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公开(公告)号:US4242449A
公开(公告)日:1980-12-30
申请号:US879786
申请日:1978-02-21
申请人: Takashi Osono , Yoshihiko Oka , Shunichi Watanabe , Takeshi Saito , Hiroshi Gushima , Keisuke Murakami , Isao Takahashi , Hiroshi Yamaguchi , Toshio Sasaki , Kiyoshi Susaki , Shuichi Takamura , Toshiaki Miyoshi
发明人: Takashi Osono , Yoshihiko Oka , Shunichi Watanabe , Takeshi Saito , Hiroshi Gushima , Keisuke Murakami , Isao Takahashi , Hiroshi Yamaguchi , Toshio Sasaki , Kiyoshi Susaki , Shuichi Takamura , Toshiaki Miyoshi
IPC分类号: C12P35/08
CPC分类号: C12P35/08 , Y10S435/803 , Y10S435/886 , Y10S435/911
摘要: The 7-methoxy-3-heterocyclic thiomethyl cephalosporin derivative possessing excellent antimicrobial activity represented by the general formula ##STR1## wherein R.sup.1 represents ##STR2## group or HOOC-- group, R.sup.2 represents a nitrogen-containing heterocyclic group, and M represents a hydrogen atom or a cation residue forming a salt.
摘要翻译: 具有由通式
表示的优异的抗微生物活性的7-甲氧基-3-杂环硫代甲基头孢菌素衍生物,其中R1表示<或者HOOC-基团,R2表示含氮杂环基,M表示氢原子 或形成盐的阳离子残留物。 -
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公开(公告)号:US4410626A
公开(公告)日:1983-10-18
申请号:US201739
申请日:1980-10-29
申请人: Hiroshi Gushima , Shunichi Watanabe , Takeshi Saito , Toshio Sasaki , Hideo Eiki , Yoshihiko Oka , Takashi Osono
发明人: Hiroshi Gushima , Shunichi Watanabe , Takeshi Saito , Toshio Sasaki , Hideo Eiki , Yoshihiko Oka , Takashi Osono
IPC分类号: A61K31/545 , A61K31/546 , A61P31/04 , C07D501/57 , C12P35/08 , C12N9/06 , C12R1/465 , C12R1/52
CPC分类号: C12P35/08 , Y10S435/886 , Y10S435/893 , Y10S435/897
摘要: 7.alpha.-Methoxy-3-p-sulfooxy or p-hydroxycinnamoyloxymethyl cephalosporin derivatives which are useful as antibiotics and as intermediates for the production of other 7.alpha.-methoxycephalosporin derivatives.
摘要翻译: 7α-甲氧基-3-对磺基氧基或对羟基肉桂酸氧甲基头孢菌素衍生物,其可用作抗生素和用作生产其它7种α-甲氧基头孢菌素衍生物的中间体。
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公开(公告)号:US4039660A
公开(公告)日:1977-08-02
申请号:US613738
申请日:1975-09-16
申请人: Takashi Osono , Shunichi Watanabe , Takeshi Saito , Hiroshi Gushima , Keisuke Murakami , Isao Takahashi , Hiroshi Yamaguchi , Toshio Sasaki , Yoshihiko Oka
发明人: Takashi Osono , Shunichi Watanabe , Takeshi Saito , Hiroshi Gushima , Keisuke Murakami , Isao Takahashi , Hiroshi Yamaguchi , Toshio Sasaki , Yoshihiko Oka
IPC分类号: C07D501/57 , A61K31/545 , A61K31/546 , A61P31/04 , C12P35/08 , A61K35/74
CPC分类号: A61K31/545 , C12P35/08 , Y10S435/886
摘要: A new antibiotic substance, designated Y-G19ZD3, is produced by the fermentation of a newly discovered microorganism Streptomyces organonensis Y-G19Z or a mutant thereof. The antibiotic substance Y-G19ZD3 is effective against gram negative bacteria and is useful also as an intermediate for the production of other antibiotics.
