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20 条记录 (耗时 0.017 秒)

    Synthesis of allofuranose
    4.
    发明授权
    Synthesis of allofuranose 有权
    异戊二烯的合成

    公开(公告)号：US06858726B2

    公开(公告)日：2005-02-22

    申请号：US10165768

    申请日：2002-06-07

    申请人： Troels Koch ,  Henrik Frydenlund Hansen

    发明人： Troels Koch ,  Henrik Frydenlund Hansen

    IPC分类号： C07H1/00

    CPC分类号： C07H1/00

    摘要： The present invention provides a novel strategy for the synthesis of allofuranose using glucofuranose as starting material in a one-pot reaction. The novel finding is that it is possible to carry out the oxidation of 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose with DMSO/acetic anhydride and a reduction reaction in one pot obtaining high yields of recrystallised and analytical pure 1,2:5,6-di-O-isopropylidene-α-D-allofuranose.

    摘要翻译： 本发明提供了在一锅反应中使用呋喃糖作为原料合成异戊二醛的新策略。 该新发现是可以用DMSO /乙酸酐进行1,2：5,6-二-O-异亚丙基-α-D-吡喃葡萄糖的氧化，并在一锅中进行还原反应，得到高产率的重结晶 和分析纯的1,2：5,6-二-O-异亚丙基-α-D-异戊二醛。

    2-or 3-dimensional geometric structures
    5.
    发明授权
    2-or 3-dimensional geometric structures 失效
    2维或3维几何结构

    公开(公告)号：US06310179B1

    公开(公告)日：2001-10-30

    申请号：US09087514

    申请日：1998-05-28

    申请人： Hans-Georg Batz ,  Troels Koch ,  Henrik Frydenlund Hansen

    发明人： Hans-Georg Batz ,  Troels Koch ,  Henrik Frydenlund Hansen

    IPC分类号： C07K104

    CPC分类号： B82Y30/00 ,  C07H21/00 ,  C07K14/003 ,  Y10S977/704 ,  Y10S977/728 ,  Y10S977/734 ,  Y10S977/753 ,  Y10S977/792 ,  Y10S977/80 ,  Y10S977/906

    摘要： Nucleic acid analogues provide a particularly useful tool for the preparation of complex polymeric structures of defined geometry because they are relatively stable to reaction conditions for the preparation of such structures and provide the opportunity to introduce reactive groups which would not be possible with usual nucleic acids. These supramolecular structures can be used to form fine networks in nanometer size, for the preparation of e.g., computer chips, new materials/polymers with conductivity and/or insulator properties, and robot arms in nanometer scale.

    摘要翻译： 核酸类似物为制备具有规定几何形状的复合聚合物结构提供了特别有用的工具，因为它们对于制备这种结构的反应条件相对稳定，并且提供引入与常规核酸不可能的反应性基团的机会。 这些超分子结构可用于形成纳米尺寸的精细网络，用于制备例如计算机芯片，具有导电性和/或绝缘体特性的新材料/聚合物以及纳米尺度的机器人手臂。

    Substituted nucleic acid mimics
    6.
    发明授权
    Substituted nucleic acid mimics 失效
    取代的核酸模拟物

    公开(公告)号：US07825215B1

    公开(公告)日：2010-11-02

    申请号：US08612661

    申请日：1996-03-08

    申请人： Leif Christensen ,  Henrik Frydenlund Hansen ,  Peter E. Nielsen

    发明人： Leif Christensen ,  Henrik Frydenlund Hansen ,  Peter E. Nielsen

    IPC分类号： C07K2/00 ,  A61K38/00 ,  C07K1/00 ,  C12Q1/68 ,  G01N33/566 ,  C07H21/02

    CPC分类号： C07H21/00

    摘要： Compositions and methods are provided for the nucleic acid mimic determination of nucleic acids. The compositions and methods may be used in the diagnosis and treatment of diseases amenable through modulation of nucleic acids which encode proteins that are implicated in disease states. In accordance with preferred embodiments, mimics are comprised of non-naturally occurring backbones to which are appended modified heterocyclic bases. Such bases preferably have sterically bulky substituents 1, 2, or 3 atoms removed from the sites of attachment to the backbone.

