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    Medical device
    1.
    发明授权
    Medical device 有权
    医疗装置

    公开(公告)号：US08048060B2

    公开(公告)日：2011-11-01

    申请号：US11505119

    申请日：2006-08-16

    申请人： Stephen Griffin ,  Elaine Lim ,  Gregory E. Mirigian

    发明人： Stephen Griffin ,  Elaine Lim ,  Gregory E. Mirigian

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0054 ,  A61L29/02 ,  A61M25/001 ,  A61M25/0045 ,  A61M25/0051 ,  A61M25/0053 ,  A61M25/0068 ,  A61M25/0097 ,  A61M25/0108 ,  A61M2025/0046 ,  A61M2205/0216 ,  A61M2205/0227 ,  A61M2205/0266

    摘要： A medical device including a shaft having an elongated inner member and an elongated tubular reinforcing member disposed over at least a portion of the inner member. In some embodiments, at least a portion of the outer surface of the inner member is spaced from the inner surface of the reinforcing member, defining a space substantially free of any other structures of the device. In some embodiments, the shaft can include a tip structure disposed on a distal portion of the inner member. In some such embodiments, the reinforcing member has a distal end, and the tip structure is disposed on the distal portion of the inner member adjacent the distal end of the reinforcing member. Additionally, in some embodiments, the reinforcing member can include a plurality of apertures defined therein, for example, to enhance the flexibility or other such characteristics of all or portions of the reinforcing member.

    摘要翻译： 一种医疗装置，包括具有细长内部构件的轴和设置在内部构件的至少一部分上的细长管状加强构件。 在一些实施例中，内部构件的外表面的至少一部分与加强构件的内表面间隔开，限定了基本上没有设备的任何其他结构的空间。 在一些实施例中，轴可以包括设置在内部构件的远侧部分上的末端结构。 在一些这样的实施例中，加强构件具有远端，并且尖端结构设置在邻近加强构件的远端的内部构件的远侧部分上。 此外，在一些实施例中，加强构件可以包括限定在其中的多个孔，例如以增强加强构件的全部或部分的柔性或其它这些特性。

    Composite braided guidewire
    3.
    发明授权
    Composite braided guidewire 失效
    复合编织导丝

    公开(公告)号：US07883474B1

    公开(公告)日：2011-02-08

    申请号：US08640259

    申请日：1996-04-30

    申请人： Gregory E. Mirigian ,  Harold E. Carrison ,  Laurent Schaller ,  Erik T. Engelson

    发明人： Gregory E. Mirigian ,  Harold E. Carrison ,  Laurent Schaller ,  Erik T. Engelson

    IPC分类号： A61M25/00

    CPC分类号： A61M25/09 ,  A61M2025/09175

    摘要： This is a composite guidewire for use with a catheter for accessing a targeted site in a lumen system of a patient's body. The guidewire core or guidewire section may be of a stainless steel or a high elasticity metal alloy, preferably a Ni—Ti alloy, also preferably having specified physical parameters. The composite guidewire assembly is especially useful for accessing peripheral or soft tissue targets. The invention includes multi-section guidewire assemblies having super-elastic alloy or stainless steel ribbon braided reinforcements along a least a portion of the core. A variation of the inventive guidewire includes a braid and a tie layer (and one or more lubricious polymers on the tie layer exterior) to enhance the guidewire's suitability for use within catheters and within the interior of vascular lumen.

