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公开(公告)号：US20140171646A1
公开(公告)日：2014-06-19
申请号：US14044661
申请日：2013-10-02
发明人： Waldo MOSSI , Giorgio CALDERARI , Wilma TAMRAZ , Tai Wah CHAN
IPC分类号： C07D453/02
CPC分类号： C07D453/02 , A61K31/415
摘要： Amorphous and polymorphic of palonosetron hydrochloride are disclosed that can be characterized by X-ray powder diffraction patterns, thermal properties, purity and methods of manufacture. These forms of palonosetron hydrochloride can be produced from solution or by solid state interconversions. The forms can be used in pharmaceutical formulations: particularly preferred uses of these formulations are in prevention and treatment of nausea and emesis arising from chemotherapy or postoperative side effects. The forms can optionally be used as mixtures of the crystalline and/or amorphous forms.
摘要翻译： 公开了盐酸帕洛诺司琼的无定形和多晶型物，其可以通过X射线粉末衍射图，热性质，纯度和制造方法来表征。 这些形式的盐酸帕洛诺司琼可以通过溶液或通过固相互变而产生。 这些形式可以用于药物制剂中：这些制剂的特别优选用途是预防和治疗由化疗或术后副作用引起的恶心和呕吐。 这些形式可以任选地用作结晶和/或无定形形式的混合物。
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公开(公告)号：US20140039000A1
公开(公告)日：2014-02-06
申请号：US14052925
申请日：2013-10-14
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Alberto Macciocchi , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee
IPC分类号： A61K31/473 , B65B55/02 , A61K47/26
CPC分类号： A61K9/08 , A61J3/00 , A61K9/0019 , A61K9/0053 , A61K31/4178 , A61K31/473 , A61K31/4747 , A61K47/02 , A61K47/12 , A61K47/16 , A61K47/183 , A61K47/26 , B65B3/04 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US08598218B2
公开(公告)日：2013-12-03
申请号：US13901288
申请日：2013-05-23
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Alberto Macciocchi , Andrew Miksztal , Thomas Malefyt , Kathleen M Lee
IPC分类号： A01N43/52
CPC分类号： A61K9/08 , A61J3/00 , A61K9/0019 , A61K9/0053 , A61K31/4178 , A61K31/473 , A61K31/4747 , A61K47/02 , A61K47/12 , A61K47/16 , A61K47/183 , A61K47/26 , B65B3/04 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US20130261592A1
公开(公告)日：2013-10-03
申请号：US13901437
申请日：2013-05-23
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Alberto Macciocchi , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee , Carmine Panuccio
IPC分类号： A61K47/26 , A61K47/02 , A61K47/12 , A61K31/473 , A61K47/18
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/0095 , A61K31/473 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , B65B7/16 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US20140193487A1
公开(公告)日：2014-07-10
申请号：US14069885
申请日：2013-11-01
IPC分类号： A61K31/496 , A61K9/48 , A61K31/473
CPC分类号： A61K31/496 , A61K9/0053 , A61K9/2054 , A61K9/4808 , A61K9/4858 , A61K31/4178 , A61K31/473 , A61K31/573 , A61K45/06 , Y10S514/872 , A61K2300/00
摘要： Provided are compositions and methods for treating or preventing nausea and vomiting in patients undergoing chemotherapy, radiotherapy, or surgery.
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公开(公告)号：US20130261149A1
公开(公告)日：2013-10-03
申请号：US13901830
申请日：2013-05-24
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Alberto Macciocchi , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/0095 , A61K31/473 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , B65B7/16 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US09186357B2
公开(公告)日：2015-11-17
申请号：US14069927
申请日：2013-11-01
IPC分类号： A61K31/496 , A61K31/573 , A61K31/473 , A61K9/48 , A61K31/4178 , A61K45/06 , A61K9/20 , A61K9/00
CPC分类号： A61K31/496 , A61K9/0053 , A61K9/2054 , A61K9/4808 , A61K9/4858 , A61K31/4178 , A61K31/473 , A61K31/573 , A61K45/06 , Y10S514/872 , A61K2300/00
摘要： Provided are compositions and methods for treating or preventing nausea and vomiting in patients undergoing chemotherapy, radiotherapy, or surgery.
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公开(公告)号：US20140194395A1
公开(公告)日：2014-07-10
申请号：US14069927
申请日：2013-11-01
IPC分类号： A61K31/496 , A61K31/573 , A61K31/473
CPC分类号： A61K31/496 , A61K9/0053 , A61K9/2054 , A61K9/4808 , A61K9/4858 , A61K31/4178 , A61K31/473 , A61K31/573 , A61K45/06 , Y10S514/872 , A61K2300/00
摘要： Provided are compositions and methods for treating or preventing nausea and vomiting in patients undergoing chemotherapy, radiotherapy, or surgery.
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公开(公告)号：US20030036563A1
公开(公告)日：2003-02-20
申请号：US10254862
申请日：2002-09-26
发明人： Stefano Bader , Enrique Hausermann , Tiziana Monti
IPC分类号： A61K031/18
CPC分类号： A61K9/0014 , A61K31/18 , A61K47/06 , A61K47/10 , A61K47/32 , Y10S514/887
摘要： The present invention relates to nimesulide topical formulations comprising a carboxyvinylpolymer neutralized as a gel-forming agent or a polyacrylamide-isoparaffin and a solvent selected from the group consisting of ethanol, isopropanol and diethylene glycol monoethyl ether, and to the process for the preparation thereof. Said formulations have advantages such as higher stability of the system and bioavailability of the active ingredient.
摘要翻译： 本发明涉及包含作为凝胶形成剂中和的羧基乙烯基聚合物或聚丙烯酰胺 - 异链烷烃和选自乙醇，异丙醇和二甘醇单乙醚的溶剂的尼美舒利局部制剂及其制备方法。 所述制剂具有诸如系统的较高稳定性和活性成分的生物利用度的优点。
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公开(公告)号：US11559523B2
公开(公告)日：2023-01-24
申请号：US17075757
申请日：2020-10-21
IPC分类号： A61K31/496 , A61K9/48 , A61K31/4178 , A61K31/473 , A61K31/573 , A61K45/06 , A61K9/20 , A61K9/00
摘要： Provided are compositions and methods for treating or preventing nausea and vomiting in patients undergoing chemotherapy, radiotherapy, or surgery.
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