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    Polymer encapsulated aluminum particulates
    1.
    发明授权
    Polymer encapsulated aluminum particulates 有权
    聚合物包封铝颗粒

    公开(公告)号：US09062209B2

    公开(公告)日：2015-06-23

    申请号：US12904711

    申请日：2010-10-14

    申请人： Chang Xu ,  Hai Hui Lin ,  Parfait Jean Marie Likibi

    发明人： Chang Xu ,  Hai Hui Lin ,  Parfait Jean Marie Likibi

    IPC分类号： C09D11/10 ,  C08F8/00 ,  C09C3/10 ,  C09C1/62 ,  C09C1/64 ,  C09C3/12 ,  C09D7/12 ,  C09D5/02 ,  C08K3/08 ,  C08K3/22 ,  C08K9/08

    CPC分类号： C09C3/10 ,  C08K3/08 ,  C08K3/22 ,  C08K9/08 ,  C09C1/62 ,  C09C1/644 ,  C09C1/648 ,  C09C3/12 ,  C09D5/028 ,  C09D7/62

    摘要： A coated platelet that includes a robust polymer coating that has substantially uniform structures, a method for producing the coated platelet and a system that includes the coated platelet are described. The disclosed method involves immobilizing initiator molecules onto the surfaces of the platelet by using surface coupling groups and polymerization from initiating sites of the initiator anchored on the surface of the platelet. The disclosed method allows uniform growth of the polymer chains so as to produce robust coated platelets with a smooth coated surface. The disclosed system includes only the disclosed coated platelet and a solvent and eliminates the need to add polymer resins separate from the resins that are covalently attached to the platelet.

    摘要翻译： 描述了包括具有基本均匀结构的坚固的聚合物涂层的涂覆血小板，制备涂覆的血小板的方法和包括涂覆的血小板的系统。 所公开的方法包括通过使用表面偶联基团将引发剂分子固定到血小板的表面上，并将聚合从引发剂的起始位点锚定在血小板的表面上。 所公开的方法允许聚合物链的均匀生长，以便制备具有光滑涂布表面的坚固的涂覆的血小板。 所公开的系统仅包括所公开的涂覆的血小板和溶剂，并且不需要添加与共价连接到血小板上的树脂分开的聚合物树脂。

    POLYMER ENCAPSULATED ALUMINUM PARTICULATES
    3.
    发明申请
    POLYMER ENCAPSULATED ALUMINUM PARTICULATES 有权
    聚合物包封的铝颗粒

    公开(公告)号：US20110130510A1

    公开(公告)日：2011-06-02

    申请号：US12904711

    申请日：2010-10-14

    申请人： Chang XU ,  Hai Hui LIN ,  Parfait Jean Marie LIKIBI

    发明人： Chang XU ,  Hai Hui LIN ,  Parfait Jean Marie LIKIBI

    IPC分类号： C09D11/10 ,  C08F8/00

    CPC分类号： C09C3/10 ,  C08K3/08 ,  C08K3/22 ,  C08K9/08 ,  C09C1/62 ,  C09C1/644 ,  C09C1/648 ,  C09C3/12 ,  C09D5/028 ,  C09D7/62

    摘要： A coated platelet that includes a robust polymer coating that has substantially uniform structures, a method for producing the coated platelet and a system that includes the coated platelet are described. The disclosed method involves immobilizing initiator molecules onto the surfaces of the platelet by using surface coupling groups and polymerization from initiating sites of the initiator anchored on the surface of the platelet. The disclosed method allows uniform growth of the polymer chains so as to produce robust coated platelets with a smooth coated surface. The disclosed system includes only the disclosed coated platelet and a solvent and eliminates the need to add polymer resins separate from the resins that are covalently attached to the platelet.

    摘要翻译： 描述了包括具有基本均匀结构的坚固的聚合物涂层的涂覆血小板，制备涂覆的血小板的方法和包括涂覆的血小板的系统。 所公开的方法包括通过使用表面偶联基团将引发剂分子固定到血小板的表面上，并将聚合从引发剂的起始位点锚定在血小板的表面上。 所公开的方法允许聚合物链的均匀生长，以便制备具有光滑涂布表面的坚固的涂覆的血小板。 所公开的系统仅包括所公开的涂覆的血小板和溶剂，并且不需要添加与共价连接到血小板上的树脂分开的聚合物树脂。

    Thermally reversible implant
    4.
    发明申请
    Thermally reversible implant 审中-公开
    热可逆植入

    公开(公告)号：US20070110784A1

    公开(公告)日：2007-05-17

    申请号：US10555455

    申请日：2004-05-03

    申请人： Yu-Ling Cheng ,  Michael May ,  John Semple ,  Hai-Hui Lin

    发明人： Yu-Ling Cheng ,  Michael May ,  John Semple ,  Hai-Hui Lin

    IPC分类号： A61F2/02 ,  A61K8/73 ,  A61K8/81

    CPC分类号： A61F2/0059

    摘要： The invention relates to the use of a thermal reversible gel, such as a copolymer composition, as a biological filler or implant. The gel has a semi-solid form at body temperature, but upon cooling to a temperature below a threshold level, the gel is liquefied and can be re-shaped, re-sized, manipulated or removed from the body. The gel may be used as a subcutaneous implant, a biological filler, joint or tissue spacer, for wrinkle filling or other cosmetic implants, as a soft-tissue replacement for reconstructive surgery, or as a barrier within the lumen of a biological structure, such as a blood vessel. The implant may be used to provide reversible birth control by providing, for example, a reversible barrier to the cervix or a reversible blockage of the lumen of the vas deferens.

