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    OBG3 globular head and uses thereof
    2.
    发明申请
    OBG3 globular head and uses thereof 失效
    OBG3球状头及其用途

    公开(公告)号：US20070275891A1

    公开(公告)日：2007-11-29

    申请号：US11132814

    申请日：2005-05-19

    申请人： Joachim Fruebis ,  Mary Erickson ,  Frances Yen-Potin ,  Bernard Bihain

    发明人： Joachim Fruebis ,  Mary Erickson ,  Frances Yen-Potin ,  Bernard Bihain

    IPC分类号： A61K38/17 ,  A61K48/00

    CPC分类号： C07K14/5759 ,  A61K38/00 ,  C12N2799/026

    摘要： The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.

    摘要翻译： 本发明涉及肥胖研究领域。 肥胖是一个严重而广泛的公共卫生问题。 已经鉴定出化合物球状的OBG3，其减少动物的体重增加。 该化合物对于减少体重和治疗与肥胖有关的疾病和病症应该是有效的。 这些肥胖相关的疾病和病症包括高脂血症，动脉粥样硬化，糖尿病和高血压。

    APM1 biallelic markers and uses thereof
    4.
    发明授权
    APM1 biallelic markers and uses thereof 失效
    APM1双标记及其用途

    公开(公告)号：US06582909B1

    公开(公告)日：2003-06-24

    申请号：US09569852

    申请日：2000-05-10

    申请人： Lydie Bougueleret ,  Bernard Bihain ,  Blake Denison ,  Frances Yen-Potin

    发明人： Lydie Bougueleret ,  Bernard Bihain ,  Blake Denison ,  Frances Yen-Potin

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6883 ,  A01K2217/05 ,  C07K14/47 ,  C12Q2600/156 ,  Y10S977/928

    摘要： The invention provides novel APM1 genomic sequences, polypeptides, antibodies, and polynucleotides including biallelic markers derived from the APM1 locus. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Additionally, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. Further, the invention provides diagnostic methods for early detection of obesity-related disorders.

    摘要翻译： 本发明提供新型APM1基因组序列，多肽，抗体和多核苷酸，包括源自APM1基因座的双重标记。 还提供了与这些双重标记物侧翼的区域杂交的引物。 本发明还提供了适用于对本发明的一种或多种双重标记物的含有核酸的样品进行基因分型的多核苷酸和方法。 另外，本发明提供了检测双重标记等位基因和表型之间和/或双重标记单元型和表型之间的统计学相关性的方法。 此外，本发明提供了用于早期检测肥胖相关疾病的诊断方法。

    OBG3 globular head and uses thereof
    10.
    发明申请
    OBG3 globular head and uses thereof 失效
    OBG3球状头及其用途

    公开(公告)号：US20050059631A1

    公开(公告)日：2005-03-17

    申请号：US10970648

    申请日：2004-10-20

    申请人： Joachim Fruebis ,  Mary Erickson ,  Frances Yen-Potin ,  Bernard Bihain

    发明人： Joachim Fruebis ,  Mary Erickson ,  Frances Yen-Potin ,  Bernard Bihain

    IPC分类号： A61K38/00 ,  C07K14/575 ,  A61K48/00 ,  C07H21/04

    CPC分类号： C07K14/5759 ,  A61K38/00 ,  C12N2799/026

    摘要： The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.

    摘要翻译： 本发明涉及肥胖研究领域。 肥胖是一个严重而广泛的公共卫生问题。 已经鉴定出化合物球状的OBG3，其减少动物的体重增加。 该化合物对于减少体重和治疗与肥胖有关的疾病和病症应该是有效的。 这些肥胖相关的疾病和病症包括高脂血症，动脉粥样硬化，糖尿病和高血压。