公开(公告)号：US09352248B2

公开(公告)日：2016-05-31

申请号：US13121359

申请日：2009-09-28

申请人： Johann Kubicek ,  Frank Schaefer ,  Joerg Labahn ,  Georg Bueldt

发明人： Johann Kubicek ,  Frank Schaefer ,  Joerg Labahn ,  Georg Bueldt

IPC分类号： C30B29/58 ,  B01D9/00 ,  B01L3/06

CPC分类号： C07K1/306 ,  B01D9/00 ,  B01D9/0077 ,  B01D2009/0086 ,  B01L3/06 ,  C07K14/705

摘要： The present invention pertains to a method for loading a crystallization device and for manufacturing a crystallization device comprising multiple receptacles with a pre-defined amount of at least one matrix-forming compound capable of forming a crystallization matrix for a membrane protein, said method comprising the following steps: a) Modifying the state of aggregation of said at least one matrix-forming compound to a fluidic state which allows dispensing said at least one matrix-forming compound, and b) dispensing a defined amount of said at least one matrix-forming compound into at least one receptacle of the crystallization device, wherein said dispensed matrix-forming compound solidifies within said receptacle. Thereby, pre-filled crystallization devices are obtained which can be used as consumables in particular in automated crystallization processes. Also provided are protein crystallization methods using respectively prepared crystallization devices.

摘要翻译： 本发明涉及一种用于装载结晶装置和用于制造结晶装置的方法，所述结晶装置包括具有预定量的至少一种能够形成膜蛋白的结晶基质的基质形成化合物的多个容器，所述方法包括 以下步骤：a）将所述至少一种基质形成化合物的聚集状态改变为允许分配所述至少一种基质形成化合物的流体状态，以及b）分配限定量的所述至少一种基质形成 化合物进入结晶装置的至少一个容器中，其中所述分配的基质形成化合物在所述容器内固化。 由此，可以获得预填充的结晶装置，其可以用作特别是在自动结晶过程中的消耗品。 还提供了使用分别制备的结晶装置的蛋白质结晶方法。

公开(公告)号：US08772723B2

公开(公告)日：2014-07-08

申请号：US14015122

申请日：2013-08-30

申请人： Frank Schaefer

发明人： Frank Schaefer

IPC分类号： G01J5/58

CPC分类号： G01N21/53 ,  G01J1/0492 ,  G01J1/1626 ,  G01N21/314 ,  G01N21/3504 ,  G01N2021/3137 ,  G01N2021/3513 ,  G01S17/88

摘要： A gas sensor device for determining a molar concentration of a gas to be detected, that absorbs light of a measurement wavelength that is characteristic of the gas in the infrared light region, includes a light emission device emitting measurement light of measurement wavelength into a solid angle region of a light absorption path extending through the gas, and a light detector measuring an intensity of at least one component of the measurement light that has propagated through the light absorption path, the light absorption path extending from the light emission device to an object outside the gas sensor device that at least partially reflects the measurement light to the light detector, and being essentially disposed outside of the gas sensor device, and means for determining the length of the light absorption path. A method for determining a concentration of a gas to be detected is also described.

摘要翻译： 用于确定吸收红外光区域中的气体特性的测定波长的光的被检测气体的摩尔浓度的气体传感器装置，包括发射测定波长的测定光为立体角的发光装置 通过气体延伸的光吸收路径的区域，以及光检测器，其测量已经通过光吸收路径传播的测量光的至少一个分量的强度，光吸收路径从发光器件延伸到外部物体 所述气体传感器装置至少部分地将测量光反射到光检测器，并且基本上布置在气体传感器装置的外部，以及用于确定光吸收路径的长度的装置。 还描述了一种用于确定待检测气体浓度的方法。

公开(公告)号：US07843025B2

公开(公告)日：2010-11-30

申请号：US12359904

申请日：2009-01-26

申请人： Hubert Benzel ,  Frank Schaefer ,  Simon Armbruster ,  Gerhard Lammel ,  Christoph Schelling ,  Joerg Brasas

发明人： Hubert Benzel ,  Frank Schaefer ,  Simon Armbruster ,  Gerhard Lammel ,  Christoph Schelling ,  Joerg Brasas

IPC分类号： H01L21/00

CPC分类号： B81B3/007 ,  B81B2201/0264 ,  B81B2203/0127 ,  B81C1/00658 ,  B81C2201/0115 ,  B81C2201/0116 ,  B81C2201/0136

摘要： A manufacturing method for a micromechanical semiconductor element includes providing on a semiconductor substrate a patterned stabilizing element having at least one opening. The opening is arranged such that it allows access to a first region in the semiconductor substrate, the first region having a first doping. Furthermore, a selective removal of at least a portion of the semiconductor material having the first doping out of the first region of the semiconductor substrate is provided. In addition, a membrane is produced above the first region using a first epitaxy layer applied on the stabilizing element. In a further method step, at least a portion of the first region is used to produce a cavity underneath the stabilizing element. In this manner, the present invention provides for the production of the patterned stabilizing element by means of a second epitaxy layer, which is applied on the semiconductor substrate.

