公开(公告)号：US5960756A

公开(公告)日：1999-10-05

申请号：US14101

申请日：1998-01-27

申请人： Eiji Miyachi ,  Hisashi Kodama ,  Yosuke Tateishi

发明人： Eiji Miyachi ,  Hisashi Kodama ,  Yosuke Tateishi

IPC分类号： F01L1/26 ,  F01L13/00

CPC分类号： F01L1/185 ,  F01L1/2405 ,  F01L1/267 ,  F01L13/0005 ,  F01L13/0015 ,  F01L2001/2438

摘要： A valve control device for an internal combustion engine includes a rotational cam shaft disposed on a cylinder head, a first cam provided on the cam shaft, a second cam provided on the cam shaft and having a larger nose portion than that of the first cam, a first rocker arm supported on a first fulcrum so as to be able to oscillate and thereby open or close an intake or exhaust valve by the first cam in response to the rotation of the cam shaft, a second rocker arm supported on a second fulcrum so as to be able to oscillate and thereby open or close an intake or exhaust valve by the second cam in response to the rotation of the cam shaft, and a moving mechanism for selectively moving the second fulcrum so as to control the opening and closing operation of the intake or exhaust valve by the second rocker arm.

摘要翻译： 一种用于内燃机的阀控制装置，包括设置在气缸盖上的旋转凸轮轴，设置在凸轮轴上的第一凸轮，设置在凸轮轴上并具有比第一凸轮更大的鼻部的第二凸轮， 第一摇臂，其支撑在第一支点上，以便能够响应于所述凸轮轴的旋转而由所述第一凸轮振动并由此打开或关闭所述进气门或排气门;第二摇臂支撑在第二支点上， 为了能够响应于凸轮轴的旋转而通过第二凸轮振动并因此打开或关闭进气门或排气阀，以及用于选择性地移动第二支点的移动机构，以便控制开关操作 进气或排气阀由第二摇臂组成。

公开(公告)号：US5441932A

公开(公告)日：1995-08-15

申请号：US25051

申请日：1993-03-02

申请人： Hisashi Kodama ,  Hironobu Hashimoto ,  Yasuhiro Kajihara

发明人： Hisashi Kodama ,  Hironobu Hashimoto ,  Yasuhiro Kajihara

IPC分类号： A61K31/70 ,  A61K31/7008 ,  A61K31/7028 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7064 ,  A61K31/7072 ,  A61K47/48 ,  A61P29/00 ,  A61P37/08 ,  C07H5/06 ,  C07H11/04 ,  C07H13/04 ,  C07H15/04 ,  C07H15/14 ,  C07H17/02 ,  C07H17/04 ,  C07H19/10 ,  C07K14/00 ,  C07K14/76 ,  C07K16/00 ,  A61K31/715 ,  A61K31/72 ,  A61K31/73

CPC分类号： C07H13/04 ,  A61K47/48238 ,  C07H15/04 ,  C07H15/14 ,  C07H17/04

摘要： An inhibitor of the biosynthesis of sugar chains containing sialic acid that is excellent in the suppression of inflammation or allergy, which comprises as an active ingredient a sugar compound of the formula (1): ##STR1## wherein R.sup.1 is a hydrogen atom, a substituted or unsubstituted aliphatic hydrocarbon group, a substituted or unsubstituted aromatic hydrocarbon group, a peptide residue or a glycoprotein, and R.sup.2 is a hydrogen atom, a sulfhydryl group, an acyloxy group, an acylthio group, an aryloxy group, an alkyloxy group or a glycothio residue. The inhibitor of the biosynthesis of sugar chains containing sialic acid may be used as a therapeutic agent for inflammation caused by sugar chains containing sialic acid.

