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公开(公告)号：US08349305B2
公开(公告)日：2013-01-08
申请号：US12127422
申请日：2008-05-27
申请人： Han Ting Chang , Dominique Charmot , Eric Connor , Florence Roger
发明人： Han Ting Chang , Dominique Charmot , Eric Connor , Florence Roger
IPC分类号： A61K31/74
CPC分类号： C08G73/02 , C08G73/0206
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供包含交联的胺聚合物的聚合物和药物组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗肾脏疾病和高磷酸血症。
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公开(公告)号：US08216560B2
公开(公告)日：2012-07-10
申请号：US12055726
申请日：2008-03-26
申请人： Dominique Charmot , Han Ting Chang , John Fordtran , Gerrit Klaerner , Jerry M. Buysse , Robert Alpern , Mingjun Liu
发明人： Dominique Charmot , Han Ting Chang , John Fordtran , Gerrit Klaerner , Jerry M. Buysse , Robert Alpern , Mingjun Liu
IPC分类号： A61K31/74
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钾结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高钾血症，例如由肾衰竭引起的高钾血症和/或使用引起高钾血症的药物。
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公开(公告)号：US07510817B2
公开(公告)日：2009-03-31
申请号：US11300657
申请日：2005-12-12
申请人： Didier Benoit , Adam Safir , Han-Ting Chang , Dominique Charmot , Isao Nishimura , Akimasa Soyano , Kenji Okamoto , Yong Wang
发明人： Didier Benoit , Adam Safir , Han-Ting Chang , Dominique Charmot , Isao Nishimura , Akimasa Soyano , Kenji Okamoto , Yong Wang
CPC分类号： C08F220/18 , C08F20/18 , C08F220/28 , G03F7/0397
摘要： The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.
摘要翻译： 本发明涉及通过活性自由基聚合技术制备光致抗蚀剂聚合物。 用作单体体积大的酯单体作为聚合组分。 链转移剂的使用包括在聚合工艺条件中。 描述了包含杂原子的聚合物末端基团的切割。
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公开(公告)号：US20070292385A1
公开(公告)日：2007-12-20
申请号：US11579251
申请日：2005-05-03
申请人： Dominique Charmot , Jerry Buysse , Han-Ting Chang , Michael Cope , David Hui
发明人： Dominique Charmot , Jerry Buysse , Han-Ting Chang , Michael Cope , David Hui
IPC分类号： A61K31/785 , A61P3/00
CPC分类号： A61K31/785 , A23L33/10 , A61K31/195 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/519 , A61K31/66 , A61K31/74
摘要： The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.
摘要翻译： 本发明提供了治疗磷脂酶相关病症的方法和组合物。 特别地，本发明提供了一种在动物受试者中治疗胰岛素相关，体重相关病症和/或胆固醇相关病症的方法。 该方法通常涉及施用定位在胃肠腔中的未吸收和/或流出的磷脂酶A2抑制剂。
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公开(公告)号：US20070185276A1
公开(公告)日：2007-08-09
申请号：US11734474
申请日：2007-04-12
申请人： Didier Benoit , Adam Safir , Han-Ting Chang , Dominique Charmot , Kenji Okamoto , Isao Nishimura , Yong Wang
发明人： Didier Benoit , Adam Safir , Han-Ting Chang , Dominique Charmot , Kenji Okamoto , Isao Nishimura , Yong Wang
IPC分类号： C08F287/00
CPC分类号： C08F220/30 , C08F2/38 , C08F20/30 , C08F220/18 , C08F293/005 , G03F7/0046 , G03F7/0397
摘要： The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.
摘要翻译： 本发明涉及通过活性自由基聚合技术制备光致抗蚀剂聚合物。 用作单体体积大的酯单体作为聚合组分。 链转移剂的使用包括在聚合工艺条件中。 描述了包含杂原子的聚合物末端基团的切割。
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6.发明申请Phospholipase inhibitors, including multi-valent phospholipase inhibitors, and use thereof, including as lumen-localized phospholipase inhibitors 审中-公开磷脂酶抑制剂，包括多价磷脂酶抑制剂及其用途，包括作为内腔定位的磷脂酶抑制剂公开(公告)号：US20070135383A1
公开(公告)日：2007-06-14
申请号：US11593176
申请日：2006-11-03
申请人： Han-Ting Chang , Dominque Charmot , Tomasz Glinka , Michael Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry Buysse
发明人： Han-Ting Chang , Dominque Charmot , Tomasz Glinka , Michael Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry Buysse
IPC分类号： A61K31/685 , A61K31/66 , A61K31/503 , A61K31/4745 , A61K31/405 , A61K31/365
CPC分类号： A61K31/404 , A61K9/0019 , A61K9/0095 , A61K31/41 , A61K31/66 , A61K47/10 , A61K47/20 , A61K47/55 , A61K47/58
摘要： The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.
