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公开(公告)号：US08445681B2
公开(公告)日：2013-05-21
申请号：US13193739
申请日：2011-07-29
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Keily , Jingrong Cao
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Keily , Jingrong Cao
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/02 , C07D471/04 , C07D487/02
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US08399478B2
公开(公告)日：2013-03-19
申请号：US13033872
申请日：2011-02-24
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , David Kay , Ronald Knegiel , Sharn Ramaya , Shazia Sadiq
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , David Kay , Ronald Knegiel , Sharn Ramaya , Shazia Sadiq
IPC分类号： A61K31/44
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase represented by formula (I): or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作由式（I）表示的蛋白激酶抑制剂的化合物或其药学上可接受的盐。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20120136000A1
公开(公告)日：2012-05-31
申请号：US12670989
申请日：2010-01-27
申请人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
发明人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
IPC分类号： A61K31/496 , A61K31/497 , A61K31/437 , A61K31/506 , A61P37/00 , A61P29/00 , A61P35/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/00 , A61P3/10 , A61P1/00 , A61P37/06 , A61P35/02 , A61P19/04 , C07D471/04
CPC分类号： C07D471/04 , A61K31/496 , A61K31/506 , C07D239/24 , C07D241/10 , C07D519/00
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US20110288095A1
公开(公告)日：2011-11-24
申请号：US13033872
申请日：2011-02-24
申请人： Guy Brenchley
发明人： Guy Brenchley
IPC分类号： A61K31/4985 , C07D487/04 , A61K31/437 , A61K31/5025 , C12N9/99 , A61P35/00 , A61P25/00 , A61P29/00 , A61P37/02 , A61P37/06 , A61P9/00 , A61P19/08 , A61P1/16 , A61P31/12 , A61P7/00 , A61P3/10 , A61P35/02 , C07D471/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US08017619B2
公开(公告)日：2011-09-13
申请号：US12713811
申请日：2010-02-26
申请人： Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
发明人： Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
IPC分类号： A01N43/54 , A61K31/505 , C07D491/00
CPC分类号： A61K31/496 , C07D239/70 , C07D239/84 , C07D333/22 , C07D333/38 , C07D333/54 , C07D333/70 , C07D471/04 , C07D487/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供了制备化合物的方法，包含该化合物的药学上可接受的组合物，以及使用该化合物和组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20090093416A1
公开(公告)日：2009-04-09
申请号：US12140497
申请日：2008-06-17
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Michael Mortimore , John R. Studley
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Michael Mortimore , John R. Studley
CPC分类号： C07D213/75 , C07D213/82 , C07D405/12 , C07D417/12
摘要： The present invention provides a compound of formula I: wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also provides pharmaceutical compositions and methods using such compositions for treating a caspase-mediated diseases and processes for preparing the compounds of the invention.
摘要翻译： 本发明提供式I化合物：其中R 1，R 2，R 3，R 4和R 5如本文所定义。 本发明还提供了使用这种组合物治疗半胱天冬酶介导的疾病的药物组合物和方法以及制备本发明化合物的方法。
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公开(公告)号：US20060122213A1
公开(公告)日：2006-06-08
申请号：US11170779
申请日：2005-06-29
申请人： Francoise Pierard , Juan-Miguel Jimenez , Ronald Knegtel , Guy Brenchley , Michael Mortimore , Francesca Mazzei
发明人： Francoise Pierard , Juan-Miguel Jimenez , Ronald Knegtel , Guy Brenchley , Michael Mortimore , Francesca Mazzei
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US06632962B2
公开(公告)日：2003-10-14
申请号：US09834052
申请日：2001-04-03
IPC分类号： C07C6112
CPC分类号： C07D213/81 , C07C233/83 , C07C235/52 , C07C237/36 , C07C255/57 , C07D207/34 , C07D209/42 , C07D213/82 , C07D277/56 , C07D307/68 , C07D333/38
摘要： This invention provides novel compounds that are effective as inhibitors of caspase and cellular apoptosis. The invention also provides methods for using the compounds to treat caspase-mediated diseases in mammals. The compounds have the general formula I: wherein X is F or Cl; R1 is COOH, COO(alkyl), or an isostere thereof; and R2 is an aryl group.
摘要翻译： 本发明提供了作为半胱天冬酶抑制剂和细胞凋亡有效的新型化合物。 本发明还提供了使用该化合物治疗哺乳动物中半胱天冬酶介导的疾病的方法。 化合物具有通式I：其中X是F或Cl; 其中，COOH，COO（烷基）或其等同物; 并且R
<2 是芳基 -
公开(公告)号：US09137973B2
公开(公告)日：2015-09-22
申请号：US13308609
申请日：2011-12-01
IPC分类号： A01N43/00 , A61K31/00 , A01N43/62 , A61K31/55 , A61K31/50 , A61K31/497 , A61K31/44 , C07D241/02 , C07D401/00 , C07D403/00 , C07D513/02 , C07D243/08 , A01K39/01
CPC分类号： A01K39/01 , C07D471/04 , C07D519/00
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US08481578B2
公开(公告)日：2013-07-09
申请号：US13234332
申请日：2011-09-16
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Keily
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Keily
IPC分类号： A61K31/4196 , C07D249/12
CPC分类号： C07D409/04 , A61K31/4196 , A61K45/06 , C07D409/14 , C12N9/99
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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