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    MICROFLUIDIC CHEMOSTAT
    2.
    发明申请
    MICROFLUIDIC CHEMOSTAT 有权
    微血管化学

    公开(公告)号：US20090018195A1

    公开(公告)日：2009-01-15

    申请号：US12182088

    申请日：2008-07-29

    申请人： Frederick Balagadde ,  Carl L. Hansen ,  Emil Kartalov ,  Stephen R. Quake

    发明人： Frederick Balagadde ,  Carl L. Hansen ,  Emil Kartalov ,  Stephen R. Quake

    IPC分类号： A01N37/02 ,  A01P1/00

    CPC分类号： C12P19/04 ,  B01L3/5027 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0877 ,  B01L2300/10 ,  B01L2300/163 ,  B01L2400/0481 ,  B01L2400/0655 ,  C12M23/16 ,  C12M23/34 ,  C12M39/00 ,  C12P1/00

    摘要： A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.

    摘要翻译： 描述了一种恒温器，其包括具有多个室的生长室。 每个隔室可以通过一个或多个可致动阀与生长室的其余部分流体隔离。 恒化器还可以包括向生长室供应生长培养基的营养供应线以及从生长室去除流体的输出端口。 另外，描述了在恒化器的生长室中防止生物膜形成的方法。 该方法可以包括以下步骤：将裂解剂加入生长室的分离部分，并将分离的部分与生长室的其余部分重新连接。

    Fluorescence detector, filter device and related methods
    3.
    发明申请
    Fluorescence detector, filter device and related methods 有权
    荧光检测器，过滤装置及相关方法

    公开(公告)号：US20080013092A1

    公开(公告)日：2008-01-17

    申请号：US11804112

    申请日：2007-05-17

    申请人： George Maltezos ,  John Lee ,  Axel Scherer ,  Emil Kartalov

    发明人： George Maltezos ,  John Lee ,  Axel Scherer ,  Emil Kartalov

    IPC分类号： G01N21/25 ,  B01D63/00 ,  F15C1/06 ,  F15C5/00

    CPC分类号： G01N21/6456 ,  G01N21/6452 ,  Y10T137/2224

    摘要： Microfluidic assay detectors and microfluidic assay detection methods are disclosed. A microfluidic chip is coupled to a light emitting device, emission filters and excitation filters. Excited fluorescent light is detected by a camera and a lens. The correspondent reading allows parallel detection of features such as antigens and biomarkers. A microfluidic filter and related methods are also disclosed. The filter can be used with on-chip fluid filtration such as whole blood filtration for microfluidic blood analysis. The filter is able to filter the necessary volume of fluid and in particular blood in an acceptable time frame.

    摘要翻译： 公开了微流控测定检测器和微流控测定检测方法。 微流控芯片耦合到发光器件，发射滤光器和激发滤光器。 激发的荧光灯由相机和透镜检测。 通讯阅读允许并行检测抗原和生物标志物等特征。 还公开了微流体过滤器和相关方法。 过滤器可用于片上流体过滤，如全血过滤用于微流体血液分析。 过滤器能够在可接受的时间范围内过滤所需体积的流体，特别是血液。

    Microfluidic autoregulator devices and arrays for operation with newtonian fluids
    4.
    发明授权
    Microfluidic autoregulator devices and arrays for operation with newtonian fluids 有权
    用于牛顿流体操作的微流控自动调节器和阵列

    公开(公告)号：US07992587B2

    公开(公告)日：2011-08-09

    申请号：US11606312

    申请日：2006-11-28

    申请人： Emil Kartalov ,  Axel Scherer ,  W. French Anderson ,  Christopher I. Walker

    发明人： Emil Kartalov ,  Axel Scherer ,  W. French Anderson ,  Christopher I. Walker

    IPC分类号： F16K31/36

    CPC分类号： G05D7/0694 ,  B01L3/5027 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0057 ,  F16K2099/008 ,  F16K2099/0084 ,  Y10T137/218 ,  Y10T137/2202 ,  Y10T137/7796

