公开(公告)号：US20130113176A1

公开(公告)日：2013-05-09

申请号：US13807264

申请日：2011-06-24

申请人： Hiroaki Eguchi ,  Masaaki Tanaka

发明人： Hiroaki Eguchi ,  Masaaki Tanaka

IPC分类号： B60G21/00

CPC分类号： B60G21/005 ,  B60G3/20 ,  B60G2200/182 ,  B62D21/11

摘要： It is an object to effectively enhance rigidity of a subframe installed to couple a pair of right and left wheel suspension members, with a simple structure, and allow a stabilizer to be adequately installed. A subframe (3) installed to couple a pair of right and left wheel suspension members (2) together comprises a cross member (31) provided with a lateral-link support portion (14, 18) supporting an end of the lateral link (5, 6), a pair of right and left side members (33) each extending from a respective one of opposite vehicle-widthwise outer ends of the cross member (31), in a vehicle longitudinal direction; and a pair of right and left reinforcing members (35) each reinforcing a coupling section between the lateral-link support portion (14, 18) of the cross member (31) or a vicinity thereof, and a respective one of the side members (33). A stabilizer (10) is installed above the cross member (31) to extend in a vehicle widthwise direction in such a manner as to couple the right and left wheel suspension members 2, and each of the reinforcing members (35) is provided with a stabilizer support section torsionably supporting the stabilizer (10).

摘要翻译： 本发明的目的在于提供一种以简单的结构，有效地提高安装在一对左右车轮悬挂部件上的刚性的刚性，能够适当地安装稳定器。 安装成将一对左右轮悬挂构件（2）联接在一起的副框架（3）包括：横向构件（31），其设置有支撑横向连杆（5）的一端的侧向支撑部分（14,18） ，6），一对左右侧构件（33），其分别从横向构件（31）的相对车宽方向外端部的相应一个沿车辆纵向方向延伸; 和一对左右加强件（35），每个加强所述横向件（31）的侧向支撑部分（14,18）或其附近之间的连接部分和相应的一个侧部件（ 33）。 在十字构件（31）上方安装有稳定器（10），以沿车宽方向延伸，从而联接左右车轮悬挂构件2，并且每个加强构件（35）设置有 稳定器支撑部分可扭转地支撑稳定器（10）。

公开(公告)号：US07547721B1

公开(公告)日：2009-06-16

申请号：US10149917

申请日：1999-12-15

申请人： Naoto Miwa ,  Michihito Inagaki ,  Hiroaki Eguchi ,  Masafumi Okumura ,  Yoshio Inagaki ,  Toru Harada

发明人： Naoto Miwa ,  Michihito Inagaki ,  Hiroaki Eguchi ,  Masafumi Okumura ,  Yoshio Inagaki ,  Toru Harada

IPC分类号： A61K31/404

CPC分类号： A61K49/0032 ,  A61K49/0021

摘要： The present invention relates to a compound defined by a formula herein, a composition and/or a method relating to one or more of the defined compounds.

摘要翻译： 本发明涉及由本文公式定义的化合物，与一种或多种所定义化合物有关的组合物和/或方法。

公开(公告)号：US20090041670A1

公开(公告)日：2009-02-12

申请号：US12147717

申请日：2008-06-27

申请人： Masayuki Kawakami ,  Hiroshi Kitaguchi ,  Kai Licha ,  Christin Perlitz ,  Hiroaki Eguchi ,  Natsuko Tsuda ,  Kazuhiro Aikawa

发明人： Masayuki Kawakami ,  Hiroshi Kitaguchi ,  Kai Licha ,  Christin Perlitz ,  Hiroaki Eguchi ,  Natsuko Tsuda ,  Kazuhiro Aikawa

IPC分类号： A61K49/00

CPC分类号： A61K49/0032 ,  A61K49/0052

摘要： A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R7, and R8 represent a C1-C10 alkyl group or the like; R3, R4, R5, R6, R9, R10, R11, and R12 represent a hydrogen atom, a C1-C6 alkyl group, an aryl group or the like; X1 and X2 represent a C1-C15 alkyl group or an aryl group and X1 and X2 in total have 0 to 4 carboxyl groups; m1, m2, and m3 represents 0 or 1; L1 to L7 independently represent a methine group; M represents a hydrogen atom, a metal, or a quaternary ammonium salt; and n represents an integer of 1 to 7 necessary for neutralizing charge.

