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公开(公告)号:US20180094076A1
公开(公告)日:2018-04-05
申请号:US15841416
申请日:2017-12-14
IPC分类号: C07K16/40 , C07K14/00 , C07K7/08 , C07K7/06 , A61K39/395
CPC分类号: C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/00
摘要: Compositions and methods for the treatment of autoimmune and inflammatory diseases are disclosed.
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公开(公告)号:US08476454B2
公开(公告)日:2013-07-02
申请号:US12759066
申请日:2010-04-13
IPC分类号: A61K31/4178 , C07D403/06
CPC分类号: C07D403/06 , A61K31/353 , A61K31/405 , A61K31/4745 , A61K38/04 , A61K45/06 , C07D209/14 , C07D403/12 , C07D403/14 , C07D471/04 , C07D513/04 , C07D517/04 , A61K2300/00
摘要: Compounds, compositions and methods for the treatment of malignancy are disclosed.
摘要翻译: 公开了用于治疗恶性肿瘤的化合物,组合物和方法。
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公开(公告)号:US07705022B2
公开(公告)日:2010-04-27
申请号:US11589024
申请日:2006-10-27
IPC分类号: A61K31/4439 , A61K31/381 , A61K31/4045 , C07D333/58 , C07D401/12 , C07D209/14
CPC分类号: C07D209/10 , C07C333/20 , C07C333/22 , C07C2602/08 , C07C2603/74 , C07D333/54 , C07D401/12
摘要: Novel indoleamine 2,3-dioxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed.
摘要翻译: 公开了新的吲哚胺2,3-双加氧酶(IDO)抑制剂,包含它们的组合物及其使用方法。
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公开(公告)号:US20100076066A1
公开(公告)日:2010-03-25
申请号:US12528466
申请日:2008-03-14
IPC分类号: A61K31/352 , C07D311/82 , C07D409/04 , A61K31/381 , A61P35/00 , A61P31/12
CPC分类号: C07D311/92 , A61K31/337 , A61K31/352 , A61K31/381 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/565 , A61K31/664 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K33/24 , A61K33/36 , A61K45/06 , C07D409/04 , C07D491/08 , C07D493/04
摘要: Novel indoleamine 2,3-dioxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed.
摘要翻译: 公开了新的吲哚胺2,3-双加氧酶(IDO)抑制剂,包含它们的组合物及其使用方法。
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公开(公告)号:US06989383B1
公开(公告)日:2006-01-24
申请号:US09445054
申请日:1998-06-04
申请人: Neal Rosen , Laura Sepp-Lorenzino , Mark M. Moasser , Allen I. Oliff , Jackson B. Gibbs , Nancy Kohl , Samuel L. Graham , George C. Prendergast
发明人: Neal Rosen , Laura Sepp-Lorenzino , Mark M. Moasser , Allen I. Oliff , Jackson B. Gibbs , Nancy Kohl , Samuel L. Graham , George C. Prendergast
IPC分类号: A61K31/495 , A61K31/50 , A61K31/335 , A61K31/35 , A61K31/34
CPC分类号: A61K31/415 , A61K31/495 , A61K41/00 , A61K45/06
摘要: The present invention relates to methods of treating cancer using a combination of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at lest two therapeutic agents selected from a group consisting of a compound which is an antineoplastic agent and a compound which is an inhibitor or prenyl-protein transferase. The invention also relates to methods of preparing such compositions.
摘要翻译: 本发明涉及使用抗肿瘤剂化合物和作为异戊烯基 - 蛋白转移酶抑制剂的化合物的组合来治疗癌症的方法,该方法包括以任何顺序依次或同时向所述哺乳动物施用量 至少两种选自由抗肿瘤剂的化合物和作为抑制剂或异戊烯基 - 蛋白质转移酶的化合物组成的组的治疗剂。 本发明还涉及制备这种组合物的方法。
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6.Bridging Integrator-2(Bin2) nucleic acid molecules and proteins and uses therefor 有权
标题翻译: 弥合整合子-2(Bin2)核酸分子和蛋白质及其用途公开(公告)号:US06831063B1
公开(公告)日:2004-12-14
申请号:US10069540
申请日:2002-02-25
申请人: George C Prendergast , Kai Ge
发明人: George C Prendergast , Kai Ge
IPC分类号: A61K3816
摘要: The present invention provides Bin2 sequences and proteins encoded thereby. Also provided are compositions and methods utilizing these sequences and proteins in the diagnosis and treatment of blood disorders, including hepatocarcinoma. Further provided are oligonucleotides derived from sequences encoding Bin2, as well as compositions and methods utilizing same for diagnostic and therapeutic purposes.
