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公开(公告)号:US09850543B2
公开(公告)日:2017-12-26
申请号:US14777211
申请日:2014-03-12
IPC分类号: A61K31/70 , C07H21/02 , C07H21/04 , C12Q1/68 , C12N15/113 , G01N33/574 , C12N5/00
CPC分类号: C12Q1/6886 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12N2320/30 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N33/57496 , G01N2333/914
摘要: The invention provides methods of detecting cancer biomarkers, such as one or more SWI/SNF complex mutations, in order to determine a cancer subject's amenability to therapeutic treatment with a BRM inhibitor. Kits, methods of screening for candidate BRM inhibitors, and associated methods of treatment are also provided.
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公开(公告)号:US20160032402A1
公开(公告)日:2016-02-04
申请号:US14777211
申请日:2014-03-12
IPC分类号: C12Q1/68 , G01N33/574 , C12N15/113
CPC分类号: C12Q1/6886 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12N2320/30 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N33/57496 , G01N2333/914
摘要: The invention provides methods of detecting cancer biomarkers, such as one or more SWI/SNF complex mutations, in order to determine a cancer subject's amenability to therapeutic treatment with a BRM inhibitor. Kits, methods of screening for candidate BRM inhibitors, and associated methods of treatment are also provided.
摘要翻译: 本发明提供了检测癌症生物标志物(例如一种或多种SWI / SNF复合体突变)的方法,以便确定癌症受试者对BRM抑制剂的治疗性治疗的适应性。 还提供了试剂盒,筛选候选BRM抑制剂的方法和相关的治疗方法。
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公开(公告)号:US20150354006A1
公开(公告)日:2015-12-10
申请号:US14434063
申请日:2013-10-15
申请人: Ho Man CHAN , Nathan P. ENGLUND , Levi GARRAWAY , Min HU , Jacob JAFFE , Gregory KRYUKOV , Jun LIU , Xianghui LIU , Rob MCDONALD , Frank Peter STEGMEIER , Zhaofu WANG , Yan WANG , Haiping WU , Feng YAN
发明人: Ho Man Chan , Nathan P. Englund , Levi Garraway , Min Hu , Jacob Jaffe , Gregory Kryukov , Jun Liu , Xianghui Liu , Rob McDonald , Frank Peter Stegmeier , Zhaofu Wang , Yan Wang , Haiping Wu , Feng Yan
IPC分类号: C12Q1/68 , G01N33/574
CPC分类号: C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , G01N33/5011 , G01N33/57426 , G01N2333/91017 , G01N2440/12 , G01N2500/04 , G01N2500/10
摘要: The invention provides methods of detecting a NSD2 mutation in a cancer cell, methods cancer diagnosis and methods of screening for NSD2 inhibitors.
摘要翻译: 本发明提供检测癌细胞NSD2突变的方法,方法癌症诊断和筛选NSD2抑制剂的方法。
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公开(公告)号:US20180258491A1
公开(公告)日:2018-09-13
申请号:US15853699
申请日:2017-12-22
IPC分类号: C12Q1/6886 , C12N15/113 , G01N33/574
CPC分类号: C12Q1/6886 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12N2320/30 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N33/57496 , G01N2333/914
摘要: The invention provides methods of detecting cancer biomarkers, such as one or more SWI/SNF complex mutations, in order to determine a cancer subject's amenability to therapeutic treatment with a BRM inhibitor. Kits, methods of screening for candidate FIRM inhibitors, and associated methods of treatment are also provided.
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