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1.发明授权公开(公告)号：US09066983B2
公开(公告)日：2015-06-30
申请号：US13319813
申请日：2010-05-14
申请人： Hirokazu Tamamura , Toru Nakahara , Wataru Nomura
发明人： Hirokazu Tamamura , Toru Nakahara , Wataru Nomura
IPC分类号： A61K39/385 , A61K39/21 , A61K47/48 , C07K14/005 , C07K16/10 , A61K39/00
CPC分类号： A61K47/48253 , A61K39/00 , A61K39/12 , A61K39/21 , A61K47/641 , A61K2039/545 , A61K2039/55566 , C07K14/005 , C07K16/1063 , C07K2317/32 , C12N2740/16122 , C12N2740/16134
摘要： An object of the present invention is to provide an HIV antibody-inducing peptide antigen that is effective in developing an antibody or a vaccine having specificity and binding activity for the three-dimensional structure of a neutralization target, i.e. the mechanism by which HIV invades a target cell; a method for synthesizing the same; a vaccine comprising the peptide antigen, or an HIV three-dimensional structure-recognizing antibody induced by the peptide antigen; and a preventive and/or therapeutic agent for HIV infection comprising the peptide antigen, the vaccine, or the HIV three-dimensional structure-recognizing antibody as an active ingredient.
摘要翻译： 本发明的目的是提供一种有效开发抗体或具有针对中和靶的三维结构具有特异性和结合活性的疫苗的HIV抗体诱导肽抗原，即HIV侵入的机制 靶细胞; 一种合成该方法的方法; 包含肽抗原或由肽抗原诱导的HIV三维结构识别抗体的疫苗; 以及用于HIV感染的预防和/或治疗剂，其包含肽抗原，疫苗或HIV三维结构识别抗体作为活性成分。
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2.发明申请公开(公告)号：US20120052090A1
公开(公告)日：2012-03-01
申请号：US13319813
申请日：2010-05-14
申请人： Hirokazu Tamamura , Toru Nakahara , Wataru Nomura
发明人： Hirokazu Tamamura , Toru Nakahara , Wataru Nomura
IPC分类号： A61K39/21 , C07C229/26 , A61P37/04 , C07C229/00 , A61P31/18 , C07K2/00 , C07K1/00
CPC分类号： A61K47/48253 , A61K39/00 , A61K39/12 , A61K39/21 , A61K47/641 , A61K2039/545 , A61K2039/55566 , C07K14/005 , C07K16/1063 , C07K2317/32 , C12N2740/16122 , C12N2740/16134
摘要： An object of the present invention is to provide an HIV antibody-inducing peptide antigen that can be used without problems for HIV, which is highly prone to mutation, and is effective in developing an antibody or a vaccine having excellent specificity and binding activity even for the three-dimensional structure of a neutralization target, i.e. the mechanism by which HIV invades a target cell; a method for synthesizing the same; a vaccine comprising the peptide antigen, or an HIV three-dimensional structure-recognizing antibody induced by the peptide antigen; and a preventive and/or therapeutic agent for HIV infection comprising the peptide antigen, the vaccine, or the HIV three-dimensional structure-recognizing antibody as an active ingredient. The synthesis method comprises using a trimer of N36 peptide derivative which is synthesized by ligating a derivative of a helical region N36 peptide in N-terminal of an HIV particle transmembrane protein gp41 to a C3-symmetric template compound having three equivalent linker structures.
摘要翻译： 本发明的目的是提供一种HIV抗体诱导肽抗原，其可以没有HIV的问题使用，其高度易于突变，并且有效地开发具有优异的特异性和结合活性的抗体或疫苗，即使对于 中和目标的三维结构，即HIV侵入目标细胞的机制; 一种合成该方法的方法; 包含肽抗原或由肽抗原诱导的HIV三维结构识别抗体的疫苗; 以及用于HIV感染的预防和/或治疗剂，其包含肽抗原，疫苗或HIV三维结构识别抗体作为活性成分。 合成方法包括使用N36肽衍生物的三聚体，其通过将HIV颗粒跨膜蛋白gp41的N-末端中的螺旋区N36肽的衍生物连接到具有三个等同连接体结构的C3对称模板化合物而合成。
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公开(公告)号：US20090036416A1
公开(公告)日：2009-02-05
申请号：US12087160
申请日：2006-12-27
IPC分类号： A61K31/555
CPC分类号： A61K31/44 , A61K33/30 , C07D213/36 , A61K2300/00
摘要： A novel non-peptide CXCR4 antagonist has a low molecular-weight and uses various aromatic compounds, each containing a dipicolylamine-zinc complex. This CXCR4 antagonist finds use, e.g., as an anti-HIV agent, a metastasis inhibitor for a malignant tumor, and a chronic rheumatoid arthritis treatment and/or prevention agent.
