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1.
公开(公告)号:US07507723B2
公开(公告)日:2009-03-24
申请号:US10312879
申请日:2001-07-06
申请人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号: A61K31/702 , A61K31/728
CPC分类号: C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要: Hyaluronic acid oligosaccharides having a size selected from sizes of 4 to 60 saccharides, fractions containing the hyaluronic acid oligosaccharides and having particular physicochemical properties, and drugs containing the same. The hyaluronic acid oligosaccharides of the present invention are extremely useful, because they exert superior pharmaceutical effects as active ingredients of a heat shock protein expression promoter, cell death inhibitor, cell injury inhibitor and cell and tissue protecting agent (e.g., organ preservation agent, antiulcer agent, antihepatopathic agent, IL-10 production promoter or IL-8 production inhibitor) and exhibit high safety.
摘要翻译: 具有选自尺寸为4至60个糖的大小的透明质酸寡糖,含有透明质酸寡糖的部分并且具有特定的理化性质,以及含有该物质的药物。 本发明的透明质酸寡糖是非常有用的,因为它们作为热休克蛋白表达启动子,细胞死亡抑制剂,细胞损伤抑制剂和细胞和组织保护剂(例如器官保存剂,抗溃疡剂)的活性成分发挥优异的药物作用 药物,抗肝病,IL-10生产促进剂或IL-8产生抑制剂),并表现出高安全性。
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2.
公开(公告)号:US07601488B2
公开(公告)日:2009-10-13
申请号:US11622673
申请日:2007-01-12
申请人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号: A01N1/02 , A61K31/702
CPC分类号: C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要: A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.
摘要翻译: 用于促进热休克蛋白的表达或用于抑制细胞损伤或细胞死亡或用于治疗需要细胞或组织保护的疾病或用于促进IL-10的产生或用于抑制IL- 如图8所示,通过施用有效量的含有包含四个糖残基并具有一定物理化学性质的透明质酸四糖的级分,或通过施用有效量的分离和基本上纯的本申请中描述的式(1)四糖。 保存器官的方法
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3.
公开(公告)号:US20070134646A1
公开(公告)日:2007-06-14
申请号:US11622673
申请日:2007-01-12
申请人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号: A01N1/02 , A61K31/728
CPC分类号: C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要: A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.
摘要翻译: 用于促进热休克蛋白的表达或用于抑制细胞损伤或细胞死亡或用于治疗需要细胞或组织保护的疾病或用于促进IL-10的产生或用于抑制IL- 如图8所示,通过施用有效量的含有包含四个糖残基并具有一定物理化学性质的透明质酸四糖的级分,或通过施用有效量的分离和基本上纯的本申请中描述的式(1)四糖。 保存器官的方法
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4.
公开(公告)号:US20080182983A1
公开(公告)日:2008-07-31
申请号:US11928833
申请日:2007-10-30
申请人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
CPC分类号: C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要: Hyaluronic acid oligosaccharides having a size selected from sizes of 4 to 60 saccharides, fractions containing the hyaluronic acid oligosaccharides and having particular physicochemical properties, and drugs containing the same. The hyaluronic acid oligosaccharides of the present invention are extremely useful, because they exert superior pharmaceutical effects as active ingredients of a heat shock protein expression promoter, cell death inhibitor, cell injury inhibitor and cell and tissue protecting agent (e.g., organ preservation agent, antiulcer agent, antihepatopathic agent, IL-10 production promoter or IL-8 production inhibitor) and exhibit high safety.
摘要翻译: 具有选自尺寸为4至60个糖的大小的透明质酸寡糖,含有透明质酸寡糖的部分并且具有特定的理化性质,以及含有该物质的药物。 本发明的透明质酸寡糖是非常有用的,因为它们作为热休克蛋白表达启动子,细胞死亡抑制剂,细胞损伤抑制剂和细胞和组织保护剂(例如器官保存剂,抗溃疡剂)的活性成分发挥优异的药物作用 药物,抗肝病,IL-10生产促进剂或IL-8产生抑制剂),并表现出高安全性。
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5.
公开(公告)号:US20070099867A1
公开(公告)日:2007-05-03
申请号:US11438819
申请日:2006-05-23
申请人: Akira Asari , Hiroko Yamanokuchi , Tadahiko Kato
发明人: Akira Asari , Hiroko Yamanokuchi , Tadahiko Kato
IPC分类号: A61K31/728
CPC分类号: A61K31/728
摘要: A pharmaceutical composition containing hyaluronan as an active ingredient is provided. A preferred hyaluronan is a tetrasaccharide (HA4) containing 2 units, with a single unit being -D-glucuronic acid-β-1,3-D-N-acetylglucosamine-β-1,4-.
