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公开(公告)号：US08242081B2
公开(公告)日：2012-08-14
申请号：US12096378
申请日：2006-12-05
CPC分类号： C07K14/001 , A61K48/00 , C07K7/08 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要： The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9RALX9RX1LX2RSLX9X3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.
摘要翻译： 本发明涉及包含由GLX9RALX9RX1LX2RSLX9X3X4X5X6X7X8（SEQ ID No：1）组成的氨基酸序列的细胞穿透肽，其中X1为A，L或G，X2为W或无，X3为R或K，X4为K， L或S，X 5为L或K，X 6为R或W，X 7为K或S，X 8为A，V或Q，X 9为W，F或Y.这些CPP可用作递送核酸 酸和/或蛋白质和/或肽在体外或体内。
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2.发明授权公开(公告)号：US08354387B2
公开(公告)日：2013-01-15
申请号：US12390913
申请日：2009-02-23
IPC分类号： C12N15/11
CPC分类号： A61K47/64
摘要： Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2 and an appropriate siRNA, wherein R1 represents any amino acid residue and more preferably K or S, R2 is null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C1-C6 alkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.
摘要翻译： 包含SEQ ID NO：1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2的肽载体和合适的siRNA的复合物，其中R 1表示任何氨基酸残基，更优选K或S，R 2为空或表示以下基团之一：半胱胺，半胱氨酸，硫醇，酰胺， 线性或分枝的任选取代的C1-C6烷基，伯胺或仲胺，奥昔克酸衍生物，脂质，磷脂或胆固醇，并且选择所述siRNA使靶mRNA沉默。
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3.发明申请公开(公告)号：US20090258926A1
公开(公告)日：2009-10-15
申请号：US12390913
申请日：2009-02-23
IPC分类号： A61K31/713
CPC分类号： A61K47/64
摘要： Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2 and an appropriate siRNA, wherein R1 represents any amino acid residue and more preferably K or S, R2 is null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C1-C6 alkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.
摘要翻译： 包含SEQ ID NO：1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2的肽载体和合适的siRNA的复合物，其中R 1表示任何氨基酸残基，更优选K或S，R 2为空或表示以下基团之一：半胱胺，半胱氨酸，硫醇，酰胺， 线性或分枝的任选取代的C1-C6烷基，伯胺或仲胺，奥昔克酸衍生物，脂质，磷脂或胆固醇，并且选择所述siRNA使靶mRNA沉默。
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公开(公告)号：US06841535B2
公开(公告)日：2005-01-11
申请号：US09915914
申请日：2001-07-26
申请人： Gilles Divita , May C. Morris , Jean Mery , Frederic Heitz , Joseph Fernandez , John Archdeacon , Kyle Horndorp
发明人： Gilles Divita , May C. Morris , Jean Mery , Frederic Heitz , Joseph Fernandez , John Archdeacon , Kyle Horndorp
CPC分类号： C07K7/08 , A61K47/64 , C07K14/001 , C12N15/87
摘要： Peptides that are useful as transfection agents are described. The peptides can facilitate the efficient cellular internalization of a broad range and size of compounds that when non-covalently complexed therewith are efficiently internalized into a cell. Advantages include but are not limited to excellent transfection efficiency, relatively low toxicity, internalization by a broad host cell spectrum, and the simplicity and cost-effectiveness that arise from not having to covalently complex the peptide with a specific molecule to be delivered. Applications include but are not limited to the delivery of diagnostics and therapeutics, as well as drug discovery, gene discovery, and the analysis and/or manipulation of other cellular and molecular biological functions. Claims are made for transfection agents, compositions of matter, including pharmaceutical compositions, reagent kits, methods of delivery, and methods of identification of additional peptides for performing and/or including in the same.
