚烷基，其可以具有卤素原子等作为取代基（ s）等，Z：可被保护的羧基等，m：1〜4的整数，n：1〜3的整数，表示单键或双键 ，或其药学上可接受的盐和含有与有效成分相同的药物组合物，除了有效的白三烯外，还具有白三烯C 4拮抗作用和白三烯E 4拮抗作用 D 4拮抗作用，可用作止喘剂，抗过敏剂和抗炎剂。

    MEDICAL COMPOSITION FOR TREATMENT OR PROPHYLAXIS OF GLAUCOMA
    7.
    发明申请
    MEDICAL COMPOSITION FOR TREATMENT OR PROPHYLAXIS OF GLAUCOMA 有权
    GLAUCOMA的治疗或预防药物组合物

    公开(公告)号：US20120190852A1

    公开(公告)日：2012-07-26

    申请号：US13260946

    申请日：2010-03-30

    申请人： Masahiko Hagihara ,  Kenji Yoneda ,  Eiji Okanari ,  Manabu Shigetomi

    发明人： Masahiko Hagihara ,  Kenji Yoneda ,  Eiji Okanari ,  Manabu Shigetomi

    IPC分类号： C07D401/14 ,  C07D409/14 ,  C07D401/12 ,  C07D405/14 ,  C07D417/14 ,  C07D417/12

    CPC分类号： A61K31/506 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/501 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14

    摘要： The present invention is to provide a medical composition for the treatment or prophylaxis of glaucoma which comprises a pyridylaminoacetic acid compound represented by the formula (1): wherein R1, R2 and R3 each independently represent a hydrogen atom or C1-C6 alkyl group, Y represents a bicyclic heteroaromatic ring group which may be substituted by a group(s) selected from the group consisting of a halogen atom, C1-C6 alkyl group, halogeno C1-C6 alkyl group, C1-C6 alkoxyl group, halogeno C1-C6 alkoxyl group and C1-C6 alkylthio group or a group -Q1-Q2 wherein Q1 represents an arylene group or 5- to 6-membered heteroarylene group, Q2 represents an aromatic group or a 5- to 6-membered ring heterocyclic group each of which may be substituted by a group(s) selected from the group consisting of a halogen atom, hydroxyl group, C1-C6 alkyl group, halogeno C1-C6 alkyl group, C1-C6 alkoxyl group and halogeno C1-C6 alkoxyl group, Z represents an aromatic group or a 5- to 6-membered heteroaromatic ring group each of which may be substituted by a group(s) selected from the group consisting of a halogen atom, C1-C6 alkyl group, halogeno C1-C6 alkyl group, C1-C6 alkoxyl group and halogeno C1-C6 alkoxyl group, or a pharmaceutically acceptable salt thereof as an effective ingredient.

    摘要翻译： 本发明提供一种治疗或预​​防青光眼的药物组合物，其包含式（1）表示的吡啶基氨基乙酸化合物：其中R1，R2和R3各自独立地表示氢原子或C1-C6烷基，Y 表示可以被选自卤素原子，C 1 -C 6烷基，卤代C 1 -C 6烷基，C 1 -C 6烷氧基，卤代C 1 -C 6烷氧基，卤代C 1 -C 6烷氧基， 基团和C 1 -C 6烷硫基或基团-Q 1 -Q 2，其中Q 1表示亚芳基或5-至6-元亚杂芳基，Q 2表示芳族基团或5至6元环杂环基，其各自可以 被选自卤素原子，羟基，C 1 -C 6烷基，卤代C 1 -C 6烷基，C 1 -C 6烷氧基和卤代C 1 -C 6烷氧基的基团取代，Z表示 芳族基团或5-至6-元杂芳族化合物 可以被选自卤素原子，C 1 -C 6烷基，卤代C 1 -C 6烷基，C 1 -C 6烷氧基和卤代C 1 -C 6烷氧基的基团取代的环氧基 ，或其药学上可接受的盐作为有效成分。