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1.发明授权公开(公告)号：US08791159B2
公开(公告)日：2014-07-29
申请号：US12879158
申请日：2010-09-10
申请人： Shinji Nakade , Hirotaka Mizuno , Takeji Ono , Masashi Minami , Hiroshi Saga , Hiroshi Hagiya , Takaki Komiya , Hiromu Habashita , Haruto Kurata , Kazuhiro Ohtsuki , Kensuke Kusumi
发明人： Shinji Nakade , Hirotaka Mizuno , Takeji Ono , Masashi Minami , Hiroshi Saga , Hiroshi Hagiya , Takaki Komiya , Hiromu Habashita , Haruto Kurata , Kazuhiro Ohtsuki , Kensuke Kusumi
IPC分类号： C07C227/36 , A61K31/235 , A61K31/197
CPC分类号： C07C229/36 , A61K31/197 , A61K31/198 , A61K31/397 , A61K31/401 , A61K31/44 , A61K31/445 , A61K45/06 , C07C229/14 , C07C229/22 , C07C229/34 , C07C233/47 , C07C255/16 , C07C255/41 , C07C271/22 , C07C323/12 , C07D205/04 , C07D207/16 , C07D211/62 , C07D211/70 , C07D217/04
摘要： A compound having an ability to bind to an SIP receptor and represented by formula (I), a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like: wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.
摘要翻译： 具有结合SIP受体并由式（I）表示的能力的化合物，其盐，其溶剂合物或其前药可用于预防和/或治疗移植排斥反应，移植物抗宿主病， 自身免疫性疾病，过敏性疾病等：其中环A为环状基团; 环B是可以具有取代基的环状基团; X是其主链中具有1至8个原子的间隔基等; Y是其主链中具有1至10个原子的间隔物等; n为0或1，其中当n为0时，m为1，R 1为氢原子或取代基，n为1时，m为0或1〜7的整数，R 1为取代基，其中， m为2以上，R 1相同或不同。
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2.发明申请Pharmaceutical Composition for Regulation of Pancreatic Juice Secretion Comprising a LPA Receptor Modulator 审中-公开用于调节包含LPA受体调节剂的胰汁分泌的药物组合物公开(公告)号：US20080234230A1
公开(公告)日：2008-09-25
申请号：US12112538
申请日：2008-04-30
申请人： Shinji Nakade , Hiroshi Saga
发明人： Shinji Nakade , Hiroshi Saga
IPC分类号： A61K31/685 , A61K31/42 , A61P1/18
CPC分类号： A61K31/661 , A61K31/00 , A61K31/42 , A61K31/66
摘要： Pharmaceutical composition for regulation of pancreatic juice secretion characterized by comprising a lisophosphatidic acid (LPA) receptor modulator. Since an LPA receptor modulator has an effect of regulating the secretion of pancreatic juice, a compound acting on this receptor is useful in treating diseases in association with disorders in pancreatic juice secretion. For example, an LPA receptor agonist is useful in treating and/or preventing pancreatic diseases and obesity, while an LPA receptor antagonist is useful in treating and/or preventing maldigestion, constipation, diarrhea and cibophobia.
摘要翻译： 用于调节胰液分泌的药物组合物，其特征在于包含赖op磷酸（LPA）受体调节剂。 由于LPA受体调节剂具有调节胰液分泌的作用，因此作用于该受体的化合物可用于治疗与胰液分泌紊乱有关的疾病。 例如，LPA受体激动剂可用于治疗和/或预防胰腺疾病和肥胖，而LPA受体拮抗剂可用于治疗和/或预防消化不良，便秘，腹泻和恐怖症。
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3.发明申请公开(公告)号：US20110020324A1
公开(公告)日：2011-01-27
申请号：US12879158
申请日：2010-09-10
申请人： Shinji NAKADE , Hirotaka Mizuno , Takeji Ono , Masashi Minami , Hiroshi Saga , Hiroshi Hagiya , Takaki Komiya , Hiromu Habashita , Haruto Kurata , Kazuhiro Ohtsuki , Kensuke Kusumi
发明人： Shinji NAKADE , Hirotaka Mizuno , Takeji Ono , Masashi Minami , Hiroshi Saga , Hiroshi Hagiya , Takaki Komiya , Hiromu Habashita , Haruto Kurata , Kazuhiro Ohtsuki , Kensuke Kusumi
IPC分类号： A61K31/197 , C07C229/36 , A61K31/198 , C07C229/34 , C07D207/16 , A61K31/401 , A61K31/40 , C07D211/60 , A61K31/445 , C07D211/62 , C07D205/04 , A61K31/397 , A61K31/24 , A61P37/06 , A61P37/08 , A61K31/56 , A61K39/395
CPC分类号： C07C229/36 , A61K31/197 , A61K31/198 , A61K31/397 , A61K31/401 , A61K31/44 , A61K31/445 , A61K45/06 , C07C229/14 , C07C229/22 , C07C229/34 , C07C233/47 , C07C255/16 , C07C255/41 , C07C271/22 , C07C323/12 , C07D205/04 , C07D207/16 , C07D211/62 , C07D211/70 , C07D217/04
摘要： A compound having an ability to bind to an S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6), for example, the compound represented by formula (I) of the present invention, a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like. wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.