摘要翻译： 描述了可用作转染剂的肽。 这些肽可以促进广泛范围和大小的化合物的有效细胞内化，当与其非共价复合时可有效地内化到细胞中。 优点包括但不限于优异的转染效率，相对低的毒性，广泛的宿主细胞谱的内化，以及不必将肽与待递送的特定分子共价复合而产生的简单性和成本效益。 应用包括但不限于诊断和治疗的传递，以及药物发现，基因发现以及其他细胞和分子生物功能的分析和/或操作。 对于转染剂，物质组合物，包括药物组合物，试剂盒，递送方法以及用于鉴定用于进行和/或包含在其中的另外的肽的方法而提出要求。
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公开(公告)号：US20110294728A1
公开(公告)日：2011-12-01
申请号：US13121057
申请日：2009-09-24
申请人： Gilles Divita , Audrey Agopian , Edwige Gros
发明人： Gilles Divita , Audrey Agopian , Edwige Gros
IPC分类号： A61K38/10 , C07K7/06 , C07K14/16 , A61P31/18 , C07H21/00 , C12N15/63 , C12N1/21 , C12N1/19 , C07K7/08 , C12N9/99
CPC分类号： C07K14/005 , C12N2740/16222
摘要： The invention concerns polypeptides derived from the HIV-1 reverse transcriptase which are capable of inhibiting said polymerase and optionally also capable of inhibiting the HIV-1 integrase 3′ processing activity, and their therapeutic applications.
摘要翻译： 本发明涉及能够抑制所述聚合酶并任选还能够抑制HIV-1整合酶3'加工活性的HIV-1逆转录酶衍生的多肽及其治疗应用。
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6.发明申请公开(公告)号：US20110064793A1
公开(公告)日：2011-03-17
申请号：US12857043
申请日：2010-08-16
申请人： Christian DeVaux , Véronique Hebmann , Gilles Divita , Frédéric Heitz , Catherine May Morris , Jean Mery , Roger S. Goody
发明人： Christian DeVaux , Véronique Hebmann , Gilles Divita , Frédéric Heitz , Catherine May Morris , Jean Mery , Roger S. Goody
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2740/16222
摘要： The invention is drawn to a novel class of drugs directed against HIV, comprising a peptide or analog comprising a decapeptide, said decapeptide containing (from N-terminus to the C-terminus) a basic amino acid in position 1, an acidic amino acid in positions 2 and 5, and a tryptophan in positions 4, 7, and 8, and to a method of treatment of HIV infections, in particular multidrug-resistant HIV infections.
摘要翻译： 本发明涉及一类针对HIV的药物，其包含十肽的肽或类似物，所述十肽含有（从N末端至C末端）位置1的碱性氨基酸，酸性氨基酸在 位置2和5以及位置4,7和8中的色氨酸，以及治疗HIV感染，特别是多重耐药性HIV感染的方法。
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公开(公告)号：US20100099626A2
公开(公告)日：2010-04-22
申请号：US12346000
申请日：2008-12-30
CPC分类号： C07K14/00
摘要： The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.
摘要翻译： 本发明涉及包含由GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8（SEQ ID No：1）组成的氨基酸序列的细胞穿透肽，其中X1为A，L或G，X2为W或无，X3为R或K，X4为K， L或S，X 5为L或K，X 6为R或W，X 7为K或S，X 8为A，V或Q，X 9为W，F或Y.这些CPP可用作递送核酸 酸和/或蛋白质和/或肽在体外或体内。
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公开(公告)号：US09376468B2
公开(公告)日：2016-06-28
申请号：US14009648
申请日：2012-04-04
IPC分类号： C07K7/08 , A61K31/713 , A61K47/48 , C12N15/11
CPC分类号： C12N15/113 , A61K31/337 , A61K31/409 , A61K31/704 , A61K31/7072 , A61K31/7105 , A61K31/713 , A61K47/48038 , A61K47/48046 , A61K47/48215 , A61K47/48246 , A61K47/48884 , A61K47/542 , A61K47/543 , A61K47/60 , A61K47/64 , A61K47/6929 , C07K7/08 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/3513 , C12N2320/32
摘要： The présent invention relates to cell-penetrating peptides char-acterized in that it comprises an amino acid séquence selected in the group consisting of X1LX2RALWX9LX3X9X4LWX9LX5X6X7X8, X1LX2LARWX9LX3X9X4LWX9LX5X6X7X8 and X1LX2ARLWX9LX3X9X4LWX9LX5X6X7X8, wherein X1 is beta-A or S, X2 is F or W, X3 is L, W, C or I, X4 is S, A, N or T, Xs is L or W, X6 is W or R, X7 is K or R, X8 is A or none, and X9 is R or S. Thèse peptides exhibit high efficiency, low toxicity and a natural tropism for lung tissues, and can be used either in simple complex with the cargo to be vectorised, or in nanoparticles comprising two layers of cell-penetrating peptides around the cargo.
