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![Pyrazolo[1,5-a]pyrimidines useful as JAK2 inhibitors](/abs-image/US/2015/01/20/US08937064B2/abs.jpg.150x150.jpg)
公开(公告)号：US08937064B2
公开(公告)日：2015-01-20
申请号：US12817785
申请日：2010-06-17
申请人： Mark Ledeboer , Valerie Marone , Michelle Stewart , David Messersmith , John Duffy , Gabriel Martinez Botella , Jon Come , Huai Gao , Albert Pierce , Francesco Salituro
发明人： Mark Ledeboer , Valerie Marone , Michelle Stewart , David Messersmith , John Duffy , Gabriel Martinez Botella , Jon Come , Huai Gao , Albert Pierce , Francesco Salituro
IPC分类号： A61K31/535 , C07D415/00 , C07D487/00 , A01N43/90 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula (I) useful as selective inhibitors of JAK2 kinase. The invention also provides pharmaceutical acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions or disorders. The invention also provides processes for preparing the compounds of the invention.
摘要翻译： 本发明涉及可用作JAK2激酶选择性抑制剂的式（I）化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08921376B2
公开(公告)日：2014-12-30
申请号：US11438748
申请日：2006-05-22
申请人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
发明人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
IPC分类号： C07D471/04 , A61K31/437 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族和ROCK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US08268999B2
公开(公告)日：2012-09-18
申请号：US13216606
申请日：2011-08-24
申请人： Alex Aronov , Jon H. Come , Kevin Michael Cottrell , Arnaud Le Tiran , Valerie Marone , Gabriel Martinez Botella , David Messersmith , Emilie Porter Huck , Ronald Lee Grey, Jr.
发明人： Alex Aronov , Jon H. Come , Kevin Michael Cottrell , Arnaud Le Tiran , Valerie Marone , Gabriel Martinez Botella , David Messersmith , Emilie Porter Huck , Ronald Lee Grey, Jr.
IPC分类号： C07D401/10 , A61K31/497
CPC分类号： C07D417/14 , C07D417/04 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20100204255A1
公开(公告)日：2010-08-12
申请号：US12761502
申请日：2010-04-16
申请人： Andreas Termin , Nicole Zimmermann , Tara Leanne Knoll , Gabriel Martinez-Botella , Esther Martinborough
发明人： Andreas Termin , Nicole Zimmermann , Tara Leanne Knoll , Gabriel Martinez-Botella , Esther Martinborough
IPC分类号： A61K31/506 , A61K31/4709 , A61P19/02 , A61P25/06 , A61P25/22 , A61P25/24 , A61P29/00 , C07D401/12 , C07D403/12 , C12N5/02
CPC分类号： C07D417/12 , C07D401/12
摘要： The present invention relates to bicyclic compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的双环化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20100160287A1
公开(公告)日：2010-06-24
申请号：US12564156
申请日：2009-09-22
申请人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
发明人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
IPC分类号： A61K31/506 , C07D401/04 , C07D403/04 , C07D417/10 , C07D403/10 , C07D405/10 , A61P35/00 , A61P9/00 , A61P19/08 , A61P37/06 , A61P29/00 , A61P37/00 , A61P31/12 , C12N5/00
CPC分类号： C07D401/14 , C07D213/74 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20090227607A1
公开(公告)日：2009-09-10
申请号：US12245069
申请日：2008-10-03
申请人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
发明人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
IPC分类号： A61K31/519 , C07D487/04 , C12N9/99
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20090088445A1
公开(公告)日：2009-04-02
申请号：US11732845
申请日：2007-04-05
申请人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
发明人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US07462612B2
公开(公告)日：2008-12-09
申请号：US11089701
申请日：2005-03-25
IPC分类号： C07D401/04 , C07D401/12 , A61K31/497 , A61K31/4439
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20070207995A1
公开(公告)日：2007-09-06
申请号：US11528779
申请日：2006-09-28
申请人： Francesco Salituro , Luc Farmer , Tiansheng Wang , Jian Wang , Randy Bethiel , Marion Wannamaker , Gabriel Martinez-Botella , John Duffy , Alexander Aronov , David Lauffer , Albert Pierce
发明人： Francesco Salituro , Luc Farmer , Tiansheng Wang , Jian Wang , Randy Bethiel , Marion Wannamaker , Gabriel Martinez-Botella , John Duffy , Alexander Aronov , David Lauffer , Albert Pierce
IPC分类号： A61K31/5377 , A61K31/52 , A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20070135466A1
公开(公告)日：2007-06-14
申请号：US11438748
申请日：2006-05-22
申请人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
发明人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
IPC分类号： A61K31/506 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族和ROCK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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