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    Vitrified composition which preserves biological materials
    1.
    发明授权
    Vitrified composition which preserves biological materials 有权
    保护生物材料的玻璃化组合物

    公开(公告)号：US08349252B2

    公开(公告)日：2013-01-08

    申请号：US12980645

    申请日：2010-12-29

    申请人： Gloria Elliott ,  Nilay Chakraborty

    发明人： Gloria Elliott ,  Nilay Chakraborty

    IPC分类号： A61L2/00 ,  A61L2/04 ,  A61L9/00 ,  A61L11/00 ,  C23F11/00

    CPC分类号： A01N1/02 ,  A01N1/0221 ,  A01N1/0294 ,  A61L2/0082 ,  C12N1/04

    摘要： The present invention relates to a method for preserving biological material comprising the steps of: providing a vitrification solution comprised of the biological material and a vitrification agent where the solution has a temperature in the range from 0.1° C. to 17.9° C.; microwaving the vitrification solution for a first period of time; allowing the vitrification solution to rest for a second period of time; repeating steps b and c until the vitrification solution enters into a glassy state.

    摘要翻译： 本发明涉及一种保存生物材料的方法，包括以下步骤：提供由生物材料和玻璃化剂组成的玻璃化溶液，其中溶液的温度范围为0.1℃至17.9℃; 在第一时间内微波玻璃化溶液; 允许玻璃化溶液休息一段时间; 重复步骤b和c，直到玻璃化溶液进入玻璃状态。

    VITRIFIED COMPOSITION WHICH PRESERVES BIOLOGICAL MATERIALS
    2.
    发明申请
    VITRIFIED COMPOSITION WHICH PRESERVES BIOLOGICAL MATERIALS 有权
    保护生物材料的维生素组合物

    公开(公告)号：US20110165553A1

    公开(公告)日：2011-07-07

    申请号：US12980645

    申请日：2010-12-29

    申请人： Gloria Elliott ,  Nilay Chakraborty

    发明人： Gloria Elliott ,  Nilay Chakraborty

    IPC分类号： A01N1/02 ,  A01N1/00 ,  C12N7/00 ,  C12N5/00 ,  C12N1/20 ,  C12N1/14 ,  C12N1/12 ,  C07K14/00

    CPC分类号： A01N1/02 ,  A01N1/0221 ,  A01N1/0294 ,  A61L2/0082 ,  C12N1/04

    摘要： The present invention relates to a method for preserving biological material comprising the steps of: providing a vitrification solution comprised of the biological material and a vitrification agent where the solution has a temperature in the range from 0.1° C. to 17.9° C.; microwaving the vitrification solution for a first period of time; allowing the vitrification solution to rest for a second period of time; repeating steps b and c until the vitrification solution enters into a glassy state.

    摘要翻译： 本发明涉及一种保存生物材料的方法，包括以下步骤：提供由生物材料和玻璃化剂组成的玻璃化溶液，其中溶液的温度范围为0.1℃至17.9℃; 在第一时间内微波玻璃化溶液; 允许玻璃化溶液休息一段时间; 重复步骤b和c，直到玻璃化溶液进入玻璃状态。

    METHODS AND COMPOSITIONS FOR THE STABILIZATION OF BIOLOGIC MATERIAL
    5.
    发明申请
    METHODS AND COMPOSITIONS FOR THE STABILIZATION OF BIOLOGIC MATERIAL 审中-公开
    生物材料稳定化的方法和组合

    公开(公告)号：US20130089912A1

    公开(公告)日：2013-04-11

    申请号：US13645745

    申请日：2012-10-05

    申请人： Gloria Elliott ,  Douglas R. MacFarlane

    发明人： Gloria Elliott ,  Douglas R. MacFarlane

    IPC分类号： C12N5/071 ,  C12N5/079 ,  C12N5/077 ,  G01K17/00 ,  C12N5/076 ,  C12N5/0793 ,  C12N5/075 ,  C12N7/00 ,  C12N5/0775

    CPC分类号： A01N1/0215 ,  A01N1/0231 ,  G01N25/4866 ,  G01N33/5014 ,  G01N33/5044

    摘要： A method of screening an organic salt for potential toxicity if used as a stabilizing agent for live cells or viruses, the method comprising: (a) providing a composition of unilamellar vesicles; then (b) contacting an organic salt to the unilamellar vesicles; and then (c) detecting a change in at least one thermal parameter of the unilamellar vesicles caused by the organic salt at said known concentration. A change in the at least one thermal parameter indicates the organic salt is potentially toxic for use as a stabilizing agent for live cells or viruses. Compositions of organic salts identified by such methods, along with methods of using the same in stabilizing live cells or viruses, are also described.

    摘要翻译： 如果用作活细胞或病毒的稳定剂，则筛选有机盐的潜在毒性的方法，所述方法包括：（a）提供单层泡囊的组合物; 然后（b）将有机盐与单层囊泡接触; 然后（c）检测在所述已知浓度下由有机盐引起的单层囊泡的至少一个热参数的变化。 至少一个热参数的改变表明有机盐对于活细胞或病毒的稳定剂而言是潜在的毒性。 还描述了通过这些方法鉴定的有机盐的组合以及在稳定活细胞或病毒中使用它们的方法。

    Preservation of biomaterials with transported preservation agents
    7.
    发明申请
    Preservation of biomaterials with transported preservation agents 审中-公开
    用运输保护剂保存生物材料

    公开(公告)号：US20070042339A1

    公开(公告)日：2007-02-22

    申请号：US10563774

    申请日：2004-08-06

    申请人： Mehmet Toner ,  Keishi Sugimachi ,  Gloria Elliott

    发明人： Mehmet Toner ,  Keishi Sugimachi ,  Gloria Elliott

    IPC分类号： A01N1/02

    CPC分类号： A01N1/02 ,  A01N1/0221

    摘要： Biomaterial are preserved by exposing them to a preservation agent having preservation properties. The biomaterial has at least one transporter that allows uptake of the preservation agent into the biomaterial for loading the biomaterial with the preservation agent to an intracellular concentration sufficient for preserving the biomaterial. The preservation agent loaded biomaterial can then be prepared for storage, for example, by freezing, freeze drying, or drying.

    摘要翻译： 通过将生物材料暴露于具有保存性能的保存剂来保存生物材料。 生物材料具有至少一个转运蛋白，其允许将保存剂吸收到生物材料中，以将生物材料与保存剂负载到足以保存生物材料的细胞内浓度。 然后可以例如通过冷冻，冷冻干燥或干燥来制备装载保存剂的生物材料以进行储存。