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    Method of detecting target nucleotide sequence, structure and preparation of the detection target used for working the detection method, and assay kit for detecting the target nucleotide sequence
    2.
    发明申请
    Method of detecting target nucleotide sequence, structure and preparation of the detection target used for working the detection method, and assay kit for detecting the target nucleotide sequence 审中-公开
    检测目标核苷酸序列的方法，用于检测方法的检测对象的结构和制备方法以及检测靶核苷酸序列的检测试剂盒

    公开(公告)号：US20060099615A1

    公开(公告)日：2006-05-11

    申请号：US11230627

    申请日：2005-09-21

    申请人： Hideki Horiuchi ,  Koji Hashimoto

    发明人： Hideki Horiuchi ,  Koji Hashimoto

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6813 ,  C12Q2521/319 ,  C12Q2525/186 ,  C12Q2533/101 ,  C12Q2537/163

    摘要： The present invention provides a method of preparing a detection target structure useful for detecting a target nucleotide sequence. For example, provided is a method of preparing a detection target structure from a target nucleic acid (1). The target nucleic acid includes a target nucleotide sequence 2 in a part. According to the method of the present invention, a nucleic acid is elongated by using a primer so as to permit the target nucleic acid to have a double strand structure in the portion other than the target nucleotide sequence 2, thereby affording a detection target structure 4. The present invention also provides the detection target structure thus prepared a detection method of the target nucleotide sequence by using the detection target structure, a kit for preparing the detection target structure, and an assay kit for detecting the target nucleotide sequence.

    摘要翻译： 本发明提供了制备用于检测靶核苷酸序列的检测靶结构的方法。 例如，提供从靶核酸（1）制备检测靶结构的方法。 靶核酸部分包含靶核苷酸序列2。 根据本发明的方法，通过使用引物使核酸伸长，以使靶核酸在靶核苷酸序列2以外的部分具有双链结构，由此提供检测目标结构4 本发明还提供了通过使用检测对象结构制备靶核苷酸序列的检测方法的检测对象结构，用于制备检测对象结构的试剂盒和检测靶核苷酸序列的检测试剂盒。

    MICROARRAY AND METHOD OF DESIGNING NEGATIVE CONTROL PROBES
    3.
    发明申请
    MICROARRAY AND METHOD OF DESIGNING NEGATIVE CONTROL PROBES 审中-公开
    微控制器和设计负控制探头的方法

    公开(公告)号：US20110071044A1

    公开(公告)日：2011-03-24

    申请号：US12883032

    申请日：2010-09-15

    申请人： Hideki HORIUCHI

    发明人： Hideki HORIUCHI

    IPC分类号： C40B30/04 ,  C40B40/06

    CPC分类号： C12Q1/6825 ,  C12Q1/6837 ,  C12Q2565/501 ,  C12Q2545/101 ,  C12Q2527/143

    摘要： According to one aspect, a microarray for nucleic acid detection includes a substrate, a negative control probe group immobilized on a first region of the substrate and provided with a plurality of first probes having different sequences, and a second probe immobilized on a second region of the substrate and containing a sequence complementary to a target nucleic acid.

    摘要翻译： 根据一个方面，用于核酸检测的微阵列包括底物，固定在所述底物的第一区域上并具有多个具有不同序列的第一探针的阴性对照探针组，以及固定在第二区上的第二探针 底物并含有与靶核酸互补的序列。

    Protecting agent for organ or tissue
    8.
    发明授权
    Protecting agent for organ or tissue 失效
    器官或组织的保护剂

    公开(公告)号：US5843969A

    公开(公告)日：1998-12-01

    申请号：US737406

    申请日：1996-11-12

    申请人： Mikio Ota ,  Hideki Horiuchi ,  Shigehisa Kitahara ,  Shiro Kondo ,  Yasuhiro Takano

    发明人： Mikio Ota ,  Hideki Horiuchi ,  Shigehisa Kitahara ,  Shiro Kondo ,  Yasuhiro Takano

    IPC分类号： A61K31/426 ,  C07D277/56 ,  A61K31/44

    CPC分类号： A61K31/426 ,  C07D277/56

    摘要： An agent composition for the therapy or prevention of the injury of an organ or a tissue containing a phenylthiazole derivative expressed by the following formula (1): ##STR1## (R.sub.1 is a C.sub.1 -C.sub.18 alkoxy group or a cyclic amino group; R.sub.2 is a cyano group or a nitro group; R.sub.3 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group), and/or its salt as an active ingredient.

    摘要翻译： PCT No.PCT / JP96 / 00924 Sec。 371日期：1996年11月12日 102（e）日期1996年11月12日PCT PCT 1996年4月4日PCT公布。 公开号WO96 / 31211 日期：1996年10月10日用于治疗或预防由下式（1）表示的含有苯基噻唑衍生物的器官或组织的损伤的药剂组合物：（1）（R1是C1-C18烷氧基 或环状氨基; R2为氰基或硝基; R3为氢原子或C1-C4烷基），和/或其盐为活性成分。

    Calcium-magnesium carbonate composite and method for the preparation thereof
    9.
    发明授权
    Calcium-magnesium carbonate composite and method for the preparation thereof 失效
    碳酸钙 - 碳酸钙复合材料及其制备方法

    公开(公告)号：US5230734A

    公开(公告)日：1993-07-27

    申请号：US917163

    申请日：1992-07-20

    申请人： Tetsuo Kumasaka ,  Hideki Horiuchi ,  Fumihiko Kaneko ,  Tatsuo Takano

    发明人： Tetsuo Kumasaka ,  Hideki Horiuchi ,  Fumihiko Kaneko ,  Tatsuo Takano

    IPC分类号： C01F11/18 ,  C09C1/00 ,  D21H19/38

    CPC分类号： D21H19/385 ,  C01F11/18 ,  C01F11/181 ,  C09C1/009 ,  C01P2004/10 ,  C01P2004/20 ,  C01P2004/52 ,  C01P2004/54 ,  C01P2004/62 ,  C01P2006/12

    摘要： A calcium-magnesium carbonate composite consisting of particles of calcium carbonate and magnesium carbonate hydroxide and having excellent properties, for example, as a pigment for paper coating is proposed, which is a uniform blend of:(A) particles of calcium carbonate having a crystalline structure of aragonite with a columnar particle configuration having a length in the range from 0.5 to 3 .mu.m and a diameter in the range from 0.1 to 0.3 pm with an aspect ratio in the range from 5 to 15; and(B) particles of magnesium carbonate hydroxide having a plate-like particle configuration with a particle diameter in the range from 2 to 7 .mu.m and a thickness in the range from 0.05 to 0.5 .mu.m,the blend having an overall specific surface area in the range from 15 to 30 m.sup.2 /g and the weight proportion of the particles of calcium carbonate to the particles of magnesium carbonate hydroxide being in the range from 95:5 to 50:50 calculated as the respective hydroxides. The carbonate composite can be prepared by the step-wise carbonation reaction of a mixed aqueous slurry of calcium and magnesium hydroxides with carbon dioxide gas under very strictly controlled conditions.