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公开(公告)号：US12128096B2
公开(公告)日：2024-10-29
申请号：US17804679
申请日：2022-05-31
发明人： Amirreza Faridmoayer , Rainer Follador , Stefan Jochen Kemmler , Michael Thomas Kowarik , Gerald Johann Posch , Fabio Serventi
IPC分类号： A61K39/09 , A61K39/102 , C08B37/00 , A61K35/74 , A61K38/00 , A61K47/36 , B01J20/32 , C07K9/00 , C07K14/315
CPC分类号： A61K39/092 , A61K39/102 , C08B37/006 , A61K35/74 , A61K38/00 , A61K47/36 , B01J20/32 , C07K9/005 , C07K14/315
摘要： The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharides comprising one or more repeat unit(s) →4)-β-D-Glcp-(1→4)-[Gro-(2→P→3)]-β-D-Galp-(1→4)-β-L-Rhap-(1→. Also provided are conjugates comprising a →4)-β-D-Glcp-(1→4)-[Gro-(2→P→3)]-β-D-Galp-(1→4)-β-L-Rhap-(1→, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.
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公开(公告)号：US12128094B2
公开(公告)日：2024-10-29
申请号：US17287268
申请日：2019-11-04
发明人： Mario Contorni , Mariagrazia Pizza , Anja Seubert
CPC分类号： A61K39/0018 , A61P31/04 , A61K2039/55505
摘要： The invention provides an immunogenic composition comprising OMVs and (a) acellular pertussis antigen, (b) a tetanus toxoid and (c) a diphtheria toxoid, wherein the OMVs are derived from Bordetella pertussis. The invention also provides compositions for use in a method for raising an immune response in a patient, comprising the step of administering to the patient a composition of the invention.
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3.发明公开公开(公告)号：US20240350410A1
公开(公告)日：2024-10-24
申请号：US18683535
申请日：2022-08-16
发明人： Rushit LODAYA , Patrick POHLHAUS , Elizabeth ZECCA , Jinjin ZHANG , Adora PADILLA , Erwan BOURLÈS , Julie ENERT
CPC分类号： A61K9/1272 , A61K9/1271 , A61K9/19 , A61K31/7105 , A61K47/183 , A61K47/22 , A61K47/26
摘要： Compositions and methods are provided for stabilization of RNA encapsulated by lipid nanoparticles during lyophilization. Novel lyophilization processes are provided. These techniques may be used to prevent the need for cold chain storage.
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公开(公告)号：US12076352B2
公开(公告)日：2024-09-03
申请号：US16973471
申请日：2019-06-18
CPC分类号： A61K35/76 , C12N7/00 , C12N2795/00043 , C12N2820/55
摘要： The present invention discloses an engineered bacteriophage capable of binding to a commensal bacterium and inserting its genome polynucleotide into the commensal bacterium, but incapable of producing progeny, incapable of carrying out a lysogenic cycle and incapable of carrying out a lytic cycle within the commensal bacterium, wherein the engineered bacteriophage comprises a genome polynucleotide including at least one gene encoding at least one heterologous antigen(s) under the control of a promoter.
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公开(公告)号：US20240226261A9
公开(公告)日：2024-07-11
申请号：US18386593
申请日：2023-11-02
发明人： Elisabeth Marie Monique BERTAUD , Ralph Leon BIEMANS , Nicolas Jean Benoit MONIOTTE , Laurent Bernard Jean STRODIOT
CPC分类号： A61K39/092 , A61K47/6415 , A61K47/646 , A61K2039/6087
摘要： The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, the present invention relates to sized Streptococcus pneumoniae serotype 6A capsular polysaccharides, in particular Streptococcus pneumoniae serotype 6A capsular polysaccharides having the average size (e.g. Mw) of the Streptococcus pneumoniae serotype 6A capsular polysaccharide is between 100-1000 kDa, suitably conjugated to a carrier protein.
