公开(公告)号：US20200172601A1

公开(公告)日：2020-06-04

申请号：US16626163

申请日：2018-06-22

申请人： Dongkyoon Kim ,  Guy Cavet ,  University of Maryland, Baltimore ,  The United States Government as Represented by the Department of Veterans Affairs

发明人： Mohammad Sajadi ,  George K. Lewis ,  Anthony DeVico ,  Amir Dashti ,  Marzena E. Pazgier ,  William David Tolbert ,  Dongkyoon Kim ,  Guy Cavet

IPC分类号： C07K16/10 ,  A61K39/42 ,  A61P31/18

摘要： The present invention provides broadly neutralizing antibodies against HIV, compositions comprising the same and methods of use thereof. Specifically, the invention provides isolated anti-HIV antibodies that are capable of neutralizing at least 95% of the HIV pseudoviruses listed in Table 1 and neutralizing 100% of the HIV clade B, G and D viruses listed in Table 1 with an IC50 value of less than 50 ug/mL. Further provides are the sequences especially complementarity-determining region (CDR) sequences of antibodies disclosed.

公开(公告)号：US09879267B2

公开(公告)日：2018-01-30

申请号：US12922420

申请日：2009-03-12

申请人： Mark Lackner ,  Lukas C. Amler ,  Guy Cavet ,  Carol O'Brien ,  Ajay Pandita

发明人： Mark Lackner ,  Lukas C. Amler ,  Guy Cavet ,  Carol O'Brien ,  Ajay Pandita

IPC分类号： C12Q1/68 ,  C12N15/113 ,  A61K47/48

CPC分类号： C12N15/1138 ,  A61K47/6809 ,  A61K47/6855 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106

摘要： Methods and compositions are provided to determine if a cancer is resistant to treatment with anti-mitotic agents, including treatment with T-DM1. The methods relate to determining if the ABCC3 gene is amplified and/or overexpressed in the cancer.

公开(公告)号：US08457903B1

公开(公告)日：2013-06-04

申请号：US13229228

申请日：2011-09-09

申请人： Robin A. Emig ,  Richard John Fox ,  Claes Gustafsson ,  Sridhar Govindarajan ,  Jeremy S. Minshull ,  Guy Cavet

发明人： Robin A. Emig ,  Richard John Fox ,  Claes Gustafsson ,  Sridhar Govindarajan ,  Jeremy S. Minshull ,  Guy Cavet

IPC分类号： G06F19/00 ,  C40B50/00 ,  C40B50/02

CPC分类号： G06F19/18 ,  C40B50/02 ,  G06F19/22 ,  G06F19/24

摘要： Computer processing methods and/or systems for minimizing and/or optimizing data strings in accordance with rules and options. Minimized data strings can represent data sequences important in certain biologic analyses and/or syntheses. In specific embodiments, a request is generated by a user at a client system and received by a server system. The server system accesses initial data indicated or provided by the client system. The server system then performs an analysis to minimize the data needed for further reactions. In specific embodiments, a server can use proprietary methods or data at the server side while protecting those proprietary methods and data from access by the client system.

摘要翻译： 根据规则和选项最小化和/或优化数据串的计算机处理方法和/或系统。 最小化的数据串可以表示在某些生物分析和/或合成中重要的数据序列。 在具体实施例中，请求由用户在客户端系统生成并由服务器系统接收。 服务器系统访问由客户端系统指示或提供的初始数据。 然后，服务器系统执行分析以最小化进一步反应所需的数据。 在具体实施例中，服务器可以在服务器端使用专有方法或数据，同时保护这些专有方法和数据免受客户端系统的访问。

公开(公告)号：US07702464B1

公开(公告)日：2010-04-20

申请号：US10232770

申请日：2002-08-30

申请人： Robin A. Emig ,  Richard John Fox ,  Claes Gustafsson ,  Sridhar Govindarajan ,  Jeremy S. Minshull ,  Guy Cavet

发明人： Robin A. Emig ,  Richard John Fox ,  Claes Gustafsson ,  Sridhar Govindarajan ,  Jeremy S. Minshull ,  Guy Cavet

IPC分类号： G06F19/00 ,  C40B50/00 ,  C40B50/02

CPC分类号： C40B50/02 ,  G06F19/22

摘要： Computer processing methods and/or systems for minimizing and/or optimizing data strings in accordance with rules and options. Minimized data strings can represent data sequences important in certain biologic analyses and/or syntheses. In specific embodiments, a request is generated by a user at a client system and received by a server system. The server system accesses initial data indicated or provided by the client system. The server system then performs an analysis to minimize the data needed for further reactions. In specific embodiments, a server can use proprietary methods or data at the server side while protecting those proprietary methods and data from access by the client system.

摘要翻译： 根据规则和选项最小化和/或优化数据串的计算机处理方法和/或系统。 最小化的数据串可以表示在某些生物分析和/或合成中重要的数据序列。 在具体实施例中，请求由用户在客户端系统生成并由服务器系统接收。 服务器系统访问由客户端系统指示或提供的初始数据。 然后，服务器系统执行分析以最小化进一步反应所需的数据。 在具体实施例中，服务器可以在服务器端使用专有方法或数据，同时保护这些专有方法和数据免受客户端系统的访问。

公开(公告)号：US20230002480A1

公开(公告)日：2023-01-05

申请号：US17677757

申请日：2022-02-22

申请人： Dongkyoon Kim ,  Guy Cavet ,  University of Maryland, Baltimore ,  The United States Government as Represented by the Department of Veterans Affairs

发明人： Mohammad Sajadi ,  George K. Lewis ,  Anthony DeVico ,  Dongkyoon Kim ,  Guy Cavet

IPC分类号： C07K16/10 ,  A61P31/18 ,  A61K39/42 ,  A61K45/06

摘要： The present invention provides broadly neutralizing antibodies against HIV, compositions comprising the same and methods of use thereof.

公开(公告)号：US20110177099A1

公开(公告)日：2011-07-21

申请号：US12922420

申请日：2009-03-12

申请人： Mark Lackner ,  Lukas C. Amler ,  Guy Cavet ,  Carol O'Brien ,  Ajay Pandita

发明人： Mark Lackner ,  Lukas C. Amler ,  Guy Cavet ,  Carol O'Brien ,  Ajay Pandita

IPC分类号： A61K39/395 ,  C12Q1/68 ,  C40B30/04 ,  G01N33/574 ,  A61K31/713 ,  A61P35/00

CPC分类号： C12N15/1138 ,  A61K47/6809 ,  A61K47/6855 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106

摘要： Methods and compositions are provided to determine if a cancer is resistant to treatment with anti-mitotic agents, including treatment with T-DM1. The methods relate to determining if the ABCC3 gene is amplified and/or overexpressed in the cancer.

摘要翻译： 提供方法和组合物以确定癌症是否耐受抗有丝分裂剂治疗，包括用T-DM1治疗。 该方法涉及确定ABCC3基因是否在癌症中被扩增和/或过表达。