摘要翻译： 1.一种近红外荧光造影剂，其特征在于，在生物体组织中的透过性优异，能够对肿瘤和/或血管进行特异性成像，其特征在于，含有式（I）表示的化合物或其药学上可接受的盐，其中R1，R2，R7， 并且R 8表示C 1 -C 10烷基等; R3，R4，R5，R6，R9，R10，R11和R12表示氢原子，C1-C6烷基，芳基等; X1和X2表示C1-C15烷基或芳基，X1和X2总共具有0至4个羧基; m1，m2，m3表示0或1; L1至L7独立地表示次甲基; M表示氢原子，金属或季铵盐; n表示中和电荷所需的1〜7的整数。

公开(公告)号：US08616567B2

公开(公告)日：2013-12-31

申请号：US13807264

申请日：2011-06-24

申请人： Hiroaki Eguchi ,  Masaaki Tanaka

发明人： Hiroaki Eguchi ,  Masaaki Tanaka

IPC分类号： B60G21/055

CPC分类号： B60G21/005 ,  B60G3/20 ,  B60G2200/182 ,  B62D21/11

摘要： It is an object to effectively enhance rigidity of a subframe installed to couple a pair of right and left wheel suspension members, with a simple structure, and allow a stabilizer to be adequately installed. A subframe (3) installed to couple a pair of right and left wheel suspension members (2) together comprises a cross member (31) provided with a lateral-link support portion (14, 18) supporting an end of the lateral link (5, 6), a pair of right and left side members (33) each extending from a respective one of opposite vehicle-widthwise outer ends of the cross member (31), in a vehicle longitudinal direction; and a pair of right and left reinforcing members (35) each reinforcing a coupling section between the lateral-link support portion (14, 18) of the cross member (31) or a vicinity thereof, and a respective one of the side members (33). A stabilizer (10) is installed above the cross member (31) to extend in a vehicle widthwise direction in such a manner as to couple the right and left wheel suspension members 2, and each of the reinforcing members (35) is provided with a stabilizer support section torsionably supporting the stabilizer (10).

摘要翻译： 本发明的目的在于提供一种以简单的结构，有效地提高安装在一对左右车轮悬挂部件上的刚性的刚性，能够适当地安装稳定器。 安装成将一对左右轮悬挂构件（2）联接在一起的副框架（3）包括：横向构件（31），其设置有支撑横向连杆（5）的一端的侧向支撑部分（14,18） ，6），一对左右侧构件（33），其分别从横向构件（31）的相对车宽方向外端部的相应一个沿车辆纵向方向延伸; 和一对左右加强件（35），每个加强所述横向件（31）的横向支撑部分（14,18）或其附近之间的连接部分和相应的一个侧部件（ 33）。 在十字构件（31）上方安装有稳定器（10），以沿车宽方向延伸，从而联接左右车轮悬挂构件2，并且每个加强构件（35）设置有 稳定器支撑部分可扭转地支撑稳定器（10）。

公开(公告)号：US20050226815A1

公开(公告)日：2005-10-13

申请号：US10506819

申请日：2003-03-07

申请人： Masayuki Kawakami ,  Hiroshi Kitaguchi ,  Kai Licha ,  Christin Perlitz ,  Hiroaki Eguchi ,  Natsuko Tsuda ,  Kazuhiro Aikawa

发明人： Masayuki Kawakami ,  Hiroshi Kitaguchi ,  Kai Licha ,  Christin Perlitz ,  Hiroaki Eguchi ,  Natsuko Tsuda ,  Kazuhiro Aikawa

IPC分类号： C07D409/14 ,  A61B1/00 ,  A61B3/10 ,  A61B3/14 ,  A61K49/00 ,  C07D209/14 ,  C07D209/60 ,  G01N21/64 ,  A61B10/00 ,  A61B5/00 ,  A61B8/00

CPC分类号： A61K49/0032 ,  A61K49/0052

摘要： A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R7, and R8 represent a C1-C10 alkyl group or the like; R3, R4, R5, R6, R9, R10, R11, and R12 represent a hydrogen atom, a C1-C6 alkyl group, an aryl group or the like; X1 and X2 represent a C1-C15 alkyl group or an aryl group and X1 and X2 in total have 0 to 4 carboxyl groups; m1, m2, and m3 represents 0 or 1; L1 to L7 independently represent a methine group; M represents a hydrogen atom, a metal, or a quaternary ammonium salt; and n represents an integer of 1 to 7 necessary for neutralizing charge.

摘要翻译： 一种近红外荧光造影剂，其在生物体组织中的渗透性优异，能够进行肿瘤和/或血管的特异性成像，其包含式（I）表示的化合物或其药学上可接受的盐，其中R 1， R 2，R 7，R 8和R 8表示C 1 -C 3烷基， 10烷基等; R 3，R 4，R 5，R 6，R 9， R 10，R 11和R 12代表氢原子，C 1 -C 12烷基， 6个烷基，芳基等; X 1和X 2代表C 1 -C 15烷基或芳基，X ^{1和X 2共有0至4个羧基; m 1，m 2，m 3，O 3表示0或1; L 1至L 7独立地表示次甲基; M表示氢原子，金属或季铵盐; n表示中和电荷所需的1〜7的整数。}

公开(公告)号：US07473415B2

公开(公告)日：2009-01-06

申请号：US10506819

申请日：2003-03-07

申请人： Masayuki Kawakami ,  Hiroshi Kitaguchi ,  Kai Licha ,  Christin Perlitz ,  Hiroaki Eguchi ,  Natsuko Tsuda ,  Kazuhiro Aikawa

发明人： Masayuki Kawakami ,  Hiroshi Kitaguchi ,  Kai Licha ,  Christin Perlitz ,  Hiroaki Eguchi ,  Natsuko Tsuda ,  Kazuhiro Aikawa

