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1.发明授权Capillary filtration and collection device for long-term monitoring of blood constituents 失效毛细管过滤和收集装置，用于长期监测血液成分公开(公告)号：US4854322A
公开(公告)日：1989-08-08
申请号：US98400
申请日：1987-09-18
Applicant: Stephen R. Ash , Elsa M. Janle-Swain
Inventor： Stephen R. Ash , Elsa M. Janle-Swain
IPC: A61B5/00 , A61B10/00 , B01D61/18 , B01D63/02 , G01N33/483 , G01N33/487
CPC classification number: A61B5/14865 , A61B5/14528 , A61B5/14542 , A61B5/1473 , A61B5/686 , B01D61/18 , B01D63/024 , A61B2010/008 , B01D2313/06
Abstract: A method and device for long term monitoring of the blood level of various blood constituents. The monitoring is accomplished by capillary filtration and collection of an ultrafiltrate of blood. Filtration of the ultrafiltrate occurs through a filter composed of hollow fibers which are implanted within an interstitial body space in fluid communication with blood capillaries. The ultrafiltrate is drawn through the filter and into an ultrafiltrate collector which extends externally of the body. The collector provides a vacuum for withdrawing the ultrafiltrate and holds discrete liquid samples of the ultrafiltrate. The method and device is particularly suited for long term monitoring of blood glucose levels in diabetic patients or other blood chemical constituents in other patients.
Abstract translation: 一种用于长期监测各种血液成分血液水平的方法和装置。 通过毛细管过滤和血液超滤液的收集来实现监测。 超滤液的过滤通过由中空纤维构成的过滤器发生，所述过滤器植入在与毛细管流体连通的间隙体空间内。 超滤液通过过滤器吸入超滤体收集器，该收集器从身体外部延伸出来。 收集器提供用于抽出超滤液的真空并保持超滤液的离散液体样品。 该方法和装置特别适用于长期监测糖尿病患者或其他患者其他血液化学成分中的血糖水平。
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2.发明授权Capillary filtration and collection method for long-term monitoring of blood constituents 失效毛细管过滤和收集方法，用于长期监测血液成分
公开(公告)号：US4777953A
公开(公告)日：1988-10-18
申请号：US18616
申请日：1987-02-25
Applicant: Stephen R. Ash , Elsa M. Janle-Swain
Inventor： Stephen R. Ash , Elsa M. Janle-Swain
IPC: G01N1/10 , A61B5/00 , A61B5/145 , A61B10/00 , B01D61/18 , B01D63/02 , G01N33/483 , G01N33/487 , A61B5/05
CPC classification number: B01D63/024 , A61B5/14528 , A61B5/14542 , A61B5/14865 , A61B5/415 , A61B5/686 , B01D61/18 , A61B2010/008 , B01D2313/06
Abstract: A method and device for long term monitoring of the blood level of various blood constituents. The monitoring is accomplished by capillary filtration and collection of an ultrafiltrate of blood. Filtration of the ultrafiltrate occurs through a filter composed of hollow fibers which are implanted within an interstitial body space in fluid communication with blood capillaries. The ultrafiltrate is drawn through the filter and into an ultrafiltrate collector which extends externally of the body. The collector provides a vacuum for withdrawing the ultrafiltrate and holds discrete liquid samples of the ultrafiltrate. The method and device is particularly suited for long term monitoring of blood glucose levels in diabetic patients or other blood chemical constituents in other patients.
Abstract translation: 一种用于长期监测各种血液成分血液水平的方法和装置。 通过毛细管过滤和血液超滤液的收集来实现监测。 超滤液的过滤通过由中空纤维构成的过滤器发生，所述过滤器植入在与毛细管流体连通的间隙体空间内。 超滤液通过过滤器吸入超滤体收集器，该收集器从身体外部延伸出来。 收集器提供用于抽出超滤液的真空并保持超滤液的离散液体样品。 该方法和装置特别适用于长期监测糖尿病患者或其他患者其他血液化学成分中的血糖水平。
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公开(公告)号：US06042561A
公开(公告)日：2000-03-28
申请号：US956001
申请日：1997-10-22
Applicant: Stephen R. Ash , Elsa M. Janle
Inventor： Stephen R. Ash , Elsa M. Janle
CPC classification number: A61M39/0247
Abstract: A non-intravascular infusion access device and method for long-term continuous infusion of drugs. The infusion access device includes a porous membrane made of a material which is biocompatible for long-term patency inside the body. The porous membrane is connected to a conducting tubing which exits from the body and is connected to a drug infusion system. At the exit site is a cuff of porous material. The cuff serves to anchor the access device in position as the surrounding body tissue grows back around the cuff. There are also two small suture retainers for stabilizing the position of the access device relative until tissue ingrowth occurs in and around the cuff.
Abstract translation: 一种用于长期连续输注药物的非血管内输液装置和方法。 输液进入装置包括由在体内长期通畅生物相容的材料制成的多孔膜。 多孔膜连接到从身体离开并连接到药物输注系统的导管。 在出口处是多孔材料的袖口。 袖带用于在周围的身体组织围绕袖带增长时将访问装置锚定在适当的位置。 还有两个小的缝线保持器，用于稳定进入装置的位置，直到组织向内生长发生在袖带内和周围。
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4.发明授权
公开(公告)号：US5002054A
公开(公告)日：1991-03-26
申请号：US360362
申请日：1989-06-02
Applicant: Stephen R. Ash , Elsa M. Janle
Inventor： Stephen R. Ash , Elsa M. Janle
IPC: A61B5/00 , A61B10/00 , B01D61/18 , B01D63/02 , G01N33/483 , G01N33/487
CPC classification number: A61B5/14865 , A61B5/14528 , A61B5/14542 , A61B5/1473 , A61B5/686 , B01D61/18 , B01D63/024 , A61B2010/008 , B01D2313/06
Abstract: An implantable filtration and collection device for collecting a filtrate containing a physiological constituent of the body present in an interstitial body space. The device is operable with a negative pressure generating source to withdraw the filtrate from the interstitial body space. The device includes a porous filter made of a material compatible for long-term patency inside the body and adapted to be implanted inside the body in fluid communication with the interstitial space. The pores in the filter are sized not to exceed a predetermined dimension corresponding to the size of the physiological constituent being filtered. A collector in the form of an elongate tube is connected to the filter and and serves to communicate the filtrate externally of the body where it may be withdrawn from the collector by a negative pressure generating source.
Abstract translation: 一种用于收集含有存在于间质体空间中的身体的生理成分的滤液的可植入过滤和收集装置。 该装置可用负压产生源操作，以从间隙体空间抽出滤液。 该装置包括多孔过滤器，其由与体内长期通畅相适应的材料制成，并适于植入体内与间隙空间流体连通。 过滤器中的孔的尺寸不超过对应于被过滤的生理成分的尺寸的预定尺寸。 细长管形式的收集器连接到过滤器，并且用于将滤液从身体外部传递到可以通过负压产生源从收集器抽出的滤液。
