公开(公告)号：US20140256782A1

公开(公告)日：2014-09-11

申请号：US14352178

申请日：2012-10-19

申请人： David S. Garvey ,  Gregory J. Larosa ,  Jeremy R. Greenwood ,  Leah L. Frye ,  Tan Quach ,  Jamie B. Cote ,  Judd Berman

发明人： David S. Garvey ,  Gregory J. Larosa ,  Jeremy R. Greenwood ,  Leah L. Frye ,  Tan Quach ,  Jamie B. Cote ,  Judd Berman

IPC分类号： C07C49/443 ,  C07C233/58 ,  C07C69/75 ,  C07C35/32 ,  C07D307/83 ,  C07D209/34

CPC分类号： C07D307/83 ,  C07C35/32 ,  C07C49/443 ,  C07C49/553 ,  C07C69/75 ,  C07C233/58 ,  C07C251/44 ,  C07C2102/24 ,  C07D209/34 ,  C07D209/46

摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic is visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

摘要翻译： 公开的化合物可用于治疗由生产有毒的视觉循环产物引起的或与生物相关的眼部疾病，其是积聚在眼睛中的视觉循环产物，例如干性成年黄斑变性，以及由突变视蛋白质蛋白质错误折叠引起或与之相关的病症 和/或视蛋白蛋白质的错误定位。 还描述了这些化合物单独或与其它治疗剂组合的组合物，以及使用这些化合物和/或组合物的治疗方法。 还公开了合成这些试剂的方法。

公开(公告)号：US07566450B2

公开(公告)日：2009-07-28

申请号：US11924794

申请日：2007-10-26

申请人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

发明人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

IPC分类号： A61K39/395

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/76

摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

公开(公告)号：US20080241923A1

公开(公告)日：2008-10-02

申请号：US11924153

申请日：2007-10-25

申请人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

发明人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

IPC分类号： C12N5/06

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/76

摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

公开(公告)号：US06491915B2

公开(公告)日：2002-12-10

申请号：US09895723

申请日：2001-06-29

申请人： Gregory J. LaRosa

发明人： Gregory J. LaRosa

IPC分类号： A61K39395

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/76

摘要： The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

公开(公告)号：US20130071381A1

公开(公告)日：2013-03-21

申请号：US13528407

申请日：2012-06-20

申请人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

发明人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K14/7158 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2319/00

摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

公开(公告)号：US20110003784A1

公开(公告)日：2011-01-06

申请号：US12802898

申请日：2010-06-16

申请人： David S. Garvey ,  Gregory J. LaRosa ,  Jeremy R. Greenwood ,  Mark L. Brewer ,  Tan Quach ,  Jamie B. Côté ,  Judd Berman

发明人： David S. Garvey ,  Gregory J. LaRosa ,  Jeremy R. Greenwood ,  Mark L. Brewer ,  Tan Quach ,  Jamie B. Côté ,  Judd Berman

IPC分类号： A61K31/397 ,  C07C61/22 ,  C07C233/58 ,  C07D295/104 ,  C07D243/24 ,  C07D241/04 ,  C07D207/36 ,  C12N5/071 ,  A61K31/19 ,  A61K31/16 ,  A61K31/4453 ,  A61K31/5375 ,  A61K31/5513 ,  A61K31/495 ,  A61K31/40 ,  A61P27/02 ,  C07K14/00

CPC分类号： C07D295/215 ,  C07B59/002 ,  C07B2200/05 ,  C07C233/10 ,  C07C275/14 ,  C07C2601/16 ,  C07D205/04 ,  C07D207/12 ,  C07D207/14 ,  C07D211/38 ,  C07D241/04 ,  C07D241/08 ,  C07D243/08 ,  C07D295/182 ,  C07D295/185 ,  C07D295/194 ,  C07D295/205 ,  C07D295/26 ,  C07D491/10 ,  C07D493/08

摘要： Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.

摘要翻译： 公开了所述化合物的化合物和组合物以及化合物的使用方法，用于治疗与视蛋白蛋白质错位定位相关的眼科疾病，突变视蛋白蛋白质的错误折叠和积聚在眼睛中的毒性视觉循环产物的产生。 还描述了用于这些方法的化合物和组合物，单独或与其它治疗剂组合。

公开(公告)号：US20080241136A1

公开(公告)日：2008-10-02

申请号：US11924794

申请日：2007-10-26

申请人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

发明人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

IPC分类号： A61K39/395

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/76

摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

公开(公告)号：US06495569B1

公开(公告)日：2002-12-17

申请号：US09838657

申请日：2001-04-19

申请人： Etsuo Ohshima ,  Hiroki Sone ,  Osamu Kotera ,  Rie Komatsu ,  Gregory J. LaRosa ,  Jay R. Luly

发明人： Etsuo Ohshima ,  Hiroki Sone ,  Osamu Kotera ,  Rie Komatsu ,  Gregory J. LaRosa ,  Jay R. Luly

IPC分类号： A61K314164

CPC分类号： C07D233/26

摘要： Disclosed are novel compounds and a method of treating inflammatory diseases. The method comprises administering to an individual in need an effective amount of an imidazolidine compound represented by Structural Formula (I): and physiologically or pharmaceutically acceptable salts thereof.

公开(公告)号：US06458353B1

公开(公告)日：2002-10-01

申请号：US09866970

申请日：2001-05-29

申请人： Gregory J. LaRosa

发明人： Gregory J. LaRosa

IPC分类号： A61K39395

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/76

摘要： The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

公开(公告)号：US06406865B2

公开(公告)日：2002-06-18

申请号：US09905847

申请日：2001-07-13

申请人： Gregory J. LaRosa

发明人： Gregory J. LaRosa

IPC分类号： G01N3353

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/76

摘要： The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

摘要翻译： 本发明涉及与哺乳动物（例如人）CC趋化因子受体2（CCR2）或受体的一部分结合并阻断配体与受体的结合的抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR2的细胞与其配体的相互作用的方法，以及在治疗，预防和诊断方法中使用抗体和片段。