公开(公告)号：US08617143B2

公开(公告)日：2013-12-31

申请号：US11952626

申请日：2007-12-07

申请人： Mark Bachman ,  Baruch Kuppermann ,  Asheesh Divetia ,  Guann Pyng Li

发明人： Mark Bachman ,  Baruch Kuppermann ,  Asheesh Divetia ,  Guann Pyng Li

IPC分类号： A61K9/22

CPC分类号： A61K9/0024 ,  A61F9/0017 ,  A61K9/025

摘要： Devices, systems and methods for delivering pre-determined quantities of an active ingredient to a biological system are provided. In various embodiments, a device for controlled release of an active ingredient is provided, including a release aperture operably associated with a deflectable member, a base with a porous membrane substrate layer, and at least one chamber juxtaposed between the release aperture and the porous membrane layer. The chamber may contain a matrix including one or more active ingredients and an agent that expands when contacted with an aqueous solution. The device is suitable for implantation in a biological system and can be used for delayed and/or time release of specific drug dosages for various indications.

摘要翻译： 提供了将预定量的活性成分输送到生物系统的装置，系统和方法。 在各种实施例中，提供了用于控制释放活性成分的装置，包括与可偏转构件可操作地相关联的释放孔，具有多孔膜基底层的基底和并置在释放孔和多孔膜之间的至少一个腔室 层。 该室可以含有包含一种或多种活性成分的基质和当与水溶液接触时膨胀的试剂。 该装置适于植入生物系统中，并且可用于各种适应症的特定药物剂量的延迟和/或时间释放。

公开(公告)号：US20120097636A1

公开(公告)日：2012-04-26

申请号：US13340240

申请日：2011-12-29

申请人： Mark Bachman ,  Guann-Pyng Li

发明人： Mark Bachman ,  Guann-Pyng Li

IPC分类号： H04R31/00

CPC分类号： H04R19/005 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/48465 ,  H01L2924/01079 ,  H01L2924/10253 ,  H01L2924/1461 ,  H01L2924/19041 ,  H01L2924/00014 ,  H01L2924/00

摘要： A micromachined microphone or speaker embedded within, or positioned on top of, a substrate suitable for carrying microelectronic chips and components. The acoustic element converts sound energy into electrical energy which is then amplified by electronic components positioned on the surface of the substrate. Alternatively, the acoustic element may be driven by electronics to produce sound. The substrate can be used in standard microelectronic packaging applications.

摘要翻译： 嵌入在适于承载微电子芯片和部件的基板内或位于其上的微机械麦克风或扬声器。 声学元件将声能转换成电能，然后由位于基板表面上的电子部件放大。 或者，声学元件可以由电子器件驱动以产生声音。 该基板可用于标准微电子封装应用。

公开(公告)号：US07695954B2

公开(公告)日：2010-04-13

申请号：US11243926

申请日：2005-10-04

申请人： Mark Bachman ,  Guann-Pyng Li ,  Nancy Allbritton ,  Christopher Sims

发明人： Mark Bachman ,  Guann-Pyng Li ,  Nancy Allbritton ,  Christopher Sims

IPC分类号： C12M1/34 ,  C12M3/00

CPC分类号： B01L3/5027 ,  B01L3/5025 ,  B01L3/5085 ,  B01L2200/0647 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2400/0454

摘要： A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. The plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses.

摘要翻译： 制造的板可使细胞，微生物，蛋白质，DNA，生物分子和其他生物培养基的样品定位在板上的特定位置或位点，以便对样品进行可寻址分析。 优选地，一些或所有的部位由可移除的材料或托盘构建，使得感兴趣的样品的子集可以容易地与板分离以用于进一步的处理或分析。 该板可以包含增强或促进样品的附着和/或功能的结构或化学处理，并且促进或辅助其分析。

公开(公告)号：US07541898B2

公开(公告)日：2009-06-02

申请号：US11849914

申请日：2007-09-04

申请人： Jiangyuan Qian ,  Hung-Pin Chang ,  Bedri A. Cetiner ,  Mark Bachman ,  Franco DeFlaviis ,  Guann-Pyng Li

发明人： Jiangyuan Qian ,  Hung-Pin Chang ,  Bedri A. Cetiner ,  Mark Bachman ,  Franco DeFlaviis ,  Guann-Pyng Li

IPC分类号： H01P1/10 ,  B81B5/00

CPC分类号： H01H59/0009 ,  H01G5/16 ,  H01G5/40 ,  H01H2001/0084 ,  Y10T29/49002 ,  Y10T29/49105 ,  Y10T29/49117 ,  Y10T29/49128 ,  Y10T29/49155 ,  Y10T29/49156

摘要： The systems and methods described herein provide for a radio frequency micro-electromechanical systems switch having two or more resonant frequencies. The switch can be configured as a capacitive shunt switch having a deflectable member coupled between two electrodes over a transmission line. A first insulator can be located between one of the electrodes and the deflectable member to form a capacitive element. The deflectable member can be deflectable between an up-state and a down-state, the down-state capacitively coupling the deflectable member with the transmission line. The degree by which the deflectable member overlaps the first insulator can be adjusted to adjust the capacitance of the capacitive element and the resulting resonant frequency.

