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13 条记录 (耗时 0.034 秒)

    DNA molecule relating to suppression of gene expression and novel protein
    3.
    发明授权
    DNA molecule relating to suppression of gene expression and novel protein 失效
    与抑制基因表达和新蛋白有关的DNA分子

    公开(公告)号：US6090783A

    公开(公告)日：2000-07-18

    申请号：US121321

    申请日：1998-07-23

    申请人： Akihiko Saiga ,  Satoshi Orita ,  Hisanaga Igarashi ,  Kouichi Okumura ,  Gaku Sakaguchi

    发明人： Akihiko Saiga ,  Satoshi Orita ,  Hisanaga Igarashi ,  Kouichi Okumura ,  Gaku Sakaguchi

    IPC分类号： A61K38/00 ,  C07K14/15 ,  C07K14/435 ,  C07K14/47

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2740/14022

    摘要： A DNA molecule having a gene expression repressing function derived from human T-cell leukemia virus type I (HTLV-I) existing in a region which is missing in a mutant provirus that is expressing p21Xm RNA but exists in the genome of a complete provirus, and a plasmid including the DNA molecule are provided. Furthermore, a novel protein (TRP-1) which specifically binds to U5RE and a structural gene for the protein is provided, which can be useful for elucidation of the transcription repression activity and elucidation of the oncogenesis mechanism of neurocytes, in which a transcriptional repressive region (U5RE) existing in the U5 region of human T-cell leukemia virus type I gene LTR is involved. Furthermore, an expression vector including the gene, a transformant into which the expression vector is introduced, and a process for producing the TRP-1 protein using the transformant are provided.

    摘要翻译： 存在于存在于表达p21Xm RNA但存在于完整前病毒基因组中的突变型原病毒中缺失的区域中的人T细胞白血病病毒I型（HTLV-I）的基因表达抑制功能的DNA分子， 并提供包含DNA分子的质粒。 此外，提供了特异性结合U5RE和蛋白质结构基因的新蛋白（TRP-1），其可用于阐明转录抑制活性和阐明神经细胞的肿瘤形成机制，其中转录抑制 涉及存在于人类T细胞白血病病毒I型基因LTR的U5区域中的区域（U5RE）。 此外，提供了包含该基因的表达载体，其中引入了表达载体的转化体和使用该转化体产生TRP-1蛋白的方法。

    DNA molecule relating to suppression of gene expression and novel protein
    5.
    发明授权
    DNA molecule relating to suppression of gene expression and novel protein 失效
    与抑制基因表达和新蛋白有关的DNA分子

    公开(公告)号：US06218522B1

    公开(公告)日：2001-04-17

    申请号：US08933803

    申请日：1997-09-19

    申请人： Akihiko Saiga ,  Satoshi Orita ,  Hisanaga Igarashi ,  Kouichi Okumura ,  Gaku Sakaguchi

    发明人： Akihiko Saiga ,  Satoshi Orita ,  Hisanaga Igarashi ,  Kouichi Okumura ,  Gaku Sakaguchi

    IPC分类号： C07H2102

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2740/14022

    摘要： A DNA molecule having a gene expression repressing function derived from human T-cell leukemia virus type I (HTLV-I) existing in a region which is missing in a mutant provirus that is expressing p21Xm RNA but exists in the genome of a complete provirus, and a plasmid including the DNA molecule are provided. Furthermore, a novel protein (TRP-1) which specifically binds to U5RE and a structural gene for the protein is provided, which can be useful for elucidation of the transcription repression activity and elucidation of the oncogenesis mechanism of neurocytes, in which a transcriptional repressive region (U5RE) existing in the U5 region of human T-cell leukemia virus type I gene LTR is involved. Furthermore, an expression vector including the gene, a transformant into which the expression vector is introduced, and a process for producing the TRP-1 protein using the transformant are provided.

    摘要翻译： 存在于存在于表达p21Xm RNA但存在于完整前病毒基因组中的突变型原病毒中缺失的区域中的人T细胞白血病病毒I型（HTLV-I）的基因表达抑制功能的DNA分子， 并提供包含DNA分子的质粒。 此外，提供了特异性结合U5RE和蛋白质结构基因的新蛋白（TRP-1），其可用于阐明转录抑制活性和阐明神经细胞的肿瘤形成机制，其中转录抑制 涉及存在于人类T细胞白血病病毒I型基因LTR的U5区域中的区域（U5RE）。 此外，提供了包含该基因的表达载体，其中引入了表达载体的转化体和使用该转化体产生TRP-1蛋白的方法。

    2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity
    10.
    发明授权
    2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity 有权

    公开(公告)号：US08658657B2

    公开(公告)日：2014-02-25

    申请号：US13123761

    申请日：2009-10-22

    申请人： Shuji Yonezawa ,  Yuuji Kooriyama ,  Gaku Sakaguchi

    发明人： Shuji Yonezawa ,  Yuuji Kooriyama ,  Gaku Sakaguchi

    IPC分类号： A01N43/54 ,  A61K31/505 ,  C07D239/02

    摘要： The present invention provides a compound which has an effect of inhibiting amyloid-β production and is useful as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-β proteins. The present invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein A is optionally substituted carbocyclic diyl or optionally substituted heterocyclic diyl; B is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is a group such as optionally substituted lower alkyl; R2 is a group such as hydrogen; and R3a and R3b are each independently a group such as hydrogen, provided that the following compound is excluded.