摘要翻译： 具有与S1P受体（特别是EDG-6，优选EDG-1和EDG-6）结合的能力的化合物，例如本发明的式（I）表示的化合物，其盐，其溶剂合物 或其前药可用于预防和/或治疗移植排斥反应，移植物抗宿主病，自身免疫性疾病，过敏性疾病等。 其中环A是环状基团; 环B是可以具有取代基的环状基团; X是其主链中具有1至8个原子的间隔物等; Y是其主链中具有1至10个原子的间隔物等; n为0或1，其中当n为0时，m为1，R 1为氢原子或取代基，n为1时，m为0或1〜7的整数，R 1为取代基，其中， m为2以上，R 1相同或不同。
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公开(公告)号：US07381979B2
公开(公告)日：2008-06-03
申请号：US11472387
申请日：2006-06-22
申请人： Tsutomu Yamashita , Shigeji Kaneko , Hiroshi Saga , Norio Takeda
发明人： Tsutomu Yamashita , Shigeji Kaneko , Hiroshi Saga , Norio Takeda
CPC分类号： A61N5/1081 , A61N5/10 , A61N2005/1087
摘要： A rotating irradiation apparatus includes a rotating gantry 3 including a front ring 19 and a rear ring 20 and is provided with a beam delivery device 11 and an irradiation device 4. The beam delivery device 11 delivers an ion beam used for particle radiotherapy. Radial support devices 61A and 61B support the front ring 19 and radial support devices 61A and 61B support the rear ring 20. Each radial support device includes a linear guide 41, an upper support structure disposed above the linear guide 41, and a lower support structure disposed below the linear guide 41. The upper support structure is movably mounted on the lower support structure and is movable in the direction of the rotational axis of the rotating gantry 3.
摘要翻译： 旋转照射装置包括旋转机架3，其包括前环19和后环20，并且设置有射束输送装置11和照射装置4.射束输送装置11输送用于粒子放射治疗的离子束。 径向支撑装置61A和61B支撑前环19，并且径向支撑装置61A和61B支撑后环20.每个径向支撑装置包括线性导向件41，设置在线性导向件41上方的上支撑结构，以及 下支撑结构设置在线性引导件41的下方。上支撑结构可移动地安装在下支撑结构上并且可沿旋转机架3的旋转轴线的方向移动。
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公开(公告)号：US07372053B2
公开(公告)日：2008-05-13
申请号：US11359484
申请日：2006-02-23
CPC分类号： F16D55/40 , A61N5/10 , A61N5/1081 , A61N2005/1087 , F16D2121/12
摘要： A rotating gantry includes a link frame for supporting a plurality of rollers which rotatably support the rotating gantry, a brake for releasing a braking force applied to at least one of the rollers upon supply of air and applying the braking force to the one roller upon discharge of air, and a solenoid valve for sealing the supplied air in the brake when closed, and discharging the air from the brake when opened. The solenoid valve is supported by a solenoid valve support member mounted to the link frame such that the solenoid valve is positioned just near the brake. The rotating gantry can be more quickly braked and stopped while maintaining high irradiation accuracy.
