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    Methods for detection and analysis of polynucleotide-binding protein interactions
    2.
    发明授权
    Methods for detection and analysis of polynucleotide-binding protein interactions 有权
    检测和分析多核苷酸结合蛋白相互作用的方法

    公开(公告)号：US08993335B2

    公开(公告)日：2015-03-31

    申请号：US10779412

    申请日：2004-02-13

    申请人： Guillermo C. Bazan ,  Shu Wang ,  Bin Liu

    发明人： Guillermo C. Bazan ,  Shu Wang ,  Bin Liu

    IPC分类号： G01N33/00 ,  C12Q1/68 ,  C07K1/00 ,  C07H21/02

    CPC分类号： C12Q1/6818 ,  Y10T436/143333 ,  C12Q2565/101

    摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PBP that can bind to the target polynucleotide. The sensor PBP comprises a signaling chromophore to absorb energy from the excited multichromophore and emit light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.

    摘要翻译： 提供了用于测定靶多核苷酸样品的方法，组合物和制品。 将怀疑含有靶多核苷酸的样品与聚阳离子多重色素和可与靶多核苷酸结合的传感器PBP接触。 传感器PBP包括信号发色团，以吸收来自激发的多色素的能量并在靶多核苷酸的存在下发光。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。

    Methods and articles for strand-specific polynucleotide detection with conjugated polymers
    3.
    发明授权
    Methods and articles for strand-specific polynucleotide detection with conjugated polymers 有权
    用共轭聚合物进行链特异性多核苷酸检测的方法和文章

    公开(公告)号：US08669055B2

    公开(公告)日：2014-03-11

    申请号：US12903176

    申请日：2010-10-12

    申请人： Guillermo C. Bazan ,  Bin Liu

    发明人： Guillermo C. Bazan ,  Bin Liu

    IPC分类号： C12Q1/68 ,  C12M1/34 ,  C07H19/00 ,  C07H21/04 ,  C07H21/02 ,  G01N21/64

    CPC分类号： C12Q1/6818 ,  C12Q2563/119 ,  C12Q2565/101 ,  C12Q2565/519 ,  C12Q2565/607 ,  C12Q2523/313

    摘要： The invention further relates to conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.

    摘要翻译： 本发明还涉及共轭聚合物，以及如本文所述使用它们的方法，制品和组合物。 在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 该方法可以在衬底上进行。 这些方法可以以阵列格式在基底上进行，其可以是传感器。 在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。 在一些方面，提供生物测定，其中在所有置换中，能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。 多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。 本文进一步描述了本发明的其它变型。

    METHODS AND COMPOSITIONS FOR DETECTION AND ANALYSIS OF POLYNUCLEOTIDES USING LIGHT HARVESTING MULTICHROMOPHORES
    5.
    发明申请
    METHODS AND COMPOSITIONS FOR DETECTION AND ANALYSIS OF POLYNUCLEOTIDES USING LIGHT HARVESTING MULTICHROMOPHORES 有权
    使用光收集多色素检测和分析多核苷酸的方法和组合物

    公开(公告)号：US20130171632A1

    公开(公告)日：2013-07-04

    申请号：US13544303

    申请日：2012-07-09

    申请人： Guillermo C. BAZAN ,  Brent S. GAYLORD ,  Shu WANG

    发明人： Guillermo C. BAZAN ,  Brent S. GAYLORD ,  Shu WANG

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6834 ,  C12Q1/6813 ,  C12Q1/6818 ,  C12Q1/6825 ,  Y10T436/143333 ,  C12Q2565/107 ,  C12Q2563/107 ,  C12Q2523/313

    摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide. The sensor polynucleotide comprises a signaling chromophore to receive energy from the excited multichromophore and increase emission in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.

    摘要翻译： 提供了用于测定靶多核苷酸样品的方法，组合物和制品。 将涉及含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器多核苷酸接触。 所述传感器多核苷酸包含用于从所述激发的多色素载体接收能量的信号发色团，并且在靶多核苷酸的存在下增加发射。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。

    Compositions for detection and analysis of polynucleotides using light harvesting multichromophores
    6.
    发明授权
    Compositions for detection and analysis of polynucleotides using light harvesting multichromophores 有权
    用于使用光收获多色素探测和分析多核苷酸的组合物

    公开(公告)号：US08101416B2

    公开(公告)日：2012-01-24

    申请号：US11746055

    申请日：2007-05-08

    申请人： Guillermo C. Bazan ,  Brent S. Gaylord

    发明人： Guillermo C. Bazan ,  Brent S. Gaylord

    IPC分类号： C12Q1/68 ,  G01N21/63

    CPC分类号： C12Q1/6818 ,  C12Q1/682 ,  Y10T436/143333 ,  C12Q2565/107 ,  C12Q2525/107 ,  C12Q2527/125

    摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PNA complementary to the target polynucleotide. A signaling chromophore absorbs energy from the excited multichromophore and emits light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits having reagents for performing such methods are also provided.