摘要翻译： 包含作为活性成分的式（1）的糖化合物的含有唾液酸的糖链的生物合成抑制剂，其具有优异的抑制炎症或过敏的作用。其中R1是氢原子 取代或未取代的脂族烃基，取代或未取代的芳香族烃基，肽残基或糖蛋白，R2为氢原子，巯基，酰氧基，酰基硫基，芳氧基，烷氧基 或糖硫醇残基。 含有唾液酸的糖链的生物合成的抑制剂可以用作由含唾液酸的糖链引起的炎症的治疗剂。

公开(公告)号：US4635593A

公开(公告)日：1987-01-13

申请号：US717277

申请日：1985-03-28

申请人： Hisashi Kodama

发明人： Hisashi Kodama

IPC分类号： F01L1/24 ,  F01L1/25

CPC分类号： F01L1/25

摘要： A hydraulic valve lifter is used in the valve train of an internal combustion engine to take up the lash on operating clearance in the valve train. The valve lifter is comprised of a first cylindrical body member having a top wall, a second cylindrical body member slidably mounted within the first body member and having a bottom wall, a plunger member slidably mounted within the second body member for defining a reservoir chamber and a pressure chamber, a guide member of thick, rigid material fixed in the first body member for guiding the second body member, and a channel member of thin light weight material fixed between the first body member and the guide member for defining an oil channel connected to the reservoir chamber.

摘要翻译： 在内燃机的气门机构中使用液压气门挺杆，以便在气门机构中的操作间隙上起到间隙。 阀提升器包括具有顶壁的第一圆柱形主体构件，可滑动地安装在第一主体构件内并具有底壁的第二圆柱形本体构件，可滑动地安装在第二主体构件内用于限定储存室的柱塞构件， 压力室，固定在第一主体构件中的用于引导第二主体构件的厚的刚性材料的引导构件以及固定在第一主体构件和引导构件之间的薄重量轻材料的通道构件，用于限定连接的油道 到储存室。

公开(公告)号：US4541374A

公开(公告)日：1985-09-17

申请号：US563246

申请日：1983-12-19

申请人： Hisashi Kodama

发明人： Hisashi Kodama

IPC分类号： F01L1/24 ,  F01L1/245

CPC分类号： F01L1/245

摘要： A hydraulic lifter for an internal combustion engine which includes a cylindrical body installed horizontally or nearly horizontally, having an oil inlet port on the surface of the body; a plunger slidably inserted into the body; a push rod seat inserted into one end of the body in contact with the plunger, having an oil outlet port; an oil reservoir formed by the plunger and a push rod seat; a pressure chamber formed by the internal wall of the body and the end face of the plunger in the other end of the body; a hole for the oil to flow in and out of the reservoir, provided in the vicinity of the junction between the plunger and the push rod seat; a first groove provided on the other surface of the plunger forming at least one turn around the plunger, to connect the oil inlet port mounted on the body with the hole for the oil to flow in and out of the reservoir; and a second groove provided on the outer surface of the push rod seat forming at least one turn around the push rod seat, to connect the hole for the oil to flow in and out of the reservoir with the oil outlet port mounted on the push rod seat.

摘要翻译： 一种用于内燃机的液压升降器，包括水平或几乎水平安装的圆柱体，在主体表面上具有进油口; 可滑动地插入到所述主体中的柱塞; 插入到与柱塞接触的主体的一端中的推杆座，具有出油口; 由所述柱塞和推杆座形成的储油器; 由所述主体的内壁和所述主体的另一端的所述柱塞的端面形成的压力室; 设置在柱塞和推杆座之间的接合处附近的用于油流入储存器的孔的孔; 设置在所述柱塞的另一个表面上的第一槽，其形成围绕所述柱塞的至少一个转弯，以将安装在所述主体上的所述油入口与所述油孔连通以流入和流出所述储存器; 以及设置在所述推杆座的外表面上的第二槽，其围绕所述推杆座形成至少一个转动，以将所述油的孔连接到所述储存器中并流入所述储存器，所述出油口安装在所述推杆上 座位。

公开(公告)号：US4535734A

公开(公告)日：1985-08-20

申请号：US473421

申请日：1983-03-09

申请人： Hisashi Kodama ,  Tooru Hamamoto ,  Tetsuomi Tamura ,  Katsujiro Sato ,  Kazuharu Yamada

发明人： Hisashi Kodama ,  Tooru Hamamoto ,  Tetsuomi Tamura ,  Katsujiro Sato ,  Kazuharu Yamada

IPC分类号： F01L1/24 ,  F01L1/245

CPC分类号： F01L1/245 ,  F01L2109/00

摘要： A self-contained hydraulic lash adjuster having a cup-shaped body and a plunger slidably disposed therein is further provided with a flexible diaphragm secured within a reservoir chamber located in the plunger with one side of said diaphragm being exposed to the atmosphere and the other side being disposed in engagement with the oil supply sealed within the hydraulic lash adjuster. An oil passage is provided in the bottom of the plunger to communicate the reservoir chamber with a pressure chamber defined between the bottom of the plunger and the bottom of the body and a one-way check valve is provided to prevent the return flow of oil through the oil passage to the reservoir. A cup-shaped cover member having apertured side walls is located in the bottom of the plunger over the oil passage to prevent the diaphragm from blocking the oil passage upon deformation of the diaphragm.