摘要翻译： 旋转机架包括用于支撑可旋转地支撑旋转机架的多个辊的连杆框架，用于在供应空气时释放施加到至少一个辊的制动力的制动器，并且在排出时向一个辊施加制动力 的空气，以及用于在关闭时密封制动器中的供应空气的电磁阀，并且在打开时从制动器排出空气。 电磁阀由安装到连杆架的电磁阀支撑件支撑，使得电磁阀恰好靠近制动器。 旋转机架可以更快地制动和停止，同时保持高的照射精度。
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公开(公告)号：US5972507A
公开(公告)日：1999-10-26
申请号：US998037
申请日：1997-12-23
申请人： Yasuo Morimoto , Noriaki Tsukida , Hiroshi Saga , Hidenao Saito
发明人： Yasuo Morimoto , Noriaki Tsukida , Hiroshi Saga , Hidenao Saito
IPC分类号： G01N33/548 , B01J20/281 , C08B9/00 , C08B16/00 , C08J3/14 , C08L1/00 , G01N30/88 , C08B15/00
CPC分类号： C08J3/14 , C08B16/00 , C08J2301/02 , Y10T428/2982
摘要： A method for producing cellulose beads which are high in sphericity and narrow in bead size distribution. Cellulose beads are produced by supplying a cellulose solution into a rotating vessel which is rotated at high speed by a rotary shaft and has outlets such as small holes and nozzles, flying droplets formed under a centrifugal acceleration of 10 to 1000 G through the outlets that have a diameter of 0.1 to 5.0 mm, and capturing the droplets with a coagulating solution to coagulate the droplets.
摘要翻译： 一种球形度高，珠粒分布窄的纤维素珠粒的制造方法。 纤维素珠通过将纤维素溶液供给到通过旋转轴高速旋转的旋转容器中并且具有诸如小孔和喷嘴的出口，通过具有10至1000G的离心加速度形成的飞沫，通过具有 直径为0.1至5.0mm，并用凝固溶液捕获液滴以使液滴凝结。
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公开(公告)号：US5962005A
公开(公告)日：1999-10-05
申请号：US60332
申请日：1998-04-15
申请人： Hiroshi Saga , Hidenao Saito
发明人： Hiroshi Saga , Hidenao Saito
CPC分类号： B01J13/0065 , A61F2/14 , G02C7/04
摘要： A transparent cellulose hydrogel having a transmittance of visible light of not less than 70%/mm and a tensile strength of not less than 10 kg/cm.sup.2, wherein the hydroxyl groups of cellulose constituting said hydrogel are not chemically crosslinked; and a process for producing a transparent cellulose hydrogel, comprising coagulation and regeneration of cellulose from a cellulose solution using an aqueous solution containing an organic solvent in a proportion of 20-95 wt %. The cellulose hydrogel of the present invention is useful as a raw material of an ophthalmic material, such as soft contact lens, artificial crystal lens, artificial cornea, artificial vitreous body and the like, a carrier of fragrance, and a base of gel and cream, and the like. In addition, the transparent cellulose hydrogel of the present invention has a densely packed and uniform structure, so that it can provide a material of a separation membrane having a small molecular cutoff and high pressure resistance.
摘要翻译： 透明纤维素水凝胶，其可见光透射率不小于70％/ mm，拉伸强度不小于10kg / cm2，其中构成所述水凝胶的纤维素的羟基不进行化学交联; 以及制造透明纤维素水凝胶的方法，其包括使用含有20-95重量％比例的有机溶剂的水溶液从纤维素溶液中凝结和再生纤维素。 本发明的纤维素水凝胶可用作眼科材料的原料，例如软性隐形眼镜，人造晶体镜片，人造角膜，人造玻璃体等，香料载体和凝胶和霜的基质 ，等等。 此外，本发明的透明纤维素水凝胶具有密集且均匀的结构，从而能够提供分子截留小且耐压高的分离膜的材料。
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公开(公告)号：US07961844B2
公开(公告)日：2011-06-14
申请号：US12438029
申请日：2007-08-29
申请人： Norio Takeda , Shigeji Kaneko , Tsutomu Yamashita , Hiroshi Saga
发明人： Norio Takeda , Shigeji Kaneko , Tsutomu Yamashita , Hiroshi Saga
CPC分类号： G21K5/10 , A61N5/10 , A61N5/1081 , A61N2005/1087
摘要： A rotating irradiation therapy apparatus used for particle beam therapy includes a rotating gantry equipped with a charged particle beam irradiation device beam transport devices for guiding a charged particle beam to the irradiation device and a roller in contact with a ring member included in the rotating gantry and supporting the gantry. A front ring is disposed in contact with the roller of a rotating body support device at one end in the axial direction of the rotating gantry, and a rear ring is disposed in contact with the roller at the other end in the axial direction of the rotating gantry. At least one intermediate ring is disposed in a position different in the axial direction of the gantry between the front and rear rings and in contact with the roller.