    摘要翻译： 提供了用于测定靶多核苷酸样品的方法，组合物和制品。 将涉及含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器PNA接触。 信号发色团从被激发的多色素吸收能量并在靶多核苷酸存在下发光。 该方法可以多路复用形式使用。 还提供了具有用于执行这些方法的试剂的试剂盒。

    Multilayer polymer light-emitting diodes for solid state lighting applications
    7.
    发明授权
    Multilayer polymer light-emitting diodes for solid state lighting applications 有权
    用于固态照明应用的多层聚合物发光二极管

    公开(公告)号：US08076842B2

    公开(公告)日：2011-12-13

    申请号：US11366186

    申请日：2006-03-01

    申请人： Xiong Gong ,  Alan J. Heeger ,  Daniel Moses ,  Guillermo C. Bazan ,  Shu Wang

    发明人： Xiong Gong ,  Alan J. Heeger ,  Daniel Moses ,  Guillermo C. Bazan ,  Shu Wang

    IPC分类号： H01L51/54 ,  H01L51/56

    CPC分类号： H01L51/50 ,  H01L51/0003 ,  H01L51/0037 ,  H01L51/0039 ,  H01L51/0042 ,  H01L51/0043 ,  H01L51/007 ,  H01L51/0085 ,  H01L51/5012 ,  H01L51/5016 ,  H01L51/5036 ,  H01L51/5048 ,  H01L51/5088 ,  Y10S428/917 ,  Y10T428/24942

    摘要： Multilayer polymer light-emitting diodes (PLEDs) are demonstrated using semiconducting polymers blended with organometallic emitters as the emissive layer and one or both of an electron transport layer and a hole transparent layer on the appropriate electron injection and hole injection sides of the emissive layer. The transport layers reduce energy potential gaps between the hole injection electrode and the emissive polymer and between the electron injection electrode and the emissive polymer. A solvent-processing based procedure for preparing these devices is also disclosed It uses nonpolar solvent-based solutions of emissive polymers to form the emissive layer and polar solvent-based solutions to form the transport layers to minimize etching and other undesirable interactions as the multiple layers are being laid down. Illumination quality white light can be obtained with stable Commission Internationale de l'Eclairage coordinates, stable color temperatures, and stable color rendering indices, all close to those of “pure” white light. These multilayer white light-emitting PLEDs are useful as backlights for liquid crystal displays and for solid state lighting applications.

    摘要翻译： 使用与有机金属发射体混合的半导体聚合物作为发射层和在发射层的合适的电子注入和空穴注入侧的电子传输层和空穴透明层中的一个或两个的多层聚合物发光二极管（PLED）。 传输层减少空穴注入电极和发射聚合物之间以及电子注入电极和发射聚合物之间的能量势隙。 还公开了用于制备这些装置的基于溶剂处理的方法。它使用发射聚合物的非极性溶剂型溶液形成发射层和极性溶剂型溶液以形成传输层，以使蚀刻和其它不希望的相互作用最小化，因为多层 正在放下 照明质量白光可以通过稳定的国际照明坐标，稳定的色温和稳定的显色指数获得，均接近于“纯”白光。 这些多层白色发光PLED可用作液晶显示器和固态照明应用的背光。

    ZWITTERIONIC GROUP VIII TRANSITION METAL INITIATORS SUPPORTED BY OLEFIN LIGANDS
    8.
    发明申请
    ZWITTERIONIC GROUP VIII TRANSITION METAL INITIATORS SUPPORTED BY OLEFIN LIGANDS 有权
    由OleFIN LiganDS支持的第八组过渡金属开关

    公开(公告)号：US20110282019A1

    公开(公告)日：2011-11-17

    申请号：US11519618

    申请日：2006-09-12

    申请人： Guillermo C. Bazan ,  Yaofeng Chen

    发明人： Guillermo C. Bazan ,  Yaofeng Chen

    IPC分类号： C08F4/80 ,  C08F10/06 ,  C09B55/00 ,  C08F10/02

    CPC分类号： C07F15/04 ,  C08F10/00 ,  C08F110/02 ,  C08F110/06 ,  C08F2500/03 ,  C08F4/7022

    摘要： A zwitterionic Group VIII transition metal complex containing the simple and relatively small 3-(arylimino)-but-1-en-2-olato ligand that catalyzes the formation of polypropylene and high molecular weight polyethylene. A novel feature of this catalyst is that the active species is stabilized by a chelated olefin adduct. The present invention also provides methods of polymerizing olefin monomers using zwitterionic catalysts, particularly polypropylene and high molecular weight polyethylene.

    摘要翻译： 含有简单且相对较小的3-（芳基亚氨基） - 丁-1-烯-2-醇配体的两性离子第VIII族过渡金属络合物，其催化聚丙烯和高分子量聚乙烯的形成。 该催化剂的一个新特征是活性物质被螯合烯烃加合物稳定。 本发明还提供使用两性离子催化剂，特别是聚丙烯和高分子量聚乙烯聚合烯烃单体的方法。

    Tetrakis(1-imidazolyl) borate (BIM4) based zwitterionic and related molecules used as electron injection layers
    9.
    发明申请
    Tetrakis(1-imidazolyl) borate (BIM4) based zwitterionic and related molecules used as electron injection layers 有权
    用作电子注入层的四（1-咪唑基）硼酸盐（BIM4）基的两性离子和相关分子

    公开(公告)号：US20100145062A1

    公开(公告)日：2010-06-10

    申请号：US12592761

    申请日：2009-12-01

    申请人： Huaping Li ,  Yunhua Xu ,  Guillermo C. Bazan

    发明人： Huaping Li ,  Yunhua Xu ,  Guillermo C. Bazan

    IPC分类号： C07F5/02

    CPC分类号： C07F5/022

    摘要： Tetrakis(1-imidazolyl)borate (BIm4) based zwitterionic and/or related molecules for the fabrication of PLEDs is provided. Device performances with these materials approaches that of devices with Ba/Al cathodes for which the cathode contact is ohmic. Methods of producing such materials, and electron injection layers and devices containing these materials are also provided.

    摘要翻译： 提供了用于制造PLED的四（1-咪唑基）硼酸盐（BIm4）基的两性离子和/或相关分子。 具有这些材料的器件性能接近具有阴极接触欧姆的Ba / Al阴极的器件。 还提供了生产这种材料的方法，以及含有这些材料的电子注入层和装置。