摘要翻译： 具有杯形主体和可滑动地设置在其中的活塞的独立液压间隙调节器还设置有固定在位于柱塞中的储存室内的柔性隔膜，所述隔膜的一侧暴露于大气，另一侧 与密封在液压间隙调节器内的油源配合。 在柱塞的底部设有油通道，以将储存室与定位在柱塞底部和主体底部之间的压力室连通，并提供单向止回阀以防止油通过 通往油藏的油路。 具有多孔侧壁的杯形盖构件位于油路的柱塞的底部，以防止膜片在隔膜变形时堵塞油路。

公开(公告)号：US4338894A

公开(公告)日：1982-07-13

申请号：US229750

申请日：1981-01-29

申请人： Hisashi Kodama

发明人： Hisashi Kodama

IPC分类号： F01L1/24

CPC分类号： F01L1/2405 ,  F01L2109/00

摘要： A self-contained hydraulic lash adjuster which does not depend upon any external source of hydraulic fluid in operation is used in the valve trains of internal combustion engines or similar mechanisms in order to take up the lash or operating clearance in the valve trains. In the lash adjuster a transmitting member such as a fulcrum is engaged with a plunger which is slidably mounted in a bore of a lash adjuster body. A clearance is provided between the transmitting member and the body which is smaller than the clearance provided between the transmitting member and the plunger to reduce the frictional wear between the plunger and the body.

摘要翻译： 在内燃机或类似机构的阀门系列中使用独立的液压间隙调节器，其不依赖于操作中的任何外部液压流体源，以便吸收阀门列中的间隙或操作间隙。 在间隙调节器中，诸如支点的传递构件与可滑动地安装在间隙调节器本体的孔中的柱塞接合。 在传动构件和主体之间设置有间隙，其小于设置在传递构件和柱塞之间的间隙，以减小柱塞和主体之间的摩擦磨损。

公开(公告)号：US4191142A

公开(公告)日：1980-03-04

申请号：US880519

申请日：1978-02-23

申请人： Hisashi Kodama

发明人： Hisashi Kodama

IPC分类号： F01L1/24 ,  F01L1/245

CPC分类号： F01L1/245 ,  F01L2109/00

摘要： A self-contained hydraulic lash adjuster, which does not depend upon any external source of hydraulic fluid in operation, is used in the valve trains of internal combustion engines in order to take up the lash or operating clearance in the valve trains. The lash adjuster comprises a cylinder member, a plunger member slidably fitted therein, said cylinder and plunger members defining a fluid pressure chamber between each end wall thereof, said plunger member forming a reservoir chamber therewithin, and an elastic bag member disposed within the reservoir chamber, the inner wall surface of said elastic bag member being normally in communication with atmospheric pressure while the outer wall surface thereof being normally in contact with the fluid in the reservoir chamber.

摘要翻译： 在内燃机的阀门列中使用独立的液压间隙调节器，其不依赖于操作中的任何外部液压流体源，以便吸收阀门列中的间隙或操作间隙。 间隙调节器包括气缸构件，可滑动地装配在其中的柱塞构件，所述气缸和柱塞构件在其每个端壁之间限定流体压力室，所述柱塞构件在其中形成储存室，弹性袋构件设置在储存室内 所述弹性袋部件的内壁面通常与大气压连通，同时其外壁面通常与储存室内的流体接触。

公开(公告)号：US5908766A

公开(公告)日：1999-06-01

申请号：US741663

申请日：1996-10-31

申请人： Takeshi Yamamoto ,  Motoko Nakashizuka ,  Ichiro Terada ,  Hisashi Kodama

发明人： Takeshi Yamamoto ,  Motoko Nakashizuka ,  Ichiro Terada ,  Hisashi Kodama

IPC分类号： C12N9/10 ,  C12P19/26 ,  C12R1/01 ,  C12P19/18 ,  C12P19/04 ,  C12P19/44

CPC分类号： C12N9/1081 ,  C12P19/26

摘要： Described is a method of production of saccharides containing sialic acid, wherein .beta.-galactoside-.alpha.-2,6-sialyltransferase is used for linking sialic acid to the 6-position of a galactose residue in a sugar chain of a glycoconjugate or the 6-position of a galactose residue in a free sugar chain, or to the 6-position of a monosaccharide having a hydroxyl group on carbon at the 6-position and being capable of forming an oligosaccharide or a glycoconjugate.

