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公开(公告)号：US6034058A
公开(公告)日：2000-03-07
申请号：US58508
申请日：1998-04-10
CPC分类号： C07K7/06 , C07K11/02 , C07K5/0819 , C07K5/0823 , C07K5/1021 , A61K38/00
摘要： The didemnin class of biologically active cyclodepsipeptides, isolated from the marine tunicate Trididemnun solidum, has shown considerable antitumor, antiviral, and immunosuppressive activities. Didemnin B (DB) and most other natural didemnins contain a common macrocycle and differ only in the composition of the side chain. In the present invention, structural modifications were introduced in the side chain to afford several didemnin analogues for structure-activity relationship studies. The latter have shown that the linear side chain portion of the didemnin core structure can be altered and, in some cases, provide significant gains in bioactivities. Of the compounds synthesized the new [Ala.sup.9 ] didemnin B is the most active against the L1210 (murine leukemia) cell line, at the 0.04 ng/mL level.
摘要翻译： 从海洋细胞Trididemnun solidum中分离出来的生物活性环糊精类的didemnin类显示出相当的抗肿瘤，抗病毒和免疫抑制活性。 Didemnin B（DB）和大多数其他天然的didemnins含有一个共同的大环，并且仅在侧链的组成上不同。 在本发明中，在侧链中引入结构修饰以提供结构 - 活性关系研究中的几种didemnin类似物。 后者已经表明，可以改变菊粉蛋白核心结构的直链侧链部分，并且在一些情况下提供生物活性的显着增益。 在合成的化合物中，新的[Ala9] didemnin B对于L1210（小鼠白血病）细胞系，在0.04ng / mL水平是最有活性的。
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公开(公告)号：US4497702A
公开(公告)日：1985-02-05
申请号：US406605
申请日：1982-08-09
CPC分类号： C10L1/224 , Y10S585/95
摘要： A hydrocarbonaceous liquid stream is modified to contain a minor amount of the amide reaction product of a polyalkylene polyamine and a neo-acid having 5 to 20 carbon atoms, the neo-acid having three alkyl groups on the carbon atom which is in the alpha position relative to the carboxylic group, whereby corrosion of iron and other metals contacted by said stream is significantly reduced.
摘要翻译： 烃类液体物流被修饰为含有少量的聚亚烷基多胺和具有5至20个碳原子的新酸的酰胺反应产物，新酸在碳原子上具有三个烷基，位于α位置 相对于羧基，由此所述物流接触的铁和其它金属的腐蚀显着降低。
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公开(公告)号：US08095728B2
公开(公告)日：2012-01-10
申请号：US12105414
申请日：2008-04-18
CPC分类号： G06F3/0659 , G06F1/3221 , G06F1/3268 , G06F3/0625 , G06F3/0689 , Y02D10/154
摘要： A method for retrieving a logical block, including receiving a request to read the logical block, and obtaining metadata associated with the logical block, wherein the metadata includes a replication type used to store the logical block and physical block locations in a storage pool for each physical block associated with the logical block. The method further includes obtaining power state information including a power state for the storage devices specified in the physical block locations, selecting a first set of physical block locations using the metadata, the power state information, and a power-usage selection policy, and generating I/O requests, where each I/O request specifies one of the first set of physical block locations. The method further includes issuing the I/O requests, receiving physical blocks in response to the I/O requests, and constructing the logical block using the physical blocks.
摘要翻译： 一种用于检索逻辑块的方法，包括接收读取逻辑块的请求，并且获得与该逻辑块相关联的元数据，其中元数据包括用于在每个存储池中存储逻辑块和物理块位置的复制类型 与逻辑块相关联的物理块。 该方法还包括获得包括在物理块位置中指定的存储设备的功率状态的功率状态信息，使用元数据选择第一组物理块位置，功率状态信息和功率使用选择策略，以及产生 I / O请求，其中每个I / O请求指定第一组物理块位置之一。 该方法还包括发出I / O请求，响应于I / O请求接收物理块，以及使用物理块构建逻辑块。
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公开(公告)号：US06571676B1
公开(公告)日：2003-06-03
申请号：US10006319
申请日：2001-12-04
申请人： Lawrence R. Folsom , Martin Hughes , Clive Tucker , Steven L. Adams , Robert J. Kogut , George R. Wilson, Jr. , Robert E. Thompson
发明人： Lawrence R. Folsom , Martin Hughes , Clive Tucker , Steven L. Adams , Robert J. Kogut , George R. Wilson, Jr. , Robert E. Thompson
IPC分类号： F41A300
摘要： A gun system has a two piece cannon assembly that is separated between a removable chamber instead of a traditional breech, and a projectile forcing cone. The chamber has a plug at one end that can accommodate any type of ignition system, and the other end is open and is attached to the barrel with a connection fitting. High pressure gases created by combustion of the propellant are sealed with a high-pressure gas compression seal at the interface between the chamber and the barrel. The connection fitting provides an attachment for a rear cannon bearing slide, which rides on rails attached to the main support structure, and also reacts any torque induced into the barrel from the actuation of the chamber/barrel locking collar. A turntable upon which are mounted two chamber elevating/support mechanisms and two projectile loader/rammer mechanisms is positioned around one of the main support structure legs.
