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公开(公告)号:US5733917A
公开(公告)日:1998-03-31
申请号:US701000
申请日:1996-08-21
申请人: Yutaka Ohuchi , Masaji Suzuki , Hajime Asanuma , Sadakazu Yokomori , Katsuo Hatayama , Yoshihiko Isobe , Haruko Kijima , Makoto Muramatsu
发明人: Yutaka Ohuchi , Masaji Suzuki , Hajime Asanuma , Sadakazu Yokomori , Katsuo Hatayama , Yoshihiko Isobe , Haruko Kijima , Makoto Muramatsu
IPC分类号: C07D451/12 , A61K31/46 , A61K31/47 , C07D451/04 , C07D451/06
CPC分类号: C07D451/12
摘要: Endo-(8-methyl-8-azabicyclo�3.2.1!oct-3-yl) 1-isopropyl-2(1H)-quinolone-3-carboxylate represented by Formula (I): ##STR1## or an acid addition salt thereof acts on a serotonin 4 receptor thereby to have a serotonin-like receptor stimulating activity, therefore has an action on activating gastrointestinal motor functions and thus is effective for the improvement of gastrointestinal conditions such as heartburn, anorexia, bowel pain or abdominal distension accompanied by chronic gastritis or postoperative gastroparesis, and further for the treatment of gastro-esophagal reflux, intestinal pseudo-obstruction or constipation.
摘要翻译: 由式(I)表示的内 - (8-甲基-8-氮杂双环[3.2.1]辛-3-基)-1-异丙基-2(1H) - 喹诺酮-3-羧酸酯: 其作用于5-羟色胺4受体,从而具有5-羟色胺样受体刺激活性,因此具有激活胃肠运动功能的作用,因此对于改善胃肠道状况如胃灼热,食欲缺乏,肠痛或腹胀伴随着 慢性胃炎或术后胃轻瘫,并进一步治疗胃食管反流,肠道假性梗阻或便秘。