摘要翻译： 微机电半导体元件的制造方法包括在半导体衬底上提供具有至少一个开口的图案化稳定元件。 开口被布置成使得其允许接近半导体衬底中的第一区域，第一区域具有第一掺杂。 此外，提供了选择性地去除半导体衬底的第一区域中具有第一掺杂的半导体材料的至少一部分。 此外，使用施加在稳定元件上的第一外延层，在第一区域上方产生膜。 在另一方法步骤中，第一区域的至少一部分用于在稳定元件下方产生空腔。 以这种方式，本发明提供了通过施加在半导体衬底上的第二外延层来生产图案化的稳定元件。

公开(公告)号：US07755152B2

公开(公告)日：2010-07-13

申请号：US12490762

申请日：2009-06-24

申请人： Hubert Benzel ,  Frank Schaefer ,  Simon Armbruster ,  Gerhard Lammel ,  Christoph Schelling ,  Joerg Brasas

发明人： Hubert Benzel ,  Frank Schaefer ,  Simon Armbruster ,  Gerhard Lammel ,  Christoph Schelling ,  Joerg Brasas

IPC分类号： H01L29/84

CPC分类号： B81C1/00182 ,  B81B2203/0127 ,  B81B2203/0315 ,  B81C2201/0115

摘要： A method for producing a micromechanical diaphragm sensor includes providing a semiconductor substrate having a first region, a diaphragm, and a cavity that is located at least partially below the diaphragm. Above at least one part of the first region, a second region is generated in or on the surface of the semiconductor substrate, with at least one part of the second region being provided as crosspieces. The diaphragm is formed by a deposited sealing layer, and includes at least a part of the crosspieces.

摘要翻译： 微机械振动膜传感器的制造方法包括提供具有至少部分地位于隔膜下方的第一区域，隔膜和空腔的半导体基板。 在第一区域的至少一部分上方，在半导体衬底的表面中或表面上产生第二区域，第二区域的至少一部分被设置为十字形。 隔膜由沉积的密封层形成，并且包括至少一部分挡条。

公开(公告)号：US07569412B2

公开(公告)日：2009-08-04

申请号：US11011898

申请日：2004-12-13

申请人： Hubert Benzel ,  Frank Schaefer ,  Simon Armbruster ,  Gerhard Lammel ,  Christoph Schelling ,  Joerg Brasas

发明人： Hubert Benzel ,  Frank Schaefer ,  Simon Armbruster ,  Gerhard Lammel ,  Christoph Schelling ,  Joerg Brasas

IPC分类号： H01L21/00

CPC分类号： B81C1/00182 ,  B81B2203/0127 ,  B81B2203/0315 ,  B81C2201/0115

摘要： A method for producing a micromechanical diaphragm sensor includes providing a semiconductor substrate having a first region, a diaphragm, and a cavity that is located at least partially below the diaphragm. Above at least one part of the first region, a second region is generated in or on the surface of the semiconductor substrate, with at least one part of the second region being provided as crosspieces. The diaphragm is formed by a deposited sealing layer, and includes at least a part of the crosspieces.

摘要翻译： 微机械振动膜传感器的制造方法包括提供具有至少部分地位于隔膜下方的第一区域，隔膜和空腔的半导体基板。 在第一区域的至少一部分上方，在半导体衬底的表面中或表面上产生第二区域，第二区域的至少一部分被设置为十字形。 隔膜由沉积的密封层形成，并且包括至少一部分挡条。

公开(公告)号：US20090127640A1

公开(公告)日：2009-05-21

申请号：US12359904

申请日：2009-01-26

申请人： Hubert Benzel ,  Frank Schaefer ,  Simon Armbruster ,  Gerhard Lammel ,  Christoph Schelling ,  Joerg Brasas

发明人： Hubert Benzel ,  Frank Schaefer ,  Simon Armbruster ,  Gerhard Lammel ,  Christoph Schelling ,  Joerg Brasas

IPC分类号： H01L29/84 ,  H01L21/3213

CPC分类号： B81B3/007 ,  B81B2201/0264 ,  B81B2203/0127 ,  B81C1/00658 ,  B81C2201/0115 ,  B81C2201/0116 ,  B81C2201/0136

摘要： A manufacturing method for a micromechanical semiconductor element includes providing on a semiconductor substrate a patterned stabilizing element having at least one opening. The opening is arranged such that it allows access to a first region in the semiconductor substrate, the first region having a first doping. Furthermore, a selective removal of at least a portion of the semiconductor material having the first doping out of the first region of the semiconductor substrate is provided. In addition, a membrane is produced above the first region using a first epitaxy layer applied on the stabilizing element. In a further method step, at least a portion of the first region is used to produce a cavity underneath the stabilizing element. In this manner, the present invention provides for the production of the patterned stabilizing element by means of a second epitaxy layer, which is applied on the semiconductor substrate.