摘要翻译： 枪系统具有两件式炮组件，其在可移除的腔室之间分离，而不是传统的后膛和弹丸强迫锥体。 该腔室的一端具有可容纳任何类型的点火系统的插头，另一端是开放的并且通过连接配件附接到筒体上。 通过推进剂燃烧产生的高压气体在室和桶之间的界面处用高压气体压缩密封密封。 连接配件提供了用于后部大炮轴承滑块的附件，其跨越附接到主支撑结构的轨道，并且还可以响应从腔室/筒锁定轴环的致动而引入到筒体中的任何扭矩。 安装有两个室升降支撑机构的转盘和两个抛射装载机/夯锤机构围绕其中一个主支撑结构支腿定位。
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公开(公告)号：US20090265519A1
公开(公告)日：2009-10-22
申请号：US12105414
申请日：2008-04-18
IPC分类号： G06F12/00
CPC分类号： G06F3/0659 , G06F1/3221 , G06F1/3268 , G06F3/0625 , G06F3/0689 , Y02D10/154
摘要： A method for retrieving a logical block, including receiving a request to read the logical block, and obtaining metadata associated with the logical block, wherein the metadata includes a replication type used to store the logical block and physical block locations in a storage pool for each physical block associated with the logical block. The method further includes obtaining power state information including a power state for the storage devices specified in the physical block locations, selecting a first set of physical block locations using the metadata, the power state information, and a power-usage selection policy, and generating I/O requests, where each I/O request specifies one of the first set of physical block locations. The method further includes issuing the I/O requests, receiving physical blocks in response to the I/O requests, and constructing the logical block using the physical blocks.
摘要翻译： 一种用于检索逻辑块的方法，包括接收读取逻辑块的请求，并且获得与该逻辑块相关联的元数据，其中元数据包括用于在每个存储池中存储逻辑块和物理块位置的复制类型 与逻辑块相关联的物理块。 该方法还包括获得包括在物理块位置中指定的存储设备的功率状态的功率状态信息，使用元数据选择第一组物理块位置，功率状态信息和功率使用选择策略，以及产生 I / O请求，其中每个I / O请求指定第一组物理块位置之一。 该方法还包括发出I / O请求，响应于I / O请求接收物理块，以及使用物理块构建逻辑块。
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公开(公告)号：US20090089343A1
公开(公告)日：2009-04-02
申请号：US11863197
申请日：2007-09-27
IPC分类号： G06F17/30
CPC分类号： G06F3/0631 , G06F3/0608 , G06F3/0625 , G06F3/0685 , Y02D10/154 , Y10S707/99956
摘要： A method for priority-based allocation in a storage pool, involving receiving a first request to write a first data item in the storage pool, wherein the storage pool includes a first hybrid drive including a first plurality of metaslabs associated with a first storage type and a second plurality of metaslabs associated with a second storage type, selecting a first target metaslab from the first and second plurality of metaslabs based on a first plurality of allocation priorities, wherein the first plurality of allocation priorities are determined using a storage and power management policy, a storage characteristic, and a power characteristic associated with the first storage type and the second storage type in the first hybrid drive, allocating a first block to the first target metaslab, and writing the first block to the first target metaslab, wherein the first block includes a first portion of the first data item.
摘要翻译： 一种用于存储池中的基于优先级分配的方法，包括接收在所述存储池中写入第一数据项的第一请求，其中所述存储池包括第一混合驱动器，所述第一混合驱动器包括与第一存储类型相关联的第一多个元模块，以及 与第二存储类型相关联的第二多个元数据库，基于第一多个分配优先级，从第一和第二多个元数据库中选择第一目标元数据，其中，使用存储和电源管理策略来确定第一多个分配优先级 存储特性和与第一混合驱动器中的第一存储类型和第二存储类型相关联的功率特性，将第一块分配给第一目标元模块，并将第一块写入第一目标元模块，其中第一块 块包括第一数据项的第一部分。
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公开(公告)号：US07297963B2
公开(公告)日：2007-11-20
申请号：US11415860
申请日：2006-05-02
IPC分类号： G01N21/64
CPC分类号： G01N33/2805 , G01N21/6402 , G01N2021/6417 , Y10T436/218
摘要： A method of evaluating thermal stability of a fuel and an apparatus used therein. The method includes heating the fuel to a given temperature, directing light through the heated fuel a first time wherein the light is of an intensity and of a wavelength to induce fluorescence and obtaining a first fluorescence data, directing the light through the fuel at least a second time that is later in time and obtaining a second fluorescence data, and measuring any changes to fluorescence from the heated fuel over time.
