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    Crystal form on N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide
    1.
    发明授权
    Crystal form on N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide 有权
    N-（4-三氟甲基苯基）-5-甲基异恶唑-4-甲酰胺的晶体形式

    公开(公告)号：US06900334B2

    公开(公告)日：2005-05-31

    申请号：US10302872

    申请日：2002-11-25

    申请人： Holger Faasch ,  Udo Hedtmann ,  Uwe Westenfelder ,  Erich Paulus

    发明人： Holger Faasch ,  Udo Hedtmann ,  Uwe Westenfelder ,  Erich Paulus

    IPC分类号： A61K31/42 ,  A61P1/00 ,  A61P3/08 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/00 ,  A61P27/02 ,  A61P27/14 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/00 ,  A61P37/08 ,  B01D9/02 ,  C07D261/18

    CPC分类号： C07D261/18

    摘要： The invention relates to a crystal modification of the compound of the formula I and the processes for the preparation of and use that crystal modifications 1. The invention is used for treating acute immunological episodes, such as sepsis, allergies, graft-versus-host and host-versus-graft-reactions, autoimmune diseases, in particular rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, psoriasis, atopic dermatitis, asthma, urticaria, rhinitis, uveitis, type II diabetes, liver fibrosis, cystic fibrosis, colitis, cancers, such as lung cancer, leukemia, ovarian cancer, sarcomas, Kaposi's sarcoma, meningioma, intestinal cancer, lymphatic cancer, brain tumors, breast cancer, pancreatic cancer, prostate cancer, or skin cancer.

    摘要翻译： 本发明涉及式I化合物的晶体改性及其制备和使用方法1。 本发明用于治疗急性免疫性发作，例如败血症，过敏，移植物抗宿主和宿主对移植物反应，自身免疫性疾病，特别是类风湿性关节炎，系统性红斑狼疮，多发性硬化，牛皮癣，特应性皮炎， 哮喘，荨麻疹，鼻炎，葡萄膜炎，II型糖尿病，肝纤维化，囊性纤维化，结肠炎，癌症，如肺癌，白血病，卵巢癌，肉瘤，卡波西肉瘤，脑膜瘤，肠癌，淋巴癌，脑肿瘤，乳腺癌 ，胰腺癌，前列腺癌或皮肤癌。

    Aromatic di-keto derivatives, processes for their production and their use as a pharmaceutical
    2.
    发明授权
    Aromatic di-keto derivatives, processes for their production and their use as a pharmaceutical 有权
    芳香族二酮衍生物，其制备方法及其作为药物的用途

    公开(公告)号：US06380257B1

    公开(公告)日：2002-04-30

    申请号：US09694790

    申请日：2000-10-24

    申请人： László Vértesy ,  Michael Kurz ,  Erich Paulus

    发明人： László Vértesy ,  Michael Kurz ,  Erich Paulus

    IPC分类号： A61K3119

    CPC分类号： C07C65/40 ,  C07D307/20

    摘要： The present invention relates to new aromatic di-keto derivatives and to their pharmaceutically acceptable salts, esters, ethers and other chemical equivalents. The derivatives are glucose-6-phosphate translocase inhibitors and can be used in the treatment of diabetes mellitus. The present invention further relates to a process for the production of the derivatives, to the use of the derivatives and their pharmaceutically acceptable salts, esters, ethers and other chemical equivalents as pharmaceuticals, in particular to their use in the treatment of diabetes mellitus, and to pharmaceutical compositions comprising the derivatives, pharmaceutically acceptable salts, esters, ethers or other chemical equivalents thereof.

    摘要翻译： 本发明涉及新的芳族二酮衍生物及其药学上可接受的盐，酯，醚和其它化学等价物。 衍生物为葡萄糖-6-磷酸转位酶抑制剂，可用于治疗糖尿病。 本发明还涉及衍生物的制备方法，衍生物及其药学上可接受的盐，酯，醚和其它化学等价物作为药物的用途，特别是其用于治疗糖尿病的方法，以及 涉及包含衍生物，药学上可接受的盐，酯，醚或其它化学等价物的药物组合物。

    Crystal form of N-(4-triflouromethylphenyl)-5-methylisoxazole-4-carboxamide
    5.
    发明授权
    Crystal form of N-(4-triflouromethylphenyl)-5-methylisoxazole-4-carboxamide 有权
    晶型N-（4-三氟甲基苯基）-5-甲基异恶唑-4-甲酰胺

    公开(公告)号：US06221891B1

    公开(公告)日：2001-04-24

    申请号：US09428499

    申请日：1999-10-28

    申请人： Holger Faasch ,  Udo Hedtmann ,  Uwe Westenfelder ,  Erich Paulus

    发明人： Holger Faasch ,  Udo Hedtmann ,  Uwe Westenfelder ,  Erich Paulus

    IPC分类号： A61K3142

    CPC分类号： C07D261/18

    摘要： The invention relates to a crystal modification of the compound of the formula I and the processes for the preparation of and use that crystal modifications 1. The invention is used for treating acute immunological episodes, such as sepsis, allergies, graft-versus-host and host-versus-graft-reactions, autoimmune diseases, in particular rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, psoriasis, atopic dermatitis, asthma, urticaria, rhinitis, uveitis, type II diabetes, liver fibrosis, cystic fibrosis, colitis, cancers, such as lung cancer, leukemia, ovarian cancer, sarcomas, Kaposi's sarcoma, meningioma, intestinal cancer, lymphatic cancer, brain tumors, breast cancer, pancreatic cancer, prostate cancer, or skin cancer.

