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![DISUBSTITUTED OCTAHYDROPYRROLO[3,4-c]PYRROLES AS OREXIN RECEPTOR MODULATORS](/abs-image/US/2012/08/16/US20120208812A1/abs.jpg.150x150.jpg)
1.发明申请DISUBSTITUTED OCTAHYDROPYRROLO[3,4-c]PYRROLES AS OREXIN RECEPTOR MODULATORS 有权作为OREXIN受体调节剂的分析的甲氧基吡咯并[3,4-c]吡咯公开(公告)号：US20120208812A1
公开(公告)日：2012-08-16
申请号：US13503231
申请日：2010-10-21
Applicant: Wenying Chai , Michael A. Letavic , Kiev S. Ly , Daniel J. Pippel , Dale A. Rudolph , Kathleen C. Sappey , Brad M. Savall , Chandravadan R. Shah , Brock T. Shireman , Akinola Soyode-Johnson , Emily M. Stocking , Devin M. Swanson
Inventor： Wenying Chai , Michael A. Letavic , Kiev S. Ly , Daniel J. Pippel , Dale A. Rudolph , Kathleen C. Sappey , Brad M. Savall , Chandravadan R. Shah , Brock T. Shireman , Akinola Soyode-Johnson , Emily M. Stocking , Devin M. Swanson
IPC: A61K31/5377 , A61K31/498 , A61K31/517 , A61K31/506 , A61K31/444 , A61K31/428 , A61K31/423 , C07D487/04 , A61P25/20 , A61P25/00 , A61P25/24 , A61P25/18 , A61P25/16 , A61P25/22 , A61P3/00 , A61P3/04 , A61P3/10 , A61P3/06 , A61P9/12 , A61P15/00 , A61P19/02 , A61P9/00 , A61P1/04 , A61P1/00 , A61P1/12 , A61K31/53
CPC classification number: C07D487/04 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/498 , A61K31/506 , A61K31/53 , A61K31/5377
Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
Abstract translation: 描述了二取代八氢吡咯并[3,4-c]吡咯化合物，其可用作食欲素受体调节剂。 这样的化合物可用于治疗由食欲素活性（例如失眠）介导的疾病状态，病症和病症的药物组合物和方法。
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2.发明授权Cycloalkyloxy- and heterocycloalkyloxypyridine compounds as modulators of the histamine H3 receptor 有权环烷氧基 - 和杂环烷氧基吡啶化合物作为组胺H3受体的调节剂公开(公告)号：US08883776B2
公开(公告)日：2014-11-11
申请号：US12272268
申请日：2008-11-17
Applicant: Michael A. Letavic , Emily M. Stocking
Inventor： Michael A. Letavic , Emily M. Stocking
IPC: C07D401/14 , A61K31/34 , A61K31/443 , A61K31/496 , A61K31/5513 , C07D409/14 , C07D407/14
CPC classification number: C07D407/14 , C07D401/14 , C07D409/14
Abstract: Certain cycloalkyloxy- and heterocycloalkyloxypyridine compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
Abstract translation: 某些环烷氧基和杂环烷氧基吡啶化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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公开(公告)号：US20090137562A1
公开(公告)日：2009-05-28
申请号：US12330574
申请日：2008-12-09
Applicant: Brett Allison , Michael P. Curtis , Cheryl A. Grice , John M. Keith , Michael A. Letavic , Jennifer M.B. Miller , Emily M. Stocking
Inventor： Brett Allison , Michael P. Curtis , Cheryl A. Grice , John M. Keith , Michael A. Letavic , Jennifer M.B. Miller , Emily M. Stocking
IPC: A61K31/551 , C07D241/04 , A61K31/495 , A61K31/5377 , A61P25/28 , C07D413/04 , C07D243/08
CPC classification number: C07C237/34 , C07D209/08 , C07D209/40 , C07D213/65 , C07D213/70 , C07D213/74 , C07D241/08 , C07D243/24 , C07D295/13 , C07D295/135 , C07D295/192 , C07D401/10 , C07D401/12 , C07D413/04
Abstract: Certain substituted benzyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.
Abstract translation: 某些取代的苄胺化合物是可用于治疗组胺H3受体和/或血清素介导的疾病的组胺H3受体和/或血清素转运体调节剂。
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公开(公告)号：US20080004258A1
公开(公告)日：2008-01-03
申请号：US11766151
申请日：2007-06-21
Applicant: John M. Keith , Michael A. Letavic , Emily M. Stocking
Inventor： John M. Keith , Michael A. Letavic , Emily M. Stocking
IPC: A61K31/551 , A61K31/135 , A61K31/445 , A61K31/495 , A61P21/00 , A61P29/00 , C07C211/00 , C07D243/06 , C07D295/00 , C07D221/00 , A61P3/00 , A61P25/00 , A61P15/00 , A61K31/5375 , A61K31/54
CPC classification number: C07C323/21 , C07C217/58 , C07C323/20 , C07C2601/02 , C07D211/38 , C07D213/64 , C07D213/65 , C07D213/70 , C07D241/08 , C07D243/08 , C07D295/08 , C07D295/096 , C07D295/135
Abstract: Certain substituted butyl and butynyl benzyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.
