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公开(公告)号：US20160254219A1
公开(公告)日：2016-09-01
申请号：US15153970
申请日：2016-05-13
Applicant: Dae Sung YOO , Han Mo KOO , Ki Tae PARK , Jun Young LIM , Tae Ki HONG
Inventor： Dae Sung YOO , Han Mo KOO , Ki Tae PARK , Jun Young LIM , Tae Ki HONG
IPC: H01L23/498 , H01L23/31 , H01L23/492
CPC classification number: H01L23/49811 , H01L23/315 , H01L23/4924 , H01L23/49572 , H01L23/49582 , H01L23/49838 , H01L23/49894 , H01L24/50 , H01L24/86 , H01L2924/0002 , H05K7/02 , H01L2924/00
Abstract: Provided is a tape for electronic devices with lead crack and a method of manufacturing the tape. According to the present invention, by forming a bending portion on a narrow circuit pattern to be connected from an inner lead to an outer lead and further forming the bending portion within a resin application portion, crack occurred in a narrow wiring width can be avoided. The tape may includes a first lead and a second lead formed on a dielectric substrate and a bending portion formed on one of the first lead and the second lead wherein the bending portion is formed within a resin application portion.
Abstract translation: 提供了一种具有铅裂的电子设备的带子和一种制造带子的方法。 根据本发明，通过在从内引线到外引线连接的窄电路图案上形成弯曲部，并且在树脂施加部内进一步形成弯曲部，可以避免窄布线宽度的裂纹。 带可以包括形成在电介质基板上的第一引线和第二引线以及形成在第一引线和第二引线之一上的弯曲部分，其中弯曲部分形成在树脂施加部分内。
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公开(公告)号：US20130308289A1
公开(公告)日：2013-11-21
申请号：US13982658
申请日：2011-10-12
Applicant: Dae Sung Yoo , Han Mo Koo , Ki Tae Park , Jun Young Lim , Tae Ki Hong
Inventor： Dae Sung Yoo , Han Mo Koo , Ki Tae Park , Jun Young Lim , Tae Ki Hong
IPC: H05K7/02
CPC classification number: H01L23/49811 , H01L23/315 , H01L23/4924 , H01L23/49572 , H01L23/49582 , H01L23/49838 , H01L23/49894 , H01L24/50 , H01L24/86 , H01L2924/0002 , H05K7/02 , H01L2924/00
Abstract: Provided is a tape for electronic devices with lead crack and a method of manufacturing the tape. According to the present invention, by forming a bending portion on a narrow circuit pattern to be connected from an inner lead to an outer lead and further forming the bending portion within a resin application portion, crack occurred in a narrow wiring width can be avoided. The tape may include a first lead and a second lead formed on a dielectric substrate and a bending portion formed on one of the first lead and the second lead wherein the bending portion is formed within a resin application portion.
Abstract translation: 提供了一种具有铅裂的电子设备的带子和一种制造带子的方法。 根据本发明，通过在从内引线到外引线连接的窄电路图案上形成弯曲部，并且在树脂施加部内进一步形成弯曲部，可以避免窄布线宽度的裂纹。 带可以包括形成在电介质基板上的第一引线和第二引线以及形成在第一引线和第二引线之一上的弯曲部分，其中弯曲部分形成在树脂施加部分内。
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3.发明授权
公开(公告)号：US5645988A
公开(公告)日：1997-07-08
申请号：US260515
申请日：1994-06-15
Applicant: George F. Vande Woude , Han-Mo Koo , Anne Monks
Inventor： George F. Vande Woude , Han-Mo Koo , Anne Monks
IPC: A61K31/335 , A61K31/475 , A61K31/54 , A61K31/57 , A61K31/70 , A61K33/24 , A61K38/46 , A61K45/06 , G01N33/50 , C12Q1/68
CPC classification number: A61K31/335 , A61K31/475 , A61K31/54 , A61K31/57 , A61K31/70 , A61K33/24 , A61K45/06 , G01N33/5011 , G01N2800/52
Abstract: The present invention involves a method of identifying drugs which selectively inhibit the growth of particular cancer cells, which method comprises: (a) contacting with the drug at least two cancer cells derived from the same type of biological material, wherein the cancer cells differ as to the presence of a particular DNA sequence, (b) measuring the effect of the drug on the growth of the cancer cells, and (c) determining whether there is a correlation between the effect of the drug on the cancer cells and the presence or absence of the DNA sequence in the cancer cells. The present invention further involves the use of such drugs.