摘要翻译: 本发明提供Bin2序列和由此编码的蛋白质。 还提供了在诊断和治疗血液病症(包括肝癌)中利用这些序列和蛋白质的组合物和方法。 还提供了衍生自编码Bin2的序列的寡核苷酸,以及利用其诊断和治疗目的的组合物和方法。
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7.Murine and human box-dependent myc-interacting protein (Bin1) and uses therefor 失效
标题翻译: 鼠和人类盒依赖性myc相互作用蛋白(Bin1)并用于其公开(公告)号:US06048702A
公开(公告)日:2000-04-11
申请号:US870126
申请日:1997-06-06
CPC分类号: C07K16/18 , C07K14/4702 , C07K14/4703 , C07K14/4747 , A61K38/00 , A61K48/00
摘要: The present invention provides antibodies raised against a Box-dependent myc-interacting polypeptide termed Bin1 or fragments thereof are provided. Also provided are compositions and methods utilizing these antibodies in the diagnosis and treatment of cancers and hyperplastic disease states. Further provided are oligonucleotides derived from sequences encoding Bin1, as well as compositions and methods utilizing same for diagnostic and therapeutic purposes.
摘要翻译: 本发明提供了针对被称为Bin1或其片段的Box依赖性myc相互作用多肽产生的抗体。 还提供了利用这些抗体在癌症和增生性疾病状态的诊断和治疗中的组合物和方法。 还提供了衍生自编码Bin1的序列的寡核苷酸,以及用于诊断和治疗目的的组合物和方法。
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8.METHODS AND COMPOSITIONS FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES 有权
标题翻译: 治疗自身免疫和炎症疾病的方法和组合公开(公告)号:US20140227279A1
公开(公告)日:2014-08-14
申请号:US14237706
申请日:2012-08-09
CPC分类号: C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/00
摘要: Compositions and methods for the treatment of autoimmune and inflammatory diseases are disclosed.
摘要翻译: 公开了用于治疗自身免疫性和炎性疾病的组合物和方法。
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公开(公告)号:US08008281B2
公开(公告)日:2011-08-30
申请号:US10551151
申请日:2004-02-20
IPC分类号: A61K31/33
CPC分类号: C07D403/06 , A61K31/353 , A61K31/405 , A61K31/4745 , A61K38/04 , A61K45/06 , C07D209/14 , C07D403/12 , C07D403/14 , C07D471/04 , C07D513/04 , C07D517/04 , A61K2300/00
摘要: Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed.
摘要翻译: 公开了用于治疗恶性和慢性病毒感染的组合物和方法。
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公开(公告)号:US20100166881A1
公开(公告)日:2010-07-01
申请号:US12722099
申请日:2010-03-11
IPC分类号: A61K33/36 , C07D209/14 , A61K31/4045 , C07D333/58 , A61K31/381 , C07C333/22 , A61K31/27 , C07D401/12 , A61K31/4439 , C07D417/06 , A61K31/427 , A61K31/337 , A61K33/24 , A61K31/282 , A61K31/437 , A61K31/519 , A61K31/661 , A61K31/513 , A61K31/7068 , A61K31/565 , A61K31/175 , A61K31/704 , A61K31/7048 , A61P35/00
CPC分类号: C07D209/10 , C07C333/20 , C07C333/22 , C07C2602/08 , C07C2603/74 , C07D333/54 , C07D401/12
摘要: Novel indoleamine 2,3-dioxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed.
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