摘要翻译： 新型非肽CXCR4拮抗剂具有低分子量并且使用各自含有二偶氮胺 - 锌络合物的各种芳族化合物。 该CXCR4拮抗剂用于例如抗HIV剂，恶性肿瘤的转移抑制剂和慢性类风湿性关节炎治疗和/或预防剂。
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公开(公告)号：US20090181897A1
公开(公告)日：2009-07-16
申请号：US12172007
申请日：2008-07-11
申请人： Nobutaka Fujii , Hirokazu Tamamura , Akira Hori
发明人： Nobutaka Fujii , Hirokazu Tamamura , Akira Hori
摘要： The present invention provides preventive and/or therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.
摘要翻译： 本发明提供含有具有CXCR4拮抗作用的肽，其酰胺，其酯或其盐的癌症和慢性类风湿性关节炎的预防和/或治疗药物。 此外，本发明提供了具有CXCR4拮抗作用的新型肽，其酰胺，其酯及其盐。
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5.发明授权Method for detecting target substance, and tag, DNA, vector, probe and detection kit for use therewith 失效检测目标物质的方法，标签，DNA，载体，探针和检测试剂盒公开(公告)号：US08445291B2
公开(公告)日：2013-05-21
申请号：US12586425
申请日：2009-09-22
IPC分类号： G01N21/76
CPC分类号： C07K14/00 , G01N21/6428 , G01N33/542 , Y10T436/13
摘要： Provide is a method for detecting a target substance, which method can visualize the expression of the target substance at any time point while reducing influences on the functions of the target substance, can use fluorescent dyes having various excitation/emission wavelengths, and can achieve easy staining process. Also provided are a tag, a DNA, a vector, a probe and a detection kit suitable for use in the above-described detection method. Specifically, the method for detecting a target substance, comprises the steps of bringing into contact with each other (a) a tag comprising a polypeptide forming an α-helix structure, the tag bound to the target substance, and (b) a probe comprising a compound bound to a fluorescent dye; and measuring the fluorescence emitted by the fluorescent dye. The binding of the tag α-helix structure to the probe compound induces a spectral change in the fluorescence emitted by the fluorescent dye.
摘要翻译： 提供是检测目标物质的方法，该方法可以在任何时间点可视化目标物质的表达，同时减少对目标物质的功能的影响，可以使用具有各种激发/发射波长的荧光染料，并且可以实现容易 染色过程。 还提供了适用于上述检测方法的标签，DNA，载体，探针和检测试剂盒。 具体而言，检测目标物质的方法包括以下步骤：（a）包含形成α-螺旋结构的多肽的标签，与靶物质结合的标签，和（b）包含 与荧光染料结合的化合物; 并测量荧光染料发出的荧光。 标记α-螺旋结构与探针化合物的结合诱导荧光染料发出的荧光的光谱变化。
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公开(公告)号：US08017585B2
公开(公告)日：2011-09-13
申请号：US12172007
申请日：2008-07-11
申请人： Nobutaka Fujii , Hirokazu Tamamura , Akira Hori
发明人： Nobutaka Fujii , Hirokazu Tamamura , Akira Hori
摘要： Peptides, their amides, esters or salts, which have CXCR4 antagonistic action, have therapeutic effects for cancer and chronic rheumatoid arthritis.
摘要翻译： 具有CXCR4拮抗作用的肽，它们的酰胺，酯或盐具有对癌症和慢性类风湿性关节炎的治疗作用。
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7.发明申请Method for detecting target substance, and tag, DNA, vector, probe and detection kit for use therewith 失效检测目标物质的方法，标签，DNA，载体，探针和检测试剂盒公开(公告)号：US20100075434A1
公开(公告)日：2010-03-25
申请号：US12586425
申请日：2009-09-22
CPC分类号： C07K14/00 , G01N21/6428 , G01N33/542 , Y10T436/13
摘要： Provide is a method for detecting a target substance, which method can visualize the expression of the target substance at any time point while reducing influences on the functions of the target substance, can use fluorescent dyes having various excitation/emission wavelengths, and can achieve easy staining process. Also provided are a tag, a DNA, a vector, a probe and a detection kit suitable for use in the above-described detection method. Specifically, the method for detecting a target substance, comprises the steps of bringing into contact with each other (a) a tag comprising a polypeptide forming an α-helix structure, the tag bound to the target substance, and (b) a probe comprising a compound bound to a fluorescent dye; and measuring the fluorescence emitted by the fluorescent dye. The binding of the tag α-helix structure to the probe compound induces a spectral change in the fluorescence emitted by the fluorescent dye.