摘要翻译： 本发明提供了治疗磷脂酶相关病症的方法和组合物。 特别地，本发明提供了一种在动物受试者中治疗胰岛素相关，体重相关病症和/或胆固醇相关病症的方法。 该方法通常涉及施用定位在胃肠腔中的未吸收和/或流出的磷脂酶A2抑制剂。
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公开(公告)号：US07030187B2
公开(公告)日：2006-04-18
申请号：US10952593
申请日：2004-09-28
IPC分类号： C08G63/91
CPC分类号： C08B37/0087 , C08B3/22 , C08B15/00 , C08B37/0057 , C08F251/02 , C08G18/6484
摘要： Cellulosic polymers, copolymers and grafts, are disclosed that adhere to fibers and surfaces during an aqueous treatment process. The cellulosic polymers having grafts and/or co-blocks are prepared using living-type free radical polymerization techniques, which provides control over the degree of substitution and graft/co-block composition and structure. These cellulosic polymers allow for the modification of fibers and surfaces to provide a desired effect.
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公开(公告)号：US06803410B2
公开(公告)日：2004-10-12
申请号：US10392188
申请日：2003-03-19
IPC分类号： C08G6391
CPC分类号： C08B37/0087 , C08B3/22 , C08B15/00 , C08B37/0057 , C08F251/02 , C08G18/6484
摘要： Cellulosic polymers, copolymers and grafts, are disclosed that adhere to fibers and surfaces during an aqueous treatment process. The cellulosic polymers having grafts and/or co-blocks are prepared using living-type free radical polymerization techniques, which provides control over the degree of substitution and graft/co-block composition and structure. These cellulosic polymers allow for the modification of fibers and surfaces to provide a desired effect.
摘要翻译： 公开了在水处理过程中粘附到纤维和表面上的纤维素聚合物，共聚物和接枝物。 具有接枝和/或共嵌段的纤维素聚合物使用活性型自由基聚合技术制备，其提供对取代度和接枝/共嵌段组成和结构的控制。 这些纤维素聚合物允许纤维和表面的改性以提供期望的效果。
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9.发明授权公开(公告)号：US06667376B2
公开(公告)日：2003-12-23
申请号：US10104740
申请日：2002-03-22
IPC分类号： C08F200
CPC分类号： C07D295/24 , C07C329/16 , C07C2601/14 , C07D207/46 , C07D209/30 , C07D291/06 , C08F2/38 , C08F293/005
摘要： Control agents that have an oxygen-nitrogen bond covalently bonded to a thiocarbonyl moiety are provided for living-type free radical polymerization of a wide variety of monomers, particularly vinyl monomers.
摘要翻译： 具有共价键合到硫代羰基部分上的氧 - 氮键的对照试剂被提供用于多种单体，特别是乙烯基单体的活性型自由基聚合。
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公开(公告)号：US06518448B2
公开(公告)日：2003-02-11
申请号：US09963174
申请日：2001-09-25
申请人： Han Ting Chang , Dominique Charmot , Yunxiao Li
发明人： Han Ting Chang , Dominique Charmot , Yunxiao Li
IPC分类号： C07C33300
CPC分类号： C08F2/38
摘要： Control agents that have a nitrogen-nitrogen bond covalently bonded to a thiocarbonyl moiety are provided for living-type free radical polymerization of a wide variety of monomers. These control agents provide superior properties for control of the polymerization and/or the properties of the polymers obtained and/or the monomers that may be polymerized. In some embodiments, a bulky group is pendant off the activated thiocarbonyl portion of the control agents. Multifunctional control agents provide the opportunity for a variety of structurally unique polymers, including block copolymers, stars and hyper-branched polymers.
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