    摘要翻译： 这是一种用于与用于进入患者身体的管腔系统中的目标部位的导管一起使用的复合导丝。 导丝芯或导丝部分可以是不锈钢或高弹性金属合金，优选Ni-Ti合金，也优选具有特定的物理参数。 复合导丝组件对于接近外周或软组织靶是特别有用的。 本发明包括具有沿着芯的至少一部分的超弹性合金或不锈钢丝带编织增强件的多段导丝组件。 本发明的导丝的变体包括编织物和连接层（以及在连接层外部的一种或多种润滑聚合物），以增强导丝线在导管内和血管内腔内的适用性。

    Medical device
    4.
    发明授权
    Medical device 有权
    医疗装置

    公开(公告)号：US07540865B2

    公开(公告)日：2009-06-02

    申请号：US11180187

    申请日：2005-07-13

    申请人： Stephen Griffin ,  Elaine Lim ,  Gregory E. Mirigian

    发明人： Stephen Griffin ,  Elaine Lim ,  Gregory E. Mirigian

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0054 ,  A61L29/02 ,  A61M25/001 ,  A61M25/0045 ,  A61M25/0051 ,  A61M25/0053 ,  A61M25/0068 ,  A61M25/0097 ,  A61M25/0108 ,  A61M2025/0046 ,  A61M2205/0216 ,  A61M2205/0227 ,  A61M2205/0266

    摘要： A medical device including a shaft having an elongated inner member and an elongated tubular reinforcing member disposed over at least a portion of the inner member. In some embodiments, at least a portion of the outer surface of the inner member is spaced from the inner surface of the reinforcing member, defining a space substantially free of any other structures of the device. In some embodiments, the shaft can include a tip structure disposed on a distal portion of the inner member. In some such embodiments, the reinforcing member has a distal end, and the tip structure is disposed on the distal portion of the inner member adjacent the distal end of the reinforcing member. Additionally, in some embodiments, the reinforcing member can include a plurality of apertures defined therein, for example, to enhance the flexibility or other such characteristics of all or portions of the reinforcing member.

    摘要翻译： 一种医疗装置，包括具有细长内部构件的轴和设置在内部构件的至少一部分上的细长管状加强构件。 在一些实施例中，内部构件的外表面的至少一部分与加强构件的内表面间隔开，限定了基本上没有设备的任何其他结构的空间。 在一些实施例中，轴可以包括设置在内部构件的远侧部分上的末端结构。 在一些这样的实施例中，加强构件具有远端，并且尖端结构设置在邻近加强构件的远端的内部构件的远侧部分上。 此外，在一些实施例中，加强构件可以包括限定在其中的多个孔，例如以增强加强构件的全部或部分的柔性或其它这些特性。

    Guide wire with adjustable flexibility
    6.
    发明授权
    Guide wire with adjustable flexibility 有权

    公开(公告)号：US07018346B2

    公开(公告)日：2006-03-28

    申请号：US10025428

    申请日：2001-12-18

    申请人： Stephen Griffin ,  Gregory E. Mirigian

    发明人： Stephen Griffin ,  Gregory E. Mirigian

    IPC分类号： A61B5/00 ,  A61M20/00

    CPC分类号： A61M25/09 ,  A61M2025/0915 ,  A61M2025/09175

    摘要： A guide wire with a distal portion having adjustable flexibility. The guide wire may include a distal polymeric member and a heat source. The heat source may be activated to cause the polymeric member to increase in temperature and increase in flexibility. The increase in flexibility of the distal portion of the guide wire enhances the ability of the guide wire to navigate tortuous vasculature to a target site. After the guide wire has been navigated to the target site, the heat source may be deactivated to cause the polymeric member to decrease in temperature and increase in stiffness. The increase in stiffness of the distal portion of the guide wire enhances support provided for devices (e.g., catheters) advanced thereon.

    High torque guidewire
    7.
    发明授权
    High torque guidewire 有权
    高扭矩导丝

    公开(公告)号：US06682493B2

    公开(公告)日：2004-01-27

    申请号：US10008446

    申请日：2001-12-03

    申请人： Gregory E. Mirigian

    发明人： Gregory E. Mirigian

    IPC分类号： A61B500

    CPC分类号： A61M25/09 ,  A61M2025/09075 ,  A61M2025/09108 ,  A61M2025/09133

    摘要： Alternative designs, materials and manufacturing methods for medical devices such as guidewires. Some embodiments are directed to a guidewire, including a core wire having a proximal portion and a distal portion, and an elongated distal assembly defining an inner lumen, the elongated distal assembly connected to the core wire adjacent the distal portion of the core wire, wherein the elongated distal assembly includes a plurality of separate and discrete interlocking segments. Some other embodiments are directed to a guidewire including a tubular segment connected to the distal portion of the corewire, wherein the tubular segment includes a plurality of notches therein to increase the lateral flexibility of the segment while maintaining rotational torqueability.