摘要翻译： 本发明涉及细胞穿透肽，其特征在于其包含在由X1LX2RALWX9LX3X9X4LWX9LX5X6X7X8，X1LX2LARWX9XXXXXXXXXXXXLLX5X6X7X8和X1LX2ARLWX9LX3X9X4LWX9LX5X6X7X8组成的组中选择的氨基酸选择性，其中X1为β-A或S，X2为F或W，X3为L ，W，C或I，X4为S，A，N或T，X为L或W，X6为W或R，X7为K或R，X8为A或无，X9为R或S. 表现出高效率，低毒性和肺组织的自然向性，并且可以与要载体的货物的简单复合物或者包含在货物周围的两层细胞穿透肽的纳米颗粒中使用。
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公开(公告)号：US20070129305A1
公开(公告)日：2007-06-07
申请号：US11294421
申请日：2005-12-06
CPC分类号： C07K14/00
摘要： The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.
摘要翻译： 本发明涉及细胞穿透肽，其包含由GLX 9 WRAX 9 WRX 1 LX 2 / SEQ ID NO：1组成的氨基酸序列， 3 （SEQ ID No：1），其中X 1是A，L或G，X 2是 W或不是X 3是R或K，X 4是K，L或S，X 5是L或K，X < S> 6是R或W，X 7是K或S，X 8是A，V或Q，X 9， / SUB>是W，F或Y.这些CPP可用作体外或体内将核酸和/或蛋白质和/或肽递送至细胞的载体。
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公开(公告)号：US20140227344A1
公开(公告)日：2014-08-14
申请号：US14009648
申请日：2012-04-04
IPC分类号： C07K7/08 , A61K31/713 , A61K47/48
CPC分类号： C12N15/113 , A61K31/337 , A61K31/409 , A61K31/704 , A61K31/7072 , A61K31/7105 , A61K31/713 , A61K47/48038 , A61K47/48046 , A61K47/48215 , A61K47/48246 , A61K47/48884 , A61K47/542 , A61K47/543 , A61K47/60 , A61K47/64 , A61K47/6929 , C07K7/08 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/3513 , C12N2320/32
摘要： The présent invention relates to cell-penetrating peptides characterized in that it comprises an amino acid séquence selected in the group consisting of X1LX2RALWX9LX3X9X4LWX9LX5X6X7X8, X1LX2LARWX9LX3X9X4LWX9LX5X6X7X8 and X1LX2ARLWX9LX3X9X4LWX9LX5X6X7X8, wherein X1 is beta-A or S, X2 is F or W, X3 is L, W, C or I, X4 is S, A, N or T, Xs is L or W, X6 is W or R, X7 is K or R, X8 is A or none, and X9 is R or S. Thèse peptides exhibit high efficiency, low toxicity and a natural tropism for lung tissues, and can be used either in simple complex with the cargo to be vectorised, or in nanoparticles comprising two layers of cell-pentrating peptides around the cargo.
摘要翻译： 本发明涉及细胞穿透肽，其特征在于其包含在由X1LX2RALWX9LX3X9X4LWX9LX5X6X7X8，X1LX2LARWX9XXXXXXXXXXXLLX5X6X7X8和X1LX2ARLWX9LX3X9X4LWX9LX5X6X7X8中选择的氨基酸选择性，其中X1是β-A或S，X2是F或W，X3是L，W C或I，X 4为S，A，N或T，X为L或W，X 6为W或R，X 7为K或R，X 8为A或无，X 9为R或S. 效率，低毒性和肺组织的自然向性，并且可以与要载体的货物的简单复合物或者包含在货物周围的两层细胞五聚肽的纳米颗粒中使用。
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