Abstract translation: 本发明涉及一种鉴定选择性抑制特定癌细胞生长的药物的方法，该方法包括：（a）与药物接触至少两种衍生自相同类型生物材料的癌细胞，其中癌细胞不同于 特定DNA序列的存在，（b）测量药物对癌细胞生长的影响，和（c）确定药物对癌细胞的作用是否存在相关性，以及 在癌细胞中没有DNA序列。 本发明还涉及使用这些药物。
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公开(公告)号：US20120186862A1
公开(公告)日：2012-07-26
申请号：US13188882
申请日：2011-07-22
Applicant: Tae Ki Hong , Han Mo Koo , Jun Young Lim , Ki Tae Park , Sang Ki Cho , Dae Sung Yoo
Inventor： Tae Ki Hong , Han Mo Koo , Jun Young Lim , Ki Tae Park , Sang Ki Cho , Dae Sung Yoo
CPC classification number: H05K1/028 , H01L23/4985 , H01L24/50 , H01L2924/01029 , H01L2924/14
Abstract: The present invention relates to a method for manufacturing a TAB tap. The method includes forming a circuit pattern region having input/output terminal pattern on a base film, and forming an exposing region at a convey region having a sprocket hole for exposing the base film. Accordingly, the present invention provides a TAB tape that improves reliability of a product by fundamentally preventing the generation of metal particles by forming exposing regions that expose a base film through selectively etching and removing a metal layer of a convey region formed at both side of a TAB tape and having a sprocket hole, and that prevents short-circuit by partially removing a base film at a predetermined region not having a circuit pattern formed thereon through etching.
Abstract translation: 本发明涉及一种制造TAB龙头的方法。 该方法包括在基膜上形成具有输入/输出端子图案的电路图案区域，并且在具有用于露出基底膜的链轮孔的输送区域处形成曝光区域。 因此，本发明提供一种TAB带，其通过基本上防止金属颗粒的产生而形成暴露区域，从而通过选择性地蚀刻和去除在 TAB带，并且具有链轮孔，并且通过在不具有通过蚀刻形成在其上的电路图案的预定区域部分地去除基底膜来防止短路。
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公开(公告)号：US07612035B2
公开(公告)日：2009-11-03
申请号：US11155691
申请日：2005-06-20
Applicant: Han-Mo Koo , Eunmi (Kay) Koo, legal representative , George F. Vande Woude , Nicholas S. Duesbery
Inventor： Han-Mo Koo , George F. Vande Woude , Nicholas S. Duesbery
IPC: A61K38/00
CPC classification number: A61K38/4886 , A61K31/166 , A61K31/275 , A61K31/352
Abstract: Inhibitors of the MAPK pathway, including MEK-directed proteases and small molecule inhibitors, are cytotoxic to human melanoma cells in vitro and in vivo via apoptotic mechanisms. These compounds are used to kill melanoma cells and to treat subjects with melanoma, either alone or in combination with other therapeutic modalities.