    摘要翻译： 本发明涉及式I化合物的晶体改性以及制备和使用晶体修饰的方法1.本发明用于治疗急性免疫性发作，例如败血症，过敏反应，移植物抗宿主和宿主 自身免疫性疾病，特别是类风湿性关节炎，系统性红斑狼疮，多发性硬化，牛皮癣，特应性皮炎，哮喘，荨麻疹，鼻炎，葡萄膜炎，II型糖尿病，肝纤维化，囊性纤维化，结肠炎，癌症等 作为肺癌，白血病，卵巢癌，肉瘤，卡波西氏肉瘤，脑膜瘤，肠癌，淋巴癌，脑肿瘤，乳腺癌，胰腺癌，前列腺癌或皮肤癌。

    Crystal form of N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide
    7.
    发明授权
    Crystal form of N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide 有权
    晶型N-（4-三氟甲基苯基）-5-甲基异恶唑-4-甲酰胺

    公开(公告)号：US06995272B2

    公开(公告)日：2006-02-07

    申请号：US10830307

    申请日：2004-04-23

    申请人： Holger Faasch ,  Udo Hedtmann ,  Uwe Westenfelder ,  Erich Paulus

    发明人： Holger Faasch ,  Udo Hedtmann ,  Uwe Westenfelder ,  Erich Paulus

    IPC分类号： C07D261/18

    CPC分类号： C07D261/18

    摘要： The invention relates to a crystal modification of the compound of the formula I and the processes for the preparation of and use that crystal modifications 1. The invention is used for treating acute immunological episodes, such as sepsis, allergies, graft-versus-host and host-versus-graft-reactions, autoimmune diseases, in particular rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, psoriasis, atopic dermatitis, asthma, urticaria, rhinitis, uveitis, type II diabetes, liver fibrosis, cystic fibrosis, colitis, cancers, such as lung cancer, leukemia, ovarian cancer, sarcomas, Kaposi's sarcoma, meningioma, intestinal cancer, lymphatic cancer, brain tumors, breast cancer, pancreatic cancer, prostate cancer, or skin cancer.

    摘要翻译： 本发明涉及式I化合物的晶体改性：化学式id =“CHEM-US-00001”num =“000

    Crystal form of N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide
    8.
    发明授权
    Crystal form of N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide 有权
    晶型N-（4-三氟甲基苯基）-5-甲基异恶唑-4-甲酰胺

    公开(公告)号：US06552202B2

    公开(公告)日：2003-04-22

    申请号：US09764258

    申请日：2001-01-19

    申请人： Holger Faasch ,  Udo Hedtmann ,  Uwe Westenfelder ,  Erich Paulus

    发明人： Holger Faasch ,  Udo Hedtmann ,  Uwe Westenfelder ,  Erich Paulus

    IPC分类号： C07D26118

    CPC分类号： C07D261/18

    摘要： The invention relates to a crystal modification of the compound of the formula I and the processes for the preparation of and use that crystal modifications 1. The invention is used for treating acute immunological episodes, such as sepsis, allergies, graft-versus-host and host-versus-graft-reactions, autoimmune diseases, in particular rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, psoriasis, atopic dermatitis, asthma, urticaria, rhinitis, uveitis, type 11 diabetes, liver fibrosis, cystic fibrosis, colitis, cancers, such as lung cancer, leukemia, ovarian cancer, sarcomas, Kaposi's sarcoma, meningioma, intestinal cancer, lymphatic cancer, brain tumors, breast cancer, pancreatic cancer, prostate cancer, or skin cancer.

    摘要翻译： 本发明涉及式I化合物的晶体改性以及制备和使用晶体修饰的方法1.本发明用于治疗急性免疫性发作，例如败血症，过敏反应，移植物抗宿主和宿主 - 反接种反应，自身免疫性疾病，特别是类风湿性关节炎，系统性红斑狼疮，多发性硬化，牛皮癣，特应性皮炎，哮喘，荨麻疹，鼻炎，葡萄膜炎，11型糖尿病，肝纤维化，囊性纤维化，结肠炎，癌症等 作为肺癌，白血病，卵巢癌，肉瘤，卡波西氏肉瘤，脑膜瘤，肠癌，淋巴癌，脑肿瘤，乳腺癌，胰腺癌，前列腺癌或皮肤癌。