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公开(公告)号:US5556621A
公开(公告)日:1996-09-17
申请号:US237249
申请日:1994-05-04
申请人: Yasushi Kawauchi , Toshiyuki Takemoto , Makoto Takayama , Masami Yokota , Masao Kato , Kimio Katsuta , Hiroshi Gushima
发明人: Yasushi Kawauchi , Toshiyuki Takemoto , Makoto Takayama , Masami Yokota , Masao Kato , Kimio Katsuta , Hiroshi Gushima
IPC分类号: C12N9/64 , A61K38/00 , A61K38/46 , A61P7/02 , C07K14/745 , C12N9/72 , C12N15/09 , C12R1/91 , A61K38/49 , C12N9/50
CPC分类号: C12N9/6459 , C12Y304/21069 , A61K38/00
摘要: The present invention relates to improved plasminogen activators (improved t-PA) which have a prolonged biological half life, an increased stability to heat and acids and can be expected to be effective as inhibiting inflammation around the site in which thrombus is formed.
摘要翻译: 本发明涉及具有延长的生物半衰期,增加的对于热和酸的稳定性的增强的纤溶酶原激活剂(改进的t-PA),并且可以预期作为抑制形成血栓的部位周围的炎症是有效的。
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公开(公告)号:US4656262A
公开(公告)日:1987-04-07
申请号:US808680
申请日:1985-12-13
申请人: Takashi Osono , Yoshihiko Oka , Shunichi Watanabe , Takeshi Saito , Hiroshi Gushima , Keisuke Murakami , Isao Takahashi , Hiroshi Yamaguchi , Toshio Sasaki , Kiyoshi Susaki , Shuichi Takamura , Toshiaki Miyoshi
发明人: Takashi Osono , Yoshihiko Oka , Shunichi Watanabe , Takeshi Saito , Hiroshi Gushima , Keisuke Murakami , Isao Takahashi , Hiroshi Yamaguchi , Toshio Sasaki , Kiyoshi Susaki , Shuichi Takamura , Toshiaki Miyoshi
IPC分类号: C07D501/57 , C12P35/08 , C07D501/28 , A61K31/545
摘要: The 7-methoxy-3-heterocyclic thiomethyl cephalosporin derivative possessing excellent antimicrobial activity represented by the general formula ##STR1## wherein R.sup.1 represents ##STR2## group or HOOC-- group, R.sup.2 represents a nitrogen-containing heterocyclic group, and M represents a hydrogen atom or a cation residue forming a salt.
摘要翻译: 具有由通式
表示的优异的抗微生物活性的7-甲氧基-3-杂环硫代甲基头孢菌素衍生物,其中R1表示<或者HOOC-基团,R2表示含氮杂环基,M表示氢原子 或形成盐的阳离子残留物。 -
公开(公告)号:US4259326A
公开(公告)日:1981-03-31
申请号:US097823
申请日:1979-11-27
申请人: Hiroshi Gushima , Shunichi Watanabe , Takeshi Saito , Toshio Sasaki , Hideo Eiki , Yoshihiko Oka , Takashi Osono
发明人: Hiroshi Gushima , Shunichi Watanabe , Takeshi Saito , Toshio Sasaki , Hideo Eiki , Yoshihiko Oka , Takashi Osono
IPC分类号: A61K31/545 , A61K31/546 , A61P31/04 , C07D501/57 , C12P35/08 , C07D501/20
CPC分类号: C12P35/08 , Y10S435/886 , Y10S435/893 , Y10S435/897
摘要: 7.alpha.-Methoxy-3-p-sulfooxy or p-hydroxycinnamoyloxymethyl cephalosporin derivatives which are useful as antibiotics and as intermediates for the production of other 7.alpha.-methoxycephalosporin derivatives.
摘要翻译: 7α-甲氧基-3-对磺基氧基或对羟基肉桂酸氧甲基头孢菌素衍生物,其可用作抗生素和用作生产其它7种α-甲氧基头孢菌素衍生物的中间体。
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