DEEP LEARNING TECHNIQUES FOR FAST ANOMALY DETECTION IN EXPERIMENTAL DATA

    公开(公告)号:US20240280522A1

    公开(公告)日:2024-08-22

    申请号:US18171541

    申请日:2023-02-20

    申请人: FEI COMPANY

    IPC分类号: G01N23/2252 G06N3/0455

    CPC分类号: G01N23/2252 G06N3/0455

    摘要: Disclosed herein are scientific instrument support systems, as well as related methods, apparatus, computing devices, and computer-readable media. Some embodiments provide a scientific instrument including detectors supporting one or more spectroscopic modalities and an imaging modality and further including an electronic controller configured to process streams of measurements received from the detectors. The electronic controller operates to generate a base image of the sample based on the measurements corresponding to the imaging modality and further operates to generate an anomaly map of the sample based on the base image and further based on differences between measured and autoencoder-reconstructed spectra corresponding to different pixels of the base image. In at least some instances, the anomaly map can beneficially be used in a quality-control procedure to identify, within seconds, specific problem spots in the sample for more-detailed inspection and/or analyses.

    Systems and methods of clamp compensation

    公开(公告)号:US12057286B2

    公开(公告)日:2024-08-06

    申请号:US18084430

    申请日:2022-12-19

    申请人: FEI Company

    IPC分类号: H01J37/02 H01J37/28

    摘要: A method of producing a compensation signal to compensate for misalignment of a drive unit clamp element can include applying a clamp element drive signal to a drive unit clamp element to engage a mover element, determining a first displacement of the mover element, and determining a first compensation signal based at least in part on the first displacement. The method can further comprise applying the first compensation signal to the drive unit shear elements and the clamp element drive signal to the drive unit clamp element and determining a second displacement of the mover element. If the second displacement is less than a preselected threshold, the first compensation signal can be combined with an initial shear element drive signal to produce a modified shear element drive signal. If the second displacement is greater than the preselected threshold, a second compensation signal can be determined.

    EELS Auto-Alignment Using Full Image Simulation

    公开(公告)号:US20240194466A1

    公开(公告)日:2024-06-13

    申请号:US18076813

    申请日:2022-12-07

    申请人: FEI Company

    IPC分类号: H01J49/00 H01J49/44

    CPC分类号: H01J49/0036 H01J49/44

    摘要: Methods and systems for automatically tuning an EELS spectrometer according to the present disclosure include obtaining an initial measurement of an EELS spectrum, generating an simulated EELS spectrum fit to the initial measurement of the EELS spectrum, and estimating one or more values of one or more aberration parameters based on the simulated EELS spectrum. Then, using the value(s) of the aberration parameter(s) to tune the optical elements of the EELS spectrometer to remove and/or reduce aberrations in the EELS system.

    HOLLOW CORE WAVEGUIDE FLOW CELL
    7.
    发明公开

    公开(公告)号:US20240167935A1

    公开(公告)日:2024-05-23

    申请号:US18515557

    申请日:2023-11-21

    申请人: FEI COMPANY

    发明人: Chien-Sheng LIAO

    IPC分类号: G01N15/14

    摘要: A flow cell for use with a spectrometer is described. The flow cell includes a waveguide having a hollow core. An inlet is fluidly coupled at a first end of the hollow core, and an outlet is fluidly coupled at a second end of the hollow core. A window at the inlet is optically coupled to the waveguide at the second end, and a mirror at the outlet is optically coupled to the waveguide at the second end. The flow cell also includes a first conduit configured to couple a fluid to the inlet, and a second conduit configured to couple the fluid to the outlet. Methods and systems using the flow cell are described. For example, methods and systems for monitoring a bioreactor.

    Charged particle beam device for inspection of a specimen with a plurality of charged particle beamlets

    公开(公告)号:US11961709B2

    公开(公告)日:2024-04-16

    申请号:US17873778

    申请日:2022-07-26

    申请人: FEI Company

    摘要: The invention relates to a charged particle beam device for inspection of a specimen with a plurality of charged particle beamlets. The charged particle beam device comprises a specimen holder for holding a specimen; a source for producing a beam of charged particles; and an illuminator for converting said beam of charged particles into a plurality of charged particle beamlets and directing said plurality of charged particle beamlets onto said specimen. According to the disclosure, the illuminator comprises a multi-aperture lens plate having a plurality of apertures for defining the corresponding plurality of charged particle beamlets; as well as at least a first electrode for generating an electrical field at a surface of the multi-aperture lens plate. The apertures in said multi-aperture lens plate have a noncircular cross-sectional shape to correct for neighbouring aperture induced aberrations. This allows for decreased spot size, and with this imaging resolution of the device is increased.

    Systems And Methods For Detecting Beam Displacement

    公开(公告)号:US20240110881A1

    公开(公告)日:2024-04-04

    申请号:US18051170

    申请日:2022-10-31

    申请人: FEI Company

    发明人: James B. McGinn

    IPC分类号: G01N23/2251

    摘要: Detectors, systems, and methods for detecting lateral beam displacement for a beam microscopy system are described herein. In one aspect, a detector can include an aperture for allowing a charged particle beam passing through the detector and irradiating a sample; and a plurality of rails arranged in a first plane extending radially outward from the aperture, wherein each of the plurality of rails is configured to detect charged particles from the charged particle beam before irradiating the sample.