Abstract translation: 某些取代的丁基和丁炔基苄胺化合物是可用于治疗组胺H 3受体和/或5-羟色胺介导的疾病的组胺H 3 N 3受体和/或5-羟色胺转运蛋白调节剂 。
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5.发明申请公开(公告)号：US20090291903A1
公开(公告)日：2009-11-26
申请号：US12468632
申请日：2009-05-19
Applicant: Nicholas I. Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
Inventor： Nicholas I. Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
IPC: A61K38/05 , C07D403/06 , A61K31/551
CPC classification number: C07D403/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
Abstract: Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
Abstract translation: 某些取代的吡咯烷酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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6.发明申请CYCLOALKYLOXY-AND HETEROCYCLOALKYLOXYPYRIDINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR 有权作为组胺H3受体的调节剂的环己基和间二氧唑啉基吡啶化合物公开(公告)号：US20090131415A1
公开(公告)日：2009-05-21
申请号：US12272268
申请日：2008-11-17
Applicant: Michael A. Letavic , Emily M. Stocking
Inventor： Michael A. Letavic , Emily M. Stocking
IPC: A61K31/55 , C07D243/08 , A61P25/00
CPC classification number: C07D407/14 , C07D401/14 , C07D409/14
Abstract: Certain cycloalkyloxy- and heterocycloalkyloxypyridine compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
Abstract translation: 某些环烷氧基和杂环烷氧基吡啶化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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7.发明申请SUBSTITUTED PHENYL PROPYL AMINES AS HISTAMINE H3 RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS 审中-公开作为组胺H3受体和丝氨酸转运蛋白调节剂的取代苯基丙氨酰胺公开(公告)号：US20080139564A1
公开(公告)日：2008-06-12
申请号：US11939881
申请日：2007-11-14
Applicant: John M. Keith , Jennifer M.B. Miller , Emily M. Stocking
Inventor： John M. Keith , Jennifer M.B. Miller , Emily M. Stocking
IPC: A61K31/5375 , A61P25/28 , C07D211/06 , A61K31/445 , C07D295/027 , A61K31/496
CPC classification number: C07D295/135 , C07D213/65
Abstract: Certain substituted phenyl propyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.
Abstract translation: 某些取代的苯基丙基胺化合物是可用于治疗组胺H 3受体和/或5-羟色胺介导的疾病的组胺H 3 N 3受体和/或5-羟色胺转运体调节剂。
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![Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators](/abs-image/US/2014/02/18/US08653263B2/abs.jpg.150x150.jpg)
8.发明授权Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators 有权二取代八氢吡咯并[3,4-c]吡咯作为食欲素受体调节剂公开(公告)号：US08653263B2
公开(公告)日：2014-02-18
申请号：US13503231
申请日：2010-10-21
Applicant: Wenying Chai , Michael A. Letavic , Kiev S. Ly , Daniel J. Pippel , Dale A. Rudolph , Kathleen C. Sappey , Brad M. Savall , Chandravadan R. Shah , Brock T. Shireman , Akinola Soyode-Johnson , Emily M. Stocking , Devin M. Swanson
Inventor： Wenying Chai , Michael A. Letavic , Kiev S. Ly , Daniel J. Pippel , Dale A. Rudolph , Kathleen C. Sappey , Brad M. Savall , Chandravadan R. Shah , Brock T. Shireman , Akinola Soyode-Johnson , Emily M. Stocking , Devin M. Swanson
IPC: C07D417/00 , C07D239/02 , C07D241/36 , C07D215/38 , A61K31/4965 , A61K31/515 , A61K31/44 , A61K31/425
CPC classification number: C07D487/04 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/498 , A61K31/506 , A61K31/53 , A61K31/5377
Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
Abstract translation: 描述了二取代八氢吡咯并[3,4-c]吡咯化合物，其可用作食欲素受体调节剂。 这样的化合物可用于治疗由食欲素活性（例如失眠）介导的疾病状态，病症和病症的药物组合物和方法。
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9.发明授权公开(公告)号：US08236792B2
公开(公告)日：2012-08-07
申请号：US12468632
申请日：2009-05-19
Applicant: Nicholas I Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
Inventor： Nicholas I Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
IPC: A61K31/55 , A61K31/497 , A61K31/445 , A61K31/40 , C07D243/08 , C07D403/00 , C07D401/00 , C07D205/00
CPC classification number: C07D403/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
Abstract: Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
Abstract translation: 某些取代的吡咯烷酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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公开(公告)号：US20100256122A1
公开(公告)日：2010-10-07
申请号：US12820365
申请日：2010-06-22
Applicant: John M. Keith , Michael A. Letavic , Emily M. Stocking
Inventor： John M. Keith , Michael A. Letavic , Emily M. Stocking
IPC: A61K31/551 , A61K31/5375 , A61K31/4453 , A61K31/54 , A61K31/495 , A61K31/137 , A61K31/5377 , A61P25/28 , A61P25/30 , A61P25/00 , A61P25/18 , A61P25/24 , A61P29/00 , A61P15/00
CPC classification number: C07C323/21 , C07C217/58 , C07C323/20 , C07C2601/02 , C07D211/38 , C07D213/64 , C07D213/65 , C07D213/70 , C07D241/08 , C07D243/08 , C07D295/08 , C07D295/096 , C07D295/135
Abstract: Certain substituted butyl and butynyl benzyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.
Abstract translation: 某些取代的丁基和丁炔基苄胺化合物是可用于治疗组胺H3受体和/或5-羟色胺介导的疾病的组胺H3受体和/或5-羟色胺转运体调节剂。
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