    摘要翻译： 提供了用于核酸的核酸模拟测定的组合物和方法。 组合物和方法可以用于诊断和治疗通过调节编码与疾病状态有关的蛋白质的核酸而适应的疾病。 根据优选实施方案，模拟物由非天然存在的骨架组成，其中是附加的修饰的杂环碱基。 这些碱优选具有从连接于主链的位点除去的空间庞大的取代基1,2或3个原子。

    RNA ANTAGONIST COMPOUNDS FOR THE INHIBITION OF APO-B100 EXPRESSION
    8.
    发明申请
    RNA ANTAGONIST COMPOUNDS FOR THE INHIBITION OF APO-B100 EXPRESSION 审中-公开
    用于抑制APO-B100表达的RNA拮抗剂化合物

    公开(公告)号：US20090118213A1

    公开(公告)日：2009-05-07

    申请号：US12066852

    申请日：2006-09-01

    申请人： Henrik Frydenlund Hansen ,  Bo Hansen ,  Majken Westergaard ,  Ellen Marie Straarup ,  Christoph Rosenbohm

    发明人： Henrik Frydenlund Hansen ,  Bo Hansen ,  Majken Westergaard ,  Ellen Marie Straarup ,  Christoph Rosenbohm

    IPC分类号： A61K31/7088 ,  C07H21/04

    CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3515

    摘要： Oligonucleotides directed against the Apo-B100 gene are provided for modulating the expression of Apo-B100. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the Apo-B100. Methods of using these compounds for modulation of Apo-B100 expression and for the treatment of diseases associated with either overexpression of Apo-B100, expression of mutated Apo-B100 or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

    摘要翻译： 提供针对Apo-B100基因的寡核苷酸用于调节Apo-B100的表达。 组合物包含针对编码Apo-B100的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节Apo-B100表达和治疗与Apo-B100的过度表达相关的疾病，突变的Apo-B100或两者的表达的方法。 疾病的例子包括肺，乳腺，结肠，前列腺，胰腺，肺，肝，甲状腺，肾，脑，睾丸，胃，肠，肠，脊髓，鼻窦，膀胱，尿道或卵巢癌等癌症。 寡核苷酸可以由脱氧核糖核苷或核酸类似物例如锁定的核酸或其组合构成。

    Potent LNA oligonucleotides for the inhibition of HIF-1a expression
    10.
    发明授权
    Potent LNA oligonucleotides for the inhibition of HIF-1a expression 有权
    用于抑制HIF-1a表达的强大的LNA寡核苷酸

    公开(公告)号：US07939507B2

    公开(公告)日：2011-05-10

    申请号：US12477261

    申请日：2009-06-03

    申请人： Majken Westergaard ,  Charlotte Albaek Thrue ,  Frank Winther Rasmussen ,  Henrik Frydenlund Hansen

    发明人： Majken Westergaard ,  Charlotte Albaek Thrue ,  Frank Winther Rasmussen ,  Henrik Frydenlund Hansen

    IPC分类号： A01N43/04 ,  C12Q1/68 ,  C12N15/63 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346

    摘要： The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of 5′-(Tx)GxGxcsasasgscsastscscsTxGxT-3′ and 5′-(Gx)TxTxascstsgscscststscsTxTxA-3′, wherein capital letters designate a beta-D-oxy-LNA nucleotide analogue, small letters designate a 2-deoxynucleotide, underline designates either a beta-D-oxy-LNA nucleotide analogue or a 2-deoxynucleotide, subscript “s” designates a phosphorothioate link between neighbouring nucleotides/LNA nucleotide analogues, and subscript “x” designates either a phosphorothioate link or a phosphorodiester link between neighbouring nucleotides/LNA nucleotide analogues, and wherein the sequence is optionally extended by up to five 2-deoxynucleotide units. The LNA oligonucleotides are useful for modulating the expression of hypoxia-inducible factor-1a (HIF-1a), e.g. in the treatment of cancer diseases, inhibiting angiogenesis, inducing apoptosis, preventing cellular proliferation, or treating an angiogenic disease, e.g. diabetic retinopathy, macular degeneration (ARMD), psoriasis, rheumatoid arthritis and other inflammatory diseases.

    摘要翻译： 本公开内容涉及由选自5' - （Tx）GxGxcsasasgscsastscscsTxGxT-3'和5' - （Gx）TxTxascstsgscscststscscTTTXA-3'的序列组成的LNA寡核苷酸，其中大写字母表示β-D-氧基 -LNA核苷酸类似物，小写字母表示2-脱氧核苷酸，下划线表示β-D-氧-LNA核苷酸类似物或2-脱氧核苷酸，下标“s”表示相邻核苷酸/ LNA核苷酸类似物之间的硫代磷酸酯连接，下标 “x”表示相邻核苷酸/ LNA核苷酸类似物之间的硫代磷酸酯连接或磷酸二酯连接，并且其中该序列任选地延伸多达五个2-脱氧核苷酸单元。 LNA寡核苷酸可用于调节缺氧诱导因子-1a（HIF-1a）的表达，例如， 在治疗癌症疾病，抑制血管发生，诱导细胞凋亡，预防细胞增殖或治疗血管生成疾病，例如， 糖尿病性视网膜病变，黄斑变性（ARMD），牛皮癣，类风湿性关节炎等炎症性疾病。