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公开(公告)号：US20110100687A1
公开(公告)日：2011-05-05
申请号：US12710926
申请日：2010-02-23
Applicant: Tae Ki Hong , Dong Guk Jo , Han Mo Koo , Jun Young Lim , Ki Tae Park , Sang Ki Cho , Dae Sung Yoo , Nak Ho Song , Joo Chul Kim , Jae Sung Jo
Inventor： Tae Ki Hong , Dong Guk Jo , Han Mo Koo , Jun Young Lim , Ki Tae Park , Sang Ki Cho , Dae Sung Yoo , Nak Ho Song , Joo Chul Kim , Jae Sung Jo
CPC classification number: H01L24/50 , H01L23/49838 , H01L23/4985 , H01L2924/01005 , H01L2924/01006 , H01L2924/01015 , H01L2924/01027 , H01L2924/01029 , H01L2924/01033 , H01L2924/01046 , H01L2924/01047 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/14 , H01L2924/181 , H01L2924/3025 , H01L2924/37001 , H05K1/11 , Y10T29/49155 , H01L2924/00
Abstract: The present invention relates to a carrier tape for TAB-package and a manufacturing method thereof, wherein a TAB tape including a wiring pattern and a metal plating layer formed on a base film comprises a transfer area including a row of sprocket holes arranged along the edges of the base film at predetermined intervals, and wherein the transfer area includes an exposure area from which the base film is exposed, such that the present invention has an advantageous effect in that no Cu layer or a metal layer exists at a portion of the sprocket holes from which friction is generated by a driving roller during assembly work between a drive IC and chips/drive IC and panel to dispense with generation of foreign objects such as Cu particles, thereby enhancing reliability of the product.
Abstract translation: 本发明涉及一种用于TAB封装的载带及其制造方法，其中包括布线图案和形成在基膜上的金属镀层的TAB带包括传送区域，其包括沿着边缘布置的一排链轮孔 并且其中转印区域包括暴露于基膜的曝光区域，使得本发明具有如下优点：在链轮的一部分处不存在Cu层或金属层 在驱动IC和芯片/驱动IC和面板之间的组装工作期间由驱动辊产生摩擦的孔，以省去诸如Cu颗粒的异物的产生，从而提高产品的可靠性。
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公开(公告)号：US20050202001A1
公开(公告)日：2005-09-15
申请号：US10512445
申请日：2003-04-24
Applicant: Han-Mo Koo , George Woude , Matt Vanbrocklin , Kathryn Eisenmann
Inventor： Han-Mo Koo , George Woude , Matt Vanbrocklin , Kathryn Eisenmann
CPC classification number: A61K8/4946 , A61K8/445 , A61K8/4953 , A61K8/498 , A61K8/64 , A61K2800/782 , A61Q19/04
Abstract: The invention provides methods and compositions that promote sunless tanning in human skin using a MAPK path-way inhibitor, particularly, a MEK-inhibitor, which induces melanogenesis in epidermal melanocytes alone or in combination with a cAMP-elevating agent. The compositions are preferably administered topically to the skin.
Abstract translation: 本发明提供使用MAPK途径抑制剂，特别是MEK抑制剂促进人皮肤日晒鞣制的方法和组合物，其在单独的表皮黑素细胞中诱导黑素生成或与cAMP升高剂组合。 组合物优选局部给予皮肤。
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公开(公告)号：US08791370B2
公开(公告)日：2014-07-29
申请号：US12710926
申请日：2010-02-23
Applicant: Tae Ki Hong , Dong Guk Jo , Han Mo Koo , Jun Young Lim , Ki Tae Park , Sang Ki Cho , Dae Sung Yoo , Nak Ho Song , Joo Chul Kim , Jae Sung Jo
Inventor： Tae Ki Hong , Dong Guk Jo , Han Mo Koo , Jun Young Lim , Ki Tae Park , Sang Ki Cho , Dae Sung Yoo , Nak Ho Song , Joo Chul Kim , Jae Sung Jo
CPC classification number: H01L24/50 , H01L23/49838 , H01L23/4985 , H01L2924/01005 , H01L2924/01006 , H01L2924/01015 , H01L2924/01027 , H01L2924/01029 , H01L2924/01033 , H01L2924/01046 , H01L2924/01047 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/14 , H01L2924/181 , H01L2924/3025 , H01L2924/37001 , H05K1/11 , Y10T29/49155 , H01L2924/00
Abstract: The present invention relates to a carrier tape for TAB-package and a manufacturing method thereof, wherein a TAB tape including a wiring pattern and a metal plating layer formed on a base film comprises a transfer area including a row of sprocket holes arranged along the edges of the base film at predetermined intervals, and wherein the transfer area includes an exposure area from which the base film is exposed, such that the present invention has an advantageous effect in that no Cu layer or a metal layer exists at a portion of the sprocket holes from which friction is generated by a driving roller during assembly work between a drive IC and chips/drive IC and panel to dispense with generation of foreign objects such as Cu particles, thereby enhancing reliability of the product.