摘要翻译： 一种评价燃料的热稳定性的方法及其中使用的装置。 该方法包括将燃料加热到给定的温度，使第一次引导光通过加热的燃料，其中光具有强度和波长以诱导荧光并获得第一荧光数据，将光引导通过燃料至少一个 第二次在时间上获得第二荧光数据，并且随时间测量来自加热燃料的荧光的任何变化。
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公开(公告)号：US4467132A
公开(公告)日：1984-08-21
申请号：US463433
申请日：1983-02-03
CPC分类号： C07C2/62 , C07C2527/03 , C07C2527/054 , C07C2527/1206 , C07C2527/173 , C07C2531/04
摘要： The efficiency of acid catalyzed alkylation of alkanes with olefins is improved by conducting the alkylation in the presence of small amounts of a neo acid.
摘要翻译： 通过在少量的新酸存在下进行烷基化，提高了烷烃与烯烃酸催化烷基化的效率。
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公开(公告)号：US07792882B2
公开(公告)日：2010-09-07
申请号：US11863197
申请日：2007-09-27
CPC分类号： G06F3/0631 , G06F3/0608 , G06F3/0625 , G06F3/0685 , Y02D10/154 , Y10S707/99956
摘要： A method for priority-based allocation in a storage pool, involving receiving a first request to write a first data item in the storage pool, wherein the storage pool includes a first hybrid drive including a first plurality of metaslabs associated with a first storage type and a second plurality of metaslabs associated with a second storage type, selecting a first target metaslab from the first and second plurality of metaslabs based on a first plurality of allocation priorities, wherein the first plurality of allocation priorities are determined using a storage and power management policy, a storage characteristic, and a power characteristic associated with the first storage type and the second storage type in the first hybrid drive, allocating a first block to the first target metaslab, and writing the first block to the first target metaslab, wherein the first block includes a first portion of the first data item.
摘要翻译： 一种用于存储池中的基于优先级分配的方法，包括接收在所述存储池中写入第一数据项的第一请求，其中所述存储池包括第一混合驱动器，所述第一混合驱动器包括与第一存储类型相关联的第一多个元模块，以及 与第二存储类型相关联的第二多个元数据库，基于第一多个分配优先级，从第一和第二多个元数据库中选择第一目标元数据，其中，使用存储和电源管理策略来确定第一多个分配优先级 存储特性和与第一混合驱动器中的第一存储类型和第二存储类型相关联的功率特性，将第一块分配给第一目标元模块，并将第一块写入第一目标元模块，其中第一块 块包括第一数据项的第一部分。
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公开(公告)号：US5337599A
公开(公告)日：1994-08-16
申请号：US863856
申请日：1992-04-06
CPC分类号： G01N33/2805
摘要： An apparatus and method for determining the thermal stability of fluids, particularly for testing the deposition characteristics of fuels, comprising a conduit system which connects in series; a test fluid reservoir having a movable piston capable of discharging the fluid, a heater section in which is mounted a heated tubular member, a time reactor of a sufficient volume to increase the residence time of the fluid therein, and a water displacement reservoir. The system also incorporates a filter located at an outlet of the heater section designed to trap deposits which may form due to the heating, and a similar filter located at an outlet of the time reactor designed to trap further deposits that may form with additional time. A differential pressure measuring device is connected across each of these filters to measure the pressure drop therethrough. The apparatus also contains a water balanced reservoir and pressure regulator whereby the entire system may be maintained at a constant pressure and prevent the discharge of volatile fluids to the atmosphere.
摘要翻译： 一种用于确定流体的热稳定性，特别是用于测试燃料的沉积特性的装置和方法，包括串联连接的导管系统; 具有能够排出流体的可移动活塞的测试流体储存器，其中安装有加热的管状构件的加热器部分，足够体积的时间反应器以增加流体在其中的停留时间和排水容器。 该系统还包括位于加热器部分的出口处的过滤器，其设计成捕获可能由于加热而形成的沉积物，以及位于时间反应器的出口处的类似过滤器，其设计成捕获可能在额外时间内形成的进一步沉积物。 差压测量装置连接在这些过滤器的每一个上，以测量其中的压降。 该装置还包含一个水平衡的储存器和压力调节器，由此整个系统可以保持在恒定的压力并且防止挥发性流体排放到大气中。
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