摘要翻译： 微机电半导体元件的制造方法包括在半导体衬底上提供具有至少一个开口的图案化稳定元件。 开口被布置成使得其允许接近半导体衬底中的第一区域，第一区域具有第一掺杂。 此外，提供了选择性地去除半导体衬底的第一区域中具有第一掺杂的半导体材料的至少一部分。 此外，使用施加在稳定元件上的第一外延层，在第一区域上方产生膜。 在另一方法步骤中，第一区域的至少一部分用于在稳定元件下方产生空腔。 以这种方式，本发明提供了通过施加在半导体衬底上的第二外延层来生产图案化的稳定元件。

公开(公告)号：US20080300410A1

公开(公告)日：2008-12-04

申请号：US12093825

申请日：2006-11-16

申请人： Mahavir Prashad ,  Yugang Liu ,  Bin Hu ,  Michael J. Girgis ,  Frank Schaefer

发明人： Mahavir Prashad ,  Yugang Liu ,  Bin Hu ,  Michael J. Girgis ,  Frank Schaefer

IPC分类号： C07D211/32

CPC分类号： C07D211/26 ,  C07D213/26

摘要： The present invention relates to salts of aryl compounds as discussed below and to methods of manufacture thereof, as well as other subject matter. More particularly, the invention relates to salts useful as intermediates for the synthesis of the cinnamanilide of formula (Y): where Ra is selected from H, OH, C1, C2, C3 or C4 alkyl; and R1 is C1, C2, C3 or C4 alkyl.

摘要翻译： 本发明涉及如下所述的芳基化合物的盐及其制备方法以及其它主题。 更具体地，本发明涉及可用作合成式（Y）的肉桂酰苯胺的中间体的盐：其中R a选自H，OH，C 1，C 2，C 3或C 4烷基; 并且R 1是C 1，C 2，C 3或C 4烷基。

公开(公告)号：US07045382B2

公开(公告)日：2006-05-16

申请号：US10472650

申请日：2002-03-13

申请人： Hubert Benzel ,  Heribert Weber ,  Hans Artmann ,  Frank Schaefer

发明人： Hubert Benzel ,  Heribert Weber ,  Hans Artmann ,  Frank Schaefer

IPC分类号： H01L21/00

CPC分类号： G01L9/0055 ,  B81B2203/033 ,  B81C1/00047 ,  B81C1/00246 ,  B81C2201/0116 ,  B81C2203/0742 ,  G01L9/0042 ,  G01L9/0045

摘要： Proposed is a method for manufacturing micromechanical sensors and sensors manufactured by this method, where openings are introduced into a semiconductor substrate. After the openings are introduced into the semiconductor substrate, a subsequent temperature treatment is carried out, in which the openings are converted into voids in the depth of the substrate.

摘要翻译： 提出了一种通过这种方法制造微机械传感器和传感器的方法，其中开口被引入到半导体衬底中。 在将开口引入半导体衬底之后，进行随后的温度处理，其中开口被转换成衬底深度的空隙。

公开(公告)号：US20060014392A1

公开(公告)日：2006-01-19

申请号：US11221228

申请日：2005-09-06

申请人： Hubert Benzel ,  Heribert Weber ,  Hans Artmann ,  Frank Schaefer

发明人： Hubert Benzel ,  Heribert Weber ,  Hans Artmann ,  Frank Schaefer

IPC分类号： H01L21/311

CPC分类号： G01L9/0042 ,  B81B2201/0264 ,  B81B2203/0127 ,  B81B2203/0315 ,  B81C1/00047 ,  B81C1/00595 ,  B81C2201/0115 ,  G01L9/0045 ,  H01L21/3063

摘要： A method is for producing a semiconductor component, e.g., a multilayer semiconductor element, e.g., a micromechanical component, e.g., a pressure sensor, having a semiconductor substrate, e.g., made of silicon, and a semiconductor component produced according to the method. To reduce the production cost of such a semiconductor component, in a first step a first porous layer is produced in the semiconductor component, and in a second step a hollow or cavity is produced under or from the first porous layer in the semiconductor component, with the hollow or cavity capable of being provided with an external access opening.

公开(公告)号：US06840111B2

公开(公告)日：2005-01-11

申请号：US10433541

申请日：2002-09-29

申请人： Hubert Benzel ,  Heribert Weber ,  Frank Schaefer

发明人： Hubert Benzel ,  Heribert Weber ,  Frank Schaefer

IPC分类号： G01L9/00 ,  H01L29/84 ,  G01L7/06

CPC分类号： G01L9/0052

摘要： A micromechanical component in which lateral deformations, i.e., deformations of the component parallel to its two main surfaces, are concentrated in a defined area of the component structure, making it possible to decouple lateral and vertical stresses in the component. The component structure includes at least one bellows-like structure in which lateral deformations of the component are concentrated. A pressure sensor having a micromechanical component of this type may be used, for example, for measured-value detection.

摘要翻译： 其中侧向变形（即，与其两个主表面平行的部件的变形）集中在部件结构的限定区域中的微机械部件，使得可以使部件中的横向和垂直应力解耦。 部件结构包括至少一个波纹管状结构，其中部件的侧向变形被集中。 可以使用具有这种类型的微机械部件的压力传感器，例如用于测量值检测。