公开(公告)号：US20120301481A1

公开(公告)日：2012-11-29

申请号：US13554245

申请日：2012-07-20

申请人： Michael Otto ,  Stanislava Kocianova ,  Cuong Vuong ,  Jovanka Voyich ,  Yufeng Yao ,  Elizabeth Fischer ,  Frank De Leo

发明人： Michael Otto ,  Stanislava Kocianova ,  Cuong Vuong ,  Jovanka Voyich ,  Yufeng Yao ,  Elizabeth Fischer ,  Frank De Leo

IPC分类号： A61K39/085 ,  A61P31/04 ,  A61K39/40

CPC分类号： C12P21/02 ,  A61K39/085 ,  A61K2039/6037 ,  A61K2039/6056 ,  A61K2039/6081 ,  C07K16/1271 ,  C07K2317/77

摘要： Immunogenic compositions and methods for eliciting an immune response against S. epidermidis and other related staphylococci are provided. The immunogenic compositions can include immunogenic conjugates of poly-γ-glutamic acid (such as γDLPGA) polypeptides of S. epidermidis, or related staphylococci that express a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against S. epidermidis, or other staphylococci, in subjects to which the conjugates are administered. A method of treating an infection caused by a Staphylococcus organism that expresses cap genes is also disclosed. The method can include selecting a subject who is at risk of or has been diagonosed with the infection by the Staphylococcus organism which expresses γPGA from the cap genes. Further, the expression of a γPGA polypeptide by the organism can then be altered.

摘要翻译： 提供了免疫原性组合物和引发针对表皮葡萄球菌和其他相关葡萄球菌的免疫应答的方法。 免疫原性组合物可以包括表达表皮葡萄球菌的多聚γ-谷氨酸（例如γDLPGA）多肽或表达γPGA多肽的相关葡萄球菌的免疫原性缀合物。 γPGA偶联物在施用共轭物的受试者中引起对表皮葡萄球菌或其他葡萄球菌的有效免疫应答。 还公开了治疗由表达帽基因的葡萄球菌生物引起的感染的方法。 该方法可以包括选择与帽基因表达γPGA的葡萄球菌生物有感染危险或已经发生交叉的对象。 此外，可以改变生物体的γPGA多肽的表达。

公开(公告)号：US08252550B2

公开(公告)日：2012-08-28

申请号：US13035716

申请日：2011-02-25

申请人： Michael Otto ,  Stanislava Kocianova ,  Cuong Vuong ,  Jovanka Voyich ,  Yufeng Yao ,  Elizabeth Fischer ,  Frank De Leo

发明人： Michael Otto ,  Stanislava Kocianova ,  Cuong Vuong ,  Jovanka Voyich ,  Yufeng Yao ,  Elizabeth Fischer ,  Frank De Leo

IPC分类号： A61K39/385

CPC分类号： C12P21/02 ,  A61K39/085 ,  A61K2039/6037 ,  A61K2039/6056 ,  A61K2039/6081 ,  C07K16/1271 ,  C07K2317/77

摘要： Immunogenic compositions and methods for eliciting an immune response against S. epidermidis and other related staphylococci are provided. The immunogenic compositions can include immunogenic conjugates of poly-γ-glutamic acid (such as γDLPGA) polypeptides of S. epidermidis, or related staphylococci that express a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against S. epidermidis, or other staphylococci, in subjects to which the conjugates are administered. A method of treating an infection caused by a Staphylococcus organism that expresses cap genes is also disclosed. The method can include selecting a subject who is at risk of or has been diagnosed with the infection by the Staphylococcus organism which expresses γPGA from the cap genes. Further, the expression of a γPGA polypeptide by the organism can then be altered.

