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公开(公告)号:US20090220521A1
公开(公告)日:2009-09-03
申请号:US12346309
申请日:2008-12-30
申请人: Randolf Kerschbaumer , Friedrich Scheiflinger , Manfred Rieger , Michael Thiele , Geert C. Mudde , Juergen Muellberg , Rene Hoet
发明人: Randolf Kerschbaumer , Friedrich Scheiflinger , Manfred Rieger , Michael Thiele , Geert C. Mudde , Juergen Muellberg , Rene Hoet
CPC分类号: C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The invention also relates to isolated heavy and light chain immunoglobulins derived from anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.
摘要翻译: 本发明涉及特异性结合巨噬细胞迁移抑制因子(MIF)的C端或中心区域的单克隆抗体及其抗原结合部分。 这些抗MIF抗体及其抗原结合部分进一步抑制人MIF生物学功能。 本发明还涉及衍生自抗MIF抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及鉴定抗MIF抗体的方法,包含这些抗体的药物组合物和使用这些抗体和组合物用于治疗MIF相关病症的方法。
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公开(公告)号:US20080095783A1
公开(公告)日:2008-04-24
申请号:US11571983
申请日:2004-07-14
申请人: Manfred Schuster , Gottfried Himmler , Gunter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
发明人: Manfred Schuster , Gottfried Himmler , Gunter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
IPC分类号: A61K39/395 , A61P43/00 , C07K16/18
CPC分类号: C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要: The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
摘要翻译: 本发明涉及衍生自亲本单克隆抗体的识别Lewis Y抗原的单克隆抗体或其衍生物或其片段,其特征在于与所述抗体或其衍生物或片段的Fc区相当的Fc区或区携带 双重杂交型N-糖基化模式,并且所述抗体显示出至少10倍的ADCC增加和至少10%的CDC活性降低。
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公开(公告)号:US20100260768A1
公开(公告)日:2010-10-14
申请号:US12767635
申请日:2010-04-26
申请人: Randolf Kerschbaumer , Friedrich Scheiflinger , Manfred Rieger , Michael Thiele , Geert C. Mudde , Juergen Muellberg , Rene Hoet
发明人: Randolf Kerschbaumer , Friedrich Scheiflinger , Manfred Rieger , Michael Thiele , Geert C. Mudde , Juergen Muellberg , Rene Hoet
IPC分类号: A61K39/395 , C07K16/24 , A61P35/00 , A61P37/02 , A61P29/00 , C07H21/04 , C12N5/07 , C12N15/63 , C12N5/10 , C12P21/08 , G01N33/53
CPC分类号: C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The invention also relates to isolated heavy and light chain immunoglobulins derived from anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.
摘要翻译: 本发明涉及特异性结合巨噬细胞迁移抑制因子(MIF)的C端或中心区域的单克隆抗体及其抗原结合部分。 这些抗MIF抗体及其抗原结合部分进一步抑制人MIF生物学功能。 本发明还涉及衍生自抗MIF抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及鉴定抗MIF抗体的方法,包含这些抗体的药物组合物和使用这些抗体和组合物用于治疗MIF相关病症的方法。
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公开(公告)号:US08668909B2
公开(公告)日:2014-03-11
申请号:US12767635
申请日:2010-04-26
申请人: Randolf Kerschbaumer , Friedrich Scheiflinger , Manfred Rieger , Michael Thiele , Geert C. Mudde , Juergen Muellberg , Rene Hoet
发明人: Randolf Kerschbaumer , Friedrich Scheiflinger , Manfred Rieger , Michael Thiele , Geert C. Mudde , Juergen Muellberg , Rene Hoet
IPC分类号: A61K39/395 , C12N15/00 , C12N5/07 , C07K16/00
CPC分类号: C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The invention also relates to isolated heavy and light chain immunoglobulins derived from anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.
摘要翻译: 本发明涉及特异性结合巨噬细胞迁移抑制因子(MIF)的C端或中心区域的单克隆抗体及其抗原结合部分。 这些抗MIF抗体及其抗原结合部分进一步抑制人MIF生物学功能。 本发明还涉及衍生自抗MIF抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及鉴定抗MIF抗体的方法,包含这些抗体的药物组合物和使用这些抗体和组合物用于治疗MIF相关病症的方法。
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公开(公告)号:US08323650B2
公开(公告)日:2012-12-04
申请号:US12786378
申请日:2010-05-24
申请人: Manfred Schuster , Gottfried Himmler , Guenter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
发明人: Manfred Schuster , Gottfried Himmler , Guenter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
IPC分类号: A61K39/395
CPC分类号: C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要: The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
摘要翻译: 本发明涉及衍生自亲本单克隆抗体的识别Lewis Y抗原的单克隆抗体或其衍生物或其片段,其特征在于与所述抗体或其衍生物或片段的Fc区相当的Fc区或区携带 双重杂交型N-糖基化模式,并且所述抗体显示出至少10倍的ADCC增加和至少10%的CDC活性降低。
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公开(公告)号:US20110020331A1
公开(公告)日:2011-01-27
申请号:US12786378
申请日:2010-05-24
申请人: Manfred Schuster , Gottfried Himmler , Günter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
发明人: Manfred Schuster , Gottfried Himmler , Günter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
IPC分类号: A61K39/395 , C07K16/00 , A61P35/00
CPC分类号: C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要: The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
摘要翻译: 本发明涉及衍生自亲本单克隆抗体的识别Lewis Y抗原的单克隆抗体或其衍生物或其片段,其特征在于与所述抗体或其衍生物或片段的Fc区相当的Fc区或区携带 双重杂交型N-糖基化模式,并且所述抗体显示出至少10倍的ADCC增加和至少10%的CDC活性降低。
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公开(公告)号:US07759464B2
公开(公告)日:2010-07-20
申请号:US11571983
申请日:2004-07-14
申请人: Manfred Schuster , Gottfried Himmler , Gunter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
发明人: Manfred Schuster , Gottfried Himmler , Gunter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
IPC分类号: C07K16/00 , A61K39/395
CPC分类号: C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要: The invention relates to a monoclonal antibody, or fragment of the antibody, that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region of the antibody, or fragment of the antibody, carries a bi-sected hybrid type N-glycosylation pattern and that the antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
摘要翻译: 本发明涉及识别Lewis Y抗原的来自亲本单克隆抗体的单克隆抗体或抗体片段,其特征在于抗体的Fc区或抗体的片段携带双链抗体, 所述杂交型N-糖基化模式,并且所述抗体显示出至少10倍的ADCC增加和至少10%的CDC活性降低。
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