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公开(公告)号:US20060173049A1
公开(公告)日:2006-08-03
申请号:US11344432
申请日:2006-01-31
申请人: Michael Malamas , William Fobare , William Solvibile , Frank Lovering , Jeffrey Condon , Albert Robichaud
发明人: Michael Malamas , William Fobare , William Solvibile , Frank Lovering , Jeffrey Condon , Albert Robichaud
IPC分类号: C07D403/02 , A61K31/4439
CPC分类号: C07D401/06 , C07D401/14 , C07D405/14 , C07D417/14
摘要: The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译: 本发明提供式I的氨基 - 吡啶化合物本发明还提供了用于抑制β-分泌酶(BACE)和治疗β-淀粉样沉积物和神经原纤维缠结的方法。
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公开(公告)号:US06828344B1
公开(公告)日:2004-12-07
申请号:US09677021
申请日:2000-09-29
申请人: Jasbir S. Seehra , Neelu Kaila , John McKew , Frank Lovering , Jean E. Bemis , YiBin Xiang
发明人: Jasbir S. Seehra , Neelu Kaila , John McKew , Frank Lovering , Jean E. Bemis , YiBin Xiang
IPC分类号: A61K31404
CPC分类号: C07D401/12 , C07D209/10 , C07D209/12 , C07D209/36 , C07D209/40 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/10
摘要: Novel compounds are disclosed which inhibit the activity of phospholipase enzymes, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.
摘要翻译: 公开了抑制磷脂酶,特别是细胞溶质磷脂酶A2活性的新型化合物。 还公开了包含这些化合物的药物组合物和使用这些组合物的治疗方法。
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公开(公告)号:US20100137298A1
公开(公告)日:2010-06-03
申请号:US12138752
申请日:2008-06-13
申请人: Jeremy Ian Levin , Thomas Saltmarsh Rush, III , Frank Lovering , Yonghan Hu , Jianchang Li , Wei Li , Jun Jun Wu , Rajeev Hotchandani , Jason Shaoyun Xiang , Xuemei Du , Derek Cecil Cole , Steve Yikkai Tam
发明人: Jeremy Ian Levin , Thomas Saltmarsh Rush, III , Frank Lovering , Yonghan Hu , Jianchang Li , Wei Li , Jun Jun Wu , Rajeev Hotchandani , Jason Shaoyun Xiang , Xuemei Du , Derek Cecil Cole , Steve Yikkai Tam
IPC分类号: A61K31/5377 , G01N33/573 , C12N9/99 , A61K31/4439 , A61K31/425 , A61K31/428 , A61K31/381 , A61K31/343 , C07D413/12 , C07D405/10 , C07D277/02 , C07D275/02 , C07D209/42 , C07D333/52 , C07D307/78 , A61P35/00
CPC分类号: C07D235/24 , C07D209/42 , C07D231/14 , C07D235/12 , C07D261/18 , C07D263/58 , C07D277/56 , C07D277/64 , C07D277/68 , C07D285/01 , C07D307/68 , C07D307/80 , C07D307/81 , C07D307/82 , C07D307/85 , C07D307/92 , C07D333/34 , C07D333/70 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D491/06 , C07D495/04
摘要: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
摘要翻译: 本发明涉及联芳基磺酰胺及其作为例如金属蛋白酶抑制剂的用途。
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公开(公告)号:US07420001B2
公开(公告)日:2008-09-02
申请号:US11001589
申请日:2004-12-01
申请人: Jeremy Ian Levin , Thomas Saltmarsh Rush, III , Frank Lovering , Yonghan Hu , Jianchang Li , Wei Li , Jun Jun Wu , Rajeev Hotchandani , Jason Shaoyun Xiang , Xuemei Du , Derek Cecil Cole , Steve Yikkai Tam
发明人: Jeremy Ian Levin , Thomas Saltmarsh Rush, III , Frank Lovering , Yonghan Hu , Jianchang Li , Wei Li , Jun Jun Wu , Rajeev Hotchandani , Jason Shaoyun Xiang , Xuemei Du , Derek Cecil Cole , Steve Yikkai Tam
IPC分类号: A61K31/343 , C07D307/81
CPC分类号: C07D235/24 , C07D209/42 , C07D231/14 , C07D235/12 , C07D261/18 , C07D263/58 , C07D277/56 , C07D277/64 , C07D277/68 , C07D285/01 , C07D307/68 , C07D307/80 , C07D307/81 , C07D307/82 , C07D307/85 , C07D307/92 , C07D333/34 , C07D333/70 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D491/06 , C07D495/04
摘要: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
摘要翻译: 本发明涉及联芳基磺酰胺及其作为例如金属蛋白酶抑制剂的用途。
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公开(公告)号:US20060211730A1
公开(公告)日:2006-09-21
申请号:US11377886
申请日:2006-03-16
申请人: Jeremy Levin , Zhong Li , George Diamantidis , Frank Lovering , Weiheng Wang , Jeffrey Condon , Yang-I Lin , Jerauld Skotnicki , Kaapjoo Park
发明人: Jeremy Levin , Zhong Li , George Diamantidis , Frank Lovering , Weiheng Wang , Jeffrey Condon , Yang-I Lin , Jerauld Skotnicki , Kaapjoo Park
IPC分类号: A61K31/4709 , C07D403/02 , C07D405/02
CPC分类号: C07D215/04 , C07D235/12 , C07D249/18 , C07D271/12 , C07D401/12 , C07D405/12
摘要: This invention provides compounds of Formula I, having the structure: that are useful in treating diseases or disorders mediated by TNF-α, such as arthritis (rheumatoid arthritis (RA), juvenile RA, psoriatic arthritis, osteoarthritis etc), tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection, ankylosing spondylitis, psoriasis, sepsis, multiple sclerosis, Crohn's disease, degenerative cartilage loss, asthma, idiopathic pulmonary fibrosis, vasculitis, systemic lupus erythematosus, irritable bowel syndrome, acute coronary syndrome, hepatitis C, cachexia, COPD, stroke or type 2 diabetes, and for alleviation of symptoms thereof. The invention further provides methods for use of the compounds.
