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公开(公告)号：US20210100656A1
公开(公告)日：2021-04-08
申请号：US17119961
申请日：2020-12-11
Applicant: Harpoon Medical, Inc.
Inventor： Peter Wilson , Stephen Epstein , Stephen Cournane
Abstract: A method comprises advancing an elongate tube to a target implantation site, the elongate tube having a needle disposed at least partially therein that has a coiled sutureform wrapped around at least a portion thereof, contacting a distal end of the elongate tube to a target tissue, projecting a tip of the needle from the distal end of the elongate tube to pierce through the target tissue such that the tip of the needle and at least a portion of the coiled sutureform project through the target tissue, advancing a pusher device within the elongate tube and over the needle to push the at least a portion of the coiled sutureform off of the tip of the needle, and proximally pulling one or more suture tails associated with the coiled sutureform to form the coiled sutureform into a knot on a distal side of the target tissue.
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公开(公告)号：US20200261073A1
公开(公告)日：2020-08-20
申请号：US16866382
申请日：2020-05-04
Applicant: University of Maryland, Baltimore , Harpoon Medical, Inc.
Inventor： James S. Gammie , Peter Wilson , Peter Boyd , William Niland
IPC: A61B17/04
Abstract: Apparatus and methods for performing a non-invasive procedure to repair a cardiac valve are described herein. In some embodiments, apparatus and methods are described herein for repairing a mitral valve using an edge-to-edge repair to secure the mitral valve leaflets. Implant securing devices are also described that can be used during a procedure to repair a mitral valve. In some embodiments, an implant securing device includes an outer member and an inner member movably disposed within the outer member. The inner member can be used to hold or secure a suture extending from an implant deployed on an atrial side of a leaflet of a mitral valve, and the outer member can be used to push or move a half hitch knot toward a ventricular side of the leaflet, which can be used to secure the implant in the desired position.
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公开(公告)号：US20230310153A1
公开(公告)日：2023-10-05
申请号：US18332309
申请日：2023-06-09
Applicant: Harpoon Medical, Inc.
Inventor： Peter Wilson , Stephen Epstein , Stephen Cournane
CPC classification number: A61F2/2457 , A61B17/0401 , A61B17/0469 , A61F2/2466 , A61B2217/005 , A61B2017/00783
Abstract: A tissue anchor delivery device includes a handle, an elongate shaft extending from the handle, a pusher tube disposed at least partially within a lumen of the elongate shaft, a pusher hub coupled to the pusher tube, a needle disposed at least partially within a lumen of the pusher tube, a needle hub coupled to the needle, and an actuator configured to be fixed to the pusher hub and the needle hub. The actuator is further configured to advance the needle hub and the pusher hub a first distance, thereby causing a tip of the needle to protrude from a distal end of the elongate shaft, disengage from the needle hub, and advance the pusher hub a second distance relative to the needle hub, thereby causing a distal end of the pusher tube to advance over the needle and push a coiled suture form off of the needle.
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公开(公告)号：US11065120B2
公开(公告)日：2021-07-20
申请号：US16167069
申请日：2018-10-22
Applicant: University of Maryland, Baltimore , Harpoon Medical, Inc.
Inventor： Felino V. Cortez, Jr. , James S. Gammie , Peter Wilson , Luke Anthony Zanetti , Julie Marie Etheridge , Stephen Cournane
Abstract: Described herein are methods and apparatus for approximating targeted tissue using locking sutures. The locking sutures can be configured to receive suture ends that are interweaved through portions of the locking sutures. In a pre-deployment configuration, a locking suture can slide along suture tails and can be positioned at a target location within a target region. Once a desired position and/or tension is achieved, the locking suture can be transitioned to a post-deployment configuration where the locking suture constricts around the suture tails to inhibit relative movement between the suture tails and the locking suture.
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公开(公告)号：US20170258464A1
公开(公告)日：2017-09-14
申请号：US15606510
申请日：2017-05-26
Applicant: Harpoon Medical, Inc. , University of Maryland, Baltimore
Inventor： James GAMMIE , Peter WILSON , Peter BOYD , William NILAND
CPC classification number: A61B17/0401 , A61B17/0487 , A61B2017/00783 , A61B2017/0406 , A61B2017/0458 , A61B2017/0474 , A61B2017/0488 , A61B2090/034
Abstract: Apparatus and methods for performing a non-invasive procedure to repair a cardiac valve are described herein. In some embodiments, apparatus and methods are described herein for repairing a mitral valve using an edge-to-edge repair to secure the mitral valve leaflets. Implant securing devices are also described that can be used during a procedure to repair a mitral valve. In some embodiments, an implant securing device includes an outer member and an inner member movably disposed within the outer member. The inner member can be used to hold or secure a suture extending from an implant deployed on an atrial side of a leaflet of a mitral valve, and the outer member can be used to push or move a half hitch knot toward a ventricular side of the leaflet, which can be used to secure the implant in the desired position.
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公开(公告)号：US11944540B2
公开(公告)日：2024-04-02
申请号：US17013495
申请日：2020-09-04
Applicant: University of Maryland, Baltimore , Harpoon Medical, Inc.
