-
公开(公告)号：US20090099604A1
公开(公告)日：2009-04-16
申请号：US12172074
申请日：2008-07-11
申请人： Paul Cho , Gregory Hoffman , Herve Chataigner
发明人： Paul Cho , Gregory Hoffman , Herve Chataigner
IPC分类号： A61B17/70
CPC分类号： A61B17/7049 , A61B17/701
摘要： A transverse spinal linking device links at least one spinal osteosynthesis bar to a transverse bar. The device may include a first part that has a vertical axis and a first jaw, a second part that has a second jaw, and a clamping resource. The first part may include a sliding surface, which may be inclined in relation to the vertical axis, and which may mate with at least one sliding surface of the second part. The sliding surfaces may be configured so that the descent of the second part results in an approach of the jaws, with the clamping action of the clamping resource causing the fixing and/or the locking of the device on the osteosynthesis bar and the fixing and/or the locking of the transverse bar.
摘要翻译： 横向脊柱连接装置将至少一个脊骨骨接合杆连接到横向杆。 该装置可以包括具有垂直轴线和第一钳口的第一部分，具有第二钳口的第二部分和夹紧资源。 第一部分可以包括滑动表面，其可以相对于垂直轴线倾斜，并且其可以与第二部分的至少一个滑动表面配合。 滑动表面可以被配置为使得第二部分的下降导致夹爪的接近，夹紧资源的夹持作用导致装置在骨接合杆上的固定和/或锁定，并且固定和/ 或横杆的锁定。
-
公开(公告)号：US5579584A
公开(公告)日：1996-12-03
申请号：US516302
申请日：1995-08-17
申请人： Gregory Hoffman
发明人： Gregory Hoffman
CPC分类号： B27G19/04 , Y10T83/7734
摘要： A movable saw guard electrically operated by a separate motor which through a gearing system moves the movable saw guard from a closed first position to an open second position upon activation of a switch that is separate from the saw motor's trigger.
摘要翻译： 一个由单独的电动机电动操作的可移动的防护罩，其通过齿轮系统将活动的防护装置从关闭的第一位置移动到打开的第二位置，在启动与锯马达的扳机分离的开关上。
-
公开(公告)号：US09850543B2
公开(公告)日：2017-12-26
申请号：US14777211
申请日：2014-03-12
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12Q1/68 , C12N15/113 , G01N33/574 , C12N5/00
CPC分类号： C12Q1/6886 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12N2320/30 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N33/57496 , G01N2333/914
摘要： The invention provides methods of detecting cancer biomarkers, such as one or more SWI/SNF complex mutations, in order to determine a cancer subject's amenability to therapeutic treatment with a BRM inhibitor. Kits, methods of screening for candidate BRM inhibitors, and associated methods of treatment are also provided.
-
公开(公告)号：US20160032402A1
公开(公告)日：2016-02-04
申请号：US14777211
申请日：2014-03-12
IPC分类号： C12Q1/68 , G01N33/574 , C12N15/113
CPC分类号： C12Q1/6886 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12N2320/30 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N33/57496 , G01N2333/914
摘要： The invention provides methods of detecting cancer biomarkers, such as one or more SWI/SNF complex mutations, in order to determine a cancer subject's amenability to therapeutic treatment with a BRM inhibitor. Kits, methods of screening for candidate BRM inhibitors, and associated methods of treatment are also provided.
摘要翻译： 本发明提供了检测癌症生物标志物（例如一种或多种SWI / SNF复合体突变）的方法，以便确定癌症受试者对BRM抑制剂的治疗性治疗的适应性。 还提供了试剂盒，筛选候选BRM抑制剂的方法和相关的治疗方法。
-
公开(公告)号：US08262700B2
公开(公告)日：2012-09-11
申请号：US12172074
申请日：2008-07-11
申请人： Paul Cho , Gregory Hoffman , Hervé Chataigner
发明人： Paul Cho , Gregory Hoffman , Hervé Chataigner
IPC分类号： A61B17/70
CPC分类号： A61B17/7049 , A61B17/701
摘要： A transverse spinal linking device links at least one spinal osteosynthesis bar to a transverse bar. The device may include a first part that has a vertical axis and a first jaw, a second part that has a second jaw, and a clamping resource. The first part may include a sliding surface, which may be inclined in relation to the vertical axis, and which may mate with at least one sliding surface of the second part. The sliding surfaces may be configured so that the descent of the second part results in an approach of the jaws, with the clamping action of the clamping resource causing the fixing and/or the locking of the device on the osteosynthesis bar and the fixing and/or the locking of the transverse bar.