Abstract translation: 本发明涉及一种用于TAB封装的载带及其制造方法，其中包括布线图案和形成在基膜上的金属镀层的TAB带包括传送区域，其包括沿着边缘布置的一排链轮孔 并且其中转印区域包括暴露于基膜的曝光区域，使得本发明具有如下优点：在链轮的一部分处不存在Cu层或金属层 在驱动IC和芯片/驱动IC和面板之间的组装工作期间由驱动辊产生摩擦的孔，以省去诸如Cu颗粒的异物的产生，从而提高产品的可靠性。
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公开(公告)号：US09480152B2
公开(公告)日：2016-10-25
申请号：US13188882
申请日：2011-07-22
Applicant: Tae Ki Hong , Han Mo Koo , Jun Young Lim , Ki Tae Park , Sang Ki Cho , Dae Sung Yoo
Inventor： Tae Ki Hong , Han Mo Koo , Jun Young Lim , Ki Tae Park , Sang Ki Cho , Dae Sung Yoo
IPC: H05K1/09 , H05K1/00 , H05K1/02 , H01L23/00 , H01L23/498
CPC classification number: H05K1/028 , H01L23/4985 , H01L24/50 , H01L2924/01029 , H01L2924/14
Abstract: The present invention relates to a method for manufacturing a TAB tap. The method includes forming a circuit pattern region having input/output terminal pattern on a base film, and forming an exposing region at a convey region having a sprocket hole for exposing the base film. Accordingly, the present invention provides a TAB tape that improves reliability of a product by fundamentally preventing the generation of metal particles by forming exposing regions that expose a base film through selectively etching and removing a metal layer of a convey region formed at both side of a TAB tape and having a sprocket hole, and that prevents short-circuit by partially removing a base film at a predetermined region not having a circuit pattern formed thereon through etching.
Abstract translation: 本发明涉及一种制造TAB龙头的方法。 该方法包括在基膜上形成具有输入/输出端子图案的电路图案区域，并且在具有用于露出基底膜的链轮孔的输送区域处形成曝光区域。 因此，本发明提供一种TAB带，其通过基本上防止金属颗粒的产生而形成暴露区域，从而通过选择性地蚀刻和去除在 TAB带，并且具有链轮孔，并且通过在不具有通过蚀刻形成在其上的电路图案的预定区域部分地去除基底膜来防止短路。
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10.发明申请Inhibition of mitogen-activated protein kinase (MAPK) pathway: a selective therapeutic strategy against melanoma 失效抑制丝裂原活化蛋白激酶（MAPK）途径：一种针对黑色素瘤的选择性治疗策略
公开(公告)号：US20050267012A1
公开(公告)日：2005-12-01
申请号：US11155691
申请日：2005-06-20
Applicant: Han-Mo Koo , George Vande Woude
Inventor： Han-Mo Koo , George Vande Woude
IPC: A61K31/166 , A61K31/275 , A61K31/352 , A61K38/16 , A61K38/43 , A61K38/45 , A61K38/48 , A61P35/00
CPC classification number: A61K38/4886 , A61K31/166 , A61K31/275 , A61K31/352
Abstract: Inhibitors of the MAPK pathway, including MEK-directed proteases and small molecule inhibitors, are cytotoxic to human melanoma cells in vitro and in vivo via apoptotic mechanisms. These compounds are used to kill melanoma cells and to treat subjects with melanoma, either alone or in combination with other therapeutic modalities.
Abstract translation: 包括MEK指导的蛋白酶和小分子抑制剂在内的MAPK途径的抑制剂通过凋亡机制在体外和体内对人黑素瘤细胞具有细胞毒性。 这些化合物用于杀死黑素瘤细胞并且治疗黑素瘤受试者，单独或与其它治疗方式组合。