    摘要翻译： 本发明涉及热可逆凝胶如共聚物组合物作为生物填料或植入物的用途。 凝胶在体温下具有半固体形式，但是当冷却到低于阈值水平时，凝胶被液化，并且可以重新成形，重新调整尺寸，操作或从身体去除。 凝胶可以用作皮肤植入物，生物填充剂，关节或组织间隔物，用于皱纹填充或其它化妆品植入物，作为用于重建手术的软组织替代物，或作为生物结构内腔内的屏障，例如 作为血管。 植入物可用于通过提供例如子宫颈的可逆屏障或输精管腔的可逆阻塞来提供可逆的节育。

    Environment responsive gelling copolymer
    9.
    发明授权
    Environment responsive gelling copolymer 失效
    环境响应胶凝共聚物

    公开(公告)号：US07193007B2

    公开(公告)日：2007-03-20

    申请号：US10221084

    申请日：2001-03-15

    申请人： Yu-Ling Cheng ,  Hai-Hui Lin

    发明人： Yu-Ling Cheng ,  Hai-Hui Lin

    IPC分类号： C08F290/04 ,  C08L53/00

    CPC分类号： C08L53/00 ,  A61L27/16 ,  A61L27/52 ,  C08F293/00 ,  C08F297/00 ,  Y10S524/916

    摘要： The invention relates to a gelable copolymer composition comprising a copolymer in a solvent. The copolymer has the structure A(B)n, wherein the core (A) is soluble in the solvent, the arms (B) are convertible between soluble and insoluble in the solent depending on an environmental condition, and n>1. The composition forms a gel under environmental conditions in which B is insoluble, through formation of B aggregates. Block copolymers comprising polyethylene glycol (PEG) and poly(N-iso-propylacrylamide) (PNIPAAm) having a liquid form at ambient temperature under aqueous conditions and a gel form at body temperature are disclosed. Copolymer compositions according to the invention can be used to form in situ implants useful in slow-release formulations of biologically active molecules

    摘要翻译： 本发明涉及在溶剂中包含共聚物的可胶凝共聚物组合物。 共聚物具有结构A（B）n，其中核（A）可溶于溶剂，臂（B）可根据环境条件在可溶性和不溶性之间转化，并且n> 1。 组合物通过形成B聚集体在环境条件下形成凝胶，其中B不溶。 公开了包含聚乙二醇（PEG）和聚环氧乙烷（PNIPAAm）在环境温度和水温条件下具有液态的嵌段共聚物和体温下的凝胶形式。 根据本发明的共聚物组合物可用于形成用于生物活性分子的缓释制剂的原位植入物

    Environment responsive gelling copolymer
    10.
    发明申请
    Environment responsive gelling copolymer 失效
    环境响应胶凝共聚物

    公开(公告)号：US20050020719A1

    公开(公告)日：2005-01-27

    申请号：US10221084

    申请日：2001-03-15

    申请人： Yu-Ling Cheng ,  Hai-Hui Lin

    发明人： Yu-Ling Cheng ,  Hai-Hui Lin

    IPC分类号： A61L27/16 ,  A61L27/52 ,  C08F293/00 ,  C08F297/00 ,  C08L53/00 ,  C08K3/00 ,  A61F2/00 ,  C08F20/54 ,  C08L1/00

    CPC分类号： C08L53/00 ,  A61L27/16 ,  A61L27/52 ,  C08F293/00 ,  C08F297/00 ,  Y10S524/916

    摘要： The invention relates to a gelable copolymer composition comprising a copolymer in a solvent. The copolymer has the structure A(B)n, wherein the core (A) is soluble in the solvent, the arms (B) are convertible between soluble and insoluble in the solent depending on an environmental condition, and n>1. The composition forms a gel under environmental conditions in which B is insoluble, through formation of B aggregates. Block copolymers comprising polyethylene glycol (PEG) and poly(N-iso-propylacrylamide) (PNIPAAm) having a liquid form at ambient temperature under aqueous conditions and a gel form at body temperature are disclosed. Copolymer compositions according to the invention can be used to form in situ implants useful in slow-release formulations of biologically active molecules.

    摘要翻译： 本发明涉及在溶剂中包含共聚物的可胶凝共聚物组合物。 共聚物具有结构A（B）n，其中核（A）可溶于溶剂，臂（B）可根据环境条件在可溶性和不溶性之间转化，并且n> 1。 组合物通过形成B聚集体在环境条件下形成凝胶，其中B不溶。 公开了包含聚乙二醇（PEG）和聚环氧乙烷（PNIPAAm）在环境温度和水温条件下具有液态的嵌段共聚物和体温下的凝胶形式。 根据本发明的共聚物组合物可用于形成用于生物活性分子的缓释制剂的原位植入物。