摘要翻译： 横向脊柱连接装置将至少一个脊骨骨接合杆连接到横向杆。 该装置可以包括具有垂直轴线和第一钳口的第一部分，具有第二钳口的第二部分和夹紧资源。 第一部分可以包括滑动表面，其可以相对于垂直轴线倾斜，并且其可以与第二部分的至少一个滑动表面配合。 滑动表面可以被配置为使得第二部分的下降导致夹爪的接近，夹紧资源的夹持作用导致装置在骨接合杆上的固定和/或锁定，并且固定和/ 或横杆的锁定。
-
公开(公告)号：US20180258491A1
公开(公告)日：2018-09-13
申请号：US15853699
申请日：2017-12-22
IPC分类号： C12Q1/6886 , C12N15/113 , G01N33/574
CPC分类号： C12Q1/6886 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12N2320/30 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N33/57496 , G01N2333/914
摘要： The invention provides methods of detecting cancer biomarkers, such as one or more SWI/SNF complex mutations, in order to determine a cancer subject's amenability to therapeutic treatment with a BRM inhibitor. Kits, methods of screening for candidate FIRM inhibitors, and associated methods of treatment are also provided.
-
公开(公告)号：US08974497B2
公开(公告)日：2015-03-10
申请号：US11958285
申请日：2007-12-17
申请人： Paul Cho , Reginald Davis , Gregory Hoffman , Alan McGee , John Williams , Arnold M. Schwartz , William D. Bradley , Alexandre Jodaitis , Herve Chataigner , Hugo Santos Benitez , Chen Zhongqiang
发明人： Paul Cho , Reginald Davis , Gregory Hoffman , Alan McGee , John Williams , Arnold M. Schwartz , William D. Bradley , Alexandre Jodaitis , Herve Chataigner , Hugo Santos Benitez , Chen Zhongqiang
IPC分类号： A61B17/70
CPC分类号： A61B17/7031 , A61B17/702 , A61B17/7032 , A61B17/7034 , A61B17/7041 , A61B17/705
摘要： A vertebral support device (1) is disclosed, which in various embodiments comprises at least two osseous anchoring implants (2), each designed to be anchored to a vertebra, and at least one linking element (3) fixed to the osseous anchoring implants (2) by fasteners (20) that maintain a fixed angle between the longitudinal axis (L) of the linking element (3) passing through rigid elements (34) of the linking element (3) and the insertion axis (DV) of the implants (2). The linking element (3) includes at least one elastic dampening element (31) that that allows the implant-bearing vertebrae some freedom of movement. The dampening element (31) accommodates the stresses imposed on the linking element (3) during movement of the vertebrae and tends to return the support device (1) to its normal configuration.
摘要翻译： 公开了一种脊椎支撑装置（1），其在各种实施例中包括至少两个骨锚固植入物（2），每个骨锚固植入物被设计成锚定到椎骨，以及至少一个固定到骨锚固植入物的连接元件（3） 2）通过在穿过连接元件（3）的刚性元件（34）的连接元件（3）的纵向轴线（L）和植入物的插入轴线（DV）之间保持固定角度的紧固件（20） （2）。 连接元件（3）包括至少一个弹性阻尼元件（31），其允许植入物承载的椎骨具有一定的运动自由度。 阻尼元件（31）容纳在椎骨运动期间施加在连接元件（3）上的应力，并且倾向于将支撑装置（1）返回到其正常构型。
-
公开(公告)号：US20080255617A1
公开(公告)日：2008-10-16
申请号：US11958285
申请日：2007-12-17
申请人： Paul Cho , Reginald Davis , Gregory Hoffman , Alan McGee , John Williams , Arnold M. Schwartz , William D. Bradley , Alexandre Jodaitis , Herve Chataigner , Hugo Santos Benitez , Chen Zhongqiang
发明人： Paul Cho , Reginald Davis , Gregory Hoffman , Alan McGee , John Williams , Arnold M. Schwartz , William D. Bradley , Alexandre Jodaitis , Herve Chataigner , Hugo Santos Benitez , Chen Zhongqiang
CPC分类号： A61B17/7031 , A61B17/702 , A61B17/7032 , A61B17/7034 , A61B17/7041 , A61B17/705
摘要： A vertebral support device (1) is disclosed, which in various embodiments comprises at least two osseous anchoring implants (2), each designed to be anchored to a vertebra, and at least one linking element (3) fixed to the osseous anchoring implants (2) by fasteners (20) that maintain a fixed angle between the longitudinal axis (L) of the linking element (3) passing through rigid elements (34) of the linking element (3) and the insertion axis (DV) of the implants (2). The linking element (3) includes at least one elastic dampening element (31) that that allows the implant-bearing vertebrae some freedom of movement. The dampening element (31) accommodates the stresses imposed on the linking element (3) during movement of the vertebrae and tends to return the support device (1) to its normal configuration.
摘要翻译： 公开了一种脊椎支撑装置（1），其在各种实施例中包括至少两个骨锚固植入物（2），每个骨锚固植入物被设计成锚定到椎骨，以及至少一个固定到骨锚固植入物的连接元件（3） 2）通过在穿过连接元件（3）的刚性元件（34）的连接元件（3）的纵向轴线（L）和植入物的插入轴线（DV）之间保持固定角度的紧固件（20） （2）。 连接元件（3）包括至少一个弹性阻尼元件（31），其允许植入物承载的椎骨具有一定的运动自由度。 阻尼元件（31）容纳在椎骨运动期间施加在连接元件（3）上的应力，并且倾向于将支撑装置（1）返回到其正常构型。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.015 秒)