摘要翻译： 提供了免疫原性组合物和引发针对表皮葡萄球菌和其他相关葡萄球菌的免疫应答的方法。 免疫原性组合物可以包括表达表皮葡萄球菌的多聚γ-谷氨酸（例如γDLPGA）多肽或表达γPGA多肽的相关葡萄球菌的免疫原性缀合物。 γPGA偶联物在施用共轭物的受试者中引起对表皮葡萄球菌或其他葡萄球菌的有效免疫应答。 还公开了治疗由表达帽基因的葡萄球菌生物引起的感染的方法。 该方法可以包括从帽基因中选择具有表达γPGA的葡萄球菌生物的风险或被诊断患有感染的受试者。 此外，可以改变生物体的γPGA多肽的表达。

公开(公告)号：US20110217312A1

公开(公告)日：2011-09-08

申请号：US13035716

申请日：2011-02-25

申请人： Michael Otto ,  Stanislava Kocianova ,  Cuong Vuong ,  Jovanka Voyich ,  Yufeng Yao ,  Elizabeth Fischer ,  Frank De Leo

发明人： Michael Otto ,  Stanislava Kocianova ,  Cuong Vuong ,  Jovanka Voyich ,  Yufeng Yao ,  Elizabeth Fischer ,  Frank De Leo

IPC分类号： A61K39/385 ,  A61K39/40 ,  C12Q1/14 ,  C12P21/00 ,  A61P31/04

CPC分类号： C12P21/02 ,  A61K39/085 ,  A61K2039/6037 ,  A61K2039/6056 ,  A61K2039/6081 ,  C07K16/1271 ,  C07K2317/77

摘要： Immunogenic compositions and methods for eliciting an immune response against S. epidermidis and other related staphylococci are provided. The immunogenic compositions can include immunogenic conjugates of poly-γ-glutamic acid (such as γDLPGA) polypeptides of S. epidermidis, or related staphylococci that express a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against S. epidermidis, or other staphylococci, in subjects to which the conjugates are administered. A method of treating an infection caused by a Staphylococcus organism that expresses cap genes is also disclosed. The method can include selecting a subject who is at risk of or has been diagnosed with the infection by the Staphylococcus organism which expresses γPGA from the cap genes. Further, the expression of a γPGA polypeptide by the organism can then be altered.

摘要翻译： 提供了免疫原性组合物和引发针对表皮葡萄球菌和其他相关葡萄球菌的免疫应答的方法。 免疫原性组合物可以包括表达表皮葡萄球菌的多聚γ-谷氨酸（例如γDLPGA）多肽或表达γPGA多肽的相关葡萄球菌的免疫原性缀合物。 γPGA偶联物在施用共轭物的受试者中引起对表皮葡萄球菌或其他葡萄球菌的有效免疫应答。 还公开了治疗由表达帽基因的葡萄球菌生物引起的感染的方法。 该方法可以包括从帽基因中选择具有表达γPGA的葡萄球菌生物的风险或被诊断患有感染的受试者。 此外，可以改变生物体的γPGA多肽的表达。

公开(公告)号：US20110229928A1

公开(公告)日：2011-09-22

申请号：US13062479

申请日：2009-09-03

申请人： David W. Dorward ,  Vinod Nair ,  Elizabeth Fischer ,  Bryan Hansen

发明人： David W. Dorward ,  Vinod Nair ,  Elizabeth Fischer ,  Bryan Hansen

IPC分类号： C12Q1/02 ,  C12M1/00 ,  C12M3/00

CPC分类号： G01N1/42 ,  G01N1/44

摘要： Embodiments are provided that provide for devices and methods for microwave-assisted cryo-sample processing. In some embodiments, a system for microwave-assisted cryo-sample processing of a sample includes a chamber adapted to receive microwave radiation and a device disposed in the chamber that is configured to maintain a sample under cryo conditions during irradiation of the sample with microwave radiation.

摘要翻译： 提供了提供用于微波辅助冷冻样品处理的装置和方法的实施例。 在一些实施例中，用于样品的微波辅助冷冻样品处理的系统包括适于接收微波辐射的室和设置在室中的装置，其被配置为在用微波辐射照射样品的同时在低温条件下保持样品 。