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公开(公告)号：US20110059068A1
公开(公告)日：2011-03-10
申请号：US12753819
申请日：2010-04-02
CPC分类号： C07K14/47 , C07K14/705 , C07K16/2818 , C07K16/2827 , C07K2317/73 , C07K2319/30
摘要： Polypeptides which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding the polypeptides, and vectors and host cells for expressing the polypeptides are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.
摘要翻译： 公开了包含参与T细胞活化的受体 - 配体对的多肽。 还公开了编码多肽的核酸分子，以及用于表达多肽的载体和宿主细胞。 多肽或其激动剂和拮抗剂用于治疗T细胞介导的病症。
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公开(公告)号：US07566772B2
公开(公告)日：2009-07-28
申请号：US11335907
申请日：2006-01-19
申请人： Larry Green , Raffaella Faggioni , Orit Foord , Scott L. Klakamp , Giorgio Senaldi , Amy K. Schneider
发明人： Larry Green , Raffaella Faggioni , Orit Foord , Scott L. Klakamp , Giorgio Senaldi , Amy K. Schneider
IPC分类号： C07K16/24
CPC分类号： C07K16/245 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , Y10S424/801 , Y10S530/867
摘要： Antibodies directed to the antigen IL-1β and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen IL-1β. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
摘要翻译： 描述针对抗原IL-1β的抗体和这种抗体的用途。 特别是针对抗原IL-1beta的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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公开(公告)号：US20060093599A1
公开(公告)日：2006-05-04
申请号：US10981300
申请日：2004-11-03
IPC分类号： A61K39/395 , C07K16/46 , C07K16/44
CPC分类号： C07K16/18 , C07K2317/21 , C07K2317/54 , C07K2317/76
摘要： The present invention is related to antibodies directed to the antigen properdin and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen properdin. Nucleotide sequences encoding, and polypeptides comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译： 本发明涉及针对抗原适配体的抗体和这种抗体的用途。 特别地，根据本发明，提供了针对抗原素的完全人单克隆抗体。 编码重组和轻链免疫球蛋白分子的核苷酸序列，特别是对应于横跨框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3， 提供。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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公开(公告)号：US07569387B2
公开(公告)日：2009-08-04
申请号：US11436207
申请日：2006-05-17
CPC分类号： C07K14/7151 , A61K38/00 , C07K2319/00 , C12N2799/021
摘要： Novel MK61 polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing MK61 polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with MK61 polypeptides.
摘要翻译： 新型MK61多肽和编码其的核酸分子。 本发明还提供了载体，宿主细胞，选择性结合剂和用于产生MK61多肽的方法。 还提供用于治疗，诊断，改善或预防MK61多肽的疾病的方法。
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公开(公告)号：US20080187531A1
公开(公告)日：2008-08-07
申请号：US11876669
申请日：2007-10-22
申请人： John S. Babcook , Jaspal S. Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah "Rozanne" Lee , Kathy Manchulenko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Jane Su
发明人： John S. Babcook , Jaspal S. Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah "Rozanne" Lee , Kathy Manchulenko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Jane Su
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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公开(公告)号：US20060140948A1
公开(公告)日：2006-06-29
申请号：US11281266
申请日：2005-11-16
申请人： Ian Foltz , Raffaella Faggioni , Giorgio Senaldi , Kathy Manchulenko , Jaspal Kang , Palaniswami Rathanaswami , Kiran Ahluwalia , Orit Foord , Scott Klakamp
发明人： Ian Foltz , Raffaella Faggioni , Giorgio Senaldi , Kathy Manchulenko , Jaspal Kang , Palaniswami Rathanaswami , Kiran Ahluwalia , Orit Foord , Scott Klakamp
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention is related to antibodies directed to IL-13 and uses of such antibodies. For example, in accordance with the present invention, there are provided human monoclonal antibodies directed to IL-13. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Additionally, methods of using these antibodies to treat patients are also provided. Additionally, IL-13 dependent biomarkers and methods of their identification and use are also provided.
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公开(公告)号：US08101178B2
公开(公告)日：2012-01-24
申请号：US11876669
申请日：2007-10-22
申请人： John S. Babcook , Jaspal S. Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah Lee , Kathy Manchulenko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Jane Su
发明人： John S. Babcook , Jaspal S. Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah Lee , Kathy Manchulenko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Jane Su
IPC分类号： A61K39/395
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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公开(公告)号：US07708993B2
公开(公告)日：2010-05-04
申请号：US11359254
申请日：2006-02-21
IPC分类号： A61K39/395
CPC分类号： C07K14/47 , C07K14/705 , C07K16/2818 , C07K16/2827 , C07K2317/73 , C07K2319/30
摘要： Polypeptides which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding the polypeptides, and vectors and host cells for expressing the polypeptides are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.
摘要翻译： 公开了包含参与T细胞活化的受体 - 配体对的多肽。 还公开了编码多肽的核酸分子，以及用于表达多肽的载体和宿主细胞。 多肽或其激动剂和拮抗剂用于治疗T细胞介导的病症。
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公开(公告)号：US07423128B2
公开(公告)日：2008-09-09
申请号：US10981300
申请日：2004-11-03
CPC分类号： C07K16/18 , C07K2317/21 , C07K2317/54 , C07K2317/76
摘要： The present invention is related to antibodies directed to the antigen properdin and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen properdin. Nucleotide sequences encoding, and polypeptides comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译： 本发明涉及针对抗原适配体的抗体和这种抗体的用途。 特别地，根据本发明，提供了针对抗原素的完全人单克隆抗体。 编码重组和轻链免疫球蛋白分子的核苷酸序列，特别是对应于横跨框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3， 提供。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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公开(公告)号：US07285269B2
公开(公告)日：2007-10-23
申请号：US10727155
申请日：2003-12-02
申请人： John S. Babcook , Jaspal S. Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah Lee , Kathy Manchulenko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Jane Su
发明人： John S. Babcook , Jaspal S. Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah Lee , Kathy Manchulenko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Jane Su
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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