    摘要翻译： 医疗设备如导线的替代设计，材料和制造方法。 一些实施例涉及导线，包括具有近端部分和远端部分的芯线，以及限定内腔的细长远端组件，细长远端组件连接到芯线的远离部分的芯线，其中， 细长远端组件包括多个单独和离散的互锁段。 一些其它实施例涉及包括连接到芯线的远端部分的管状区段的导丝，其中管状区段包括多个凹口，以增加段的侧向柔性，同时保持旋转可逆性。

    Embolic coils with offset helical and twisted helical shapes
    8.
    发明授权
    Embolic coils with offset helical and twisted helical shapes 失效
    具有偏移螺旋和扭曲螺旋形状的栓塞线圈

    公开(公告)号：US5639277A

    公开(公告)日：1997-06-17

    申请号：US538557

    申请日：1995-09-29

    申请人： Michael J. Mariant ,  Gregory E. Mirigian ,  Nga T. Van ,  Roberto L. Orellana ,  Christopher G. M. Ken

    发明人： Michael J. Mariant ,  Gregory E. Mirigian ,  Nga T. Van ,  Roberto L. Orellana ,  Christopher G. M. Ken

    IPC分类号： A61M25/00 ,  A61B17/12 ,  A61F2/82 ,  A61L27/00 ,  F16F1/04 ,  A61M29/00

    CPC分类号： A61B17/1215 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12145 ,  F16F1/04

    摘要： This is a surgical device that, in particular, is for forming a vasoocclusion or embolism. Typically, it is a helically wound coil in which the helix is wound in such a way as to have multiple axially offset, longitudinal or focal axes. Another important facet of the invention is the presence of small diameter secondary coil windings adjacent large diameter coil windings. The device is sufficiently flexible and small that it may be delivered to a site within the vasculature of the human body using a pusher and a catheter. The device is generally linear when within the catheter but relaxes to form the multi-focal form after delivery from the distal end of the catheter lumen. Various mechanical connections may also be used to discharge the inventive coil from its pusher. Similarly, the coil may be attached to a pusher using a sacrificial joint, which sacrificial joint is dissolved by imposition of a small voltage within the human body. The device may be used alone or in conjunction with other coils or with a fibrous thrombotic attachments or the substrate to localize subsequent infusion of tissue adhesives, other particulate embolization devices, or chemotherapeutic agents in abnormal blood vessels and tissues.

    摘要翻译： 这是一种手术装置，特别是用于形成血栓栓塞或栓塞。 通常，它是螺旋缠绕的线圈，其中螺旋线被卷绕成具有多个轴向偏移的纵向或焦点轴线。 本发明的另一个重要方面是存在与大直径线圈绕组相邻的小直径次级线圈绕组。 该装置具有足够的柔性和小度，使得其可以使用推动器和导管将其输送到人体脉管系统内的部位。 该装置在导管内通常是线性的，但是在从导管腔的远端递送之后松弛以形成多焦点形式。 也可以使用各种机械连接来从其推动器排出本发明的线圈。 类似地，线圈可以使用牺牲接头附接到推动器，该牺牲接头通过在人体内施加小的电压而被溶解。 该装置可以单独使用或与其它线圈一起使用，或与纤维性血栓形成附着物或基质一起使用，以便将异常血管和组织中的组织粘合剂，其它颗粒栓塞装置或化学治疗剂的随后输注定位。

