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1.发明授权Method for obtaining a natural mixture of conjugated equine estrogens depleted in non-conjugated lipophilic compounds 有权用于获得耗尽非共轭亲脂化合物的共轭马雌激素的天然混合物的方法公开(公告)号：US08815299B2
公开(公告)日：2014-08-26
申请号：US12138808
申请日：2008-06-13
CPC分类号： A61K31/56
摘要： A method for obtaining an extract containing the natural mixture of conjugated equine estrogens by liquid-liquid extraction of the mixture of conjugated equine estrogens, wherein the mixture obtained is depleted in non-conjugated lipophilic compounds selected from the group consisting of non-conjugated flavonoids, non-conjugated isoflavonoids, non-conjugated norisoprenoids, non-conjugated steroids, in particular androstane and pregnane steroids, and comparable non-conjugated compounds.
摘要翻译： 一种通过液 - 液萃取共轭马雌激素混合物获得含有共轭马雌激素天然混合物的提取物的方法，其中获得的混合物耗尽未缀合的亲脂性化合物，其选自非共轭类黄酮， 非共轭异黄酮，非共轭诺非生物，非共轭类固醇，特别是雄甾烷和孕烷类固醇，以及可比较的非共轭化合物。
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2.发明申请Method For Obtaining a Natural Mixture of Conjugated Equine Estrogens Depleted in Non-Conjugated Lipophilic Compounds 有权在非共轭亲脂性化合物中消失的共轭马雌激素的天然混合物的获得方法公开(公告)号：US20090023699A1
公开(公告)日：2009-01-22
申请号：US12138808
申请日：2008-06-13
IPC分类号： A61K31/565
CPC分类号： A61K31/56
摘要： A method for obtaining an extract containing the natural mixture of conjugated equine estrogens by liquid-liquid extraction of the mixture of conjugated equine estrogens, wherein the mixture obtained is depleted in non-conjugated lipophilic compounds selected from the group consisting of non-conjugated flavonoids, non-conjugated isoflavonoids, non-conjugated norisoprenoids, non-conjugated steroids, in particular androstane and pregnane steroids, and comparable non-conjugated compounds.
摘要翻译： 一种通过液 - 液萃取共轭马雌激素混合物获得含有共轭马雌激素天然混合物的提取物的方法，其中获得的混合物耗尽未缀合的亲脂性化合物，其选自非共轭类黄酮， 非共轭异黄酮，非共轭诺非生物，非共轭类固醇，特别是雄甾烷和孕烷类固醇，以及可比较的非共轭化合物。
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3.发明授权Enzyme immobilzation on a macropermable agglomerate of microporous .alpha.- a 失效微波（ALPHA） - 氧化铝氢氧化物颗粒的无机聚合物的酶解
公开(公告)号：US5229284A
公开(公告)日：1993-07-20
申请号：US737983
申请日：1991-07-30
申请人： Dirk Bonse , Hubert Schindler , Hans-Joerg Mueller
发明人： Dirk Bonse , Hubert Schindler , Hans-Joerg Mueller
摘要： Enzymes are immboilized on an inorganic carrier which is a round, macropermeable agglomerate having a mulberry-type structure formed from spherical microporous .alpha.-aluminum oxide hydroxide particles. An organic polycondensate having free organic functional groups as enzyme binding sites penetrates the agglomerate. The .alpha.-aluminum oxide hydroxide particles of the agglomerate retain essentially their form prior to agglomeration. The polycondensate is prepared by reacting a polyimine with a dialdehyde or an epoxy compound. Preferably, the polyimine is polyethyleneimine, the dialdehyde is glutardialdehyde and the epoxy compound is an epoxy-functional silicon resin, an aliphatic diepoxide or an aliphatic triepoxide. The agglomerate is prepared by granulating the .alpha.-aluminum oxide hydroxide particles in the presence of the polyimine to form the agglomerate having the polyimine dispersed throughout and then reacting the polyimine with the dialdehyde or the epoxy compound. A preferred enzyme is glucose isomerase.
摘要翻译： 酶在无机载体上进行无菌化，该无机载体是具有由球形微孔α-铝氧化物氢氧化物颗粒形成的桑树型结构的圆形，可渗透聚集体。 具有游离有机官能团作为酶结合位点的有机缩聚物渗透附聚物。 附聚物的α-二氧化铝氢氧化物颗粒在凝聚之前基本保持其形式。 缩聚物通过聚亚胺与二醛或环氧化合物反应来制备。 优选地，聚亚胺是聚乙烯亚胺，二醛是戊二醛，环氧化合物是环氧官能的硅树脂，脂族二环氧化物或脂族三环氧化物。 通过在聚亚胺的存在下对α-氧化铝氢氧化物颗粒进行造粒来制备附聚物，以形成聚亚胺分散在其中的聚集体，然后使聚亚胺与二醛或环氧化合物反应。 优选的酶是葡萄糖异构酶。
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