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公开(公告)号:US08937078B2
公开(公告)日:2015-01-20
申请号:US12703705
申请日:2010-02-10
申请人: Scott D. Bembenek , Frances M. Hocutt , Barry Eastman Leonard, Jr. , Michael H. Rabinowitz , Mark D. Rosen , Kyle T. Tarantino , Hariharan Venkatesan
发明人: Scott D. Bembenek , Frances M. Hocutt , Barry Eastman Leonard, Jr. , Michael H. Rabinowitz , Mark D. Rosen , Kyle T. Tarantino , Hariharan Venkatesan
IPC分类号: A61K31/517 , C07D403/04
CPC分类号: C07D403/04
摘要: Quinazolinone compounds of formula (I) are described, which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity. Thus, the compounds may be administered to treat, e.g., anemia, vascular disorders, metabolic disorders, and wound healing.
摘要翻译: 描述了式(I)的喹唑啉酮化合物,其可用作脯氨酰羟化酶抑制剂。 这些化合物可用于治疗由脯氨酰羟化酶活性介导的疾病状态,病症和病症的药物组合物和方法。 因此,可以施用化合物以治疗例如贫血,血管疾病,代谢紊乱和伤口愈合。
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公开(公告)号:US20100204226A1
公开(公告)日:2010-08-12
申请号:US12703705
申请日:2010-02-10
申请人: Scott D. Bembenek , Frances M. Hocutt , Barry Eastman Leonard, JR. , Michael H. Rabinowitz , Mark D. Rosen , Kyle T. Tarantino , Hariharan Venkatesan
发明人: Scott D. Bembenek , Frances M. Hocutt , Barry Eastman Leonard, JR. , Michael H. Rabinowitz , Mark D. Rosen , Kyle T. Tarantino , Hariharan Venkatesan
IPC分类号: A61K31/517 , C07D403/04 , C07D487/04 , A61K31/519 , C07D413/14 , A61K31/5377 , A61P7/06 , A61P9/10 , A61P3/10 , A61P3/04 , A61P1/00 , A61P1/04 , A61P31/00 , A61P17/02 , C07D401/14
CPC分类号: C07D403/04
摘要: Quinazolinone compounds of formula (I) are described, which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity. Thus, the compounds may be administered to treat, e.g., anemia, vascular disorders, metabolic disorders, and wound healing.
摘要翻译: 描述了式(I)的喹唑啉酮化合物,其可用作脯氨酰羟化酶抑制剂。 这些化合物可用于治疗由脯氨酰羟化酶活性介导的疾病状态,病症和病症的药物组合物和方法。 因此,可以施用化合物以治疗例如贫血,血管疾病,代谢紊乱和伤口愈合。
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