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    Stilbene derivative crystal and method for producing the same
    6.
    发明授权
    Stilbene derivative crystal and method for producing the same 失效
    二苯乙烯衍生物晶体及其制造方法

    公开(公告)号：US06784315B2

    公开(公告)日：2004-08-31

    申请号：US10243649

    申请日：2002-09-16

    申请人： Shinichiro Takahashi ,  Yoko Sugawara ,  Hiroyuki Matsueda

    发明人： Shinichiro Takahashi ,  Yoko Sugawara ,  Hiroyuki Matsueda

    IPC分类号： C07C23305

    CPC分类号： A61K31/167 ,  C07C231/24 ,  C07C237/08 ,  C07C237/04

    摘要： A Type IV crystal of (Z)-N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide hydrochloride, which can be produced by crystallization using a solvent containing water at 2% by weight at the maximum and which has a X ray powder diffraction pattern containing peaks at least at 13.4°, 18.7°, 19.4°, and 22.5° (2&thgr;), is provided. This compound is useful as an effective ingredient for a carcinostatic agent. The crystal of the present invention has excellent properties desirable from the standpoint of the production of medicinal products, i.e., reduced water adsorption and extremely high stability to water. Also provided are a method for producing the Type IV crystal thereof and a method for use of the crystal.

    摘要翻译： （Z）-N- [2-甲氧基-5- [2-（3,4,5-三甲氧基苯基）乙烯基]苯基] -L-丝氨酰胺盐酸盐的IV型晶体，其可以通过使用含有 提供最大为2重量％的水，并且其具有含有至少13.4°，18.7°，19.4°和22.5°（2θ）的峰的X射线粉末衍射图。 该化合物可用作制癌剂的有效成分。 本发明的结晶从药物生产的观点出发，具有优异的性能，即减少水分吸附和极高的水稳定性。 还提供了其IV型晶体的制造方法和使用该晶体的方法。