摘要翻译： 描述了一种生产含有唾液酸的糖的方法，其中使用β-半乳糖苷-α-2,6-唾液酸转移酶将唾液酸与糖缀合物的糖链中的半乳糖残基的6-位连接， 在游离糖链中的半乳糖残基的位置，或6-位上具有羟基的单糖的6-位，并且能够形成寡糖或糖缀合物。

公开(公告)号：US5762265A

公开(公告)日：1998-06-09

申请号：US720958

申请日：1996-10-04

申请人： Tomoko Kitamura ,  Shigeaki Matsubayashi ,  Yasuyuki Shintani ,  Hisashi Kodama

发明人： Tomoko Kitamura ,  Shigeaki Matsubayashi ,  Yasuyuki Shintani ,  Hisashi Kodama

IPC分类号： F24F11/00 ,  G05D23/19 ,  G05D23/00

CPC分类号： G05D23/1917 ,  F24F11/006 ,  F24F2011/0057

摘要： Complaint rate calculation means for calculating complaint rates in consideration of thermal feeling entered from vote value input means, a data storage unit for storing complaint rates together with indoor thermal conditions, updating means for calculating a function representing the relationship between thermal conditions and complaint rates in accordance with stored data, and predicted thermal condition calculation means for calculating thermal setting values by substituting entered control information into the function representing the relationship between thermal conditions and complaint rates, can convert a complaint vote of each inhabitant to a characteristic thermal feeling of a group so as to directly reflect the feeling on air-conditioning control.

摘要翻译： 投诉率计算装置，用于考虑从投票价值输入装置输入的热感觉来计算投诉率;数据存储单元，用于将投诉率与室内热条件一起存储;更新装置，用于计算代表热条件和投诉率之间的关系的函数 根据存储的数据，以及预测热条件计算装置，用于通过将输入的控制信息代入表示热条件和投诉率之间的关系的函数来计算热定值，可以将每个居民的投诉投票转换为组的特征热感 以直接反映空调控制的感觉。

公开(公告)号：US5621086A

公开(公告)日：1997-04-15

申请号：US530255

申请日：1995-08-31

申请人： Yasuhiro Kajihara ,  Takashi Ebata ,  Hisashi Kodama

发明人： Yasuhiro Kajihara ,  Takashi Ebata ,  Hisashi Kodama

IPC分类号： C07H19/10 ,  C07H13/00 ,  A61K31/70 ,  C07H15/00

CPC分类号： C07H19/10

摘要： The present invention is drawn to methods of manufacturing a sialic acid derivative suitable for industrial production. With a method of the present invention, Tetra-O-acetylsialic acid (4a) and acetylcytidine-5'-O-amidite (5a) are condensed in the presence of an acid catalyst to obtain a phosphite (6a). The phosphite (6a) is oxidized with t-butylhydroperoxide to obtain a phosphate (9a). The phosphate (9a) is deprotected with an alkali to obtain CMP-sialic acid (1a). ##STR1## The present invention further encompasses a novel sialic acid derivative.

摘要翻译： PCT No.PCT / JP95 / 00418 Sec。 371日期1995年8月31日 102（e）日期1995年8月31日PCT 1995年3月14日PCT PCT。 公开号WO95 / 25115 PCT 日期1995年9月21日本发明涉及制造适用于工业生产的唾液酸衍生物的方法。 利用本发明的方法，在酸催化剂存在下，将四-O-乙酰唾液酸（4a）和乙酰胞苷-5'-O-脒（5a）缩合得到亚磷酸酯（6a）。 亚磷酸酯（6a）被叔丁基过氧化氢氧化，得到磷酸盐（9a）。 磷酸盐（9a）用碱去保护，得到CMP-唾液酸（1a）。 （1a）本发明还包括一种新的唾液酸衍生物。