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公开(公告)号:US20060183790A1
公开(公告)日:2006-08-17
申请号:US11352820
申请日:2006-02-13
申请人: Derek Cole , Eric Manas , Lee Jennings , Frank Lovering , Joseph Stock , William Moore , John Ellingboe , Jeffrey Condon , Mohani Sukhdeo , Ping Zhou , JunJun Wu , Koi Morris
发明人: Derek Cole , Eric Manas , Lee Jennings , Frank Lovering , Joseph Stock , William Moore , John Ellingboe , Jeffrey Condon , Mohani Sukhdeo , Ping Zhou , JunJun Wu , Koi Morris
IPC分类号: A61K31/40 , C07D207/22
CPC分类号: C07D207/327 , C07D207/33 , C07D207/333 , C07D207/335 , C07D207/337 , C07D207/36 , C07D401/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/10 , C07D417/12
摘要: The present invention provides an azolylacylquanidine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
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公开(公告)号:US06916841B2
公开(公告)日:2005-07-12
申请号:US10075079
申请日:2002-05-08
申请人: Jasbir S. Seehra , Neelu Kaila , John C. McKew , Frank Lovering , Jean E. Bemis , YiBin Xiang
发明人: Jasbir S. Seehra , Neelu Kaila , John C. McKew , Frank Lovering , Jean E. Bemis , YiBin Xiang
IPC分类号: C07D209/12 , C07D209/30 , C07D209/36 , C07D209/40 , C07D209/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/10 , A61K31/40 , C07D209/04 , C07D209/18
CPC分类号: C07D401/12 , C07D209/12 , C07D209/30 , C07D209/36 , C07D209/40 , C07D209/42 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/10
摘要: Novel compounds are disclosed which inhibit the activity of phospholipase enzymes in a mammal, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.
摘要翻译: 公开了新的化合物,其抑制哺乳动物中磷脂酶的活性,特别是胞浆磷脂酶A 2 N 2。 还公开了包含这些化合物的药物组合物和使用这些组合物的治疗方法。
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公开(公告)号:US20050143422A1
公开(公告)日:2005-06-30
申请号:US11001589
申请日:2004-12-01
申请人: Jeremy Levin , Thomas Rush , Frank Lovering , Yonghan Hu , Jianchang Li , Wei Li , Jun Wu , Rajeev Hotchandani , Jason Xiang , Xuemei Du , Derek Cole , Steve Tam
发明人: Jeremy Levin , Thomas Rush , Frank Lovering , Yonghan Hu , Jianchang Li , Wei Li , Jun Wu , Rajeev Hotchandani , Jason Xiang , Xuemei Du , Derek Cole , Steve Tam
IPC分类号: C07D209/42 , C07D231/14 , C07D235/12 , C07D235/24 , C07D261/18 , C07D263/58 , C07D277/56 , C07D277/64 , C07D277/68 , C07D285/00 , C07D285/01 , C07D307/68 , C07D307/80 , C07D307/81 , C07D307/82 , C07D307/85 , C07D307/92 , C07D333/34 , C07D333/70 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D491/06 , C07D495/04 , A61K31/445 , A61K31/4025 , A61K31/4178 , C07D43/14 , C07D49/14
CPC分类号: C07D235/24 , C07D209/42 , C07D231/14 , C07D235/12 , C07D261/18 , C07D263/58 , C07D277/56 , C07D277/64 , C07D277/68 , C07D285/01 , C07D307/68 , C07D307/80 , C07D307/81 , C07D307/82 , C07D307/85 , C07D307/92 , C07D333/34 , C07D333/70 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D491/06 , C07D495/04
摘要: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
摘要翻译: 本发明涉及联芳基磺酰胺及其作为例如金属蛋白酶抑制剂的用途。
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公开(公告)号:US06500853B1
公开(公告)日:2002-12-31
申请号:US09686616
申请日:2000-10-11
申请人: Jasbir S. Seehra , John C. McKew , Frank Lovering , Jean E. Bemis , YiBin Xiang , Lihren Chen , John L. Knopf
发明人: Jasbir S. Seehra , John C. McKew , Frank Lovering , Jean E. Bemis , YiBin Xiang , Lihren Chen , John L. Knopf
IPC分类号: A61K31405
CPC分类号: C07D209/22 , C07D209/18 , C07D209/20 , C07D209/42
摘要: This invention concerns compounds and pharmaceutical compositions useful for treating or preventing inflammatory conditions in a mammal, the methods comprising administration of novel pharmaceutically useful compounds of the general formulae: or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined in the specification.
摘要翻译: 本发明涉及可用于治疗或预防哺乳动物炎症状况的化合物和药物组合物,所述方法包括给予新的药学上有用的通式化合物或其药学上可接受的盐,其中R 1 -R 5如本说明书中所定义。
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