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公开(公告)号：US20240181038A1
公开(公告)日：2024-06-06
申请号：US18283632
申请日：2022-03-25
申请人： GLAXOSMITHKLINE BIOLOGICALS SA , UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Ventzislav Bojidarov VASSILEV , Corey MALLETT , Ronan ROUXEL , Normand BLAIS , Masaru KANEKIYO , Barney S. GRAHAM
IPC分类号： A61K39/145 , A61K39/00 , A61K39/385 , A61P31/16 , C07K14/005
CPC分类号： A61K39/145 , A61K39/385 , A61P31/16 , C07K14/005 , A61K2039/53 , A61K2039/55555 , C12N2760/16122 , C12N2760/16134
摘要： The present invention relates to a carrier-formulated mRNA comprising at least one coding sequence encoding an influenza HA stem polypeptide, and to related aspects.
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公开(公告)号：US11957749B2
公开(公告)日：2024-04-16
申请号：US16772194
申请日：2018-12-14
发明人： Virginia Ammendola , Babak Bayat , Clarisse Lorin , Ventzislav Bojidarov Vassilev , Alessandra Vitelli
CPC分类号： A61K39/292 , A61K39/39 , A61P31/20 , C07K14/005 , C12N7/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C07K2319/40 , C12N2710/10343 , C12N2710/24143 , C12N2730/10122 , C12N2730/10134
摘要： The present invention relates to immunogenic compositions and combinations thereof which may find use in immunisation regimens for the treatment of chronic hepatitis B. An immunogenic composition comprises a replication-defective chimpanzee adenoviral (ChAd) vector comprising polynucleotides encoding HBs, HBc human invariant chain (hIi) fused to the HBc. Another immunogenic composition comprises a Modified Vaccinia Virus Ankara (MVA) vector comprising polynucleotides encoding HBs and HBc. Another immunogenic composition comprises recombinant HBs, C-terminal truncated recombinant HBc and an adjuvant containing MPL and QS-21.
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公开(公告)号：US11951161B2
公开(公告)日：2024-04-09
申请号：US16815635
申请日：2020-03-11
IPC分类号： A61K39/395 , A61K39/015 , A61K39/04 , A61K39/29 , A61K39/00
CPC分类号： A61K39/015 , A61K39/04 , A61K39/292 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , A61K2039/70 , C12N2730/10134 , Y02A50/30
摘要： Methods of inducing an immune response comprising at least two administrations of an adjuvanted immunogenic composition, wherein the second administration contains reduced amounts of antigen and adjuvant.
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公开(公告)号：US20240110926A1
公开(公告)日：2024-04-04
申请号：US18257412
申请日：2021-12-15
CPC分类号： G01N33/6869 , A61K45/00 , G01N2333/525 , G01N2333/545 , G01N2800/122 , G01N2800/26 , G01N2800/52
摘要： The present invention relates to antibiotic agents for use in the treatment of patients presenting with an exacerbation of chronic obstructive pulmonary disease (COPD). More particularly the present invention relates to antibiotic agents for use in the treatment of COPD exacerbations in patients that, through analysis, have been identified as having an increased concentration of the IL-1α and TNF-α cytokine biomarkers in a biological sample taken from said patient. The present invention is further directed to methods of diagnosing and methods of treating a patient presenting with an exacerbation of COPD, said methods including identifying 1 the patient is suffering from an exacerbation that is associated with a bacterial infection.
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公开(公告)号：US11939357B2
公开(公告)日：2024-03-26
申请号：US17346362
申请日：2021-06-14
发明人： Matthew Bottomley , Vega Masignani
IPC分类号： C07K14/22 , A61K39/00 , A61K39/095
CPC分类号： C07K14/22 , A61K39/095 , A61K2039/575 , C07K2319/33
摘要： The inventors have identified residues within variant 2 and variant 3 of meningococcal fHpb which can be modified to enhance their properties.
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