摘要翻译： 用于粒子束治疗的旋转照射治疗装置包括：装备有带电粒子束照射装置的旋转台架，用于将带电粒子束引导到照射装置的光束传送装置和与包括在旋转台架中的环构件接触的辊; 支撑龙门架。 在旋转机架的轴向的一端设置有与旋转体支撑装置的滚子接触的前环，在旋转轴的轴向的另一端设置有与滚子接触的后环 龙门架 至少一个中间环设置在前后环之间与台架的轴向不同的位置，并与辊接触。
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公开(公告)号：US20100163755A1
公开(公告)日：2010-07-01
申请号：US12438029
申请日：2007-08-29
申请人： Norio Takeda , Shigeji Kaneko , Tsutomu Yamashita , Hiroshi Saga
发明人： Norio Takeda , Shigeji Kaneko , Tsutomu Yamashita , Hiroshi Saga
CPC分类号： G21K5/10 , A61N5/10 , A61N5/1081 , A61N2005/1087
摘要： A rotating irradiation therapy apparatus used for particle beam therapy includes a rotating gantry equipped with a charged particle beam irradiation device beam transport devices for guiding a charged particle beam to the irradiation device and a roller in contact with a ring member included in the rotating gantry and supporting the gantry. A front ring is disposed in contact with the roller of a rotating body support device at one end in the axial direction of the rotating gantry and a rear ring is disposed in contact with the roller at the other end in the axial direction of the rotating gantry. At least one intermediate ring is disposed in a position different in the axial direction of the gantry between the front and rear rings and in contact with the roller.
摘要翻译： 用于粒子束治疗的旋转照射治疗装置包括：装备有带电粒子束照射装置的旋转台架，用于将带电粒子束引导到照射装置的光束传送装置和与包括在旋转台架中的环构件接触的辊; 支撑龙门架。 在旋转机架的轴向的一端设置有与旋转体支撑装置的辊接触的前环，并且在旋转机架的轴向上的另一端设置有与辊接触的后环 。 至少一个中间环设置在前后环之间与台架的轴向不同的位置，并与辊接触。
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公开(公告)号：US20070023699A1
公开(公告)日：2007-02-01
申请号：US11472387
申请日：2006-06-22
申请人： Tsutomu Yamashita , Shigeji Kaneko , Hiroshi Saga , Norio Takeda
发明人： Tsutomu Yamashita , Shigeji Kaneko , Hiroshi Saga , Norio Takeda
IPC分类号： H01J37/08
CPC分类号： A61N5/1081 , A61N5/10 , A61N2005/1087
摘要： A rotating irradiation apparatus includes a rotating gantry 3 including a front ring 19 and a rear ring 20 and is provided with a beam delivery device 11 and an irradiation device 4. The beam delivery device 11 delivers an ion beam used for particle radiotherapy. Radial support devices 61A and 61B support the front ring 19 and radial support devices 61A and 61B support the rear ring 20. Each radial support device includes a linear guide 41, an upper support structure disposed above the linear guide 41, and a lower support structure disposed below the linear guide 41. The upper support structure is movably mounted on the lower support structure and is movable in the direction of the rotational axis of the rotating gantry 3.
摘要翻译： 旋转照射装置包括旋转机架3，其包括前环19和后环20，并且设置有射束输送装置11和照射装置4.射束输送装置11输送用于粒子放射治疗的离子束。 径向支撑装置61A和61B支撑前环19，并且径向支撑装置61A和61B支撑后环20.每个径向支撑装置包括线性导向件41，设置在线性导向件41上方的上支撑结构，以及 下支撑结构设置在线性引导件41的下方。上支撑结构可移动地安装在下支撑结构上并且可沿旋转机架3的旋转轴线的方向移动。
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