    摘要： By use of the vias a microfluidic autoregulator is fabricated comprising an origin of a fluid, a sink for the fluid, a main flow channel coupling the origin and the sink, a valve communicated to the main flow channel to selectively control flow of fluid therethrough, and means dependent on flow through the main flow channel for creating a pressure differential across the valve to at least partially activate the valve to control flow of fluid through the main flow channel. The means for dependent on flow for creating a pressure differential comprises either a dead-end detour channel from the flow channel to the valve, or a loop channel fed back to the control chamber of the valve.

    摘要翻译： 通过使用通孔，制造微流体自动调节器，该微流控自动调节器包括流体的来源，用于流体的水槽，连接原点和水槽的主流动通道，连通到主流动通道的阀，以选择性地控制流体的流动， 并且取决于通过主流动通道的流动的装置，用于在阀门两端产生压差，至少部分地启动阀门，以控制通过主流动通道的流体流动。 用于产生压力差的用于依赖于流动的装置包括从流动通道到阀门的死端迂回通道或反馈到阀的控制室的回路通道。

    MICROFLUIDIC CHEMOSTAT
    9.
    发明申请
    MICROFLUIDIC CHEMOSTAT 有权
    微血管化学

    公开(公告)号：US20120065277A1

    公开(公告)日：2012-03-15

    申请号：US13197654

    申请日：2011-08-03

    申请人： Frederick Balagadde ,  Carl L. Hansen ,  Emil Kartalov ,  Stephen R. Quake

    发明人： Frederick Balagadde ,  Carl L. Hansen ,  Emil Kartalov ,  Stephen R. Quake

    IPC分类号： A01N61/00 ,  A01P1/00 ,  C12M1/00

    CPC分类号： C12P19/04 ,  B01L3/5027 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0877 ,  B01L2300/10 ,  B01L2300/163 ,  B01L2400/0481 ,  B01L2400/0655 ,  C12M23/16 ,  C12M23/34 ,  C12M39/00 ,  C12P1/00

    摘要： A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.

    摘要翻译： 描述了一种恒温器，其包括具有多个室的生长室。 每个隔室可以通过一个或多个可致动阀与生长室的其余部分流体隔离。 恒化器还可以包括向生长室供应生长培养基的营养供应线以及从生长室去除流体的输出端口。 另外，描述了在恒化器的生长室中防止生物膜形成的方法。 该方法可以包括以下步骤：将裂解剂加入生长室的分离部分，并将分离的部分与生长室的其余部分重新连接。

    MICROFLUIDIC CHEMOSTAT
    10.
    发明申请
    MICROFLUIDIC CHEMOSTAT 有权
    微血管化学

    公开(公告)号：US20140141497A1

    公开(公告)日：2014-05-22

    申请号：US13850988

    申请日：2013-03-26

    申请人： Frederick Balagadde ,  Carl L. Hansen ,  Emil Kartalov ,  Stephen R. Quake

    发明人： Frederick Balagadde ,  Carl L. Hansen ,  Emil Kartalov ,  Stephen R. Quake

    IPC分类号： C12M1/00

    CPC分类号： C12P19/04 ,  B01L3/5027 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0877 ,  B01L2300/10 ,  B01L2300/163 ,  B01L2400/0481 ,  B01L2400/0655 ,  C12M23/16 ,  C12M23/34 ,  C12M39/00 ,  C12P1/00

    摘要： A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.

    摘要翻译： 描述了一种恒温器，其包括具有多个室的生长室。 每个隔室可以通过一个或多个可致动阀与生长室的其余部分流体隔离。 恒化器还可以包括向生长室供应生长培养基的营养供应线以及从生长室去除流体的输出端口。 另外，描述了在恒化器的生长室中防止生物膜形成的方法。 该方法可以包括以下步骤：将裂解剂加入生长室的分离部分，并将分离的部分与生长室的其余部分重新连接。