Inventor： Michael Nicholas D'ambra , Felino V. Cortez, Jr. , James S. Gammie , Peter Wilson , Stephen Epstein , Stephen Cournane , Julie Marie Etheridge , Peter Boyd
IPC: A61F2/24
CPC classification number: A61F2/2466 , A61F2/2457 , A61F2/2463 , A61F2/2487 , A61F2/2412 , A61F2/2427 , A61F2/2445 , A61F2/2451 , A61F2/246
Abstract: Described herein are devices and methods for mitral valve repair. The devices and methods implant a plurality of distal anchors at an annulus of the mitral valve (e.g., the posterior annulus) and tension artificial chordae to pull the portion of the annulus toward an opposite edge and inward into the ventricle. This can effectively reduce the size of the orifice and increase coaptation. The delivery devices can be configured to be actuated to form a distal anchor made of a pre-formed knot. The delivery devices deliver the pre-formed knot in an elongate configuration. Actuation of the delivery device causes the pre-formed knot to transition from the elongate configuration to the deployed configuration by approximating opposite ends of a suture coupled to a coiled configuration to form one or more loops. After formation of the knot, the delivery device can be withdrawn.
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公开(公告)号：US20220387015A1
公开(公告)日：2022-12-08
申请号：US17337315
申请日：2021-06-02
Applicant: Harpoon Medical, Inc. , University of Maryland, Baltimore
Inventor： William Niland , Felino V. Cortez, JR. , James S. Gammie , Michael Nicholas D'ambra , Peter Wilson , Stephen Cournane
Abstract: Described herein are devices for approximating targeted tissue by intertwining two or more sutures together. The sutures are attached to the targeted tissue and routed to a twister device. The twister device secures end portions of the sutures and twists them to intertwine the sutures. Controlling the number of twists provides control over the forces applied to the targeted tissue. In conjunction with visualization feedback, real-time adjustments can be made to achieved targeted results, such as elimination of mitral regurgitation when the disclosed methods and apparatus are applied to mitral valve repair.
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公开(公告)号：US20210338429A1
公开(公告)日：2021-11-04
申请号：US17379904
申请日：2021-07-19
Applicant: University of Maryland, Baltimore , Harpoon Medical, Inc.
Inventor： Felino V. Cortez, JR. , James S. Gammie , Peter Wilson , Luke Anthony Zanetti , Julie Marie Etheridge , Stephen Cournane
Abstract: Described herein are methods and apparatus for approximating targeted tissue using locking sutures. The locking sutures can be configured to receive suture ends that are interweaved through portions of the locking sutures. In a pre-deployment configuration, a locking suture can slide along suture tails and can be positioned at a target location within a target region. Once a desired position and/or tension is achieved, the locking suture can be transitioned to a post-deployment configuration where the locking suture constricts around the suture tails to inhibit relative movement between the suture tails and the locking suture.
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公开(公告)号：US20180289480A1
公开(公告)日：2018-10-11
申请号：US15950458
申请日：2018-04-11
Applicant: University of Maryland, Baltimore , Harpoon Medical, Inc.
Inventor： Michael Nicholas D'ambra , Felino V. Cortez, JR. , James S. Gammie , Peter Wilson , Stephen Epstein , Stephen Cournane , Julie Marie Etheridge , Peter Boyd
IPC: A61F2/24
CPC classification number: A61F2/2445 , A61F2/2412 , A61F2/2427 , A61F2/2451 , A61F2/2457 , A61F2/2466
Abstract: Described herein are devices and methods for mitral valve repair. The devices and methods implant a plurality of distal anchors at an annulus of the mitral valve (e.g., the posterior annulus) and tension artificial chordae to pull the portion of the annulus toward an opposite edge and inward into the ventricle. This can effectively reduce the size of the orifice and increase coaptation. The anchor points of the artificial chordae can be offset from the apex of the heart to achieve a targeted force vector on the annulus. In addition, some embodiments include distal anchors implanted in the posterior leaflet in addition to those at the posterior annulus. This allows differential tensioning to be applied to provide for greater flexibility in treating various configurations of mitral valves to improve coaptation.
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公开(公告)号：US12201525B2
公开(公告)日：2025-01-21
申请号：US18332309
申请日：2023-06-09
Applicant: Harpoon Medical, Inc.
Inventor： Peter Wilson , Stephen Epstein , Stephen Cournane
Abstract: A tissue anchor delivery device includes a handle, an elongate shaft extending from the handle, a pusher tube disposed at least partially within a lumen of the elongate shaft, a pusher hub coupled to the pusher tube, a needle disposed at least partially within a lumen of the pusher tube, a needle hub coupled to the needle, and an actuator configured to be fixed to the pusher hub and the needle hub. The actuator is further configured to advance the needle hub and the pusher hub a first distance, thereby causing a tip of the needle to protrude from a distal end of the elongate shaft, disengage from the needle hub, and advance the pusher hub a second distance relative to the needle hub, thereby causing a distal end of the pusher tube to advance over the needle and push a coiled suture form off of the needle.