摘要翻译： 本文所述的系统和方法提供具有两个或更多个谐振频率的射频微机电系统开关。 开关可以被配置为具有通过传输线耦合在两个电极之间的可偏转构件的电容分流开关。 第一绝缘体可以位于电极之间和可偏转构件之间，以形成电容元件。 可偏转构件可以在上升状态和下降状态之间偏转，下降状态将可偏转构件与传输线电容耦合。 可以调节可偏转构件与第一绝缘体重叠的程度，以调整电容元件的电容和所得到的谐振频率。

公开(公告)号：US20080180178A1

公开(公告)日：2008-07-31

申请号：US11911800

申请日：2006-04-28

申请人： Huai Gao ,  Haitao Zhang ,  Guann-Pyng Li

发明人： Huai Gao ,  Haitao Zhang ,  Guann-Pyng Li

IPC分类号： H03F3/04

CPC分类号： H03F3/191 ,  H03F1/565 ,  H03F3/195 ,  H03F3/211 ,  H03F3/602 ,  H03F2200/111 ,  H03F2200/225 ,  H03F2200/318 ,  H03F2200/36 ,  H03F2200/391 ,  H03H7/38

摘要： Provided herein is a power amplifier having a multiple stage power amplifier section and an output matching network section. The multiple stage power amplifier section can include multiple power amplifier stages with interstage matching circuits located therebetween. The output matching network can be configured to match the multiple stage power amplifier section at multiple different frequencies or frequency bands. The power amplifier device is capable of selective operation within one of multiple different frequencies or frequency bands.

摘要翻译： 本文提供的是具有多级功率放大器部分和输出匹配网络部分的功率放大器。 多级功率放大器部分可以包括多个功率放大器级，其间具有级间匹配电路。 输出匹配网络可以配置为在多个不同频率或频带上匹配多级功率放大器部分。 功率放大器装置能够在多个不同频率或频带之一内进行选择性操作。

公开(公告)号：US20080177153A1

公开(公告)日：2008-07-24

申请号：US11952626

申请日：2007-12-07

申请人： Mark Bachman ,  Baruch Kupperman ,  Asheesh Divetia ,  Guann Pyng Li

发明人： Mark Bachman ,  Baruch Kupperman ,  Asheesh Divetia ,  Guann Pyng Li

IPC分类号： A61K9/22 ,  A61B5/00 ,  A61F9/00

CPC分类号： A61K9/0024 ,  A61F9/0017 ,  A61K9/025

摘要： Devices, systems and methods for delivering pre-determined quantities of an active ingredient to a biological system are provided.

摘要翻译： 提供了将预定量的活性成分输送到生物系统的装置，系统和方法。

公开(公告)号：US20070292312A1

公开(公告)日：2007-12-20

申请号：US11742006

申请日：2007-04-30

申请人： Mark Bachman ,  Yuli Wang ,  Christopher Sims ,  Nancy Allbritton ,  Guann-Pyng Li

发明人： Mark Bachman ,  Yuli Wang ,  Christopher Sims ,  Nancy Allbritton ,  Guann-Pyng Li

IPC分类号： B01L3/02 ,  G01N35/00 ,  G03F7/038

CPC分类号： B01L3/502707 ,  B01L3/5085 ,  B01L3/5088 ,  B01L2200/0647 ,  B01L2300/0636 ,  B01L2300/0822 ,  B01L2300/0829 ,  B01L2300/089 ,  B01L2400/0454 ,  G01N2035/00158

摘要： A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. The plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses.

摘要翻译： 制造的板可使细胞，微生物，蛋白质，DNA，生物分子和其他生物培养基的样品定位在板上的特定位置或位点，以便对样品进行可寻址分析。 优选地，一些或所有的部位由可移除的材料或托盘构建，使得感兴趣的样品的子集可以容易地与板分离以用于进一步的处理或分析。 该板可以包含增强或促进样品的附着和/或功能的结构或化学处理，并且促进或辅助其分析。

公开(公告)号：US20060042959A1

公开(公告)日：2006-03-02

申请号：US10967913

申请日：2004-10-18

申请人： Mark Bachman ,  Guann-Pyng Li ,  Liang Wu

发明人： Mark Bachman ,  Guann-Pyng Li ,  Liang Wu

IPC分类号： C02F1/461

CPC分类号： B01D19/0073 ,  B01D1/14 ,  B01D3/009 ,  B01D3/12 ,  B01D5/0027 ,  B01L3/502792 ,  B01L3/5088 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/10 ,  B01L2300/1822 ,  B01L2300/1861

摘要： A microfluidic dynamic vapor control system adapted to change the chemistry of small drops by dynamically controlling the vapor content surrounding the drops. The small volume surface area ratio makes this an efficient mechanism for controlling chemistry in nanovolumes. The system uses small reservoirs of material that can produce vapor on demand, and microfluidic channels that direct the vapor into a small chamber that holds a drop of the solution of interest. By changing the vapors that enter the chamber, the chemical composition of the drop can be modified.