摘要翻译： 提供是检测目标物质的方法，该方法可以在任何时间点可视化目标物质的表达，同时减少对目标物质的功能的影响，可以使用具有各种激发/发射波长的荧光染料，并且可以实现容易 染色过程。 还提供了适用于上述检测方法的标签，DNA，载体，探针和检测试剂盒。 具体地，检测目标物质的方法包括以下步骤：（a）包含形成α-螺旋结构的多肽的标签，与靶物质结合的标签，和（b）包含 与荧光染料结合的化合物; 并测量荧光染料发出的荧光。 标签α-螺旋结构与探针化合物的结合诱导荧光染料发出的荧光的光谱变化。
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公开(公告)号：US20060264378A1
公开(公告)日：2006-11-23
申请号：US10525838
申请日：2003-08-26
申请人： Nobutaka Fujii , Hirokazu Tamamura , Akira Hori
发明人： Nobutaka Fujii , Hirokazu Tamamura , Akira Hori
摘要： The present invention provides preventive and/or therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.
摘要翻译： 本发明提供含有具有CXCR4拮抗作用的肽，其酰胺，其酯或其盐的癌症和慢性类风湿性关节炎的预防和/或治疗药物。 此外，本发明提供了具有CXCR4拮抗作用的新型肽，其酰胺，其酯及其盐。
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9.发明申请PEPTIDE WHICH CAN INDUCE ANTIBODY CAPABLE OF RECOGNIZING STEREOSTRUCTURE OF HIV 审中-公开可以诱导能够识别艾滋病毒结构的抗原肽公开(公告)号：US20140056935A1
公开(公告)日：2014-02-27
申请号：US14009757
申请日：2012-04-03
申请人： Hirokazu Tamamura , Tetsuo Narumi , Wataru Nomura , Chie Hashimoto , Jun A. Komano , Kosuke Miyauchi
发明人： Hirokazu Tamamura , Tetsuo Narumi , Wataru Nomura , Chie Hashimoto , Jun A. Komano , Kosuke Miyauchi
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K39/12 , A61K47/60 , C12N2740/16011 , C12N2740/16134
摘要： An object of the present invention is to provide a peptide capable of inducing a superior or new neutralizing antibody against HIV, so that HIV infectious disease can be prevented and treated or a greater variety of preventive or therapeutic options can be offered. This object is achieved by using a peptide inducing an HIV's three-dimensional structure-recognizing antibody that recognizes a trimer region of C34, wherein three molecules of a derivative of a helical region C34 peptide at C-terminal region of transmembrane protein gp41 of an HIV particle are ligated via a C3-symmetric template compound having three equivalent linker structures.
摘要翻译： 本发明的目的是提供能够诱导针对HIV的优异或新的中和抗体的肽，从而可以预防和治疗HIV感染性疾病，或者可以提供更多种的预防或治疗选择。 该目的通过使用诱导识别C34三聚体区域的HIV的三维结构识别抗体的肽来实现，其中三分子的HIV跨膜蛋白gp41的C-末端区域的螺旋区C34肽的衍生物 颗粒通过具有三个等效连接体结构的C3对称模板化合物连接。
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公开(公告)号：US08410059B2
公开(公告)日：2013-04-02
申请号：US13178737
申请日：2011-07-08
申请人： Nobutaka Fujii , Hirokazu Tamamura , Akira Hori
发明人： Nobutaka Fujii , Hirokazu Tamamura , Akira Hori
摘要： Therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt are described. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.
摘要翻译： 描述了含有具有CXCR4拮抗作用的肽，其酰胺，其酯或其盐的用于癌症和慢性类风湿性关节炎的治疗药物。 此外，本发明提供了具有CXCR4拮抗作用的新型肽，其酰胺，其酯及其盐。
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