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    METHOD FOR DETECTING MAGNETICALLY MARKED OBJECTS AND CORRESPONDING DEVICE
    2.
    发明申请
    METHOD FOR DETECTING MAGNETICALLY MARKED OBJECTS AND CORRESPONDING DEVICE 审中-公开
    用于检测磁性标记物体和相应装置的方法

    公开(公告)号：US20130124101A1

    公开(公告)日：2013-05-16

    申请号：US13698587

    申请日：2011-04-13

    申请人： Helmut Eckert

    发明人： Helmut Eckert

    IPC分类号： G06F19/10

    CPC分类号： G16B99/00 ,  G01R33/0029 ,  G01R33/091 ,  G01R33/1269

    摘要： Magnetically marked objects, in particular biological objects, such as cells, are continuously detected by moving at least one magnetically marked object in a magnetic field, measuring a local change in the magnetic field caused by the magnetically marked object, generating a signal, in particular a digitized signal, based on the measured local change in the magnetic field, conditioning the generated signal by at least one convolution of the generated signal using a mathematical function, and evaluating the conditioned signal. The evaluation of the signal includes determining extreme values, in particular maximum values, of the signal and comparing the determined extreme values with a threshold value, in particular a predefined threshold value, which, if exceeded, indicates detection of the object.

    摘要翻译： 通过在磁场中移动至少一个磁性标记的物体来连续检测磁标记的物体，特别是生物物体，例如细胞，测量由磁性标记的物体引起的磁场的局部变化，特别是产生信号 基于所测量的磁场局部变化，数字化信号，使用数学函数对生成的信号进行至少一次卷积调节生成的信号，并评估调节信号。 对信号的评估包括确定信号的极值，特别是最大值，并将确定的极值与阈值，特别是预定义的阈值进行比较，如果超过，阈值指示对象的检测。

    Polysaccharide-polypeptide conjugate
    3.
    发明授权
    Polysaccharide-polypeptide conjugate 有权
    多糖 - 多肽缀合物

    公开(公告)号：US08153135B2

    公开(公告)日：2012-04-10

    申请号：US11223993

    申请日：2005-09-13

    申请人： Hans Loibner ,  Helmut Eckert

    发明人： Hans Loibner ,  Helmut Eckert

    IPC分类号： A61K39/395 ,  C07K16/46

    CPC分类号： A61K47/6851 ,  A61K47/61 ,  A61K47/646

    摘要： Disclosed is a method of producing a polysaccharide-polypeptide conjugate by reacting a polysaccharide with a polypeptide which contains at least one free amino group, wherein a polysaccharide carrier comprising vicinal hydroxyl groups is oxidized under ring opening to create vicinal aldehyde groups and is reacted with one or more base-instable antigenic polypeptide(s) containing at least one free amino group, the polypeptide(s) being bound directly to the polysaccharide carrier via at least one azomethine bond.

    摘要翻译： 公开了通过使多糖与含有至少一个游离氨基的多肽反应制备多糖 - 多肽缀合物的方法，其中包含连位羟基的多糖载体在开环下被氧化以产生连位醛基并与一个 或多个含有至少一个游离氨基的碱基不稳定抗原多肽，所述多肽通过至少一个偶氮甲碱键直接结合至多糖载体。

    Immunotherapy of rectal cancer
    5.
    发明申请
    Immunotherapy of rectal cancer 审中-公开
    直肠癌免疫治疗

    公开(公告)号：US20060246056A1

    公开(公告)日：2006-11-02

    申请号：US10558166

    申请日：2004-05-24

    申请人： Hans Loibner ,  Helmut Eckert ,  Gottfried Himmler

    发明人： Hans Loibner ,  Helmut Eckert ,  Gottfried Himmler

    IPC分类号： A61K39/395

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/3046

    摘要： Described is the use of an immunotherapeutic agent targeting a human tumor associated antigen for the production of a medicament for immunotherapy of patients with rectal cancer or being at risk of rectal cancer, wherein the immunotherapeutic agent is a vaccine, an antibody or derivative or fragment thereof.

    摘要翻译： 描述了靶向人肿瘤相关抗原的免疫治疗剂用于生产用于直肠癌患者或直肠癌风险的免疫治疗药物的用途，其中所述免疫治疗剂是疫苗，抗体或其衍生物或片段 。