摘要翻译: 提供含有透明质酸作为活性成分的药物组合物。 优选的透明质酸是含有2个单元的四糖(HA4),单个单元是D-葡萄糖醛酸-β-1,3-D-N-乙酰葡糖胺-β-1,4-。
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6.
公开(公告)号:US20050090661A1
公开(公告)日:2005-04-28
申请号:US10312879
申请日:2001-07-06
申请人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号: A61K31/702 , A61K31/728 , A61P1/04 , A61P1/16 , A61P43/00 , C07H7/033 , C08B37/08 , C08B37/00
CPC分类号: C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要: Hyaluronic acid oligosaccharides having a size selected from sizes of 4 to 60 saccharides, fractions containing the hyaluronic acid oligosaccharides and having particular physicochemical properties, and drugs containing the same. The hyaluronic acid oligosaccharides of the present invention are extremely useful, because they exert superior pharmaceutical effects as active ingredients of a heat shock protein expression promoter, cell death inhibitor, cell injury inhibitor and cell and tissue protecting agent (e.g., organ preservation agent, antiulcer agent, antihepatopathic agent, IL-10 production promoter or IL-8 production inhibitor) and exhibit high safety.
摘要翻译: 具有选自尺寸为4至60个糖的大小的透明质酸寡糖,含有透明质酸寡糖的部分并且具有特定的理化性质,以及含有该物质的药物。 本发明的透明质酸寡糖是非常有用的,因为它们作为热休克蛋白表达启动子,细胞死亡抑制剂,细胞损伤抑制剂和细胞和组织保护剂(例如器官保存剂,抗溃疡剂)的活性成分发挥优异的药物作用 药物,抗肝病,IL-10生产促进剂或IL-8产生抑制剂),并表现出高安全性。
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7.
公开(公告)号:US08314079B2
公开(公告)日:2012-11-20
申请号:US13115435
申请日:2011-05-25
申请人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号: A61K31/702
CPC分类号: C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要: A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.
摘要翻译: 用于促进热休克蛋白的表达或用于抑制细胞损伤或细胞死亡或用于治疗需要细胞或组织保护的疾病或用于促进IL-10的产生或用于抑制IL- 如图8所示,通过施用有效量的含有包含四个糖残基并具有一定物理化学性质的透明质酸四糖的级分,或通过施用有效量的分离和基本上纯的本申请中描述的式(1)四糖。 保存器官的方法
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8.
公开(公告)号:US20110224169A1
公开(公告)日:2011-09-15
申请号:US13115435
申请日:2011-05-25
申请人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号: A61K31/702 , A61P1/16 , A61P1/04
CPC分类号: C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要: A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.
摘要翻译: 用于促进热休克蛋白的表达或用于抑制细胞损伤或细胞死亡或用于治疗需要细胞或组织保护的疾病或用于促进IL-10的产生或用于抑制IL- 如图8所示,通过施用有效量的含有包含四个糖残基并具有一定物理化学性质的透明质酸四糖的级分,或通过施用有效量的分离和基本上纯的本申请中描述的式(1)四糖。 保存器官的方法
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9.
公开(公告)号:US20090291914A1
公开(公告)日:2009-11-26
申请号:US12472479
申请日:2009-05-27
申请人: Akira ASARI , Hitoshi KURIHARA , Tomomi SHIBATA , Yuka MIYAZAKI , Hiroko YAMANOKUCHI , Akira TAWADA , Takahiro MASA , Yuji MATSUZAKI
发明人: Akira ASARI , Hitoshi KURIHARA , Tomomi SHIBATA , Yuka MIYAZAKI , Hiroko YAMANOKUCHI , Akira TAWADA , Takahiro MASA , Yuji MATSUZAKI
IPC分类号: A61K31/728 , A61P1/16 , A61P1/04
CPC分类号: C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要: A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.
摘要翻译: 用于促进热休克蛋白的表达或用于抑制细胞损伤或细胞死亡或用于治疗需要细胞或组织保护的疾病或用于促进IL-10的产生或用于抑制IL- 如图8所示,通过施用有效量的含有包含四个糖残基并具有一定物理化学性质的透明质酸四糖的级分,或通过施用有效量的分离和基本上纯的本申请中描述的式(1)四糖。 保存器官的方法
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