IPC分类号： A61K51/00 ,  A61M36/14

CPC分类号： A61K49/0032 ,  A61K49/0052

摘要： A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R7, and R8 represent a C1-C10 alkyl group or the like; R3, R4, R5, R6, R9, R10, R11, and R12 represent a hydrogen atom, a C1-C6 alkyl group, an aryl group or the like; X1 and X2 represent a C1-C15 alkyl group or an aryl group and X1 and X2 in total have 0 to 4 carboxyl groups; m1, m2, and m3 represents 0 or 1; L1 to L7 independently represent a methine group; M represents a hydrogen atom, a metal, or a quaternary ammonium salt; and n represents an integer of 1 to 7 necessary for neutralizing charge.

摘要翻译： 1.一种近红外荧光造影剂，其特征在于，在生物体组织中的透过性优异，能够对肿瘤和/或血管进行特异性成像，其特征在于，含有式（I）表示的化合物或其药学上可接受的盐，其中R1，R2，R7， 并且R 8表示C 1 -C 10烷基等; R3，R4，R5，R6，R9，R10，R11和R12表示氢原子，C1-C6烷基，芳基等; X1和X2表示C1-C15烷基或芳基，X1和X2总共具有0至4个羧基; m1，m2，m3表示0或1; L1至L7独立地表示次甲基; M表示氢原子，金属或季铵盐; n表示中和电荷所需的1〜7的整数。

公开(公告)号：US20080083702A1

公开(公告)日：2008-04-10

申请号：US11905865

申请日：2007-10-05

申请人： Fumiaki Kataoka ,  Youhei Fujimura ,  Takeshi Tonegawa ,  Yasumoto Kubo ,  Hiroaki Eguchi ,  Shigeo Itoh ,  Tatsuo Yamaura

发明人： Fumiaki Kataoka ,  Youhei Fujimura ,  Takeshi Tonegawa ,  Yasumoto Kubo ,  Hiroaki Eguchi ,  Shigeo Itoh ,  Tatsuo Yamaura

IPC分类号： B05D1/00 ,  B01J19/00

CPC分类号： H01J9/025 ,  B82Y10/00 ,  H01J31/123 ,  H01J2201/30446 ,  H01J2201/30469

摘要： A method for manufacturing an electron emitting device includes disposing a cathode substrate and an anode substrate to be faced to each other in a depressurized atmosphere containing an activation gas, the cathode substrate including a carbon layer formed by applying a paste having a fibrous carbon and carbon impurities on a cathode conductor and drying the coated paste. The method further includes applying a reverse bias voltage to the cathode conductor of the cathode substrate and an anode conductor of the anode substrate, thereby activating the carbon layer.

摘要翻译： 一种电子发射器件的制造方法，其特征在于，在含有活性气体的减压气氛中配置阴极基板和阳极基板，所述阴极基板和阳极基板包括通过涂布具有纤维状碳和碳的糊料形成的碳层 阴极导体上的杂质和干燥涂覆的糊状物。 该方法还包括向阴极衬底的阴极导体和阳极衬底的阳极导体施加反向偏置电压，由此激活碳层。

公开(公告)号：US07488468B1

公开(公告)日：2009-02-10

申请号：US09787394

申请日：1999-09-16

申请人： Naoto Miwa ,  Michihito Inagaki ,  Hiroaki Eguchi ,  Masafumi Okumura ,  Yoshio Inagaki ,  Toru Harada

发明人： Naoto Miwa ,  Michihito Inagaki ,  Hiroaki Eguchi ,  Masafumi Okumura ,  Yoshio Inagaki ,  Toru Harada

IPC分类号： A61B5/00 ,  C09B23/08 ,  G01N33/53 ,  C07D291/00 ,  C07D231/06 ,  C09K11/06 ,  A01N43/38

CPC分类号： A61K49/0032 ,  C09B23/0008 ,  C09B23/0016 ,  C09B23/0025 ,  C09B23/0033 ,  C09B23/0041 ,  C09B23/0066 ,  C09B23/06 ,  C09B23/086 ,  Y10S436/80

摘要： A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living body, exposing the body to an excitation light, and detecting near infrared fluorescence from the contrast agent. The near infrared fluorescent contrast agent of the present invention is excited by an excitation light and emits near infrared fluorescence. This infrared fluorescence is superior in transmission through biological tissues. Thus, detection of lesions in the deep part of a living body has been made possible. In addition, the inventive contrast agent is superior in water solubility and low toxic, and therefore, it can be used safely.

摘要翻译： 一种分子内具有3个以上的磺酸基的化合物的近红外荧光造影剂，以及荧光成像方法，其特征在于，将本发明的近红外荧光造影剂引入生物体内，将其暴露于激发光 ，并从造影剂中检测近红外荧光。 本发明的近红外荧光造影剂被激发光激发并发射近红外荧光。 这种红外荧光在通过生物组织的传播方面是优越的。 因此，能够检测活体深部的病变。 此外，本发明的造影剂的水溶性和低毒性优异，因此可以安全使用。