    Medical device
    9.
    发明授权
    Medical device 有权
    医疗装置

    公开(公告)号：US08636716B2

    公开(公告)日：2014-01-28

    申请号：US13477755

    申请日：2012-05-22

    申请人： Stephen A. Griffin ,  Elaine Lim ,  Gregory E. Mirigian

    发明人： Stephen A. Griffin ,  Elaine Lim ,  Gregory E. Mirigian

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0054 ,  A61L29/02 ,  A61M25/001 ,  A61M25/0045 ,  A61M25/0051 ,  A61M25/0053 ,  A61M25/0068 ,  A61M25/0097 ,  A61M25/0108 ,  A61M2025/0046 ,  A61M2205/0216 ,  A61M2205/0227 ,  A61M2205/0266

    摘要： A medical device including a shaft having an elongated inner member and an elongated tubular reinforcing member disposed over at least a portion of the inner member. In some embodiments, at least a portion of the outer surface of the inner member is spaced from the inner surface of the reinforcing member, defining a space substantially free of any other structures of the device. In some embodiments, the shaft can include a tip structure disposed on a distal portion of the inner member. In some such embodiments, the reinforcing member has a distal end, and the tip structure is disposed on the distal portion of the inner member adjacent the distal end of the reinforcing member. Additionally, in some embodiments, the reinforcing member can include a plurality of apertures defined therein, for example, to enhance the flexibility or other such characteristics of all or portions of the reinforcing member.

    摘要翻译： 一种医疗装置，包括具有细长内部构件的轴和设置在所述内部构件的至少一部分上的细长管状加强构件。 在一些实施例中，内部构件的外表面的至少一部分与加强构件的内表面间隔开，限定了基本上没有设备的任何其他结构的空间。 在一些实施例中，轴可以包括设置在内部构件的远侧部分上的末端结构。 在一些这样的实施例中，加强构件具有远端，并且尖端结构设置在邻近加强构件的远端的内部构件的远侧部分上。 此外，在一些实施例中，加强构件可以包括限定在其中的多个孔，例如以增强加强构件的全部或部分的柔性或其它这些特性。

    Medical device
    10.
    发明授权
    Medical device 有权
    医疗装置

    公开(公告)号：US08182465B2

    公开(公告)日：2012-05-22

    申请号：US12470261

    申请日：2009-05-21

    申请人： Stephen Griffin ,  Elaine Lim ,  Gregory E. Mirigian

    发明人： Stephen Griffin ,  Elaine Lim ,  Gregory E. Mirigian

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0054 ,  A61L29/02 ,  A61M25/001 ,  A61M25/0045 ,  A61M25/0051 ,  A61M25/0053 ,  A61M25/0068 ,  A61M25/0097 ,  A61M25/0108 ,  A61M2025/0046 ,  A61M2205/0216 ,  A61M2205/0227 ,  A61M2205/0266

    摘要： A medical device including a shaft having an elongated inner member and an elongated tubular reinforcing member disposed over at least a portion of the inner member. In some embodiments, at least a portion of the outer surface of the inner member is spaced from the inner surface of the reinforcing member, defining a space substantially free of any other structures of the device. In some embodiments, the shaft can include a tip structure disposed on a distal portion of the inner member. In some such embodiments, the reinforcing member has a distal end, and the tip structure is disposed on the distal portion of the inner member adjacent the distal end of the reinforcing member. Additionally, in some embodiments, the reinforcing member can include a plurality of apertures defined therein, for example, to enhance the flexibility or other such characteristics of all or portions of the reinforcing member.

    摘要翻译： 一种医疗装置，包括具有细长内部构件的轴和设置在内部构件的至少一部分上的细长管状加强构件。 在一些实施例中，内部构件的外表面的至少一部分与加强构件的内表面间隔开，限定了基本上没有设备的任何其他结构的空间。 在一些实施例中，轴可以包括设置在内部构件的远侧部分上的末端结构。 在一些这样的实施例中，加强构件具有远端，并且尖端结构设置在邻近加强构件的远端的内部构件的远侧部分上。 此外，在一些实施例中，加强构件可以包括限定在其中的多个孔，例如以增强加强构件的全部或部分的柔性或其它这些特性。