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公开(公告)号:US20060063944A1
公开(公告)日:2006-03-23
申请号:US10509377
申请日:2003-04-02
申请人: Yoshiaki Nabuchi , Hiroshi Araya , Setsu Kawata , Kazumi Morikawa , Yoshitake Kanbe , Yoshihito Ohtake , Shinichi Kaiho , Kenji Taniguchi , Toshiaki Tsunenari , Hisashi Takasu
发明人: Yoshiaki Nabuchi , Hiroshi Araya , Setsu Kawata , Kazumi Morikawa , Yoshitake Kanbe , Yoshihito Ohtake , Shinichi Kaiho , Kenji Taniguchi , Toshiaki Tsunenari , Hisashi Takasu
CPC分类号: C07J1/00 , A61K31/566
摘要: A compound of formula (I) (where X1 and X2 represent independently a hydrogen atom or a group of formula (II) R1 represents a linear or branched halogenoalkyl group having 1-7 carbon atoms; Ra represents a hydroxyl group and Rb represents a linear or branched alkynyl group having 2-5 carbon atoms, or Ra and Rb, when taken together with the carbon to which they are bound, represent a carbonyl group; m is an integer of 2-14; n is an integer of 2-7; provided that X1 and X2 are not both a hydrogen atom), stereoisomers of the compound, or hydrates, salts or esters thereof, as well as a pharmaceutical composition containing a therapeutically effective amount of the compound.
摘要翻译: 式(I)化合物
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公开(公告)号:US07081256B2
公开(公告)日:2006-07-25
申请号:US10171982
申请日:2002-06-17
申请人: Ryuji Kubota , Hiroshi Araya , Kouki Obata , Nobuyuki Kimura , Hiroyuki Fukui , Hidetsugu Takagaki
发明人: Ryuji Kubota , Hiroshi Araya , Kouki Obata , Nobuyuki Kimura , Hiroyuki Fukui , Hidetsugu Takagaki
CPC分类号: A61K31/4704 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/205 , A61K9/2054
摘要: A quinolinone derivative pharmaceutical composition comprising a quinolinone derivative represented by the structural formula (I): wherein the quinolinone derivative is in the form of particles, which have an average particle diameter of 0.5 to 10 μm and such a particle size distribution that particles having a particle diameter of 15 μm or less account for 90% or more of the totality of the particles, and also have a fusion enthalpy of 30 J/g or more, and the surface of the particles are coated with a water-soluble composition containing a water-soluble polymer, can quickly dissolve an active ingredient in the digestive tract and is also superior in long-term storage stability.
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