摘要翻译： 一种微流体动态蒸汽控制系统，其适于通过动态地控制液滴周围的蒸气含量来改变小液滴的化学性质。 体积小的表面积比使其成为控制纳米体系化学的有效机制。 该系统使用可以根据需要产生蒸气的小储层材料，以及将蒸汽引导到保持一滴感兴趣的溶液的小室的微流体通道。 通过改变进入室的蒸气，可以改变液滴的化学成分。

公开(公告)号：US20050248423A1

公开(公告)日：2005-11-10

申请号：US11080112

申请日：2005-03-14

申请人： Jiangyuan Qian ,  Hung-Pin Chang ,  Bedri Cetiner ,  Mark Bachman ,  Franco DeFlaviis ,  Guann-Pyng Li

发明人： Jiangyuan Qian ,  Hung-Pin Chang ,  Bedri Cetiner ,  Mark Bachman ,  Franco DeFlaviis ,  Guann-Pyng Li

IPC分类号： H01H59/00 ,  H01P1/10

CPC分类号： H01H59/0009 ,  H01G5/16 ,  H01G5/40 ,  H01H2001/0084 ,  Y10T29/49002 ,  Y10T29/49105 ,  Y10T29/49117 ,  Y10T29/49128 ,  Y10T29/49155 ,  Y10T29/49156

摘要： The systems and methods described herein provide for a radio frequency micro-electromechanical systems switch having two or more resonant frequencies. The switch can be configured as a capacitive shunt switch having a deflectable member coupled between two electrodes over a transmission line. A first insulator can be located between one of the electrodes and the deflectable member to form a capacitive element. The deflectable member can be deflectable between an up-state and a down-state, the down-state capacitively coupling the deflectable member with the transmission line. The degree by which the deflectable member overlaps the first insulator can be adjusted to adjust the capacitance of the capacitive element and the resulting resonant frequency.

摘要翻译： 本文所述的系统和方法提供具有两个或更多个谐振频率的射频微机电系统开关。 开关可以被配置为具有通过传输线耦合在两个电极之间的可偏转构件的电容分流开关。 第一绝缘体可以位于电极之间和可偏转构件之间，以形成电容元件。 可偏转构件可以在上升状态和下降状态之间偏转，下降状态将可偏转构件与传输线电容耦合。 可以调节可偏转构件与第一绝缘体重叠的程度，以调整电容元件的电容和所得到的谐振频率。

公开(公告)号：US06241480B1

公开(公告)日：2001-06-05

申请号：US09472646

申请日：1999-12-27

申请人： Charles Ye Yingjie Chu ,  Guann Pyng Li

发明人： Charles Ye Yingjie Chu ,  Guann Pyng Li

IPC分类号： F04F1100

CPC分类号： F04F99/00 ,  F04B7/00 ,  F04B17/044 ,  F04B19/006

摘要： A micropump fabricated in a planar substrate is provided with a valving chamber which is communicated to a pumping chamber. The valving chamber has an inlet and outlet port. Both the valving chamber and pumping chamber have a liquid, electrically conductive piston disposed therein, which liquid piston is nonmiscible with the pumped working fluid and nonreactive with the substrate in which the chambers are formed. The valving piston is magnetohydrodynamically driven to selectively close either the inlet port or the outlet port. The pumping piston is magnetohydrodynamically driven to pull or push the working fluid through one of the inlet or outlet ports, through the valving chamber, into the pumping chamber, back out of the pumping chamber and through the other one of the inlet or outlet ports after activation of the valving piston. Both direct current and inductive magnetohydrodynamic drives are contemplated. The valving and/or pumping chambers may be shaped or narrowed in their dimensions to impose a mechanical bias on the respective valving and/or pumping pistons to assume a preferred position in their respective chambers when the magnetohydrodynamic drive is turned off.

摘要翻译： 在平面基板中制造的微型泵设置有阀室，其连通到泵送室。 阀室具有入口和出口。 阀室和泵送室均具有设置在其中的液体导电活塞，该液体活塞与泵送的工作流体不可混合，并且与形成腔室的基板不反应。 阀门活塞被磁流体动力驱动以选择性地关闭入口端口或出口端口。 泵送活塞被磁流体动力驱动以将工作流体通过其中一个入口或出口端口，通过阀门室进入泵送室，从泵送室返回并通过另一个入口或出口端口 启动阀门活塞。 考虑了直流和感应磁流体动力传动。 阀门和/或泵送室可以在其尺寸上成形或变窄，以在相应的阀门和/或泵送活塞上施加机械偏置，以在磁流体动力传动装置关闭时在其各自的室中呈现优选位置。