公开(公告)号：US12110294B2

公开(公告)日：2024-10-08

申请号：US17243911

申请日：2021-04-29

申请人： Gilead Sciences, Inc.

发明人： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC分类号： C07D487/04 ,  A61K45/06 ,  C07D519/00 ,  C07K16/28

CPC分类号： C07D487/04 ,  A61K45/06 ,  C07D519/00 ,  C07K16/2818 ,  C07K16/2827

摘要： The present disclosure provides pyrimidine dione compounds of Formula I






and pharmaceutical compositions thereof, for treating cancer, including solid tumors either-used alone or in combination with other anti-cancer agents.

公开(公告)号：US20240307502A1

公开(公告)日：2024-09-19

申请号：US18673424

申请日：2024-05-24

申请人： Gilead Sciences, Inc. ,  Novo Nordisk A/S

发明人： Constantine Stephen Djedjos ,  Bryan John McColgan ,  Robert Paul Myers ,  Gangadharan Mani Subramanian ,  Lene Melchiorsen ,  Morten Hansen

IPC分类号： A61K38/26 ,  A61K9/00 ,  A61K31/4439 ,  A61K31/519 ,  A61P1/16 ,  A61P3/04 ,  A61P3/10

CPC分类号： A61K38/26 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/4439 ,  A61K31/519 ,  A61P1/16 ,  A61P3/04 ,  A61P3/10

摘要： The present disclosure relates to a method of treating non-alcoholic steatohepatitis (NASH) comprising administering to a subject with NASH a combination therapy comprising semaglutide, firsocostat, and/or cilofexor.

公开(公告)号：US12084510B2

公开(公告)日：2024-09-10

申请号：US16797364

申请日：2020-02-21

申请人： GILEAD SCIENCES, INC. ,  NATIONAL RESEARCH COUNCIL OF CANADA

发明人： Ilia Alexandre Tikhomirov ,  Maria L. Jaramillo ,  Maureen D. O'Connor-McCourt ,  Traian Sulea ,  Renald Gilbert ,  Bruno Gaillet ,  Jason Baardsnes ,  Myriam Banville ,  Suzanne Grothe

IPC分类号： C07K16/30 ,  C07K16/28

CPC分类号： C07K16/30 ,  C07K16/2863 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567

摘要： Herein described are antibodies to epidermal growth factor receptor (EGER) having an EGER binding affinity that is sufficient to kill disease cells presenting EGFR at high density, but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells.

公开(公告)号：US12077537B2

公开(公告)日：2024-09-03

申请号：US18110126

申请日：2023-02-15

申请人： Gilead Sciences, Inc.

发明人： Chienhung Chou ,  Scott E. Lazerwith ,  John O. Link ,  Scott D. Schroeder ,  Winston C. Tse ,  Jennifer R. Zhang

IPC分类号： C07D513/06 ,  A61K31/4365 ,  A61K31/437 ,  A61K45/06 ,  C07D403/12 ,  C07D471/04 ,  C07D471/06 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  A61K45/06 ,  C07D403/12 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

摘要： The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of a Retroviridae viral infection, including an infection caused by the HIV virus.

公开(公告)号：US20240263190A1

公开(公告)日：2024-08-08

申请号：US18414151

申请日：2024-01-16

申请人： Gilead Sciences, Inc.

发明人： Daniel Rohrer ,  Peter Brams

IPC分类号： C12N15/85 ,  C07K16/18

CPC分类号： C12N15/8509 ,  C07K16/18 ,  A01K2207/15 ,  A01K2227/105

摘要： Human immunoglobulin light chain transgene constructs are provided that encode two different rearranged light chain V-J regions arranged in such a manner that one of the two alternate light chains is expressed from the construct upon recombination in B cells. Transgenic animals comprising the transgene are also provided. The binary light chain transgene thus allows for expression of two alternate fixed light chains in the animals. Methods of using the transgenic animals are also provided.

公开(公告)号：US12053517B2

公开(公告)日：2024-08-06

申请号：US17574465

申请日：2022-01-12

申请人： Gilead Sciences, Inc.

发明人： Jiani Li ,  Xinan Liu ,  Azure T. Makadzange ,  Stephen R. Martin ,  Hesham Shehata ,  Evguenia Svarovskaia

IPC分类号： A61K39/12 ,  A61P31/18 ,  C07K14/005 ,  C07K16/10 ,  C07K16/28 ,  C12N15/10 ,  C12N15/86 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61P31/18 ,  C07K14/005 ,  C07K16/1045 ,  C07K16/2818 ,  C07K16/2827 ,  C12N15/1082 ,  C12N15/86 ,  A61K2039/53 ,  A61K2039/70 ,  C12N2710/10343 ,  C12N2710/16143 ,  C12N2740/15034 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2740/16234 ,  C12N2760/10043

摘要： Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.

公开(公告)号：US20240246986A1

公开(公告)日：2024-07-25

申请号：US18601528

申请日：2024-03-11

申请人： Gilead Sciences, Inc.

发明人： Mark J. Bartlett ,  Daniel H. Byun ,  Yifan Deng ,  Jennifer L. Cosman Ellis ,  Rao V. Kalla ,  Richard L. Mackman ,  Dustin S. Siegel ,  Xianhuang Zeng

IPC分类号： C07D487/04 ,  A61K9/00 ,  A61K45/06 ,  A61P31/14 ,  C07D519/00 ,  C07F9/6561

CPC分类号： C07D487/04 ,  A61K9/0053 ,  A61K45/06 ,  A61P31/14 ,  C07D519/00 ,  C07F9/6561

摘要： Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20240238285A1

公开(公告)日：2024-07-18

申请号：US18543923

申请日：2023-12-18

申请人： Gilead Sciences, Inc.

发明人： Manoj C. Desai ,  Mingzhe Ji ,  Haolun Jin ,  Hyung-Jung Pyun ,  Teresa Alejandra Trejo Martin

IPC分类号： A61K31/4985 ,  C07D471/14 ,  C07D471/18

CPC分类号： A61K31/4985 ,  C07D471/14 ,  C07D471/18

摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):




including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US12030906B2

公开(公告)日：2024-07-09

申请号：US18099477

申请日：2023-01-20

申请人： Gilead Sciences, Inc.

发明人： Katrien Brak ,  Ernest A. Carra ,  Lars V. Heumann ,  Nate Larson

IPC分类号： C07H19/00 ,  A61P31/14 ,  C07F9/6561

CPC分类号： C07H19/00 ,  A61P31/14 ,  C07F9/6561 ,  C07B2200/13

摘要： The present invention relates to novel salts and crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate for use in treating viral infections. In some embodiments, the viral infection is caused by a virus selected from the group consisting of Arenaviridae, Coronaviridae, Filoviridae, Flaviviridae, and Paramyxoviridae.

公开(公告)号：US20240199596A1

公开(公告)日：2024-06-20

申请号：US18413767

申请日：2024-01-16

申请人： Gilead Sciences, Inc.

发明人： Michael Graupe ,  Juan A. Guerrero ,  Stephen D. Holmbo ,  Jesse M. Jacobsen ,  Tetsuya Kobayashi ,  Leena B. Patel ,  Heath A. Weaver ,  Jie Xu ,  Suet C. Yeung

IPC分类号： C07D413/14 ,  C07D239/95 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/04 ,  C07D417/12 ,  C07D471/04

CPC分类号： C07D413/14 ,  C07D239/95 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/04 ,  C07D417/12 ,  C07D471/04 ,  C07B2200/05

摘要： The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.