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公开(公告)号：US06448415B1
公开(公告)日：2002-09-10
申请号：US09908884
申请日：2001-07-20
Applicant: Sang Jo Lee , Myung Joon Seo , Nak Cheol Jeong , Gun Cheol Kim , Hyun Woung Hong , Sul A Kim
Inventor： Sang Jo Lee , Myung Joon Seo , Nak Cheol Jeong , Gun Cheol Kim , Hyun Woung Hong , Sul A Kim
IPC: C07D49300
CPC classification number: C07D307/33 , C07D309/30 , C07D493/04 , C07D493/10
Abstract: The present invention relates to a new process for effectively converting the chirality of 4- or 5-position carbon of a 1,4-lactone- or 1,5-lactone sugar compound which comprises reacting the lactone compound with secondary amine and sulfonyl group-containing compound. The compound of which chirality is converted according to the present invention can be advantageously used for preparing such expensive rare sugar compounds as L-ribose, D-talose, etc.
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2.发明授权Composition comprising an extract of Tiarella polyphylla and tiarellic acid isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity 有权组合物，其包含从其中分离的天竺葵提取物和由其分离的含有抗炎，抗过敏和抗哮喘活性的叶酸
公开(公告)号：US07763286B2
公开(公告)日：2010-07-27
申请号：US11989053
申请日：2006-07-18
Applicant: Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Joong Ku Lee , Sang Ku Lee , Jung Hee Kim , Doo Young Kim , Gui Hua Quan , Ok Kyoung Kwon , Eun Ah Kim , Soon Ja Choi , Guang Hai Shen , Mi Jin Kim , Bo Young Park , Byung Sun Min , Gyoon Hee Han , Hea Young Park , Gun Cheol Kim , Joo Heon Kim , So Young Kim
Inventor： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Joong Ku Lee , Sang Ku Lee , Jung Hee Kim , Doo Young Kim , Gui Hua Quan , Ok Kyoung Kwon , Eun Ah Kim , Soon Ja Choi , Guang Hai Shen , Mi Jin Kim , Bo Young Park , Byung Sun Min , Gyoon Hee Han , Hea Young Park , Gun Cheol Kim , Joo Heon Kim , So Young Kim
CPC classification number: C07J53/00 , A23L33/105 , A61K36/185 , Y10S514/826
Abstract: The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC4 release in vitro test and the suppressive effect on the IgE level and the cytokine (IL-4, IL-5 and IL-13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
Abstract translation: 本发明涉及一种组合物，其中含有天竺葵提取物和从其中分离得到的具有抗炎，抗过敏和抗哮喘活性的天竺葵酸。 Tiarella polyphylla的提取物和从其中分离的tiarellic酸显示对LTC4释放体外试验的抑制作用和对IgE水平和细胞因子（IL-4，IL-5和IL-13）产生，气道高反应性的抑制作用 ，和OVA诱导的哮喘小鼠白细胞浸润。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
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公开(公告)号：US06670458B2
公开(公告)日：2003-12-30
申请号：US09931020
申请日：2001-08-17
Applicant: Sang Jo Lee , Myung Joon Seo , Nak Cheol Jeong , Gun Cheol Kim , Hyun Woung Hong , Sul A Kim
Inventor： Sang Jo Lee , Myung Joon Seo , Nak Cheol Jeong , Gun Cheol Kim , Hyun Woung Hong , Sul A Kim
IPC: C07H1500
CPC classification number: C07H1/00
Abstract: The present invention relates to a process for effectively preparing L-ribose, which is recognized as being highly important in relation to the development of new antiviral medicines, from 1,4-lactone compound.
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4.发明申请Composition comprising an extract of tiarella polyphylla and tiarellic acid isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity 有权组合物，其包含从其中分离的天竺葵提取物和由其分离的天竺葵酸，其具有抗炎，抗过敏和抗哮喘活性
公开(公告)号：US20090148542A1
公开(公告)日：2009-06-11
申请号：US11989053
申请日：2006-07-18
Applicant: Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Joong Ku Lee , Sang Ku Lee , Jung Hee Kim , Doo Young Kim , Gui Hua Quan , Ok Kyoung Kwon , Eun Ah Kim , Soon Ja Choi , Guang Hai Shen , Mi Jin Kim , Bo Young Park , Byung Sun Min , Gyoon Hee Han , Hea Young Park , Gun Cheol Kim , Joo Heon Kim , So Young Kim
Inventor： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Joong Ku Lee , Sang Ku Lee , Jung Hee Kim , Doo Young Kim , Gui Hua Quan , Ok Kyoung Kwon , Eun Ah Kim , Soon Ja Choi , Guang Hai Shen , Mi Jin Kim , Bo Young Park , Byung Sun Min , Gyoon Hee Han , Hea Young Park , Gun Cheol Kim , Joo Heon Kim , So Young Kim
CPC classification number: C07J53/00 , A23L33/105 , A61K36/185 , Y10S514/826
Abstract: The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC4 release in vitro test and the suppressive effect on the IgE level and the cytokine (IL-4, IL-5 and IL-13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
Abstract translation: 本发明涉及一种组合物，其中含有天竺葵提取物和从其中分离得到的具有抗炎，抗过敏和抗哮喘活性的天竺葵酸。 Tiarella polyphylla的提取物和从其中分离的tiarellic酸显示对LTC4释放体外试验的抑制作用和对IgE水平和细胞因子（IL-4，IL-5和IL-13）产生，气道高反应性的抑制作用 ，和OVA诱导的哮喘小鼠白细胞浸润。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
